LOCUS       NM_002585               7087 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens PBX homeobox 1 (PBX1), transcript variant 1, mRNA.
ACCESSION   NM_002585
VERSION     NM_002585.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7087)
  AUTHORS   Huang,N., Zhang,H., Huang,Z., Wu,X., Zhang,N., Jiang,Y., Chen,C.
            and Zhuang,J.
  TITLE     Whole Exome Sequencing Revealing a Novel PBX1 Gene Variant in a
            Chinese Family Causing Recurrent Neonatal Death
  JOURNAL   Birth Defects Res 116 (8), e2396 (2024)
   PUBMED   39189629
  REMARK    GeneRIF: Whole Exome Sequencing Revealing a Novel PBX1 Gene Variant
            in a Chinese Family Causing Recurrent Neonatal Death.
REFERENCE   2  (bases 1 to 7087)
  AUTHORS   Choi,S.C., Park,Y.P., Roach,T., Jimenez,D., Fisher,A., Zadeh,M.,
            Ma,L., Sobel,E.S., Ge,Y., Mohamadzadeh,M. and Morel,L.
  TITLE     Lupus susceptibility gene Pbx1 controls the development, stability,
            and function of regulatory T cells via Rtkn2 expression
  JOURNAL   Sci Adv 10 (13), eadi4310 (2024)
   PUBMED   38536923
  REMARK    GeneRIF: Lupus susceptibility gene Pbx1 controls the development,
            stability, and function of regulatory T cells via Rtkn2 expression.
REFERENCE   3  (bases 1 to 7087)
  AUTHORS   Kao,T.W., Chen,H.H., Lin,J., Wang,T.L. and Shen,Y.A.
  TITLE     PBX1 as a novel master regulator in cancer: Its regulation,
            molecular biology, and therapeutic applications
  JOURNAL   Biochim Biophys Acta Rev Cancer 1879 (2), 189085 (2024)
   PUBMED   38341110
  REMARK    GeneRIF: PBX1 as a novel master regulator in cancer: Its
            regulation, molecular biology, and therapeutic applications.
            Review article
REFERENCE   4  (bases 1 to 7087)
  AUTHORS   Zhang,L., Guo,H., Zhang,X., Wang,L., Wei,F., Zhao,Y., Wang,B.,
            Meng,Y. and Li,Y.
  TITLE     Small nucleolar RNA Snora73 promotes psoriasis progression by
            sponging miR-3074-5p and regulating PBX1 expression
  JOURNAL   Funct Integr Genomics 24 (1), 15 (2024)
   PUBMED   38240925
  REMARK    GeneRIF: Small nucleolar RNA Snora73 promotes psoriasis progression
            by sponging miR-3074-5p and regulating PBX1 expression.
            Erratum:[Funct Integr Genomics. 2024 Jan 30;24(1):21. doi:
            10.1007/s10142-024-01306-1.. PMID: 38286903]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7087)
  AUTHORS   Wen,Y., Chen,H., Wang,Y., Sun,Y., Dou,F., Du,X., Liu,T. and Chen,C.
  TITLE     Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human
            peripheral blood serve as potential biomarkers for the assessment
            and prediction of vascular aging
  JOURNAL   Hereditas 161 (1), 3 (2024)
   PUBMED   38173016
  REMARK    GeneRIF: Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from
            human peripheral blood serve as potential biomarkers for the
            assessment and prediction of vascular aging.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7087)
  AUTHORS   Lu,Q., Knoepfler,P.S., Scheele,J., Wright,D.D. and Kamps,M.P.
  TITLE     Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively
            with the products of multiple murine Hox genes, some of which are
            themselves oncogenes
  JOURNAL   Mol Cell Biol 15 (7), 3786-3795 (1995)
   PUBMED   7791786
REFERENCE   7  (bases 1 to 7087)
  AUTHORS   Monica,K., Galili,N., Nourse,J., Saltman,D. and Cleary,M.L.
  TITLE     PBX2 and PBX3, new homeobox genes with extensive homology to the
            human proto-oncogene PBX1
  JOURNAL   Mol Cell Biol 11 (12), 6149-6157 (1991)
   PUBMED   1682799
REFERENCE   8  (bases 1 to 7087)
  AUTHORS   Hunger,S.P., Galili,N., Carroll,A.J., Crist,W.M., Link,M.P. and
            Cleary,M.L.
  TITLE     The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1
            coding sequences in acute lymphoblastic leukemias
  JOURNAL   Blood 77 (4), 687-693 (1991)
   PUBMED   1671560
REFERENCE   9  (bases 1 to 7087)
  AUTHORS   Kamps,M.P., Murre,C., Sun,X.H. and Baltimore,D.
  TITLE     A new homeobox gene contributes the DNA binding domain of the
            t(1;19) translocation protein in pre-B ALL
  JOURNAL   Cell 60 (4), 547-555 (1990)
   PUBMED   1967983
REFERENCE   10 (bases 1 to 7087)
  AUTHORS   Nourse,J., Mellentin,J.D., Galili,N., Wilkinson,J., Stanbridge,E.,
            Smith,S.D. and Cleary,M.L.
  TITLE     Chromosomal translocation t(1;19) results in synthesis of a
            homeobox fusion mRNA that codes for a potential chimeric
            transcription factor
  JOURNAL   Cell 60 (4), 535-545 (1990)
   PUBMED   1967982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359255.12, DB270853.1,
            DA760179.1, BC101578.1, AK291415.1, BX647313.1, DA483403.1,
            AK022962.1, AL390119.25 and AL049381.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 31, 2019 this sequence version replaced NM_002585.3.
            
            Summary: This gene encodes a nuclear protein that belongs to the
            PBX homeobox family of transcriptional factors. Studies in mice
            suggest that this gene may be involved in the regulation of
            osteogenesis and required for skeletal patterning and programming.
            A chromosomal translocation, t(1;19) involving this gene and
            TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic
            leukemia. The resulting fusion protein, in which the DNA binding
            domain of E2A is replaced by the DNA binding domain of this
            protein, transforms cells by constitutively activating
            transcription of genes regulated by the PBX protein family.
            Alternatively spliced transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Jun
            2017].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the longest isoform (1, also known as
            isoform PBX1a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK291415.1, M86546.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000420696.7/ ENSP00000405890.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AL359255.12        7160-7335
            177-449             DB270853.1         2-274
            450-450             AL359255.12        7609-7609
            451-767             DA760179.1         235-551
            768-1962            BC101578.1         181-1375
            1963-2249           AK291415.1         1469-1755
            2250-2744           BX647313.1         2670-3164
            2745-3054           DA483403.1         338-647
            3055-3499           BX647313.1         3475-3919
            3500-3591           AK022962.1         506-597
            3592-4925           BX647313.1         4012-5345
            4926-7041           AL390119.25        14712-16827
            7042-7086           AL049381.1         2226-2270
            7087-7087           AL390119.25        16873-16873
FEATURES             Location/Qualifiers
     source          1..7087
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..7087
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="PBX homeobox 1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:HGNC:8632"
                     /db_xref="MIM:176310"
     exon            1..830
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     CDS             640..1932
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pre-B-cell leukemia transcription factor 1; homeobox
                     protein PRL; homeobox protein PBX1; pre-B-cell leukemia
                     homeobox 1"
                     /codon_start=1
                     /product="pre-B-cell leukemia transcription factor 1
                     isoform 1"
                     /protein_id="NP_002576.1"
                     /db_xref="CCDS:CCDS1246.1"
                     /db_xref="GeneID:5087"
                     /db_xref="HGNC:HGNC:8632"
                     /db_xref="MIM:176310"
                     /translation="MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIG
                     DILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTD
                     PQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQI
                     YHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQS
                     TCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGIT
                     VSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGS
                     SSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQ
                     MYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN"
     exon            831..904
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1149
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1340
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1476
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1636
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1749
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..1839
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..7087
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2306..2311
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AATAAA"
     polyA_site      2329
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="major polyA site"
     regulatory      3728..3733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AATAAA"
     regulatory      3756..3761
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AATAAA"
     polyA_site      3761
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="major polyA site"
     polyA_site      3778
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="major polyA site"
     regulatory      5296..5301
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AAGAAA"
     polyA_site      5316
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="major polyA site"
     regulatory      5342..5347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AATAAA"
     polyA_site      5361
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
     regulatory      6748..6753
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
                     /note="hexamer: AATAAA"
     polyA_site      6765
                     /gene="PBX1"
                     /gene_synonym="CAKUHED"
ORIGIN      
        1 aaacaaaagc aggaggctga cggggctgct ggagtttgca gagacacgga ggaggagaga
       61 gcctgtgctt tgcctgccgc cgcggctggg ggagatctgg cttttgcaac agcccacccc
      121 ctttgagatc actctggccc ggagtggggg tggggggcag cggggggtgg ggggggaaag
      181 tttgcattgc aatccccctg ccttcctctc ctttctcccg atcaatgcat atttgcaaaa
      241 ggattaagcc acagatttaa gcgccgggag cccatttctg ccttgcaaag gagaccggac
      301 tgaaaaacct aaagccagct ctgatttctt ttcgccaagt gggaaggtgg tttatttttc
      361 ttgctttttg gagtcaacac ccttccccac cagcccttat ccccaccctc accccgcaac
      421 cccttcacgc cccctccccc tccccctcct catcctccca ccatcctcta aagaggcaaa
      481 gggatttttt ttttcttttg gtcttctttt ttcccccttc cctgtttatc ctgaaaagga
      541 tttgaagaca agcttgaagg ataaaaagcc ttggtgcttc ccaggagccg agccgaggag
      601 cagaagagga agagccgggg gctgccgtag cctttggaga tggacgagca gcccaggctg
      661 atgcattccc atgctggggt cgggatggcc ggacaccccg gcctgtccca gcacttgcag
      721 gatggggccg gagggaccga gggggagggc gggaggaagc aggacattgg agacatttta
      781 cagcaaatta tgaccatcac agaccagagt ttggatgagg cgcaggccag aaaacatgct
      841 ttaaactgcc acagaatgaa gcctgccttg tttaatgtgt tgtgtgaaat caaagaaaaa
      901 acagttttga gtatccgagg agcccaggag gaggaaccca cagaccccca gctgatgcgg
      961 ctggacaaca tgctgttagc ggaaggcgtg gcggggcctg agaagggcgg agggtcggcg
     1021 gcagcggcgg cagcggcggc ggcttctgga ggggcaggtt cagacaactc agtggagcat
     1081 tcagattaca gagccaaact ctcacagatc agacaaatct accatacgga gctggagaaa
     1141 tacgagcagg cctgcaacga gttcaccacc cacgtgatga atctcctgcg agagcaaagc
     1201 cggaccaggc ccatctcccc aaaggagatt gagcggatgg tcagcatcat ccaccgcaag
     1261 ttcagctcca tccagatgca gctcaagcag agcacgtgcg aggcggtgat gatcctgcgt
     1321 tcccgatttc tggatgcgcg gcggaagaga cggaatttca acaagcaagc gacagaaatc
     1381 ctgaatgaat atttctattc ccatctcagc aacccttacc ccagtgagga agccaaagag
     1441 gagttagcca agaagtgtgg catcacagtc tcccaggtat caaactggtt tggaaataag
     1501 cgaatccggt acaagaagaa cataggtaaa tttcaagagg aagccaatat ttatgctgcc
     1561 aaaacagctg tcactgctac caatgtgtca gcccatggaa gccaagctaa ctcgccctca
     1621 actcccaact cggctggttc ttccagttct tttaacatgt caaactctgg agatttgttc
     1681 atgagcgtgc agtcactcaa tggggattct taccaagggg cccaggttgg agccaacgtg
     1741 caatcacagg tggataccct tcgccatgtt atcagccaga caggaggata cagtgatgga
     1801 ctcgcagcca gtcagatgta cagtccgcag ggcatcagtg ctaatggagg ttggcaggat
     1861 gctactaccc cttcatcagt gacctcccct acagaaggcc ctggcagtgt tcactctgat
     1921 acctccaact gatctcccag caatcgcatc ccggctgacc ctgtgcccca gttggggcag
     1981 gggcaggagg gagggtttct ctcccaacgc tgaagcggtc agactggagg tcgaagcaat
     2041 cagcaaacac aataagagtc tccttctctt ctcttctttg ggatgctatt tcagccaatc
     2101 tggacacttc tttatactct cttccctttt ttttctgggt agaagccacc cttccctgcc
     2161 tccagctgtc agcctggttt tcgtcatctt ccctgcccct gtgcctctgt cctagactcc
     2221 cggggtcccc gccctctctc atatcactga aggatatttt caacaattag aggaatttaa
     2281 agaggaaaaa aattacaaag aaaataataa aagtgtttgt acgttttcat gctggtggtt
     2341 tgaggagcca aatttacctc actcgaatcc ctcactccct atgttaacag gcaatccttc
     2401 tctgtttctc ttattactct cactacctct tagcaggaat actccacatt gccctattca
     2461 ttccaggcct ccctgcttcc tcttgctctt cctccctggg gacagtactg attggaacac
     2521 tttcctcctc ttccttccta gccccagcta ttcactgggg actgtcatag ctgggattct
     2581 aaaggtgcca catttttcag tttcatctcc actaggttgg ttcccgggca ggaagtcagg
     2641 cagcagggaa ggacacggga acagcaggtg gagaattcct acagtctttc ttaccctgct
     2701 agcaatagct ctcagtttca gaggcacagt ctttggagac cattcagcac tgagaaagca
     2761 atatttagaa cctattgcaa aactgggcct gagttaggca tggtgatgaa tgcatcagca
     2821 aggaatagaa agttcttatc gtgaaaccct tcaacctcaa ctatgccttc atagacacac
     2881 acgttcatgc acatgtaggc acatgtacca tctcacatct tcactttccc gagatgccat
     2941 atacaattac ctacattaat aactgtagca ctatgccttt tgagcccgag agagggaatt
     3001 agtgactcta agtgaaggtc actgacacag agaagcagta tgtgtctggg gcttccagga
     3061 cctgcaggcc cactagcgtg cacttaccag aatggcatac acaggacctg atcatgagga
     3121 agaccaggtt tccagtgtaa actactcttg ttcccaccac ctctggagca ctcagggagc
     3181 cccatacagt acttacaatg tctttaatgg acttgattct gtttaatttt ttgttttata
     3241 ttaggcacac tgtattaatt ttccaaaatg ttataccaca ctatgttctt ggtcctgacc
     3301 tattgctctg gaggaaagag ttgtataaga acgtggctca tgtgaacttt tgctagcttc
     3361 atttgaggac ctgagaatca tggggaaagg gaaggtaatg ttttcattga aatcatcaca
     3421 gtgattttta ttccctggga acacagcgtg tactaaaaat acatgagaaa atagcatgta
     3481 tatgaaagct attctcaaaa gtcacctgag ctcaccatct tcatagccaa ccctaccagt
     3541 tataaagatg gcagctctat cacttgatta agtgggaggt ggtcaaatat tttggtgcct
     3601 cattttcttc atctgtgaga tgggaactgt tatgcctggc ttactaagag tcttgtgaga
     3661 gactgagaag ttgattttgt tcatatccaa tctgtaaatg cgaagtcagg ggaagtaatg
     3721 tccctgaaat aaacgggttc atgccatcta gggacaataa atggttttct tgttgtaact
     3781 tctggttaat atcagtacct tgatgtcatc accgtgatga caaagagaag agttattgtt
     3841 gatcttcttg gttttggtct gtctcttttc ttaggataaa gaaaaacttc caaactagaa
     3901 aaacaggccc tggttccctt agtttgcact tgaacccaat atgttgcctt gtacatactt
     3961 ggtccctgtc acattgactg cttgggaggc ttccagggag aagtatgaga ccctgagggg
     4021 tgagaatggg cagctagcaa gaacatggaa attctgcttg gcactacagt cataaataga
     4081 aaacactgtg tgtgctcagg ggagcagggg atgccactga agaaactcaa gggaatgtgt
     4141 atttgaagga aatgcaaaaa ctaagtattt agcaaaatga aattatgcct tgatgactaa
     4201 aaggcactag aaaggttgtg tctactaact tcagccctaa tcagaacaga tgcctagaag
     4261 gagcattttt gtgacaactt catagtgatt agaatcagtg gagaactcca tcttagtggc
     4321 aggaatataa tgaaactacc cacgcaagaa catggttgaa tcacatttgc ttgacttagg
     4381 gcaaagtacg aaagagagac aaaagggttc tcttggaaac aagaagagtg actccagatg
     4441 tggcctgaat aattgccatg ttaagttaat gcaaaagatc agaacagggc tacatttgca
     4501 caggcagttt ctctccgggc cgtagttttc actgatgatc acctttcaca gcattttccc
     4561 caaccagcat ttcacttagt cttctctata cccagcacct cccccggcac ccccggcaag
     4621 cccactatca cttccgactt ccaacgtggc atccgtgaga tctgtccaca ttaggcgaag
     4681 caggagaaca ctgagagcag caggatgggt ttggaaagag catgcctctg gaaacacagc
     4741 ttcctgggaa ttcacatgag gccagtccta cagagagcaa gatgcacccc aggatttctt
     4801 cattttctaa tagatgtggg agtgctccat tttccccgac agcgaatttc ccctgagaaa
     4861 cgatactaga ccctgggttt gcccaccttg taactcttcc ttatctcctc cttttcatcc
     4921 ctaatccatc ctccctctgg catggaattg acgcccgtgc agtacatttg ccaagtggca
     4981 ccttctttca atttatgttt tattttgcta tggtggtgat tctttatttg ctggttgtct
     5041 tttctcacac atctttctct ctgtctctct ctttcctgct ctttgttttt ctgcccagaa
     5101 aaacctgact tcgataccaa aaaagatgaa actacagaaa ctcaaattta aaaaaaactt
     5161 taaaagaaac aaaaaaatac tcaacgattc tttcagcttt attaacattt tccattgttt
     5221 cttgcgactt gtgtctcgtt ctttgtagta ttgatgatga acatttgata atgaatgttc
     5281 ttgtatattc agataaagaa aaaaaaaacc aaaaaagcgg tctgaattta atagtgttta
     5341 taataaaaat tttaaaaatg accctcatag cacgcaaaac aggatgggga atttcccctc
     5401 ttctttctgt gacaatgcgc atcattcctg cattagtttt taacaccaga ctacctacat
     5461 tcatcatttc cctcattttt cttttatttt cttgcatttg tgaattagtt caagaatgct
     5521 agaaaagtgt cgagttgtgc acatccattt cttgtttcac aatgtttaaa agtgacagta
     5581 attcattttg taaactaaaa aaaaaaaaaa aaaggttgga atagtgagca taataggtac
     5641 aacctaacac attattatgt ttattaactt tgagacccag aaataaattc ttttcttttc
     5701 ttgattcttg ctcttaaaaa tacaaaaaaa aaaatgtttt gttttgtgtt atttttggtt
     5761 tgtttattgg ggggcttttt ttaattgtca ggattatgat cttgctgttt ttcttcaata
     5821 tgtatacaag gtgatgtgaa aagatgactt gggcagagga gtaagaacaa gtaggcttgt
     5881 tcttctactt tgcttcagaa ttcagttaat gccaaaagcg aagatcaagc ccatgttgat
     5941 gtctcgttgc tcacctgcat ttccagagag tgtgacactc atgcagtccc tgagaaaaat
     6001 aaaatcaggg acatacttct ccttttagcc ttttaaaaat tcaaaaacgt ttagtccaag
     6061 ggaacttttt atgctatcag gaaaggtttt tgctgttttt gattctgatt atcacagcca
     6121 agtactttgt tttatttctc cctaattaat aactacattc catgaggcct cttccaacca
     6181 aagaggcctt ttcttccagg agagtcccgc aggagatgct ggtatgatgg gcaccattgg
     6241 ttaagtaaac tacatgcagg aagaagtcct tggggccagt ctgccagctg agtcctggtt
     6301 ttggatgaag agttaatgag atattgggcc aggctcaatg ctgtagtttt aatgctaaga
     6361 ggttacgttt acttcacaga gtacacctct tagtaacctc tgacttaggc agctgcttaa
     6421 agcaaattgc aaaactggct tgatttggaa tgtttttatt agaggaaaaa agaaagccat
     6481 attatctgga aaaaaattca ttttaaatac catcattcaa caaattatgt tcagaaagtg
     6541 gtcagaactt aagcaagaaa agtaaagaaa gaatgcagaa ttgtggagca atgctttagg
     6601 aaatatttct acctgaacac ttgtactctt gaagtcacaa caaaataatg atgagctttt
     6661 cacatcacct ttatggtttc aatccctagc tcaaagcttc ctggaatctt ttattttttg
     6721 taaacttttt tttcttttgt taaaataaat aaaacattca atgtttttct ccttttctct
     6781 cttattactt ctttcctttg gcattttcaa tttgaaatgc tttcctttgg ttgttggttt
     6841 tattctcccc ctacccctcc ccttttctta ttattcagaa tataaacctg caaagctctg
     6901 ctctgttttg gttttgaaag tttaagcttt tctgcttctg tgagagcaca ggcttctgtc
     6961 ccttttgatt ccaactgaac ttttgtgttc tctaatgata ctaacacggt gtaggtttta
     7021 cagtctccta atttgtactg gtaatgcata ttccaaataa atagtttctt ttgttgcaaa
     7081 aaaaaat
//
