LOCUS       NM_021635               2506 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens prostate and breast cancer overexpressed 1 (PBOV1),
            mRNA.
ACCESSION   NM_021635
VERSION     NM_021635.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Dong,H., Huang,C. and Huang,J.
  TITLE     FBXL19-AS1 promotes the progression of nasopharyngeal carcinoma by
            acting as a competing endogenous RNA to sponge miR-431 and
            upregulate PBOV1
  JOURNAL   Mol Med Rep 24 (3) (2021)
   PUBMED   34278444
  REMARK    GeneRIF: FBXL19AS1 promotes the progression of nasopharyngeal
            carcinoma by acting as a competing endogenous RNA to sponge miR431
            and upregulate PBOV1.
REFERENCE   2  (bases 1 to 2506)
  AUTHORS   Kong,Q., Han,J., Deng,H., Wu,F., Guo,S. and Ye,Z.
  TITLE     miR-431-5p alters the epithelial-to-mesenchymal transition markers
            by targeting UROC28 in hepatoma cells
  JOURNAL   Onco Targets Ther 11, 6489-6503 (2018)
   PUBMED   30323624
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2506)
  AUTHORS   Yang,C.A., Li,J.P., Yen,J.C., Lai,I.L., Ho,Y.C., Chen,Y.C.,
            Lan,J.L. and Chang,J.G.
  TITLE     lncRNA NTT/PBOV1 Axis Promotes Monocyte Differentiation and Is
            Elevated in Rheumatoid Arthritis
  JOURNAL   Int J Mol Sci 19 (9), 2806 (2018)
   PUBMED   30231487
  REMARK    GeneRIF: Overexpression of PBOV1 in THP-1 cells resulted in cell
            cycle G1 arrest, differentiation into macrophages, a marked
            increase in IL-10 and CXCL10 mRNA levels, and upregulation of the
            costimulatory molecules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2506)
  AUTHORS   Guo,Y., Wu,Z., Shen,S., Guo,R., Wang,J., Wang,W., Zhao,K., Kuang,M.
            and Shuai,X.
  TITLE     Nanomedicines reveal how PBOV1 promotes hepatocellular carcinoma
            for effective gene therapy
  JOURNAL   Nat Commun 9 (1), 3430 (2018)
   PUBMED   30143633
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2506)
  AUTHORS   Wang,L., Niu,C.H., Wu,S., Wu,H.M., Ouyang,F., He,M. and He,S.Y.
  TITLE     PBOV1 correlates with progression of ovarian cancer and inhibits
            proliferation of ovarian cancer cells
  JOURNAL   Oncol Rep 35 (1), 488-496 (2016)
   PUBMED   26549570
  REMARK    GeneRIF: Study shows that patients with high PBOV1 expression had
            longer overall survival; patients with low PBOV1 expression had
            shorter survival suggesting that PBOV1 may play an important role
            in suppressing ovarian cancer proliferation and carcinogenesis.
REFERENCE   6  (bases 1 to 2506)
  AUTHORS   Loizidou,M.A., Cariolou,M.A., Neuhausen,S.L., Newbold,R.F.,
            Bashiardes,E., Marcou,Y., Michael,T., Daniel,M., Kakouri,E.,
            Papadopoulos,P., Malas,S., Hadjisavvas,A. and Kyriacou,K.
  TITLE     Genetic variation in genes interacting with BRCA1/2 and risk of
            breast cancer in the Cypriot population
  JOURNAL   Breast Cancer Res Treat 121 (1), 147-156 (2010)
   PUBMED   19714462
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 2506)
  AUTHORS   Doak,S.H., Jenkins,S.A., Hurle,R.A., Varma,M., Hawizy,A.,
            Kynaston,H.G. and Parry,J.M.
  TITLE     Bone morphogenic factor gene dosage abnormalities in prostatic
            intraepithelial neoplasia and prostate cancer
  JOURNAL   Cancer Genet Cytogenet 176 (2), 161-165 (2007)
   PUBMED   17656261
  REMARK    GeneRIF: Approximately half of the prostate tumors displayed
            increased copy numbers of the BMP2, BMP5, BMP7, and UC28 gene loci,
            which may account for their abnormal gene expression patterns in
            neoplastic prostate tissue.
REFERENCE   8  (bases 1 to 2506)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 2506)
  AUTHORS   Kamagata,C., Tsuji,N., Kondoh,K., Sasaki,M., Kobayashi,D.,
            Yagihashi,A. and Watanabe,N.
  TITLE     Enhanced expression of the UROC28 gene in human breast cancer:
            relationship to ERBB2 gene expression
  JOURNAL   Anticancer Res 22 (6C), 4087-4091 (2002)
   PUBMED   12553037
  REMARK    GeneRIF: UROC28 mRNA expression was greater in breast cancers than
            in noncancerous tissues (p < 0.0001), as was ERBB2 mRNA.
REFERENCE   10 (bases 1 to 2506)
  AUTHORS   An,G., Ng,A.Y., Meka,C.S., Luo,G., Bright,S.P., Cazares,L.,
            Wright,G.L. Jr. and Veltri,R.W.
  TITLE     Cloning and characterization of UROC28, a novel gene overexpressed
            in prostate, breast, and bladder cancers
  JOURNAL   Cancer Res 60 (24), 7014-7020 (2000)
   PUBMED   11156405
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031433.4, BC069109.1 and
            AF189269.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_021635.2.
            
            Summary: This intronless gene encodes a protein of unknown
            function. Its expression is up-regulated in some types of cancer,
            including prostate, breast, and bladder cancer. [provided by
            RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AF189269.1, AF189270.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000527246.3/ ENSP00000432353.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL031433.4         29796-29796
            2-2112              BC069109.1         1-2111
            2113-2434           AF189269.1         2116-2437
            2435-2497           BC069109.1         2434-2496
            2498-2506           AF189269.1         2504-2512
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q23.3"
     gene            1..2506
                     /gene="PBOV1"
                     /gene_synonym="dJ171N11.2; UC28; UROC28"
                     /note="prostate and breast cancer overexpressed 1"
                     /db_xref="GeneID:59351"
                     /db_xref="HGNC:HGNC:21079"
                     /db_xref="MIM:605669"
     exon            1..2506
                     /gene="PBOV1"
                     /gene_synonym="dJ171N11.2; UC28; UROC28"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..504
                     /gene="PBOV1"
                     /gene_synonym="dJ171N11.2; UC28; UROC28"
                     /codon_start=1
                     /product="prostate and breast cancer overexpressed gene 1
                     protein"
                     /protein_id="NP_067648.1"
                     /db_xref="CCDS:CCDS5190.1"
                     /db_xref="GeneID:59351"
                     /db_xref="HGNC:HGNC:21079"
                     /db_xref="MIM:605669"
                     /translation="MRAFLRNQKYEDMHNIIHILQIRKLRHRLSNFPRLPGILAPETV
                     LLPFCYKVFRKKEKVKRSQKATEFIDYSIEQSHHAILTPLQTHLTMKGSSMKCSSLSS
                     EAILFTLTLQLTQTLGLECCLLYLSKTIHPQII"
ORIGIN      
        1 gaccttaaat atatcgaggt ggctaattga tgtataataa tttacaaaat tattcttcta
       61 tgctacagag ctacaattca atttacagta gtaaatatga gggccttctt aaggaaccag
      121 aaatatgagg atatgcacaa tattattcac attttacaga tcagaaaatt gaggcacaga
      181 ttaagtaact tcccaaggct accaggcatt ctagctccag aaactgtgct cttaccattc
      241 tgctacaagg tatttcgaaa aaaagaaaaa gtaaaaagaa gtcaaaaggc aacagagttc
      301 attgattatt ccatagaaca gtcacaccat gcaattctca cacccttgca gacacacttg
      361 accatgaaag gttcctcaat gaaatgttcc tcattatctt cagaagccat attattcaca
      421 ttgactttgc agttaactca gaccctaggt ctggaatgct gtcttctcta cttatccaaa
      481 actatacatc cacagatcat ataaactctc agccctgctg caaagccttt ccagaaaaat
      541 aaaaatggtt gaaaaggcaa ttctgctacc aatgactgtt taagcccagc caagtaactg
      601 aaccattcca acttcaattt acttatgaaa agaatttgat gatgtaggag gttatttcaa
      661 ttctaaaata caaacccatg ttgatctttc tcaatcttga actcatagat tattatctat
      721 tatctcaatt tagtttgtta tttatcctag tgggccatta aaaactacca catgtgtttc
      781 tgtctctcca ttagtcaata actaaactaa cgagcaatta gtaagccatg tgccagatgc
      841 tccgctaggc accagaggga taaaaacaat acttatagta taccactaat tttcgcttag
      901 taactagtga aatgttcaag tcatgcctga gtcaagagtt gaggagacat tacaatgtgt
      961 aatggaaacc aaggaaagtg aaactttgga taagtgggga ctagtgtatt tatatattta
     1021 attgatttct gactctatca ttggcctcca aacacagatt gtgtttttct ttggttttgt
     1081 tttcttcact atgggatctt ctgtgcccag cacagtgcct gacacataga aaacaatcaa
     1141 atatttgctg aataaatgat taaaaaatca gagaactttc ccattctgtt tggatctata
     1201 gaacatccag agtaagtgat gagggcctct gcatttatat gcgcttaaat taagattatg
     1261 tgagaaaagt ttaaagacac ttagtagagt gattttgaaa tatagtaaac acttggaaat
     1321 ggtggtgctt taaaaagata ttaatagata atatgaaaat ctccatctca aaaataatgc
     1381 ataaactatt taaaggaaaa tcacatctcc aggctttcaa tgtttgttca ttactttttc
     1441 atatattttt accatctgct gaaggcagtc atatcaaagg gtaaagaaag atgggaggaa
     1501 aactcagtaa gaattatatt agtctgtttg caaagtagaa aaagattctc atcactcaac
     1561 cttatgagca ggaagaggga aggctgtttg agaaccattt acttagcaga accacatatt
     1621 ttagacactt ccctgcatta actgcacaaa caatatgttt gcaaacttgt tagatcaacc
     1681 tccaacaacg acacattcag gagttaaata tttttcatca aacattggat ttttccttaa
     1741 cgctagagat tgctacaaat cttctgaagg gtctcaatgg cttcaggcta agaagagatt
     1801 tctccctgtt ataagcagca agacaaatta gccatttcac tctcaaactt cactaatgat
     1861 cacattcttt ccaaaaggaa ctctagaaga ccaaatgccc cgagttaaga acatcaaaac
     1921 taaccatctg aagaaacttc ccaagtgtaa gactctgcca ttaaaacatt accgagaggg
     1981 gactcaaaca gtctttcttc ctttgtcgtg tttcttgctc ccagaccaag gcactgacga
     2041 cagtactgat acataattta aaagcacact cccttccact ttgtaatacc agaactctaa
     2101 ttggacaccc tgaagcttag gactaccagc catacaaata gtaaactctg tccacgattc
     2161 actcatctgt gtattttcta tagatgttta ctaggcgttt gttatataaa aataccccgg
     2221 ccaggcacgg tggctcacgc ctgtaatccc agcactttgg gaggtgggtg gatcacctga
     2281 ggtcgggagt tcgagaccag cctgaccagc atggtggaac ccccatctct actaaaaaca
     2341 caaaaaatta gccgggcgtg gtggcacatg cctgtaatcc cagctactca ggaggctgag
     2401 gcggagaatt gcttgaaccc ggaaggtgga ggttgcggtg agctgagatt gcactattgc
     2461 actccagcct gggcaacagg agtaaaactc ccccccaccc aaaaaa
//
