LOCUS       NM_022129               2588 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens phenazine biosynthesis like protein domain containing
            (PBLD), transcript variant 1, mRNA.
ACCESSION   NM_022129
VERSION     NM_022129.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2588)
  AUTHORS   Han,L., Lin,X., Yan,Q., Gu,C., Li,M., Pan,L., Meng,Y., Zhao,X.,
            Liu,S. and Li,A.
  TITLE     PBLD inhibits angiogenesis via impeding VEGF/VEGFR2-mediated
            microenvironmental cross-talk between HCC cells and endothelial
            cells
  JOURNAL   Oncogene 41 (13), 1851-1865 (2022)
   PUBMED   35140333
  REMARK    GeneRIF: PBLD inhibits angiogenesis via impeding
            VEGF/VEGFR2-mediated microenvironmental cross-talk between HCC
            cells and endothelial cells.
REFERENCE   2  (bases 1 to 2588)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2588)
  AUTHORS   Zhu,M., Wang,F., Mi,H., Li,L., Wang,J., Han,M. and Gu,Y.
  TITLE     Long noncoding RNA MEG3 suppresses cell proliferation, migration
            and invasion, induces apoptosis and paclitaxel-resistance via
            miR-4513/PBLD axis in breast cancer cells
  JOURNAL   Cell Cycle 19 (23), 3277-3288 (2020)
   PUBMED   33121324
  REMARK    GeneRIF: Long noncoding RNA MEG3 suppresses cell proliferation,
            migration and invasion, induces apoptosis and paclitaxel-resistance
            via miR-4513/PBLD axis in breast cancer cells.
REFERENCE   4  (bases 1 to 2588)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2588)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2588)
  AUTHORS   Zhang,J., Kang,B., Tan,X., Bai,Z., Liang,Y., Xing,R., Shao,J.,
            Xu,N., Wang,R., Liu,S. and Lu,Y.
  TITLE     Comparative analysis of the protein profiles from primary gastric
            tumors and their adjacent regions: MAWBP could be a new protein
            candidate involved in gastric cancer
  JOURNAL   J Proteome Res 6 (11), 4423-4432 (2007)
   PUBMED   17929853
REFERENCE   7  (bases 1 to 2588)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   8  (bases 1 to 2588)
  AUTHORS   Grupe,A., Li,Y., Rowland,C., Nowotny,P., Hinrichs,A.L., Smemo,S.,
            Kauwe,J.S., Maxwell,T.J., Cherny,S., Doil,L., Tacey,K., van
            Luchene,R., Myers,A., Wavrant-De Vrieze,F., Kaleem,M.,
            Hollingworth,P., Jehu,L., Foy,C., Archer,N., Hamilton,G.,
            Holmans,P., Morris,C.M., Catanese,J., Sninsky,J., White,T.J.,
            Powell,J., Hardy,J., O'Donovan,M., Lovestone,S., Jones,L.,
            Morris,J.C., Thal,L., Owen,M., Williams,J. and Goate,A.
  TITLE     A scan of chromosome 10 identifies a novel locus showing strong
            association with late-onset Alzheimer disease
  JOURNAL   Am J Hum Genet 78 (1), 78-88 (2006)
   PUBMED   16385451
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 2588)
  AUTHORS   van Dijk,M., Mulders,J., Poutsma,A., Konst,A.A., Lachmeijer,A.M.,
            Dekker,G.A., Blankenstein,M.A. and Oudejans,C.B.
  TITLE     Maternal segregation of the Dutch preeclampsia locus at 10q22 with
            a new member of the winged helix gene family
  JOURNAL   Nat Genet 37 (5), 514-519 (2005)
   PUBMED   15806103
REFERENCE   10 (bases 1 to 2588)
  AUTHORS   Iriyama,C., Matsuda,S., Katsumata,R. and Hamaguchi,M.
  TITLE     Cloning and sequencing of a novel human gene which encodes a
            putative hydroxylase
  JOURNAL   J Hum Genet 46 (5), 289-292 (2001)
   PUBMED   11355021
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016395.5, CB121561.1 and AI114748.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022129.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.235937.1,
                                           SRR1803613.113805.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358769.7/ ENSP00000351619.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC016395.5         13103-13103
            2-535               CB121561.1         2-535
            536-973             AI114748.1         70-507
            974-2588            AC016395.5         61757-63371
FEATURES             Location/Qualifiers
     source          1..2588
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.3"
     gene            1..2588
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /note="phenazine biosynthesis like protein domain
                     containing"
                     /db_xref="GeneID:64081"
                     /db_xref="HGNC:HGNC:23301"
                     /db_xref="MIM:612189"
     exon            1..145
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            146..288
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             205..1071
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /note="isoform a is encoded by transcript variant 1;
                     phenazine biosynthesis-like domain-containing protein;
                     MAWD-binding protein; epididymis secretory protein Li 306;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="phenazine biosynthesis-like domain-containing
                     protein isoform a"
                     /protein_id="NP_071412.2"
                     /db_xref="CCDS:CCDS7277.2"
                     /db_xref="GeneID:64081"
                     /db_xref="HGNC:HGNC:23301"
                     /db_xref="MIM:612189"
                     /translation="MKLPIFIADAFTARAFRGNPAAVCLLENELDEDMHQKIAREMNL
                     SETAFIRKLHPTDNFAQSSCFGLRWFTPASEVPLCGHATLASAAVLFHKIKNMNSTLT
                     FVTLSGELRARRAEDGIVLDLPLYPAHPQDFHEVEDLIKTAIGNTLVQDICYSPDTQK
                     LLVRLSDVYNRSFLENLKVNTENLLQVENTGKVKGLILTLKGEPGGQTQAFDFYSRYF
                     APWVGVAEDPVTGSAHAVLSSYWSQHLGKKEMHAFQCSHRGGELGISLRPDGRVDIRG
                     GAAVVLEGTLTA"
     exon            289..388
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            389..487
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            488..597
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            598..627
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            628..716
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            717..895
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            896..958
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     exon            959..2588
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /note="hexamer: AATAAA"
     polyA_site      2588
                     /gene="PBLD"
                     /gene_synonym="HEL-S-306; MAWBP; MAWDBP"
                     /note="major polyA site"
ORIGIN      
        1 agaattacaa aggaggccgt ctgcctcctt tgtcctggat ttgggagttg agcaccttcg
       61 tcgccattgg ctttcctccc ccagctccag cctctctcat cttgggaatc tgcgtcagaa
      121 gtcactcgca gtcccgtcag cccagaagac gtaaagcagg ctaccagcaa ttttgagaac
      181 ttgcaaaaac agcttgcaag gaaaatgaag cttcctattt tcatagcaga tgcattcaca
      241 gcaagagcat ttcgtgggaa tcctgctgct gtttgcctcc tagaaaatga attggatgaa
      301 gacatgcatc agaaaattgc aagggagatg aacctctctg aaactgcttt tatccgaaaa
      361 ctgcacccga cagacaactt tgcacaaagt tcctgctttg gactgagatg gtttacacca
      421 gcgagtgagg tcccactctg tggccatgcc accctggctt ctgcagctgt gctgtttcac
      481 aaaataaaaa acatgaatag cacgctcacg tttgtcactc tgagtggaga actaagggcc
      541 agacgagcag aggatggcat cgtcctggac ttgcctcttt atccagccca cccccaggac
      601 ttccatgaag tagaggactt gataaagact gccataggca acacactggt ccaggacatc
      661 tgttattctc cagataccca aaagctcctc gtccgcctca gtgacgttta caacaggtcg
      721 tttctggaga acctgaaagt gaacacggag aatctgctgc aagttgaaaa cacagggaag
      781 gtgaaagggc ttattcttac ccttaaagga gagcctggtg ggcagaccca agcatttgac
      841 ttttactcaa gatattttgc accgtgggtt ggtgtggctg aagacccagt gacagggtct
      901 gcacacgctg ttctcagcag ctactggtcc cagcatctgg ggaagaaaga aatgcatgct
      961 tttcagtgtt cccaccgagg aggagagctg ggaatttccc ttcgtccaga cggaagggtt
     1021 gacattagag gaggtgcagc tgttgtttta gagggcacac tgacagccta gaggtggtta
     1081 tgctgtgacg ctgctgtctc taaccaccaa gtattttctg cttaaaaaga aatgtaaggg
     1141 gctgccttta gcaaatgtgc gtagtagtct acttaatcct catgttaaaa atcgaaaaat
     1201 gggccaggcg cagtggctca tgcctgtaat cgtagcactt tgagaggcca aggtgggtgg
     1261 atcacctgag gtcaggggtt cgacaccagc ctggccaaca tggtgaaacc tcgtctctac
     1321 tacaaataca aaaattagct gggtgtggtg ccacatgcct gtaattccag ctacttggga
     1381 ggctgaggca tggagaatcg cttgaaccca ggaggcagaa gttgcagtga gcagagatca
     1441 caccactgca ctccagcctg ggcaacagag taagactcca tccacacaca cacacacaca
     1501 cacaaaattg aaaagtgaag acattttaat ggagatttaa tagtgcttcc agactaatga
     1561 actaatggag ttttggctcc actcatgagt gtatttgaaa tgtaagtaac cagctacaaa
     1621 gaataatgtc acttcatttg attatgacta ccaatcaaga gaaggaggaa tacatttctg
     1681 aggagtgata ctaaaccatt tgagcttaaa tgagtacctg attttgcagc cattaaaatg
     1741 agtcaataac tatgtggaaa tatagaaaaa tattttataa tataatacta agaaagagga
     1801 cagtaggcca taaagtgtta gcagtgttat gctatgtcta tataaataag catgggccat
     1861 taaaaatagc aaactgaaaa cagttcatgt gtggggggca agtttagaag taattttaat
     1921 gtatctaaga agtgatttcc tttattgttg tactcaggta cgaagactaa aaatcaggat
     1981 gaatccagaa aattaacaca aaaaagtatg tattaggcta cttcctgtca tagtgaaatt
     2041 aaacactcaa agtaatgtaa tctcagctgg gcgtggcggc tcatgcctgt aatcccagca
     2101 ctttggcagg acaaggcagg aggatcactt gaacctagga gttcgagacc agcctgggca
     2161 acacagcgag aacttgtctc tattaaaaaa aaaaaaagga atgtaatttc aatctttttc
     2221 ttgatatatg gcttgagaat gataatgtaa aaggaattct tctcttactt caataaaatg
     2281 ggttttaaca taactttaaa ttcagttaaa tatacaatat tgaataccta tagttgactt
     2341 tgggatgggg actttttcaa gtcattaaga gtgtttgttt aaggtgatct cattgatggt
     2401 agttctcagc cgtctcaaaa actgcaagct aatcagtcag acattcttta atgaccccaa
     2461 ttttttcact ttaattgtta ccatgttttc tatttttact gatttttgct aaagcatgta
     2521 agagtgaatt tattatagca gtaatcttgt gtttctcctg atgtgcaata aatcaataat
     2581 tcaccagc
//
