LOCUS       NM_018492               1836 bp    mRNA    linear   PRI 20-MAY-2024
DEFINITION  Homo sapiens PDZ binding kinase (PBK), transcript variant 1, mRNA.
ACCESSION   NM_018492
VERSION     NM_018492.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Lu,H., Huang,Y., Ni,X., Ma,T., Chang,T., Liu,M., Li,N., Lu,P.,
            Yuan,P., Liu,L., Shi,F., Xiao,J., Xiao,H., Duan,Q. and Zhu,F.
  TITLE     TOPK promotes the development of psoriasis and worenine alleviates
            psoriasiform dermatitis by inhibiting TOPK activity
  JOURNAL   J Eur Acad Dermatol Venereol 38 (5), 851-863 (2024)
   PUBMED   38131517
  REMARK    GeneRIF: TOPK promotes the development of psoriasis and worenine
            alleviates psoriasiform dermatitis by inhibiting TOPK activity.
REFERENCE   2  (bases 1 to 1836)
  AUTHORS   Joo,N.R., Park,S.A., Park,J.H. and Oh,S.M.
  TITLE     TOPK inhibits TNF-alpha-induced granulosa cell apoptosis via
            regulation of SIRT1/p53
  JOURNAL   Biochem Biophys Res Commun 664, 128-135 (2023)
   PUBMED   37148702
  REMARK    GeneRIF: TOPK inhibits TNF-alpha-induced granulosa cell apoptosis
            via regulation of SIRT1/p53.
REFERENCE   3  (bases 1 to 1836)
  AUTHORS   Wu,W., Xu,J., Gao,D., Xie,Z., Chen,W., Li,W., Yuan,Q., Duan,L.,
            Zhang,Y., Yang,X., Chen,Y., Dong,Z., Liu,K. and Jiang,Y.
  TITLE     TOPK promotes the growth of esophageal cancer in vitro and in vivo
            by enhancing YB1/eEF1A1 signal pathway
  JOURNAL   Cell Death Dis 14 (6), 364 (2023)
   PUBMED   37328464
  REMARK    GeneRIF: TOPK promotes the growth of esophageal cancer in vitro and
            in vivo by enhancing YB1/eEF1A1 signal pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1836)
  AUTHORS   Cai,C., Yao,S., Zou,Y., Lu,H., Chen,X., Wang,Y., Zheng,K., Zhu,F.,
            Wang,Y., Xiong,H. and Zhu,J.
  TITLE     KRASG12C mutation-induced TOPK overexpression contributes to tumour
            progression in non-small cell lung cancer
  JOURNAL   J Cell Mol Med 27 (12), 1637-1652 (2023)
   PUBMED   37226642
  REMARK    GeneRIF: KRAS[G12C] mutation-induced TOPK overexpression
            contributes to tumour progression in non-small cell lung cancer.
REFERENCE   5  (bases 1 to 1836)
  AUTHORS   Feng,T., Jiang,R., Yin,L., Xu,C., Ma,J., Yin,W., Jin,J., Lu,T.,
            Liu,X., Lyu,Y., Yang,Y., Ying,L., Hu,Q., Su,D. and Ling,S.
  TITLE     PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm
            progression by activating the AKT/mTOR pathway
  JOURNAL   Mol Carcinog 62 (5), 716-726 (2023)
   PUBMED   36807309
  REMARK    GeneRIF: PDZ-binding kinase aggravates pancreatic neuroendocrine
            neoplasm progression by activating the AKT/mTOR pathway.
REFERENCE   6  (bases 1 to 1836)
  AUTHORS   Nandi,A., Tidwell,M., Karp,J. and Rapoport,A.P.
  TITLE     Protein expression of PDZ-binding kinase is up-regulated in
            hematologic malignancies and strongly down-regulated during
            terminal differentiation of HL-60 leukemic cells
  JOURNAL   Blood Cells Mol Dis 32 (1), 240-245 (2004)
   PUBMED   14757441
  REMARK    GeneRIF: TOPK protein is up-regulated in a variety of hematologic
            malignancies and may be involved in leukemic cell growth; 4 of 5
            clinical that strongly expressed TOPK also strongly expressed
            phosphorylated c-Myc
REFERENCE   7  (bases 1 to 1836)
  AUTHORS   Simons-Evelyn,M., Bailey-Dell,K., Toretsky,J.A., Ross,D.D.,
            Fenton,R., Kalvakolanu,D. and Rapoport,A.P.
  TITLE     PBK/TOPK is a novel mitotic kinase which is upregulated in
            Burkitt's lymphoma and other highly proliferative malignant cells
  JOURNAL   Blood Cells Mol Dis 27 (5), 825-829 (2001)
   PUBMED   11783945
  REMARK    GeneRIF: PBK/TOPK is upregulated in Burkitt's lymphoma and other
            highly proliferative malignant cells and during normal fetal
            development.
REFERENCE   8  (bases 1 to 1836)
  AUTHORS   Zhao,S., Dai,J., Zhao,W., Xia,F., Zhou,Z., Wang,W., Gu,S., Ying,K.,
            Xie,Y. and Mao,Y.
  TITLE     PDZ-binding kinase participates in spermatogenesis
  JOURNAL   Int J Biochem Cell Biol 33 (6), 631-636 (2001)
   PUBMED   11378444
REFERENCE   9  (bases 1 to 1836)
  AUTHORS   Abe,Y., Matsumoto,S., Kito,K. and Ueda,N.
  TITLE     Cloning and expression of a novel MAPKK-like protein kinase,
            lymphokine-activated killer T-cell-originated protein kinase,
            specifically expressed in the testis and activated lymphoid cells
  JOURNAL   J Biol Chem 275 (28), 21525-21531 (2000)
   PUBMED   10781613
REFERENCE   10 (bases 1 to 1836)
  AUTHORS   Gaudet,S., Branton,D. and Lue,R.A.
  TITLE     Characterization of PDZ-binding kinase, a mitotic kinase
  JOURNAL   Proc Natl Acad Sci U S A 97 (10), 5167-5172 (2000)
   PUBMED   10779557
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB028500.1 and BC015191.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018492.3.
            
            Summary: This gene encodes a serine/threonine protein kinase
            related to the dual specific mitogen-activated protein kinase
            kinase (MAPKK) family. Evidence suggests that mitotic
            phosphorylation is required for its catalytic activity. The encoded
            protein may be involved in the activation of lymphoid cells and
            support testicular functions, with a suggested role in the process
            of spermatogenesis. Overexpression of this gene has been implicated
            in tumorigenesis. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript, and encodes the shorter isoform (1). Variants 1 and 3
            encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB027249.1, EU794685.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301905.9/ ENSP00000301905.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               DB028500.1         279-563
            286-1836            BC015191.1         278-1828
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p21.1"
     gene            1..1836
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /note="PDZ binding kinase"
                     /db_xref="GeneID:55872"
                     /db_xref="HGNC:HGNC:18282"
                     /db_xref="MIM:611210"
     exon            1..166
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            167..244
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             187..1155
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /EC_number="2.7.12.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     cancer/testis antigen 84; epididymis luminal protein 164;
                     T-LAK cell-originated protein kinase;
                     spermatogenesis-related protein kinase; MAPKK-like protein
                     kinase; serine/threonine protein kinase;
                     lymphokine-activated killer T-cell-originated protein
                     kinase"
                     /codon_start=1
                     /product="lymphokine-activated killer T-cell-originated
                     protein kinase isoform 1"
                     /protein_id="NP_060962.2"
                     /db_xref="CCDS:CCDS6063.1"
                     /db_xref="GeneID:55872"
                     /db_xref="HGNC:HGNC:18282"
                     /db_xref="MIM:611210"
                     /translation="MEGISNFKTPSKLSEKKKSVLCSTPTINIPASPFMQKLGFGTGV
                     NVYLMKRSPRGLSHSPWAVKKINPICNDHYRSVYQKRLMDEAKILKSLHHPNIVGYRA
                     FTEANDGSLCLAMEYGGEKSLNDLIEERYKASQDPFPAAIILKVALNMARGLKYLHQE
                     KKLLHGDIKSSNVVIKGDFETIKICDVGVSLPLDENMTVTDPEACYIGTEPWKPKEAV
                     EENGVITDKADIFAFGLTLWEMMTLSIPHINLSNDDDDEDKTFDESDFDDEAYYAALG
                     TRPPINMEELDESYQKVIELFSVCTNEDPKDRPSAAHIVEALETDV"
     exon            245..338
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            339..481
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            482..651
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            652..781
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            782..958
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1836
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1536..1541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /note="hexamer: AATAAA"
     polyA_site      1566
                     /gene="PBK"
                     /gene_synonym="CT84; HEL164; Nori-3; SPK; TOPK"
                     /note="major polyA site"
ORIGIN      
        1 gaaagccagg agggttcgaa ttgcaacggc agctgccggg cgtatgtgtt ggtgctagag
       61 gcagctgcag ggtctcgctg ggggccgctc gggaccaatt ttgaagaggt acttggccac
      121 gacttatttt cacctccgac ctttccttcc aggcggtgag actctggact gagagtggct
      181 ttcacaatgg aagggatcag taatttcaag acaccaagca aattatcaga aaaaaagaaa
      241 tctgtattat gttcaactcc aactataaat atcccggcct ctccgtttat gcagaagctt
      301 ggctttggta ctggggtaaa tgtgtaccta atgaaaagat ctccaagagg tttgtctcat
      361 tctccttggg ctgtaaaaaa gattaatcct atatgtaatg atcattatcg aagtgtgtat
      421 caaaagagac taatggatga agctaagatt ttgaaaagcc ttcatcatcc aaacattgtt
      481 ggttatcgtg cttttactga agccaatgat ggcagtctgt gtcttgctat ggaatatgga
      541 ggtgaaaagt ctctaaatga cttaatagaa gaacgatata aagccagcca agatcctttt
      601 ccagcagcca taattttaaa agttgctttg aatatggcaa gagggttaaa gtatctgcac
      661 caagaaaaga aactgcttca tggagacata aagtcttcaa atgttgtaat taaaggcgat
      721 tttgaaacaa ttaaaatctg tgatgtagga gtctctctac cactggatga aaatatgact
      781 gtgactgacc ctgaggcttg ttacattggc acagagccat ggaaacccaa agaagctgtg
      841 gaggagaatg gtgttattac tgacaaggca gacatatttg cctttggcct tactttgtgg
      901 gaaatgatga ctttatcgat tccacacatt aatctttcaa atgatgatga tgatgaagat
      961 aaaacttttg atgaaagtga ttttgatgat gaagcatact atgcagcgtt gggaactagg
     1021 ccacctatta atatggaaga actggatgaa tcataccaga aagtaattga actcttctct
     1081 gtatgcacta atgaagaccc taaagatcgt ccttctgctg cacacattgt tgaagctctg
     1141 gaaacagatg tctagtgatc atctcagctg aagtgtggct tgcgtaaata actgtttatt
     1201 ccaaaatatt tacatagtta ctatcagtag ttattagact ctaaaattgg catatttgag
     1261 gaccatagtt tcttgttaac atatggataa ctatttctaa tatgaaatat gcttatattg
     1321 gctataagca cttggaattg tactgggttt tctgtaaagt tttagaaact agctacataa
     1381 gtactttgat actgctcatg ctgacttaaa acactagcag taaaacgctg taaactgtaa
     1441 cattaaattg aatgaccatt acttttatta atgatctttc ttaaatattc tatattttaa
     1501 tggatctact gacattagca ctttgtacag tacaaaataa agtctacatt tgtttaaaac
     1561 actgaacctt ttgctgatgt gtttatcaaa tgataactgg aagctgagga gaatatgcct
     1621 caaaaagagt agctccttgg atacttcaga ctctggttac agattgtctt gatctcttgg
     1681 atctcctcag atctttggtt tttgctttaa tttattaaat gtattttcca tactgagttt
     1741 aaaatttatt aatttgtacc ttaagcattt cccagctgtg taaaaacaat aaaactcaaa
     1801 taggatgata aagaataaag gacactttgg gtacca
//
