LOCUS       NM_007349               3864 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens PAX interacting protein 1 (PAXIP1), mRNA.
ACCESSION   NM_007349
VERSION     NM_007349.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3864)
  AUTHORS   Nakata,Y., Nagasawa,S., Sera,Y., Yamasaki,N., Kanai,A.,
            Kobatake,K., Ueda,T., Koizumi,M., Manabe,I., Kaminuma,O. and
            Honda,H.
  TITLE     PTIP epigenetically regulates DNA damage-induced cell cycle arrest
            by upregulating PRDM1
  JOURNAL   Sci Rep 14 (1), 17987 (2024)
   PUBMED   39097652
  REMARK    GeneRIF: PTIP epigenetically regulates DNA damage-induced cell
            cycle arrest by upregulating PRDM1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3864)
  AUTHORS   Harvey-Jones,E., Raghunandan,M., Robbez-Masson,L.,
            Magraner-Pardo,L., Alaguthurai,T., Yablonovitch,A., Yen,J.,
            Xiao,H., Brough,R., Frankum,J., Song,F., Yeung,J., Savy,T.,
            Gulati,A., Alexander,J., Kemp,H., Starling,C., Konde,A., Marlow,R.,
            Cheang,M., Proszek,P., Hubank,M., Cai,M., Trendell,J., Lu,R.,
            Liccardo,R., Ravindran,N., Llop-Guevara,A., Rodriguez,O.,
            Balmana,J., Lukashchuk,N., Dorschner,M., Drusbosky,L., Roxanis,I.,
            Serra,V., Haider,S., Pettitt,S.J., Lord,C.J. and Tutt,A.N.J.
  TITLE     Longitudinal profiling identifies co-occurring BRCA1/2 reversions,
            TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant
            advanced breast cancer
  JOURNAL   Ann Oncol 35 (4), 364-380 (2024)
   PUBMED   38244928
  REMARK    GeneRIF: Longitudinal profiling identifies co-occurring BRCA1/2
            reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP
            inhibitor-resistant advanced breast cancer.
REFERENCE   3  (bases 1 to 3864)
  AUTHORS   Gupta,N., Sarkar,S., Mehta,P., Sankhwar,S.N. and Rajender,S.
  TITLE     Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes correlate
            with sperm motility in idiopathic infertility
  JOURNAL   Andrologia 54 (9), e14517 (2022)
   PUBMED   35768906
  REMARK    GeneRIF: Polymorphisms in the HSF2, LRRC6, MEIG1 and PTIP genes
            correlate with sperm motility in idiopathic infertility.
REFERENCE   4  (bases 1 to 3864)
  AUTHORS   Wang,Q., Hu,J., Han,G., Wang,P., Li,S., Chang,J., Gao,K., Yin,R.,
            Li,Y., Zhang,T., Chai,J., Gao,Z., Zhang,T., Cheng,Y., Guo,C.,
            Wang,J., Liu,W., Cui,M., Xu,Y., Hou,J., Zhu,Q.F., Feng,Y.Q. and
            Zhang,H.
  TITLE     PTIP governs NAD+ metabolism by regulating CD38 expression to drive
            macrophage inflammation
  JOURNAL   Cell Rep 38 (13), 110603 (2022)
   PUBMED   35354042
  REMARK    GeneRIF: PTIP governs NAD(+) metabolism by regulating CD38
            expression to drive macrophage inflammation.
REFERENCE   5  (bases 1 to 3864)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 3864)
  AUTHORS   Jowsey,P.A., Doherty,A.J. and Rouse,J.
  TITLE     Human PTIP facilitates ATM-mediated activation of p53 and promotes
            cellular resistance to ionizing radiation
  JOURNAL   J Biol Chem 279 (53), 55562-55569 (2004)
   PUBMED   15456759
  REMARK    GeneRIF: hPTIP (PAXIP1) shows increased association with 53BP1 in
            response to ionizing radiation but not in response to other
            DNA-damaging agents.
REFERENCE   7  (bases 1 to 3864)
  AUTHORS   Manke,I.A., Lowery,D.M., Nguyen,A. and Yaffe,M.B.
  TITLE     BRCT repeats as phosphopeptide-binding modules involved in protein
            targeting
  JOURNAL   Science 302 (5645), 636-639 (2003)
   PUBMED   14576432
  REMARK    GeneRIF: identified tandem BRCT (BRCA1 carboxyl-terminal) domains
            in PTIP and in BRCA1 as phosphoserine- or phosphothreonine-specific
            binding modules that recognize substrates phosphorylated by the
            kinases ATM and ATR in response to gamma-irradiation
REFERENCE   8  (bases 1 to 3864)
  AUTHORS   Cho,E.A., Prindle,M.J. and Dressler,G.R.
  TITLE     BRCT domain-containing protein PTIP is essential for progression
            through mitosis
  JOURNAL   Mol Cell Biol 23 (5), 1666-1673 (2003)
   PUBMED   12588986
REFERENCE   9  (bases 1 to 3864)
  AUTHORS   Hoffmeister,A., Ropolo,A., Vasseur,S., Mallo,G.V., Bodeker,H.,
            Ritz-Laser,B., Dressler,G.R., Vaccaro,M.I., Dagorn,J.C., Moreno,S.
            and Iovanna,J.L.
  TITLE     The HMG-I/Y-related protein p8 binds to p300 and Pax2
            trans-activation domain-interacting protein to regulate the
            trans-activation activity of the Pax2A and Pax2B transcription
            factors on the glucagon gene promoter
  JOURNAL   J Biol Chem 277 (25), 22314-22319 (2002)
   PUBMED   11940591
  REMARK    GeneRIF: PTIP (PAXIP1) is a strong inhibitor of the
            trans-activation activities of Pax2A and Pax2B on the glucagon gene
            promoter and p8 binding to PTIP prevents inhibition of this
            promoter.
REFERENCE   10 (bases 1 to 3864)
  AUTHORS   Lechner,M.S., Levitan,I. and Dressler,G.R.
  TITLE     PTIP, a novel BRCT domain-containing protein interacts with Pax2
            and is associated with active chromatin
  JOURNAL   Nucleic Acids Res 28 (14), 2741-2751 (2000)
   PUBMED   10908331
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093726.3, CR993144.1,
            BQ222021.1, AK123600.1 and BC033781.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_007349.3.
            
            Summary: This gene is a member of the paired box (PAX) gene family
            and encodes a nuclear protein with six BRCT (breast cancer
            carboxy-terminal) domains. This protein plays a critical role in
            maintaining genome stability, condensation of chromatin and
            progression through mitosis. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404141.6/ ENSP00000384048.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC093726.3         77323-77474         c
            153-208             CR993144.1         113-168
            209-708             BQ222021.1         1-500
            709-3863            AK123600.1         696-3850
            3864-3864           BC033781.1         2953-2953
FEATURES             Location/Qualifiers
     source          1..3864
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.2"
     gene            1..3864
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /note="PAX interacting protein 1"
                     /db_xref="GeneID:22976"
                     /db_xref="HGNC:HGNC:8624"
                     /db_xref="MIM:608254"
     exon            1..276
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..3405
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /note="protein encoded by CAG trinucleotide repeats; PAX
                     transcription activation domain interacting protein 1
                     like; PAX interacting (with transcription-activation
                     domain) protein 1"
                     /codon_start=1
                     /product="PAX-interacting protein 1"
                     /protein_id="NP_031375.3"
                     /db_xref="CCDS:CCDS47753.1"
                     /db_xref="GeneID:22976"
                     /db_xref="HGNC:HGNC:8624"
                     /db_xref="MIM:608254"
                     /translation="MSDQAPKVPEEMFREVKYYAVGDIDPQVIQLLKAGKAKEVSYNA
                     LASHIISEDGDNPEVGEAREVFDLPVVKPSWVILSVQCGTLLPVNGFSPESCQIFFGI
                     TACLSQVSSEDRSALWALVTFYGGDCQLTLNKKCTHLIVPEPKGEKYECALKRASIKI
                     VTPDWVLDCVSEKTKKDEAFYHPRLIIYEEEEEEEEEEEEVENEEQDSQNEGSTDEKS
                     SPASSQEGSPSGDQQFSPKSNTEKSKGELMFDDSSDSSPEKQERNLNWTPAEVPQLAA
                     AKRRLPQGKEPGLINLCANVPPVPGNILPPEVRGNLMAAGQNLQSSERSEMIATWSPA
                     VRTLRNITNNADIQQMNRPSNVAHILQTLSAPTKNLEQQVNHSQQGHTNANAVLFSQV
                     KVTPETHMLQQQQQAQQQQQQHPVLHLQPQQIMQLQQQQQQQISQQPYPQQPPHPFSQ
                     QQQQQQQAHPHQFSQQQLQFPQQQLHPPQQLHRPQQQLQPFQQQHALQQQFHQLQQHQ
                     LQQQQLAQLQQQHSLLQQQQQQQIQQQQLQRMHQQQQQQQMQSQTAPHLSQTSQALQH
                     QVPPQQPPQQQQQQQPPPSPQQHQLFGHDPAVEIPEEGFLLGCVFAIADYPEQMSDKQ
                     LLATWKRIIQAHGGTVDPTFTSRCTHLLCESQVSSAYAQAIRERKRCVTAHWLNTVLK
                     KKKMVPPHRALHFPVAFPPGGKPCSQHIISVTGFVDSDRDDLKLMAYLAGAKYTGYLC
                     RSNTVLICKEPTGLKYEKAKEWRIPCVNAQWLGDILLGNFEALRQIQYSRYTAFSLQD
                     PFAPTQHLVLNLLDAWRVPLKVSAELLMSIRLPPKLKQNEVANVQPSSKRARIEDVPP
                     PTKKLTPELTPFVLFTGFEPVQVQQYIKKLYILGGEVAESAQKCTHLIASKVTRTVKF
                     LTAISVVKHIVTPEWLEECFRCQKFIDEQNYILRDAEAEVLFSFSLEESLKRAHVSPL
                     FKAKYFYITPGICPSLSTMKAIVECAGGKVLSKQPSFRKLMEHKQNSSLSEIILISCE
                     NDLHLCREYFARGIDVHNAEFVLTGVLTQTLDYESYKFN"
     exon            277..411
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            412..455
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..519
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            520..633
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            634..1269
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1993
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2088
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2184
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2185..2322
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2444
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2445..2629
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2630..2673
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2744
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2745..2847
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..3016
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3117
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3118..3252
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3328
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3329..3389
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3864
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3843..3848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /note="hexamer: AATAAA"
     polyA_site      3864
                     /gene="PAXIP1"
                     /gene_synonym="CAGF28; CAGF29; PACIP1; PAXIP1L; PTIP;
                     TNRC2"
                     /note="major polyA site"
ORIGIN      
        1 gcttcgggcg ctcggcgcgg gcgcgggcgg gggcgcggag ggcgggggag cggaccccga
       61 ttcgcaggac cgggcccggg ctgcgcgggc agggccgttg gcggggcgag tgggggcgcc
      121 gggcgccgcg ggggccgggg gcggggggtg ggcggggccg ggcgccgccg cggagcctcc
      181 cgggccgccg cgatcatgtc ggaccaggcg cccaaagttc ctgaggagat gttcagggag
      241 gtcaagtatt acgcggtggg cgacatcgac ccgcaggtta ttcagcttct caaggctgga
      301 aaagcgaagg aagtttccta caatgcacta gcctcacaca taatctcaga ggatggggac
      361 aatccagagg tgggagaagc tcgggaagtc tttgacttac ctgttgtaaa gccttcttgg
      421 gtgattctgt ccgttcagtg tggaactctt ctgccagtaa atggtttttc tccagaatca
      481 tgtcagattt tttttggaat cactgcctgc ctttctcagg tgtcatctga agacagaagt
      541 gccctgtggg ctttggttac gttctatggg ggagattgcc agctaaccct caataagaaa
      601 tgcacgcatt tgattgttcc agagccaaag ggggagaaat acgaatgtgc tttaaagcga
      661 gcaagtatta aaattgtgac tcctgactgg gttctggatt gcgtatcaga gaaaaccaaa
      721 aaggacgaag cattttatca tcctcgtctg attatttatg aagaggaaga agaggaagag
      781 gaagaggagg aggaagtaga aaatgaggaa caagattctc agaatgaggg tagtacagat
      841 gagaagtcaa gccctgccag ctctcaagaa gggtctcctt caggtgacca gcagttttca
      901 cctaaatcca acactgaaaa atctaaaggg gaattaatgt ttgatgattc ttcagattca
      961 tcaccggaaa aacaggagag aaatttaaac tggaccccgg ccgaagtccc acagttagct
     1021 gcagcaaaac gcaggctgcc tcagggaaag gagcctgggt tgattaactt gtgtgccaat
     1081 gtcccacccg tcccaggtaa cattttgccc cctgaggtcc ggggtaattt aatggctgct
     1141 ggacaaaacc tccaaagttc tgaaagatca gaaatgatag ctacctggag tccagctgta
     1201 cggacactga ggaatattac taataatgct gacattcagc agatgaaccg gccatcaaat
     1261 gtagcacata tcttacagac tctttcagca cctacgaaaa atttagaaca gcaggtgaat
     1321 cacagccagc agggacatac aaatgccaat gcagtgctgt ttagccaagt gaaagtgact
     1381 ccagagacac acatgctaca gcagcagcag caggcccagc agcagcagca gcagcacccg
     1441 gttttacacc ttcagcccca gcagataatg cagctccagc agcagcagca gcagcagatc
     1501 tctcagcaac cttaccccca gcagccgccg catccatttt cacagcaaca gcagcagcag
     1561 cagcaagccc atccgcatca gttttcacag caacagctac agtttccaca gcaacagttg
     1621 catcctccac agcagctgca tcgccctcag cagcagctcc agccctttca gcagcagcat
     1681 gccctgcagc agcagttcca tcagctgcag cagcaccagc tccagcagca gcagcttgcc
     1741 cagctccagc agcagcacag cctgctccag cagcagcagc aacagcagat tcagcagcag
     1801 cagctccagc gcatgcacca gcagcagcag cagcagcaga tgcaaagtca gacagcgcca
     1861 cacttgagtc agacgtcaca ggcgctgcag catcaggttc cacctcagca gcccccgcag
     1921 cagcagcagc aacagcagcc accaccatcg cctcagcagc atcagctttt tggacatgat
     1981 ccagcagtgg agattccaga agaaggcttc ttattgggat gtgtgtttgc aattgcggat
     2041 tatccagagc agatgtctga taagcaactg ctggccacct ggaaaaggat aatccaggca
     2101 catggcggca ctgttgaccc caccttcacg agtcgatgca cgcaccttct ctgtgagagt
     2161 caagtcagca gcgcgtatgc acaggcaata agagaaagaa agagatgtgt tactgcacac
     2221 tggttaaaca cagtcttaaa gaagaagaaa atggtaccgc cgcaccgagc ccttcacttc
     2281 ccagtggcct tcccaccagg aggaaagcca tgttcacagc atattatttc tgtgactgga
     2341 tttgttgata gtgacagaga tgacctaaaa ttaatggctt atttggcagg tgccaaatat
     2401 acgggttatc tatgccgcag caacacagtc ctcatctgta aagaaccaac tggtttaaag
     2461 tatgaaaaag ccaaagagtg gaggataccc tgtgtcaacg cccagtggct tggcgacatt
     2521 cttctgggaa actttgaggc actgaggcag attcagtata gtcgctacac ggcattcagt
     2581 ctgcaggatc catttgcccc tacccagcat ttagttttaa atcttttaga tgcttggaga
     2641 gttcccttaa aagtgtctgc agagttgttg atgagtataa gactacctcc caaactgaaa
     2701 cagaatgaag tagctaatgt ccagccttct tccaaaagag ccagaattga agacgtacca
     2761 cctcccacta aaaagctaac tccagaattg accccttttg tgcttttcac tggattcgag
     2821 cctgtccagg ttcaacagta tattaagaag ctctacattc ttggtggaga ggttgcggag
     2881 tctgcacaga agtgcacaca cctcattgcc agcaaagtga ctcgcaccgt gaagttcctg
     2941 acggcgattt ctgtcgtgaa gcacatagtg acgccagagt ggctggaaga atgcttcagg
     3001 tgtcagaagt tcattgatga gcagaactac attctccgag atgctgaggc agaagtactt
     3061 ttctctttca gcttggaaga atccttaaaa cgggcacacg tttctccact ctttaaggca
     3121 aaatattttt acatcacacc tggaatctgc ccaagtcttt ccactatgaa ggcaatcgta
     3181 gagtgtgcag gaggaaaggt gttatccaag cagccatctt tccggaagct catggagcac
     3241 aagcagaact cgagtttgtc ggaaataatt ttaatatcct gtgaaaatga ccttcattta
     3301 tgccgagaat attttgccag aggcatagat gttcacaatg cagagttcgt tctgactgga
     3361 gtgctcactc aaacgctgga ctatgaatca tataagttta actgatggcg tctaggctgc
     3421 cgtgcatgtc gactcctgcg gtgcggggct ggctgtctgg ctggcgagga gctgctgcgc
     3481 ttccttcaca tgctcttgtt ttccagctgc tttcctgggg gatcagactg tgaagcagga
     3541 agacagatat aataaatata ctgcatcttt ttaagatgtg caattttatt ctgaggaaac
     3601 ataaattatg ttttgtatta tatgacttta agagcccaca ttaggtttta tgattcattt
     3661 gccaggtttt taaatgtttt cacaaaactg ttacgggact tcaactagaa ataaaatggt
     3721 gtaaataaag accttgctat ctctaaatta tggatgttaa agatttgaaa tgttttgtac
     3781 tttgattatt tttatttctt atactctgtt ttcttttata ttgatatctt gcccacattt
     3841 taaataaatg tacttttgaa ctta
//
