LOCUS       NM_003466               4055 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens paired box 8 (PAX8), transcript variant PAX8A, mRNA.
ACCESSION   NM_003466
VERSION     NM_003466.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4055)
  AUTHORS   Luo,Y., Liu,X., Chen,Y., Tang,Q., He,C., Ding,X., Hu,J., Cai,Z.,
            Li,X., Qiao,H. and Zou,Z.
  TITLE     Targeting PAX8 sensitizes ovarian cancer cells to ferroptosis by
            inhibiting glutathione synthesis
  JOURNAL   Apoptosis 29 (9-10), 1499-1514 (2024)
   PUBMED   38853202
  REMARK    GeneRIF: Targeting PAX8 sensitizes ovarian cancer cells to
            ferroptosis by inhibiting glutathione synthesis.
REFERENCE   2  (bases 1 to 4055)
  AUTHORS   Kang,N., Zhao,Z., Wang,Z., Ning,J., Wang,H., Zhang,W., Ruan,X.,
            Gao,M. and Zheng,X.
  TITLE     METTL3 regulates thyroid cancer differentiation and
            chemosensitivity by modulating PAX8
  JOURNAL   Int J Biol Sci 20 (9), 3426-3441 (2024)
   PUBMED   38993572
  REMARK    GeneRIF: METTL3 regulates thyroid cancer differentiation and
            chemosensitivity by modulating PAX8.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4055)
  AUTHORS   Ji,N., Lee,Y., Lee,S.H. and Kim,H.S.
  TITLE     Diagnostic Value of Immunostaining for Thyroid Transcription Factor
            1 (TTF1) and Paired Box 8 (PAX8) in Distinguishing Pulmonary
            Metastases of Mesonephric and Mesonephric-like Adenocarcinomas from
            Primary Lung Adenocarcinomas
  JOURNAL   Anticancer Res 44 (5), 2159-2170 (2024)
   PUBMED   38677751
  REMARK    GeneRIF: Diagnostic Value of Immunostaining for Thyroid
            Transcription Factor 1 (TTF1) and Paired Box 8 (PAX8) in
            Distinguishing Pulmonary Metastases of Mesonephric and
            Mesonephric-like Adenocarcinomas from Primary Lung Adenocarcinomas.
REFERENCE   4  (bases 1 to 4055)
  AUTHORS   Dehbi,M. and Pelletier,J.
  TITLE     PAX8-mediated activation of the wt1 tumor suppressor gene
  JOURNAL   EMBO J 15 (16), 4297-4306 (1996)
   PUBMED   8861958
REFERENCE   5  (bases 1 to 4055)
  AUTHORS   Poleev,A., Wendler,F., Fickenscher,H., Zannini,M.S., Yaginuma,K.,
            Abbott,C. and Plachov,D.
  TITLE     Distinct functional properties of three human paired-box-protein,
            PAX8, isoforms generated by alternative splicing in thyroid, kidney
            and Wilms' tumors
  JOURNAL   Eur J Biochem 228 (3), 899-911 (1995)
   PUBMED   7737192
REFERENCE   6  (bases 1 to 4055)
  AUTHORS   Eccles,M.R., Yun,K., Reeve,A.E. and Fidler,A.E.
  TITLE     Comparative in situ hybridization analysis of PAX2, PAX8, and WT1
            gene transcription in human fetal kidney and Wilms' tumors
  JOURNAL   Am J Pathol 146 (1), 40-45 (1995)
   PUBMED   7856737
REFERENCE   7  (bases 1 to 4055)
  AUTHORS   Kozmik,Z., Kurzbauer,R., Dorfler,P. and Busslinger,M.
  TITLE     Alternative splicing of Pax-8 gene transcripts is developmentally
            regulated and generates isoforms with different transactivation
            properties
  JOURNAL   Mol Cell Biol 13 (10), 6024-6035 (1993)
   PUBMED   8413205
REFERENCE   8  (bases 1 to 4055)
  AUTHORS   Stapleton,P., Weith,A., Urbanek,P., Kozmik,Z. and Busslinger,M.
  TITLE     Chromosomal localization of seven PAX genes and cloning of a novel
            family member, PAX-9
  JOURNAL   Nat Genet 3 (4), 292-298 (1993)
   PUBMED   7981748
REFERENCE   9  (bases 1 to 4055)
  AUTHORS   Pilz,A.J., Povey,S., Gruss,P. and Abbott,C.M.
  TITLE     Mapping of the human homologs of the murine paired-box-containing
            genes
  JOURNAL   Mamm Genome 4 (2), 78-82 (1993)
   PUBMED   8431641
REFERENCE   10 (bases 1 to 4055)
  AUTHORS   Poleev,A., Fickenscher,H., Mundlos,S., Winterpacht,A., Zabel,B.,
            Fidler,A., Gruss,P. and Plachov,D.
  TITLE     PAX8, a human paired box gene: isolation and expression in
            developing thyroid, kidney and Wilms' tumors
  JOURNAL   Development 116 (3), 611-623 (1992)
   PUBMED   1337742
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AU141429.1, BC001060.2,
            AC016683.7 and BM726535.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003466.3.
            
            Summary: This gene encodes a member of the paired box (PAX) family
            of transcription factors. Members of this gene family typically
            encode proteins that contain a paired box domain, an octapeptide,
            and a paired-type homeodomain. This nuclear protein is involved in
            thyroid follicular cell development and expression of
            thyroid-specific genes. Mutations in this gene have been associated
            with thyroid dysgenesis, thyroid follicular carcinomas and atypical
            follicular thyroid adenomas. Alternatively spliced transcript
            variants encoding different isoforms have been described. [provided
            by RefSeq, Mar 2010].
            
            Transcript Variant: This variant (PAX8A) represents the longest
            transcript and encodes the longest isoform (PAX8A).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001060.2, X69699.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429538.8/ ENSP00000395498.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AU141429.1         1-9
            10-1536             BC001060.2         1-1527
            1537-4012           AC016683.7         53297-55772         c
            4013-4055           BM726535.1         298-340
FEATURES             Location/Qualifiers
     source          1..4055
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..4055
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /note="paired box 8"
                     /db_xref="GeneID:7849"
                     /db_xref="HGNC:HGNC:8622"
                     /db_xref="MIM:167415"
     exon            1..91
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            92..191
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1519
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /note="isoform PAX8A is encoded by transcript variant
                     PAX8A; paired domain gene 8; paired box protein Pax-8"
                     /codon_start=1
                     /product="paired box protein Pax-8 isoform PAX8A"
                     /protein_id="NP_003457.1"
                     /db_xref="CCDS:CCDS46398.1"
                     /db_xref="GeneID:7849"
                     /db_xref="HGNC:HGNC:8622"
                     /db_xref="MIM:167415"
                     /translation="MPHNSIRSGHGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRP
                     CDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPKVATPKVVEKIGDYKRQNPTM
                     FAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQPFNLPMDSCVATKSLSPGHTLI
                     PSSAVTPPESPQSDSLGSTYSINGLLGIAQPGSDKRKMDDSDQDSCRLSIDSQSSSSG
                     PRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHTKGEQGLYPLPLLNSTLDDGKA
                     TLTPSNTPLGRNLSTHQTYPVVADPHSPFAIKQETPEVSSSSSTPSSLSSSAFLDLQQ
                     VGSGVPPFNAFPHAASVYGQFTGQALLSGREMVGPTLPGYPPHIPTSGQGSYASSAIA
                     GMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAFDHL
                     "
     exon            192..357
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            358..555
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            556..644
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            645..767
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            768..943
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1064
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1253
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1254..1355
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1442
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..4055
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2672..2677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /note="hexamer: AATAAA"
     polyA_site      2690
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /note="major polyA site"
     regulatory      4020..4025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
                     /note="hexamer: AATAAA"
     polyA_site      4055
                     /gene="PAX8"
                     /gene_synonym="PAX-8"
ORIGIN      
        1 gggaacaaac ttcagaagga ggagagacac cgggcccagg gcaccctcgc gggcggaccc
       61 aagcagtgag ggcctgcagc cggccggcca gggcagcggc aggcgcggcc cggacctacg
      121 ggaggaagcc ccgagccctc ggcgggctgc gagcgactcc ccggcgatgc ctcacaactc
      181 catcagatct ggccatggag ggctgaacca gctgggaggg gcctttgtga atggcagacc
      241 tctgccggaa gtggtccgcc agcgcatcgt agacctggcc caccagggtg taaggccctg
      301 cgacatctct cgccagctcc gcgtcagcca tggctgcgtc agcaagatcc ttggcaggta
      361 ctacgagact ggcagcatcc ggcctggagt gatagggggc tccaagccca aggtggccac
      421 ccccaaggtg gtggagaaga ttggggacta caaacgccag aaccctacca tgtttgcctg
      481 ggagatccga gaccggctcc tggctgaggg cgtctgtgac aatgacactg tgcccagtgt
      541 cagctccatt aatagaatca tccggaccaa agtgcagcaa ccattcaacc tccctatgga
      601 cagctgcgtg gccaccaagt ccctgagtcc cggacacacg ctgatcccca gctcagctgt
      661 aactcccccg gagtcacccc agtcggattc cctgggctcc acctactcca tcaatgggct
      721 cctgggcatc gctcagcctg gcagcgacaa gaggaaaatg gatgacagtg atcaggatag
      781 ctgccgacta agcattgact cacagagcag cagcagcgga ccccgaaagc accttcgcac
      841 ggatgccttc agccagcacc acctcgagcc gctcgagtgc ccatttgagc ggcagcacta
      901 cccagaggcc tatgcctccc ccagccacac caaaggcgag cagggcctct acccgctgcc
      961 cttgctcaac agcaccctgg acgacgggaa ggccaccctg accccttcca acacgccact
     1021 ggggcgcaac ctctcgactc accagaccta ccccgtggtg gcagatcctc actcaccctt
     1081 cgccataaag caggaaaccc ccgaggtgtc cagttctagc tccacccctt cctctttatc
     1141 tagctccgcc tttttggatc tgcagcaagt cggctccggg gtcccgccct tcaatgcctt
     1201 tccccatgct gcctccgtgt acgggcagtt cacgggccag gccctcctct cagggcgaga
     1261 gatggtgggg cccacgctgc ccggataccc accccacatc cccaccagcg gacagggcag
     1321 ctatgcctcc tctgccatcg caggcatggt ggcaggaagt gaatactctg gcaatgccta
     1381 tggccacacc ccctactcct cctacagcga ggcctggcgc ttccccaact ccagcttgct
     1441 gagttcccca tattattaca gttccacatc aaggccgagt gcaccgccca ccactgccac
     1501 ggcctttgac catctgtagt tgccatgggg acagtgggag cgactgagca acaggaggac
     1561 tcagcctggg acaggcccca gagagtcaca caaaggaatc tttatttatt acatgaaaaa
     1621 taaccacaag tccagcattg cggcacactc cctgtgtggt taatttaatg aaccatgaaa
     1681 gacaggatga ccttggacaa ggccaaactg tcctccaaga ctccttaatg aggggcagga
     1741 gtcccaggga aagagaacca tgccatgctg aaaaagacaa aattgaagaa gaaatgtagc
     1801 ccccagccgg tacccaccaa aggagagaag aagcaatagc cgaggaactt ggggggatgg
     1861 cgaatggttc ctgcccgggc ccaaggggtg cacagggcac ctccatggct ccattattaa
     1921 cacaactcta gcaattatgg accataagca cttccctcca gcccacaagt cacagcctgg
     1981 tgccgaggct ctcctcacca gccacccagg gagtcacctc cctcagcctc ccgcctgccc
     2041 cacacggagg ctctggctgt cctctttctc cactccattt gcttggctct ttctacacct
     2101 ccctcttggg catgggctga gggctggagc gagtccctca gaaattccac caggctgtca
     2161 gctgacctct tttgcctgct gctgtgaagg tatagcacca ccccaggtcc tcctgcagtg
     2221 cggcatcccc ttggcagctg ccgtcagcca ggccagcccc agggagctta aaacagacat
     2281 tccacagggc ctgggcccct gggaggtgag gtgtggtgtg cggcttcacc cagggcagaa
     2341 caaggcagaa tcgcaggaaa cccgcttccc cttcctgaca gctcctgcca agccaaatgt
     2401 gcttcctgca gctcacgccc accagctact gaagggaccc aaggcacccc ctgaagccag
     2461 cgatagaggg tccctctctg ctccccagca gctcctgccc ccaaggcctg actgtatata
     2521 ctgtaaatga aactttgttt gggtcaagct tccttctttc taacccccag actttggcct
     2581 ctgagtgaaa tgtctctctt tgccctgtgg ggcttctctc cttgatgctt ctttcttttt
     2641 ttaaagacaa cctgccatta ccacatgact caataaacca ttgctcttca tctcaggctt
     2701 tggggttggc tggggaagga ggcatcccgg ggctgggctt tctcccaaga acatcagagc
     2761 tgagtagccg acaaactcac tttggggccg tgggctggaa gggaccatct gatgccccag
     2821 agctctggct tggccttctc cctctgcctt taattcacgt tgaacgctgg gtacctcact
     2881 catcccaagt tcttcaacac tgagcaaatg caaggatagc acagtactga gccaaccata
     2941 gactccccac aaggagttgc tgttgttatt aacaggaagc cagagaatca gcagggtggg
     3001 ttagtgaggg atccgggaat agctgtgact ggagcctgca taaacagctc tgaagggaga
     3061 gagaagactg ggctctcttg tgtgccaggc acagtatgga aggcttcata taagttaagc
     3121 tgaaattagc cctgttttac atacagcttc attttacata tgaggaaact gaggctttga
     3181 aaaaaatgag atgtcttgtc caagatgaaa agtagtagat tcaaccaagt cctcttactc
     3241 taagcccaac gcttttaccc aaaaccccag agtcctcatc agggatgcca aatggttcta
     3301 gacccagtgg aggttctgga gctgccactg gggatttaat ttcttttgat ttgctaaaga
     3361 tttgacctga ctgaatggag aggtagagtg tagtgtggcc aggacaaggt gagggaggct
     3421 gtagagactt agcactttag gccaaccacc tccaggaaat ctgggaaatg caatgtgaca
     3481 gctcgggctc tgcactccag ggggctgtct ggtgtccaca tggaccttct ccatgtggga
     3541 cacagctgga acaagggggc aggggcctgc agctgggatg cccaggtgaa tatgggcagc
     3601 tggacaaaca acactgggat tgagtcagat agaaggggcc caaggactcc agggctggga
     3661 ggacagaggc tgggagagag ggctcttacc tccttaggcc tcccaaagag cggttaggga
     3721 tgctgccatg gatggcatgg cagggggaac cctcctggaa gaaaatccat ctcttctgaa
     3781 gggatctgag atgcggctgg tttttcaatg gcagaacttc cctctgcagc gcgactccga
     3841 atccatgaca tctgagagtc ttcctgacca caaacctctg ggatcccgag ggctccctac
     3901 ccaagaatca ctttgagcac agcatcccaa ggagcccata gagcgatccc ttgcattcac
     3961 agccacagcc cctctgggga cactctgtac ccccggcaga ccctttccaa ctcacaacca
     4021 ataaaggggc ttgggctgtg ctttgactaa ggtga
//
