LOCUS       NM_016734               8704 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens paired box 5 (PAX5), transcript variant 1, mRNA.
ACCESSION   NM_016734
VERSION     NM_016734.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8704)
  AUTHORS   Bhattacharya,S., Harris,H.L., Islam,R., Bodas,S., Polavaram,N.,
            Mishra,J., Das,D., Seshacharyulu,P., Kalluchi,A., Pal,A., Kohli,M.,
            Lele,S.M., Muders,M., Batra,S.K., Ghosh,P.M., Datta,K., Rowley,M.J.
            and Dutta,S.
  TITLE     Understanding the function of Pax5 in development of
            docetaxel-resistant neuroendocrine-like prostate cancers
  JOURNAL   Cell Death Dis 15 (8), 617 (2024)
   PUBMED   39183332
  REMARK    GeneRIF: Understanding the function of Pax5 in development of
            docetaxel-resistant neuroendocrine-like prostate cancers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8704)
  AUTHORS   Tang,H., Yang,J., Xu,J., Zhang,W., Geng,A., Jiang,Y. and Mao,Z.
  TITLE     The transcription factor PAX5 activates human LINE1
            retrotransposons to induce cellular senescence
  JOURNAL   EMBO Rep 25 (8), 3263-3275 (2024)
   PUBMED   38866979
  REMARK    GeneRIF: The transcription factor PAX5 activates human LINE1
            retrotransposons to induce cellular senescence.
REFERENCE   3  (bases 1 to 8704)
  AUTHORS   Yan,Z., Liu,H. and Wang,K.
  TITLE     Diagnostic efficacy of SEPT9 and PAX5 gene methylation in
            gastrointestinal cancer and precancerous lesions
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (7), 128-133 (2024)
   PUBMED   39097885
  REMARK    GeneRIF: Diagnostic efficacy of SEPT9 and PAX5 gene methylation in
            gastrointestinal cancer and precancerous lesions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8704)
  AUTHORS   Li,L., Zhang,D. and Cao,X.
  TITLE     EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms
  JOURNAL   Front Immunol 15, 1320689 (2024)
   PUBMED   38318177
  REMARK    GeneRIF: EBF1, PAX5, and MYC: regulation on B cell development and
            association with hematologic neoplasms.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8704)
  AUTHORS   Fouad,F.M. and Eid,J.I.
  TITLE     PAX5 fusion genes in acute lymphoblastic leukemia: A literature
            review
  JOURNAL   Medicine (Baltimore) 102 (20), e33836 (2023)
   PUBMED   37335685
  REMARK    GeneRIF: PAX5 fusion genes in acute lymphoblastic leukemia: A
            literature review.
            Review article
REFERENCE   6  (bases 1 to 8704)
  AUTHORS   Mullighan,C.G., Goorha,S., Radtke,I., Miller,C.B.,
            Coustan-Smith,E., Dalton,J.D., Girtman,K., Mathew,S., Ma,J.,
            Pounds,S.B., Su,X., Pui,C.H., Relling,M.V., Evans,W.E.,
            Shurtleff,S.A. and Downing,J.R.
  TITLE     Genome-wide analysis of genetic alterations in acute lymphoblastic
            leukaemia
  JOURNAL   Nature 446 (7137), 758-764 (2007)
   PUBMED   17344859
REFERENCE   7  (bases 1 to 8704)
  AUTHORS   Busslinger,M., Klix,N., Pfeffer,P., Graninger,P.G. and Kozmik,Z.
  TITLE     Deregulation of PAX-5 by translocation of the Emu enhancer of the
            IgH locus adjacent to two alternative PAX-5 promoters in a diffuse
            large-cell lymphoma
  JOURNAL   Proc Natl Acad Sci U S A 93 (12), 6129-6134 (1996)
   PUBMED   8650231
REFERENCE   8  (bases 1 to 8704)
  AUTHORS   Stapleton,P., Weith,A., Urbanek,P., Kozmik,Z. and Busslinger,M.
  TITLE     Chromosomal localization of seven PAX genes and cloning of a novel
            family member, PAX-9
  JOURNAL   Nat Genet 3 (4), 292-298 (1993)
   PUBMED   7981748
REFERENCE   9  (bases 1 to 8704)
  AUTHORS   Pilz,A.J., Povey,S., Gruss,P. and Abbott,C.M.
  TITLE     Mapping of the human homologs of the murine paired-box-containing
            genes
  JOURNAL   Mamm Genome 4 (2), 78-82 (1993)
   PUBMED   8431641
REFERENCE   10 (bases 1 to 8704)
  AUTHORS   Adams,B., Dorfler,P., Aguzzi,A., Kozmik,Z., Urbanek,P.,
            Maurer-Fogy,I. and Busslinger,M.
  TITLE     Pax-5 encodes the transcription factor BSAP and is expressed in B
            lymphocytes, the developing CNS, and adult testis
  JOURNAL   Genes Dev 6 (9), 1589-1607 (1992)
   PUBMED   1516825
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161781.12, M96944.1 and
            AL450267.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016734.2.
            
            Summary: This gene encodes a member of the paired box (PAX) family
            of transcription factors. The central feature of this gene family
            is a novel, highly conserved DNA-binding motif, known as the paired
            box. Paired box transcription factors are important regulators in
            early development, and alterations in the expression of their genes
            are thought to contribute to neoplastic transformation. This gene
            encodes the B-cell lineage specific activator protein that is
            expressed at early, but not late stages of B-cell differentiation.
            Its expression has also been detected in developing CNS and testis
            and so the encoded protein may also play a role in neural
            development and spermatogenesis. This gene is located at 9p13,
            which is involved in t(9;14)(p13;q32) translocations recurring in
            small lymphocytic lymphomas of the plasmacytoid subtype, and in
            derived large-cell lymphomas. This translocation brings the potent
            E-mu enhancer of the IgH gene into close proximity of the PAX5
            promoter, suggesting that the deregulation of transcription of this
            gene contributes to the pathogenesis of these lymphomas.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M96944.1, AY463952.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358127.9/ ENSP00000350844.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AL161781.12        128689-128850       c
            163-3439            M96944.1           1-3277
            3440-8704           AL450267.10        50961-56225         c
FEATURES             Location/Qualifiers
     source          1..8704
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p13.2"
     gene            1..8704
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /note="paired box 5"
                     /db_xref="GeneID:5079"
                     /db_xref="HGNC:HGNC:8619"
                     /db_xref="MIM:167414"
     exon            1..283
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1413
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     B-cell lineage specific activator; paired box protein
                     Pax-5; paired box homeotic gene 5; transcription factor
                     PAX 5; paired domain gene 5"
                     /codon_start=1
                     /product="paired box protein Pax-5 isoform 1"
                     /protein_id="NP_057953.1"
                     /db_xref="CCDS:CCDS6607.1"
                     /db_xref="GeneID:5079"
                     /db_xref="HGNC:HGNC:8619"
                     /db_xref="MIM:167414"
                     /translation="MDLEKNYPTPRTSRTGHGGVNQLGGVFVNGRPLPDVVRQRIVEL
                     AHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPGVIGGSKPKVATPKVVEKIAEY
                     KRQNPTMFAWEIRDRLLAERVCDNDTVPSVSSINRIIRTKVQQPPNQPVPASSHSIVS
                     TGSVTQVSSVSTDSAGSSYSISGILGITSPSADTNKRKRDEGIQESPVPNGHSLPGRD
                     FLRKQMRGDLFTQQQLEVLDRVFERQHYSDIFTTTEPIKPEQTTEYSAMASLAGGLDD
                     MKANLASPTPADIGSSVPGPQSYPIVTGRDLASTTLPGYPPHVPPAGQGSYSAPTLTG
                     MVPGSEFSGSPYSHPQYSSYNDSWRFPNPGLLGSPYYYSAAARGAAPPAAATAYDRH"
     exon            284..449
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            450..647
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            648..712
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            713..841
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1017
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1147
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1249
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1336
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..8704
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8675..8680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /note="hexamer: AATAAA"
     polyA_site      8704
                     /gene="PAX5"
                     /gene_synonym="ALL3; BSAP; PAX-5"
                     /note="major polyA site"
ORIGIN      
        1 agttccttaa tcatttcacg gtgccttcgg acgctttttt tccacctaaa acgtttagtt
       61 tcagctcagt gatcagctac cccagctcgg cgggggagcg gaaggcttga attattccga
      121 cctgtgagcg gcccctggca ccaaaaaaaa aaaaaaaaaa aaaaaaaaaa gaaaaaaaaa
      181 ggcacaaaaa agtggaaact tttccctgtc cattccatca agtcctgaaa aatcaaaatg
      241 gatttagaga aaaattatcc gactcctcgg accagcagga caggacatgg aggagtgaat
      301 cagcttgggg gggtttttgt gaatggacgg ccactcccgg atgtagtccg ccagaggata
      361 gtggaacttg ctcatcaagg tgtcaggccc tgcgacatct ccaggcagct tcgggtcagc
      421 catggttgtg tcagcaaaat tcttggcagg tattatgaga caggaagcat caagcctggg
      481 gtaattggag gatccaaacc aaaggtcgcc acacccaaag tggtggaaaa aatcgctgaa
      541 tataaacgcc aaaatcccac catgtttgcc tgggagatca gggaccggct gctggcagag
      601 cgggtgtgtg acaatgacac cgtgcctagc gtcagttcca tcaacaggat catccggaca
      661 aaagtacagc agccacccaa ccaaccagtc ccagcttcca gtcacagcat agtgtccact
      721 ggctccgtga cgcaggtgtc ctcggtgagc acggattcgg ccggctcgtc gtactccatc
      781 agcggcatcc tgggcatcac gtcccccagc gccgacacca acaagcgcaa gagagacgaa
      841 ggtattcagg agtctccggt gccgaacggc cactcgcttc cgggcagaga cttcctccgg
      901 aagcagatgc ggggagactt gttcacacag cagcagctgg aggtgctgga ccgcgtgttt
      961 gagaggcagc actactcaga catcttcacc accacagagc ccatcaagcc cgagcagacc
     1021 acagagtatt cagccatggc ctcgctggct ggtgggctgg acgacatgaa ggccaatctg
     1081 gccagcccca cccctgctga catcgggagc agtgtgccag gcccgcagtc ctaccccatt
     1141 gtgacaggcc gtgacttggc gagcacgacc ctccccgggt accctccaca cgtccccccc
     1201 gctggacagg gcagctactc agcaccgacg ctgacaggga tggtgcctgg gagtgagttt
     1261 tccgggagtc cctacagcca ccctcagtat tcctcgtaca acgactcctg gaggttcccc
     1321 aacccggggc tgcttggctc cccctactat tatagcgctg ccgcccgagg agccgcccca
     1381 cctgcagccg ccactgccta tgaccgtcac tgacccttgg agccaggcgg gcaccaaaca
     1441 ctgatggcac ctattgaggg tgacagccac ccagccctcc tgaagatagc cagagagccc
     1501 atgagaccgt cccccagcat cccccacttg cctgaagctc ccctcttcct ctcttcctcc
     1561 agggactctg gggccctttg gtggggccgt tggacttctg gatgcttgtc tatttctaaa
     1621 agccaatcta tgagcttctc ccgatggcca ctgggtctct gcaaaccaat agactgtcct
     1681 gcaaataacc gcagccccag cccagcctgc ctgtcctcca gctgtctgac tatccatcca
     1741 tcataaccac cccagcctgg gaaggagagc ttgcttttgt tgcttcagca gcacccatgt
     1801 aaataccttc ttgcttttct gtgggcctga aggtccgact gagaagactg ctccacccat
     1861 gatgcatctc gcactcttgg tgcatcaccg gacatcttag acctatggca gagcatcctc
     1921 tctgccctgg gtgaccctgg caggtgcgct cagagctgtc ctcaagatgg aggatgctgc
     1981 ccttgggccc cagcctcctg ctcatccctc cttctttagt atctttacga ggagtctcac
     2041 tgggctggtt gtgctgcagg ctccccctga ggcccctctc caagaggagc acactttggg
     2101 gagatgtcct ggtttcctgc ctccatttct ctgggaccga tgcagtatca gcagctcttt
     2161 tccagatcaa agaactcaaa gaaaactgtc tgggagattc ctcagctact tttccgaagc
     2221 agaatgtcat ccgaggtatt gattacattg tggactttga atgtgagggc tggatgggac
     2281 gcaggagatc atctgatccc agccaaggag gggcctgagg ctctccctac tccctcagcc
     2341 cctggaacgg tgttttctga ggcatgccca ggttcaggtc acttcggaca cctgccatgg
     2401 acacttcacc caccctccag gaccccagca agtggattct gggcaagcct gttccggtga
     2461 tgtagacaat aattaacaca gaggactttc ccccacaccc agatcacaaa cagcctacag
     2521 ccagaacttc tgagcatcct ctcggggcag accctccccg tcctcgtgga gcttagcagg
     2581 cagctgggca tggaggtgct ggggctgggg cagatgccta atttcgcaca atgcatgccc
     2641 acctgttgat ctaaggggcc gcgatggtca gggccacggc caagggccac gggaacttgg
     2701 agagggagct tggagaactc actgtgggct agggtggtca gaggaagcca gcagggaaga
     2761 tctgggggac agaggaaggc ctcctgaggg aggggcagga gagcagtgag gagctgctgt
     2821 gtgacctggg agtgattttg acatgggggt gccaggtgcc atcatctctt tacctggggc
     2881 cttaattcct tgcatagtct ctcttgtcaa gtcagaacag ccaggtagag cccttgtcca
     2941 aacctgggct gaatgacagt gatgagaggg ggcttggcct tcttaggtga caatgtcccc
     3001 catatctgta tgtcaccagg atggcagaga gccagggcag agagagactg gacttgggat
     3061 cagcaggcca ggcaggtctt gtcctggtcc tggccacatg tctttgctgt gggacctcag
     3121 acaaaaccct gcacctcttt gagccttggc tgccttggtg cagcagggtc atctgtaggg
     3181 ccaccccaca gctctttcct tcccctcctc tctccaggga gccggggctg tgagaggatc
     3241 atctggggca ggccctccac ttccaagcaa gcagatgggg gtgggcacct gaggcccaat
     3301 aatatttgga ccaagtggga aacaagaaca ctcggagggg cgggaatcag aagagcctgg
     3361 aaaaagacct agcccaactt cccttgtggg aaactgaggc ccagcttggg gaaggccagg
     3421 accatgcagg gagaaaaagc agacttcctc tggccaccgc taagtatttt gttccctaag
     3481 tcccccacag ggtggtggaa cagaagagaa aactaaggct cagcaaggtg gagtcctcaa
     3541 gcagtgactg gtgggggtgg ggctgggact cgggctcctg acccccaacc catggtgttc
     3601 cctgtcaccc tggtctatcc acatctccta ttcctgagga gagttgacag taagagcagt
     3661 gagagatggt tctgggcccc atgccctaga caatcagtct gtaagaactg ccaaggaagc
     3721 ctggtcaccc aggccaggga tggagcccag cgagctcaca gcaggcacat gcacccccgc
     3781 ccccacccag aacctgcggg gcaaagaagg gaggtagttg gggccagagt ccacctccag
     3841 gagccagggt gagctggctg cagcttccac ctgtcaggta aggtaggaga aggtatgtta
     3901 cctggcatct ctctccctgc ctccctccat ttagcaggaa gtggtggggt caggggtctt
     3961 cagcacagac ttcttgagcc tctgccccct gtcacccttc ttttggaatg atgtgtaccc
     4021 acatctttgg atcctgccct ccttgtggtt ccaggctgtt gggaggaggt cagcctcccc
     4081 tgaaccagct gcctgaggca tgcagcatcc ttcctcggca aagcccacct ggctcacagc
     4141 ggccccctct ccccatcctg ttcctcttct tgccctgtaa tgagctcccc ccataccttt
     4201 cctccctcac ctgaggcttt gctggtcctc agattggttt tgtatttgtg agacaaccac
     4261 ttgactcctg ggctgccagg cggaagcaca agcgcacatg gatgcacacg gatgttctca
     4321 cacacacacg cccgctctca ccaattcaca gcacctcgtg gtccagcgga gctgcctggg
     4381 agcttggtga ggatggctcc aaaggacaca agccgttgag tagatgccag agaattctga
     4441 atggaaaaca caagtccggg gcctcaccag catcgtggca gaaggcctgg ggcatttctc
     4501 catgggcctt cttccctgtg ttcgagctct gacttttgga aaaggacatt gtggatttta
     4561 tgaaaatttc tcataccatc agtctagctc caacctagaa aaattggatg atatatcaaa
     4621 cccaacatcc ctttcccaag gcaccttagt taaggctagc ccttccataa ctgacattgt
     4681 acggtgcttt gcaatcctca accactctgt ggagcaaaga gcatgatgcc tactttatag
     4741 acggggaaat tgacatttgg ggctctcacg gcaacataga ggcgaagtga attctcagat
     4801 ctccaggccc cattctctct ccaccgagtt gtgctcctgt catgggagtg tatggcttaa
     4861 agacactccc ccacccccat tccctagaaa tcccccagac ccacaatcag gcaagaaaga
     4921 acagggaccc agaggctggc ctgacctagg ggcctgcagg ttggcggctt tgtttcctaa
     4981 gaacattgaa acctgcggag tctttgacca aatccacaac agtgcttctg aggtttcatc
     5041 cagactcttt cccagctgtc cctgaggttc agagggtatc agagtcaatt caaggccatg
     5101 ccataatccc tgaccaggcc tggacatggg tccagccctg actccagggg tccaggtgcc
     5161 aaggtcatgt gctgtccccc acttcccttt ctttgccttc gcactttgga acaggctcca
     5221 ggcctggctg tgacagtatg caggagtgcc caagccaggg ccaccagggt gtccacagcc
     5281 cctggaaaca cagatcacaa tctcaagtcc cctgaatgaa ctgcttcctg ggtgaacggg
     5341 gtggtgtagc cttgccactc gggcagcgca ccagacagta cggtgcagca gtgcccgaga
     5401 tgcccagaag tgtgcctgcc cccctgagtg gcattcaagt atgaaaactt gtaaaatttt
     5461 ctgtcggcct aaagaaaaat gtccatgggc caaacttgac ccactgggca ccagcctgtg
     5521 agccccaatg cctgtcaatt gccccctttc tcattcacct cctgtccttt gttgcagatt
     5581 tggaggagat gggagcccag agaggtgaga gatgtgcttc agggtgtcca gcaaggcagg
     5641 ggtagaaacg ggcacgccca gagcctgcca ctctcccagg cctcatcttg ggctcttgca
     5701 agtcttgcgc tttgaagatg gagttgggtg gaaggtcaga ggcgctgggg acgggattgg
     5761 ggagctgctg ggttttcagg ggaggtcagt gctgcttggg cacctttcac atgtgcaggg
     5821 aagagactca gatgtggcca cagggcactg aggggtgaaa tccatttacc agaagtcacg
     5881 ctccagaacg actgcccagc cttggcagcc agtggctcca gccaccccct cctcatgaca
     5941 ttcagccaga attgagctcc aagccaggga agcaaatctt aaaaaccaac caagcaccct
     6001 gacacagccc tagaaacacg atgagtctga aatacagctt cccaggaggg gagtctaaga
     6061 tacagcttcc cgggagggtg gaaaccaact cctgccccac ggccaggcca ggcccaggca
     6121 ggcatgggtg gatcccacag ggctctgagc tagaccggct ccacggtggc cccactacga
     6181 ggccagttct gcagtcttgg ccttgtcacc catcgagagg ctgctctgat ggttcccagc
     6241 cacacaccag ctctcctggg gaaactattt ctttcgttct tttggcctcg gagaggtccg
     6301 aggcaagtac atttcttaaa aggtaataaa atgcattatt ggaaagttgg acagtcaggc
     6361 cacgactcct agcccacggc gtgccccacc tcccagcagc cccttcagcc ccttgcccct
     6421 gttgccccaa acctcagggt tccctcttgc atattcatgg gggaaccaca gtgctgatgt
     6481 gtacttcccc actgtcagct cggctgcacc tcgtgtggcg ccaggtccca agggcctctg
     6541 cagaggccag gctgtgagcc ccttgcctgc ctgctcccct gatgaggcaa cagcttctct
     6601 gaaatgagct gccggccagg agcaggcagg caccagcctg tctttccttt tctggtaatt
     6661 cctcagcact gaggctccgt tcctgggcac cccaggattg aagggaacct cagaatcatg
     6721 tcactgccat tctagagttt caatccaagg ggtccccttt agctcatctc caagatgggt
     6781 aaacgtagcc accattcaga aagcccagaa attcttgttc ccacatctta gacccctgag
     6841 caacacaagg agaaaatgca gctgcttacc tattaatatc tactgaggga caatcagcaa
     6901 agcctcaaag gagtcgtctc aggtagggta cttggcctgt ggcaggagag acagaggcac
     6961 aaacccaccc acccatcagc ttccggtggc tgatcggggc ccagggaggg aagcaggtga
     7021 aacagcaggg tgggggtgac ttggcagtcg tgcatctcct ccccgactct gaggcctggc
     7081 aggaggaggc cacaccagcc tcacctgccc tgacccccgc cccccaccct gtgaccctgt
     7141 ggctatggcc gctggtcgcc cttgtcccca aaatcaccat gcctgtggcc acgtccctca
     7201 tcttctccaa aagcatcatt aagaacaagt gattttggat gatggatttt tgatttacaa
     7261 acggcgcatt tcccttggag tggaacagaa aggaaaccat ttaatggcgc ccttcttttc
     7321 aagcatgaat acattttaat gaaactattt tattgtattt gaggaaatgg agagttgaac
     7381 attccaacca atcaatagcc aattaattgc tataaagcta aaaagaaaat aaataaatcc
     7441 tgagtctatt ttaaacactg caaaaagttc agagcctcag aatctggcct tcccctccat
     7501 aaggtgcacg agcatgtaaa cacacacaca cacacacaca cacacacaca cacactcact
     7561 cactccccta cacctcagac atacttgaaa ctcagaaaca gcactgagtc tccccatgcc
     7621 aattcttgcc tgctgtcttc gacttgggtc agagaaggtg agcagacccg gcagcagcct
     7681 gtcccggggc tcaggaagag gcaggcccat cccctggccc caagcaccca gcacaacaga
     7741 gggtggcggg cagtgagggc ctggcgttgc ctgggcccca cttctcagcc ccagctgctg
     7801 ggcctccaag gttgggctga ggatggagtt ttggctctgg gtttgccctg actcctgctg
     7861 gaagacgctg ccctggtttt tcaccctcta gtggccttgg acattgagta tttgtagaaa
     7921 tgcagattac attgcaaatg gaaacctttg ccaggaagac acatgcattt tgcttttaat
     7981 tctttgagac atttgatttt gtcttaggga ctgacctttc agcatcaaag aaatacatat
     8041 ctactgtatc cgccaaagtt tgtgatgcct gcatagacgc ttacttgtaa aaaaaaaaaa
     8101 atacaaaaaa atacaaaaaa accaacaaca aaaaccacaa ttgaattgcc tttgaaagtg
     8161 ggagatgatc tgtctccaac ggattgaaaa aaaaaaatgc ttcttaaaaa atgtgtatgt
     8221 tttgtattct ttttttctag tagaaaataa ctgacttgaa atattggtgg tttttttctt
     8281 agtgacgtgt gttgcttttg tgtgtaataa tatttgaatg taattacagc agtgccaatt
     8341 tgccaaagat gttggacata tttttctttt ttggggagga gggcagggct aggggtggga
     8401 cttgggagaa aacaggggtg gggttttggt ttaatttttt ttttactttt ttttccttgt
     8461 caaacctgaa atttgtggct tccttttaag ttaaatggtt gactgcaaca cctttatttt
     8521 agattagttg gagaaacatg caataagatt ggcgtagttt caatatctgt gtgtcttttc
     8581 atgagtggct gttacttgtg aagaattgat tttatgtaac ctttatgtga gataattatt
     8641 tgtaaatatt tgccataatt ttattggttc ctaaaataaa agtaattttt taagttcaga
     8701 aaaa
//
