LOCUS       NM_002583               8991 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens pro-apoptotic WT1 regulator (PAWR), transcript variant
            1, mRNA.
ACCESSION   NM_002583
VERSION     NM_002583.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8991)
  AUTHORS   Winfree,R.L., Erreger,K., Phillips,J., Seto,M., Wang,Y.,
            Schneider,J.A., Bennett,D.A., Schrag,M.S., Hohman,T.J. and
            Hamm,H.E.
  TITLE     Elevated protease-activated receptor 4 (PAR4) gene expression in
            Alzheimer's disease predicts cognitive decline
  JOURNAL   Neurobiol Aging 140, 93-101 (2024)
   PUBMED   38761538
  REMARK    GeneRIF: Elevated protease-activated receptor 4 (PAR4) gene
            expression in Alzheimer's disease predicts cognitive decline.
REFERENCE   2  (bases 1 to 8991)
  AUTHORS   Zhang,Y., Li,Z., Wang,J., Chen,H., He,R. and Wu,H.
  TITLE     CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes
            via the Signal Regulation of miR-370-3p/PAWR Axis
  JOURNAL   Cardiovasc Ther 2022, 7125602 (2022)
   PUBMED   35251305
  REMARK    GeneRIF: CircTRRAP Knockdown Has Cardioprotective Function in
            Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8991)
  AUTHORS   Heo,Y., Jeon,H. and Namkung,W.
  TITLE     PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are
            Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells
  JOURNAL   Int J Mol Sci 23 (2), 776 (2022)
   PUBMED   35054966
  REMARK    GeneRIF: PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways
            Are Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8991)
  AUTHORS   Qinan,W., Ling,Z. and Bing,C.
  TITLE     PAR-4: a possible new target for age-related disease
  JOURNAL   Expert Opin Ther Targets 18 (8), 917-927 (2014)
   PUBMED   24890982
  REMARK    Review article
REFERENCE   5  (bases 1 to 8991)
  AUTHORS   Hebbar,N., Shrestha-Bhattarai,T. and Rangnekar,V.M.
  TITLE     Cancer-selective apoptosis by tumor suppressor par-4
  JOURNAL   Adv Exp Med Biol 818, 155-166 (2014)
   PUBMED   25001535
  REMARK    GeneRIF: The cancer cell specific activity of Par-4 is elicited
            through intracellular as well as extracellular mechanisms.
            Review article
REFERENCE   6  (bases 1 to 8991)
  AUTHORS   Irby,R.B. and Kline,C.L.
  TITLE     Par-4 as a potential target for cancer therapy
  JOURNAL   Expert Opin Ther Targets 17 (1), 77-87 (2013)
   PUBMED   23062118
  REMARK    Review article
REFERENCE   7  (bases 1 to 8991)
  AUTHORS   Kruman,I.I., Nath,A., Maragos,W.F., Chan,S.L., Jones,M.,
            Rangnekar,V.M., Jakel,R.J. and Mattson,M.P.
  TITLE     Evidence that Par-4 participates in the pathogenesis of HIV
            encephalitis
  JOURNAL   Am J Pathol 155 (1), 39-46 (1999)
   PUBMED   10393834
REFERENCE   8  (bases 1 to 8991)
  AUTHORS   Johnstone,R.W., Tommerup,N., Hansen,C., Vissing,H. and Shi,Y.
  TITLE     Mapping of the human PAWR (par-4) gene to chromosome 12q21
  JOURNAL   Genomics 53 (2), 241-243 (1998)
   PUBMED   9790775
REFERENCE   9  (bases 1 to 8991)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
  REMARK    GeneRIF: Par-4 expression is increased in vulnerable neurons in
            Alzheimer's disease, and contributes to apoptotic neuronal cell
            death in the disease.
REFERENCE   10 (bases 1 to 8991)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN280333.1, BC007018.1,
            U63809.1 and AC027288.26.
            
            On Nov 22, 2018 this sequence version replaced NM_002583.3.
            
            Summary: This gene encodes a tumor suppressor protein that
            selectively induces apoptosis in cancer cells through intracellular
            and extracellular mechanisms. The intracellular mechanism involves
            the inhibition of pro-survival pathways and the activation of
            Fas-mediated apoptosis, while the extracellular mechanism involves
            the binding of a secreted form of this protein to glucose regulated
            protein 78 (GRP78) on the cell surface, which leads to activation
            of the extrinsic apoptotic pathway. This gene is located on the
            unstable human chromosomal 12q21 region and is often deleted or
            mutated different tumors. The encoded protein also plays an
            important role in the progression of age-related diseases.
            [provided by RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63809.1, DRR138511.28563.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328827.9/ ENSP00000328088.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-375               CN280333.1         50-424
            376-836             BC007018.1         268-728
            837-1081            U63809.1           841-1085
            1082-1616           BC007018.1         974-1508
            1617-1626           U63809.1           1621-1630
            1627-1904           BC007018.1         1520-1797
            1905-8991           AC027288.26        4498-11584
FEATURES             Location/Qualifiers
     source          1..8991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..8991
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="pro-apoptotic WT1 regulator"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:HGNC:8614"
                     /db_xref="MIM:601936"
     exon            1..93
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            94..756
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1263
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcriptional repressor PAR4; WT1-interacting protein;
                     prostate apoptosis response protein 4; prostate apoptosis
                     response protein PAR-4; prostate apoptosis response-4;
                     PRKC, apoptosis, WT1, regulator"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein isoform 1"
                     /protein_id="NP_002574.2"
                     /db_xref="CCDS:CCDS31863.1"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:HGNC:8614"
                     /db_xref="MIM:601936"
                     /translation="MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGG
                     GSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAA
                     PGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKR
                     RSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEP
                     PRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLE
                     KEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKV
                     VGQLTR"
     exon            757..888
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            889..923
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1071
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1176
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..8991
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6052..6057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="hexamer: AATAAA"
     polyA_site      6079
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="major polyA site"
     regulatory      8968..8973
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="hexamer: AATAAA"
     polyA_site      8991
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
ORIGIN      
        1 actttccgcg cggcggaaga gcgcgcgcca gcttcggcac acctgggagc cggatcccag
       61 ccctacgcct cgtcccctac aagctcctcc aagccccgcc ggctgctgtg ggagcggcgg
      121 ccgtccctct cctggaggtc gtctcctggc atcctcgggg ccgcaggaag gaagaggagg
      181 cagcggccgg agccctggtg ggcggcctga ggtgagagcc cgaccggccc ctttgggaat
      241 atggcgaccg gtggctaccg gaccagcagc ggcctcggcg gcagcaccac agacttcctg
      301 gaggagtgga aggcgaaacg cgagaagatg cgcgccaagc agaacccccc gggcccggcc
      361 cccccgggag ggggcagcag cgacgccgct gggaagcccc ccgcgggggc tctgggcacc
      421 ccggcggccg ccgctgccaa cgagctcaac aacaacctcc cgggcggcgc gccggccgca
      481 cctgccgtcc ccggtcccgg gggcgtgaac tgcgcggtcg gctccgccat gctgacgcgg
      541 gcggcccccg gcccgcggcg gtcggaggac gagcccccag ccgcctctgc ctcggctgca
      601 ccgccgcccc agcgtgacga ggaggagccg gacggcgtcc cagagaaggg caagagctcg
      661 ggccccagtg ccaggaaagg caaggggcag atcgagaaga ggaagctgcg ggagaagcgg
      721 cgctccaccg gcgtggtcaa catccctgcc gcagagtgct tagatgagta cgaagatgat
      781 gaagcagggc agaaagagcg gaaacgagaa gatgcaatta cacaacagaa cactattcag
      841 aatgaagctg taaacttact agatccaggc agttcctatc tgctacagga gccacctaga
      901 acagtttcag gcagatataa aagcacaacc agtgtctctg aagaagatgt ctcaagtaga
      961 tattctcgaa cagatagaag tgggttccct agatataaca gggatgcaaa tgtttcaggt
     1021 actctggttt caagtagcac actggaaaag aaaattgaag atcttgaaaa ggaagtagta
     1081 agagaaagac aagaaaacct aagacttgtg agactgatgc aagataaaga ggaaatgatt
     1141 ggaaaactca aagaagaaat tgatttatta aatagagacc tagatgacat agaagatgaa
     1201 aatgaacagc taaagcagga aaataaaact cttttgaaag ttgtgggtca gctgaccagg
     1261 tagaggattc aagactcaat gtggaaaaaa tattttaaac tactgattga atgttaatgg
     1321 tcaatgctag cacaatattc ctatgctgca atacattaaa ataactaagc aagtatattt
     1381 atttctagca aacagatgtt tgttttcaaa atacttcttt ttcattattg gttttaaaaa
     1441 agcattatcc ttttatctca caaataagta atatctttca gttattaaat gatagataat
     1501 gcctttttgg ttttgtgtgg tattcaacta atacatggtt taaagtcaca gccgtttgaa
     1561 tatattttat cttggtagta cattttctcc cttaggaata tacatagtct ttgtttacat
     1621 gagttcaaat acttttggga tgttaccttc acatgtccta ttactgatgt gtgcaacctt
     1681 ttatgtgttg atgactcact cataaaggtt tttgtctact gtcatttgtt ctttccactt
     1741 attctaagca tttagagtaa tagagtcata cttttttata acagcaacct tttaaaagga
     1801 aagctcttat aaagtcactg tcatgtttta gttgactaaa tataaattta agagaatact
     1861 tgaattgtgc tatagtaaat aaaaatttac tattttgtgt ttgaatattg aaaaattgaa
     1921 tcactttaac tcctgaaaaa catacaattg taatttcaat gtaaaatttc ttatgtaggt
     1981 actacctttt tttatcgttc caaggtttgc tagtgaacac aggatatttt aaaagttttt
     2041 tattcttcgg gcctggaaag tgtacaaagt cagtgtagga gaaaaaaatc catattttta
     2101 tattagcatg cacactaaaa accaaaatat tattcatact taaaacattc atacaaaaca
     2161 atatgtaagc agaaatagta ctaaaatact ttgcctaatt tctaagttga agaataacac
     2221 tgggacacag ttttttcata tgagagaata ttccgctatt tcaaatttaa gggattttct
     2281 tcctaacatt gaaattttaa aaacagagtt acttctaaat aattatacag attttttctt
     2341 ctattaaata ttattattta gaattgtttt tgtattacat attcatgtta agaaccccgt
     2401 cttcccttaa aatacattaa aattatgaca tttttgcttt gtgattgaat ttcaaatagc
     2461 agtatggtat ccttttatct agttaatata tgaaagtggc ttgaatatag tcaaatccat
     2521 tttaggtact ctactgactt tttccttcac ttgccaagcc cttttattgt tcactgttag
     2581 aaaaatagag aaggtgagac agctggggga aaatgtggag taaatgataa tcaaatgttg
     2641 aattctaaaa gtctctacat ttacctaggt tggctttctc ccccagttca gaagtttcca
     2701 gcttggccaa tcatcagaat cacttgagga acttagaaag aactccctgg ctgtagctcc
     2761 tatgtaggtt taggttgaga ctctggattc cacaattttt aaaggttacc atctgaggtt
     2821 tctgatcata gtctactttt gaagcagctg ctgctgtttc tttattccat tgaacaccct
     2881 ggaattgaca taattttatc tatcagcatt tctccccttt tagtttattt aataattaac
     2941 ccggtctcca gggcagtttt catatgacca tgtgtatatt cactgctcac gaaaaagttt
     3001 aatgttagat taccaaattt aatatagtta cagaattact gcataagggc ttcccttctt
     3061 ggagactctt acccagcatg ggaacagtga tctgcccaca tgacagggtg gtatgccagg
     3121 catagttaac tgcttttggt tgtgaggtac tcatcttcct ttagttaccc ttagttatgt
     3181 ggcacacatg tccttattgc ctagttcgtc atccacactt tggatcttgt gaaaatgctg
     3241 ttagtatcca accttaaaat atattagtat atgggttttt attaaaagaa ttactttgaa
     3301 ttttctattt aattcatatg taaataaagg aacatttcat ttcacttaaa aaaattatat
     3361 cagttattag gctgggtgca gtggctcatg cctgtaatcc cagcactttg ggaggccaag
     3421 gcgggtggat taccagagtt cgggagtttg agaccagctt gaccaacatg gagaaacccc
     3481 gtctctacta aaaatacaaa attagccagg tgtggtggcg catgcctgta atcctggcta
     3541 ctcaggaggc tgaggcagga gaatcgcttg aaaacccagg agacagaggt tgcggtgagc
     3601 tgagattgcg ccattgtact ccagcctggg caagaagagc gaaactctgt ctccaaaaaa
     3661 aaaaaaaaaa aaattattaa tacttttaaa gactgagctg tttaagaatt ttttggggaa
     3721 catttctagc agtgattttt ttggccttta atgatagcgt aaagacagga gccttacaac
     3781 ttaggcaaag catttcacat gcagtccttc ttccatctca aaatatgtac ttattttaca
     3841 tacagaattt tacactaacc attgaaaaat aaagtaggat ctgctacagt ttcacctgaa
     3901 aatttataaa aagtgttgag attggtagaa ggtagttttt aagtacatgt gcactaccct
     3961 aaaagacttg tctattgtca ataaagtgtt agtatttgtg aaattattat tcctgttcag
     4021 aaatactatt tcttaaatct cctgggaatt tgtggcataa taaagcacat tcaaagttct
     4081 aatgtattta tgagctcatt ttcaaaatag taagtttgtc atctttaaaa tgaacatgac
     4141 ttgcctcctt gatttctgaa atgaattaat tgaagattgc tatagtaatc tttatttcat
     4201 ctttctagag ttgttgacaa ttttattata caacagttac cattagagaa ggagggaagg
     4261 gcttttgggt gtgtatttat aggtactaag ggatttacta aatatagtag attagcactg
     4321 tcacacttgt tcaagtagtt tcaaacatag aaaattaagt atcaggtatg tggagcaatg
     4381 tagttttttt ttttcttcag tttaaaaaat ttttaattgt ggtagaagca atgtattctt
     4441 aaggtgaaaa acctacctcg gttacatgtg gtttgtgttt tttggattaa tctggatttt
     4501 ataattagaa ataaaaatgt aagattttga atccacttaa tttcttgaaa atagtacaag
     4561 tcagtgtaat agagaagcat tcatatattc aacactgtaa gacaaaacag cagagacctt
     4621 ggatttgata attgatctga tatcctggac agtattcata tgtacagtga taggtatctt
     4681 tctttggagt tttttttttg tgcatatgtg tatagtttta tgggttctga gttggtgacc
     4741 agtaagttgc atgtagtgct ggcacttact taataactat tcatgatatt gttaataact
     4801 tgttatagga ttgtattccc aattacagtc tctaagattg taattgatat tatctgagag
     4861 gtagtgtgac aactttcttt tgttgttaca ttaagccgaa aacataatac taatagacaa
     4921 ctaacagttt gcttatcagg cacatcaact aaggcacctc cccccatgct aagtttctcc
     4981 tggatatatg gaagttgatt gtttcccagt ttaaaaactt gaactaatat ctcctaagaa
     5041 aatctgagtc catattgttt ttattttact tagctagaat ctcatagcat gttaaagtca
     5101 tatccttatc cccactaaaa ataactatgt ctatgtgaga ggaatatagt atgtgggagc
     5161 tgtattaaat actattacag gtgttacaga atctttaaat aaatggacat ggaccaactt
     5221 tccatctagt agtgtacgat ctatatagtg catgtcagta gcacaaaatg cagtcttagc
     5281 attagcctgt ctaatctgaa tagtttactc aaaagtactt ctttgtgtta agtattcagc
     5341 cactgttttt agatctagtt aataggttct atttaatttg ctacaacatt tactgaatgg
     5401 tggagtgaaa aaactgatgc atactgggaa atatctacca ttttttaaag ataatgttaa
     5461 ttaggaaaag aacactttta aggaatttat agcagtgatg aaatgaattc agttatatca
     5521 gatacaccaa actgttgatg gtatttaaat gtgacttcaa gttagtattt ctgtatatat
     5581 tattgattac tggtttgttt ttagatatgt aagtctgttc taatctacag ttcacatatc
     5641 gacagttact ctggtaataa tagaatgtta gtgatgatca cttggtggat gttgattaag
     5701 tgcctgtgtt ttgtttcctc ctctggatac caaataggtg tatgctactt ttttggtgaa
     5761 cttatttctt ggaagatttg gctatgctat tcagggtttt tattcttatg tttttcttct
     5821 aaatttaagt agcatcctgc tgctaccata ttaaagctaa aatttaactt ttgctgaaga
     5881 atcagctaat tcaggtaatc caaatatttg tggaaaaaca tctggataat ttattgaaca
     5941 cattagtatt gtgttagaca gctttgatca ttcccatttc ataggttttt attgtggaat
     6001 agtcaactta atatagattc actttcaatt tgcatgtata aagtaatact caataaaatt
     6061 tttttcattt atttttcaac agtggttatt ttttttcttc ctgtactatc agtaaaatcc
     6121 tgactatgag ttttactttt gaagctaaag gataatgctg gtaatctaat tatgtacctc
     6181 ttacagaaac catatgcagc actttaaaaa tctttatttg gtatattatt ttaggtggac
     6241 aatgatttaa gactcaaagc catcatatta aggtctaaat acattagtgg tggggtttct
     6301 cgaataaatg aggaagtgca caaaagttca gcctgactga aaattttaat tgtgttttaa
     6361 aactacatga ataatttctt gattcaaaat cagaactctt ataaactaaa tctgatggtg
     6421 tccaaagaat ttcaggtcct tcaaagtttg taaaagataa gtaggggcct aggaatataa
     6481 aaatttagac ttttttagta aatggtttac ataacctttt gtcttaattt gtcattcttc
     6541 atacacaggc acaagctaat cagtcttctc tacttctaga actctaaatc ttctcagtaa
     6601 tgtcatacaa gtctaacaag aggaaaagca tccttaagtc agtctattta gataaactct
     6661 tcaagtccct atataaggac gtattccact agcaagccag taaatttttc caaggtcaca
     6721 taatcttaca tgaaatggaa cctttcatct tagacttcat caaactcaat tttttccctt
     6781 ctagattcac tttgtgttta tgcatgcatg cacgcgtgca cacaattcta tcagcagctg
     6841 taaactaccc acatattttc ttaatctcat tttttcagtt tttcttcatc tttaaaagag
     6901 gttacatttc attcctggtc aactcttaaa aagaattatg taatgttggg ccttcatatt
     6961 aaagagagag actggttata agatccttta cagtccattc attttattct gatgtctaac
     7021 cagatagaca ctagcaagca aaacttccct cttaatcctg gaccaaatgc ataattttac
     7081 tgtcactttc aaaaatctgt tatgactgaa tcaaaatcct tttaaagaaa ggaaaaagct
     7141 ccttttgtgt caaatagttg aacaacatga aaacagtatg agccggttaa agatagattg
     7201 aatttttact ttacacatat gaaaaacagt aagttttgac tgctgtgtat gttattcatg
     7261 ttaatatgtg ctcagttatt cactattgtt aatccacata taatcagttg ctatccctgg
     7321 ttagacacac tatggaactt gaaatgcaca atatttacat tgttagaggc ttctatccaa
     7381 atatctgcat tcctttaaaa tgtgaactat ttgctgtgat taaccaaagg tagattatgt
     7441 catcagtgga cattttagct ttatggaaac aaattattaa gaaatgaata gaaaggtgtc
     7501 tttttctttg tgtagtgcaa aagcctaaag ctatcagtca aaggcctaag aaatccacat
     7561 ttgaaaaacg taaatcatga ttggtaagaa tacattcatc tgatagtatt gagaaaagtt
     7621 gaaaaactgt tagccttcca taacacatta aacattttat gtatggatgg ctgaaagtat
     7681 tgagaaaagc tgaaaaactg ttagccttcc ataacacatt aaacgttttg tgtatggatg
     7741 gcttaggaca ataaacaaca tcattaaagt aaaattatgt cagtctgttc atattaactt
     7801 atttaaatca atgaaaattt tgatgagatg actaaatgga tgctttggaa atgcaggatt
     7861 ataggaggcc taaaagtgca tcttgtttct tgtaaccctt ttaaaaccaa tatgcctggc
     7921 taggtgcagt ggctcatgcc tgtaatacca acggggtaac acagggttat gccgtctata
     7981 caaaaaaata aatgagctgg gcaagatggc atgcacctgt agtcccagct gcttggtagg
     8041 ctgaggggga aggattgctt gagcctggga ggtcgagact gcagtgagcc aagatcacac
     8101 cactgcactc cagcctgggt gacagagcaa gactctacct caaaaataaa aataatcaat
     8161 atagtttcaa tgaagcaaag catctcaggt aacaatttga gcataacttt aaccataact
     8221 tatgatagca taataacatt cattagtaat tcagtagccg tatgtgccag gctgtgttag
     8281 gtgctttata tattgtttaa tttttaaaaa cttgtggagt gtacagattg gtaaggtgac
     8341 attgtatcac aaagctagtc tttgagtcca aagttttgtg gttttatgtt atgatatact
     8401 tttatcatgg aattgtctta ttaaatgttt tgccagtggt tcttaaagtg tgtttctgac
     8461 accagtagca ttgacttcac ttagaaacct gttagaaata caaattattt ggccccaccc
     8521 aacacttgag tcacaaactt tgcagatggg gctcaatctg ttttaacaag cgcttcatgt
     8581 aattttgatg caggcctaag tttttgagcc actgcagtat gcatttctat ttttaagcaa
     8641 agatcttggt ctttcttttt ggacattgta gaaataacat gaacttgttt tttgtttgtt
     8701 tttgttttgt tttgttttaa gctcctgatc tttgttggtt atgttgcaaa agattgtatc
     8761 aggagaagcc tcagcatgga cattggcatc ctgacataac ccccattaat ttagtattct
     8821 ttctgaaact caaatggatt ctcaagtcca agagactatg gaataaaatc attgtttgtc
     8881 tgtgttaagt tttatctctg ttattgcctg aagacttttg gtaacaataa tgcgctttca
     8941 tcaaactttt aagacttgat tggaaaaaat aaatgtatgt ttcatcagtt a
//
