LOCUS       NP_002574                340 aa            linear   PRI 28-APR-2025
DEFINITION  PRKC apoptosis WT1 regulator protein isoform 1 [Homo sapiens].
ACCESSION   NP_002574
VERSION     NP_002574.2
DBSOURCE    REFSEQ: accession NM_002583.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 340)
  AUTHORS   Winfree,R.L., Erreger,K., Phillips,J., Seto,M., Wang,Y.,
            Schneider,J.A., Bennett,D.A., Schrag,M.S., Hohman,T.J. and
            Hamm,H.E.
  TITLE     Elevated protease-activated receptor 4 (PAR4) gene expression in
            Alzheimer's disease predicts cognitive decline
  JOURNAL   Neurobiol Aging 140, 93-101 (2024)
   PUBMED   38761538
  REMARK    GeneRIF: Elevated protease-activated receptor 4 (PAR4) gene
            expression in Alzheimer's disease predicts cognitive decline.
REFERENCE   2  (residues 1 to 340)
  AUTHORS   Zhang,Y., Li,Z., Wang,J., Chen,H., He,R. and Wu,H.
  TITLE     CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes
            via the Signal Regulation of miR-370-3p/PAWR Axis
  JOURNAL   Cardiovasc Ther 2022, 7125602 (2022)
   PUBMED   35251305
  REMARK    GeneRIF: CircTRRAP Knockdown Has Cardioprotective Function in
            Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 340)
  AUTHORS   Heo,Y., Jeon,H. and Namkung,W.
  TITLE     PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are
            Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells
  JOURNAL   Int J Mol Sci 23 (2), 776 (2022)
   PUBMED   35054966
  REMARK    GeneRIF: PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways
            Are Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 340)
  AUTHORS   Qinan,W., Ling,Z. and Bing,C.
  TITLE     PAR-4: a possible new target for age-related disease
  JOURNAL   Expert Opin Ther Targets 18 (8), 917-927 (2014)
   PUBMED   24890982
  REMARK    Review article
REFERENCE   5  (residues 1 to 340)
  AUTHORS   Hebbar,N., Shrestha-Bhattarai,T. and Rangnekar,V.M.
  TITLE     Cancer-selective apoptosis by tumor suppressor par-4
  JOURNAL   Adv Exp Med Biol 818, 155-166 (2014)
   PUBMED   25001535
  REMARK    GeneRIF: The cancer cell specific activity of Par-4 is elicited
            through intracellular as well as extracellular mechanisms.
            Review article
REFERENCE   6  (residues 1 to 340)
  AUTHORS   Irby,R.B. and Kline,C.L.
  TITLE     Par-4 as a potential target for cancer therapy
  JOURNAL   Expert Opin Ther Targets 17 (1), 77-87 (2013)
   PUBMED   23062118
  REMARK    Review article
REFERENCE   7  (residues 1 to 340)
  AUTHORS   Kruman,I.I., Nath,A., Maragos,W.F., Chan,S.L., Jones,M.,
            Rangnekar,V.M., Jakel,R.J. and Mattson,M.P.
  TITLE     Evidence that Par-4 participates in the pathogenesis of HIV
            encephalitis
  JOURNAL   Am J Pathol 155 (1), 39-46 (1999)
   PUBMED   10393834
REFERENCE   8  (residues 1 to 340)
  AUTHORS   Johnstone,R.W., Tommerup,N., Hansen,C., Vissing,H. and Shi,Y.
  TITLE     Mapping of the human PAWR (par-4) gene to chromosome 12q21
  JOURNAL   Genomics 53 (2), 241-243 (1998)
   PUBMED   9790775
REFERENCE   9  (residues 1 to 340)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
  REMARK    GeneRIF: Par-4 expression is increased in vulnerable neurons in
            Alzheimer's disease, and contributes to apoptotic neuronal cell
            death in the disease.
REFERENCE   10 (residues 1 to 340)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN280333.1, BC007018.1,
            U63809.1 and AC027288.26.
            
            On Nov 15, 2004 this sequence version replaced NP_002574.1.
            
            Summary: This gene encodes a tumor suppressor protein that
            selectively induces apoptosis in cancer cells through intracellular
            and extracellular mechanisms. The intracellular mechanism involves
            the inhibition of pro-survival pathways and the activation of
            Fas-mediated apoptosis, while the extracellular mechanism involves
            the binding of a secreted form of this protein to glucose regulated
            protein 78 (GRP78) on the cell surface, which leads to activation
            of the extrinsic apoptotic pathway. This gene is located on the
            unstable human chromosomal 12q21 region and is often deleted or
            mutated different tumors. The encoded protein also plays an
            important role in the progression of age-related diseases.
            [provided by RefSeq, Aug 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U63809.1, DRR138511.28563.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328827.9/ ENSP00000328088.4
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..340
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     Protein         1..340
                     /product="PRKC apoptosis WT1 regulator protein isoform 1"
                     /note="transcriptional repressor PAR4; WT1-interacting
                     protein; prostate apoptosis response protein 4; prostate
                     apoptosis response protein PAR-4; prostate apoptosis
                     response-4; PRKC, apoptosis, WT1, regulator"
                     /calculated_mol_wt=36436
     Region          1..253
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Region          68..72
                     /region_name="B30.2/SPRY domain-binding motif.
                     /evidence=ECO:0000269|PubMed:20561531"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Site            108
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Region          145..203
                     /region_name="Selective for apoptosis induction in cancer
                     cells (SAC)"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Region          145..161
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Site            163
                     /site_type="phosphorylation"
                     /note="Phosphothreonine, by PKA.
                     /evidence=ECO:0000250|UniProtKB:Q62627; propagated from
                     UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Site            231
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96IZ0.1)"
     Region          268..>327
                     /region_name="FPP"
                     /note="Filament-like plant protein, long coiled-coil;
                     pfam05911"
                     /db_xref="CDD:461778"
     Region          300..340
                     /region_name="Leucine-zipper"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96IZ0.1)"
     CDS             1..340
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /coded_by="NM_002583.4:241..1263"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS31863.1"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:HGNC:8614"
                     /db_xref="MIM:601936"
ORIGIN      
        1 matggyrtss glggsttdfl eewkakrekm rakqnppgpa ppgggssdaa gkppagalgt
       61 paaaaaneln nnlpggapaa pavpgpggvn cavgsamltr aapgprrsed eppaasasaa
      121 pppqrdeeep dgvpekgkss gpsarkgkgq iekrklrekr rstgvvnipa aecldeyedd
      181 eagqkerkre daitqqntiq neavnlldpg ssyllqeppr tvsgrykstt svseedvssr
      241 ysrtdrsgfp rynrdanvsg tlvssstlek kiedlekevv rerqenlrlv rlmqdkeemi
      301 gklkeeidll nrdlddiede neqlkqenkt llkvvgqltr
//
