LOCUS       NM_001354732            8924 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens pro-apoptotic WT1 regulator (PAWR), transcript variant
            2, mRNA.
ACCESSION   NM_001354732
VERSION     NM_001354732.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8924)
  AUTHORS   Winfree,R.L., Erreger,K., Phillips,J., Seto,M., Wang,Y.,
            Schneider,J.A., Bennett,D.A., Schrag,M.S., Hohman,T.J. and
            Hamm,H.E.
  TITLE     Elevated protease-activated receptor 4 (PAR4) gene expression in
            Alzheimer's disease predicts cognitive decline
  JOURNAL   Neurobiol Aging 140, 93-101 (2024)
   PUBMED   38761538
  REMARK    GeneRIF: Elevated protease-activated receptor 4 (PAR4) gene
            expression in Alzheimer's disease predicts cognitive decline.
REFERENCE   2  (bases 1 to 8924)
  AUTHORS   Zhang,Y., Li,Z., Wang,J., Chen,H., He,R. and Wu,H.
  TITLE     CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes
            via the Signal Regulation of miR-370-3p/PAWR Axis
  JOURNAL   Cardiovasc Ther 2022, 7125602 (2022)
   PUBMED   35251305
  REMARK    GeneRIF: CircTRRAP Knockdown Has Cardioprotective Function in
            Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8924)
  AUTHORS   Heo,Y., Jeon,H. and Namkung,W.
  TITLE     PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways Are
            Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells
  JOURNAL   Int J Mol Sci 23 (2), 776 (2022)
   PUBMED   35054966
  REMARK    GeneRIF: PAR4-Mediated PI3K/Akt and RhoA/ROCK Signaling Pathways
            Are Essential for Thrombin-Induced Morphological Changes in MEG-01
            Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8924)
  AUTHORS   Qinan,W., Ling,Z. and Bing,C.
  TITLE     PAR-4: a possible new target for age-related disease
  JOURNAL   Expert Opin Ther Targets 18 (8), 917-927 (2014)
   PUBMED   24890982
  REMARK    Review article
REFERENCE   5  (bases 1 to 8924)
  AUTHORS   Hebbar,N., Shrestha-Bhattarai,T. and Rangnekar,V.M.
  TITLE     Cancer-selective apoptosis by tumor suppressor par-4
  JOURNAL   Adv Exp Med Biol 818, 155-166 (2014)
   PUBMED   25001535
  REMARK    GeneRIF: The cancer cell specific activity of Par-4 is elicited
            through intracellular as well as extracellular mechanisms.
            Review article
REFERENCE   6  (bases 1 to 8924)
  AUTHORS   Irby,R.B. and Kline,C.L.
  TITLE     Par-4 as a potential target for cancer therapy
  JOURNAL   Expert Opin Ther Targets 17 (1), 77-87 (2013)
   PUBMED   23062118
  REMARK    Review article
REFERENCE   7  (bases 1 to 8924)
  AUTHORS   Kruman,I.I., Nath,A., Maragos,W.F., Chan,S.L., Jones,M.,
            Rangnekar,V.M., Jakel,R.J. and Mattson,M.P.
  TITLE     Evidence that Par-4 participates in the pathogenesis of HIV
            encephalitis
  JOURNAL   Am J Pathol 155 (1), 39-46 (1999)
   PUBMED   10393834
REFERENCE   8  (bases 1 to 8924)
  AUTHORS   Johnstone,R.W., Tommerup,N., Hansen,C., Vissing,H. and Shi,Y.
  TITLE     Mapping of the human PAWR (par-4) gene to chromosome 12q21
  JOURNAL   Genomics 53 (2), 241-243 (1998)
   PUBMED   9790775
REFERENCE   9  (bases 1 to 8924)
  AUTHORS   Guo,Q., Fu,W., Xie,J., Luo,H., Sells,S.F., Geddes,J.W., Bondada,V.,
            Rangnekar,V.M. and Mattson,M.P.
  TITLE     Par-4 is a mediator of neuronal degeneration associated with the
            pathogenesis of Alzheimer disease
  JOURNAL   Nat Med 4 (8), 957-962 (1998)
   PUBMED   9701251
  REMARK    GeneRIF: Par-4 expression is increased in vulnerable neurons in
            Alzheimer's disease, and contributes to apoptotic neuronal cell
            death in the disease.
REFERENCE   10 (bases 1 to 8924)
  AUTHORS   Johnstone,R.W., See,R.H., Sells,S.F., Wang,J., Muthukkumar,S.,
            Englert,C., Haber,D.A., Licht,J.D., Sugrue,S.P., Roberts,T.,
            Rangnekar,V.M. and Shi,Y.
  TITLE     A novel repressor, par-4, modulates transcription and growth
            suppression functions of the Wilms' tumor suppressor WT1
  JOURNAL   Mol Cell Biol 16 (12), 6945-6956 (1996)
   PUBMED   8943350
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073569.26, AC073595.31 and
            AC027288.26.
            
            On Aug 14, 2020 this sequence version replaced NM_001354732.1.
            
            Summary: This gene encodes a tumor suppressor protein that
            selectively induces apoptosis in cancer cells through intracellular
            and extracellular mechanisms. The intracellular mechanism involves
            the inhibition of pro-survival pathways and the activation of
            Fas-mediated apoptosis, while the extracellular mechanism involves
            the binding of a secreted form of this protein to glucose regulated
            protein 78 (GRP78) on the cell surface, which leads to activation
            of the extrinsic apoptotic pathway. This gene is located on the
            unstable human chromosomal 12q21 region and is often deleted or
            mutated different tumors. The encoded protein also plays an
            important role in the progression of age-related diseases.
            [provided by RefSeq, Aug 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3960525.1,
                                           SRR14038197.1125083.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-26                AC073569.26        40276-40301         c
            27-689              AC073569.26        39449-40111         c
            690-821             AC073595.31        26618-26749         c
            822-856             AC073595.31        19117-19151         c
            857-1004            AC073595.31        2053-2200           c
            1005-1109           AC027288.26        2030-2134
            1110-8924           AC027288.26        3770-11584
FEATURES             Location/Qualifiers
     source          1..8924
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.2"
     gene            1..8924
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="pro-apoptotic WT1 regulator"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:HGNC:8614"
                     /db_xref="MIM:601936"
     exon            1..26
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            27..689
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1196
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="isoform 1 is encoded by transcript variant 2;
                     transcriptional repressor PAR4; WT1-interacting protein;
                     prostate apoptosis response protein 4; prostate apoptosis
                     response protein PAR-4; prostate apoptosis response-4;
                     PRKC, apoptosis, WT1, regulator"
                     /codon_start=1
                     /product="PRKC apoptosis WT1 regulator protein isoform 1"
                     /protein_id="NP_001341661.1"
                     /db_xref="CCDS:CCDS31863.1"
                     /db_xref="GeneID:5074"
                     /db_xref="HGNC:HGNC:8614"
                     /db_xref="MIM:601936"
                     /translation="MATGGYRTSSGLGGSTTDFLEEWKAKREKMRAKQNPPGPAPPGG
                     GSSDAAGKPPAGALGTPAAAAANELNNNLPGGAPAAPAVPGPGGVNCAVGSAMLTRAA
                     PGPRRSEDEPPAASASAAPPPQRDEEEPDGVPEKGKSSGPSARKGKGQIEKRKLREKR
                     RSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAVNLLDPGSSYLLQEP
                     PRTVSGRYKSTTSVSEEDVSSRYSRTDRSGFPRYNRDANVSGTLVSSSTLEKKIEDLE
                     KEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDIEDENEQLKQENKTLLKV
                     VGQLTR"
     exon            690..821
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..856
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1004
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1109
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..8924
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5985..5990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="hexamer: AATAAA"
     polyA_site      6012
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="major polyA site"
     regulatory      8901..8906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
                     /note="hexamer: AATAAA"
     polyA_site      8924
                     /gene="PAWR"
                     /gene_synonym="Par-4; PAR4"
ORIGIN      
        1 ggcgatcgtc ggggtccgta ctgtagcccc gccggctgct gtgggagcgg cggccgtccc
       61 tctcctggag gtcgtctcct ggcatcctcg gggccgcagg aaggaagagg aggcagcggc
      121 cggagccctg gtgggcggcc tgaggtgaga gcccgaccgg cccctttggg aatatggcga
      181 ccggtggcta ccggaccagc agcggcctcg gcggcagcac cacagacttc ctggaggagt
      241 ggaaggcgaa acgcgagaag atgcgcgcca agcagaaccc cccgggcccg gcccccccgg
      301 gagggggcag cagcgacgcc gctgggaagc cccccgcggg ggctctgggc accccggcgg
      361 ccgccgctgc caacgagctc aacaacaacc tcccgggcgg cgcgccggcc gcacctgccg
      421 tccccggtcc cgggggcgtg aactgcgcgg tcggctccgc catgctgacg cgggcggccc
      481 ccggcccgcg gcggtcggag gacgagcccc cagccgcctc tgcctcggct gcaccgccgc
      541 cccagcgtga cgaggaggag ccggacggcg tcccagagaa gggcaagagc tcgggcccca
      601 gtgccaggaa aggcaagggg cagatcgaga agaggaagct gcgggagaag cggcgctcca
      661 ccggcgtggt caacatccct gccgcagagt gcttagatga gtacgaagat gatgaagcag
      721 ggcagaaaga gcggaaacga gaagatgcaa ttacacaaca gaacactatt cagaatgaag
      781 ctgtaaactt actagatcca ggcagttcct atctgctaca ggagccacct agaacagttt
      841 caggcagata taaaagcaca accagtgtct ctgaagaaga tgtctcaagt agatattctc
      901 gaacagatag aagtgggttc cctagatata acagggatgc aaatgtttca ggtactctgg
      961 tttcaagtag cacactggaa aagaaaattg aagatcttga aaaggaagta gtaagagaaa
     1021 gacaagaaaa cctaagactt gtgagactga tgcaagataa agaggaaatg attggaaaac
     1081 tcaaagaaga aattgattta ttaaatagag acctagatga catagaagat gaaaatgaac
     1141 agctaaagca ggaaaataaa actcttttga aagttgtggg tcagctgacc aggtagagga
     1201 ttcaagactc aatgtggaaa aaatatttta aactactgat tgaatgttaa tggtcaatgc
     1261 tagcacaata ttcctatgct gcaatacatt aaaataacta agcaagtata tttatttcta
     1321 gcaaacagat gtttgttttc aaaatacttc tttttcatta ttggttttaa aaaagcatta
     1381 tccttttatc tcacaaataa gtaatatctt tcagttatta aatgatagat aatgcctttt
     1441 tggttttgtg tggtattcaa ctaatacatg gtttaaagtc acagccgttt gaatatattt
     1501 tatcttggta gtacattttc tcccttagga atatacatag tctttgttta catgagttca
     1561 aatacttttg ggatgttacc ttcacatgtc ctattactga tgtgtgcaac cttttatgtg
     1621 ttgatgactc actcataaag gtttttgtct actgtcattt gttctttcca cttattctaa
     1681 gcatttagag taatagagtc atactttttt ataacagcaa ccttttaaaa ggaaagctct
     1741 tataaagtca ctgtcatgtt ttagttgact aaatataaat ttaagagaat acttgaattg
     1801 tgctatagta aataaaaatt tactattttg tgtttgaata ttgaaaaatt gaatcacttt
     1861 aactcctgaa aaacatacaa ttgtaatttc aatgtaaaat ttcttatgta ggtactacct
     1921 ttttttatcg ttccaaggtt tgctagtgaa cacaggatat tttaaaagtt ttttattctt
     1981 cgggcctgga aagtgtacaa agtcagtgta ggagaaaaaa atccatattt ttatattagc
     2041 atgcacacta aaaaccaaaa tattattcat acttaaaaca ttcatacaaa acaatatgta
     2101 agcagaaata gtactaaaat actttgccta atttctaagt tgaagaataa cactgggaca
     2161 cagttttttc atatgagaga atattccgct atttcaaatt taagggattt tcttcctaac
     2221 attgaaattt taaaaacaga gttacttcta aataattata cagatttttt cttctattaa
     2281 atattattat ttagaattgt ttttgtatta catattcatg ttaagaaccc cgtcttccct
     2341 taaaatacat taaaattatg acatttttgc tttgtgattg aatttcaaat agcagtatgg
     2401 tatcctttta tctagttaat atatgaaagt ggcttgaata tagtcaaatc cattttaggt
     2461 actctactga ctttttcctt cacttgccaa gcccttttat tgttcactgt tagaaaaata
     2521 gagaaggtga gacagctggg ggaaaatgtg gagtaaatga taatcaaatg ttgaattcta
     2581 aaagtctcta catttaccta ggttggcttt ctcccccagt tcagaagttt ccagcttggc
     2641 caatcatcag aatcacttga ggaacttaga aagaactccc tggctgtagc tcctatgtag
     2701 gtttaggttg agactctgga ttccacaatt tttaaaggtt accatctgag gtttctgatc
     2761 atagtctact tttgaagcag ctgctgctgt ttctttattc cattgaacac cctggaattg
     2821 acataatttt atctatcagc atttctcccc ttttagttta tttaataatt aacccggtct
     2881 ccagggcagt tttcatatga ccatgtgtat attcactgct cacgaaaaag tttaatgtta
     2941 gattaccaaa tttaatatag ttacagaatt actgcataag ggcttccctt cttggagact
     3001 cttacccagc atgggaacag tgatctgccc acatgacagg gtggtatgcc aggcatagtt
     3061 aactgctttt ggttgtgagg tactcatctt cctttagtta cccttagtta tgtggcacac
     3121 atgtccttat tgcctagttc gtcatccaca ctttggatct tgtgaaaatg ctgttagtat
     3181 ccaaccttaa aatatattag tatatgggtt tttattaaaa gaattacttt gaattttcta
     3241 tttaattcat atgtaaataa aggaacattt catttcactt aaaaaaatta tatcagttat
     3301 taggctgggt gcagtggctc atgcctgtaa tcccagcact ttgggaggcc aaggcgggtg
     3361 gattaccaga gttcgggagt ttgagaccag cttgaccaac atggagaaac cccgtctcta
     3421 ctaaaaatac aaaattagcc aggtgtggtg gcgcatgcct gtaatcctgg ctactcagga
     3481 ggctgaggca ggagaatcgc ttgaaaaccc aggagacaga ggttgcggtg agctgagatt
     3541 gcgccattgt actccagcct gggcaagaag agcgaaactc tgtctccaaa aaaaaaaaaa
     3601 aaaaaattat taatactttt aaagactgag ctgtttaaga attttttggg gaacatttct
     3661 agcagtgatt tttttggcct ttaatgatag cgtaaagaca ggagccttac aacttaggca
     3721 aagcatttca catgcagtcc ttcttccatc tcaaaatatg tacttatttt acatacagaa
     3781 ttttacacta accattgaaa aataaagtag gatctgctac agtttcacct gaaaatttat
     3841 aaaaagtgtt gagattggta gaaggtagtt tttaagtaca tgtgcactac cctaaaagac
     3901 ttgtctattg tcaataaagt gttagtattt gtgaaattat tattcctgtt cagaaatact
     3961 atttcttaaa tctcctggga atttgtggca taataaagca cattcaaagt tctaatgtat
     4021 ttatgagctc attttcaaaa tagtaagttt gtcatcttta aaatgaacat gacttgcctc
     4081 cttgatttct gaaatgaatt aattgaagat tgctatagta atctttattt catctttcta
     4141 gagttgttga caattttatt atacaacagt taccattaga gaaggaggga agggcttttg
     4201 ggtgtgtatt tataggtact aagggattta ctaaatatag tagattagca ctgtcacact
     4261 tgttcaagta gtttcaaaca tagaaaatta agtatcaggt atgtggagca atgtagtttt
     4321 tttttttctt cagtttaaaa aatttttaat tgtggtagaa gcaatgtatt cttaaggtga
     4381 aaaacctacc tcggttacat gtggtttgtg ttttttggat taatctggat tttataatta
     4441 gaaataaaaa tgtaagattt tgaatccact taatttcttg aaaatagtac aagtcagtgt
     4501 aatagagaag cattcatata ttcaacactg taagacaaaa cagcagagac cttggatttg
     4561 ataattgatc tgatatcctg gacagtattc atatgtacag tgataggtat ctttctttgg
     4621 agtttttttt ttgtgcatat gtgtatagtt ttatgggttc tgagttggtg accagtaagt
     4681 tgcatgtagt gctggcactt acttaataac tattcatgat attgttaata acttgttata
     4741 ggattgtatt cccaattaca gtctctaaga ttgtaattga tattatctga gaggtagtgt
     4801 gacaactttc ttttgttgtt acattaagcc gaaaacataa tactaataga caactaacag
     4861 tttgcttatc aggcacatca actaaggcac ctccccccat gctaagtttc tcctggatat
     4921 atggaagttg attgtttccc agtttaaaaa cttgaactaa tatctcctaa gaaaatctga
     4981 gtccatattg tttttatttt acttagctag aatctcatag catgttaaag tcatatcctt
     5041 atccccacta aaaataacta tgtctatgtg agaggaatat agtatgtggg agctgtatta
     5101 aatactatta caggtgttac agaatcttta aataaatgga catggaccaa ctttccatct
     5161 agtagtgtac gatctatata gtgcatgtca gtagcacaaa atgcagtctt agcattagcc
     5221 tgtctaatct gaatagttta ctcaaaagta cttctttgtg ttaagtattc agccactgtt
     5281 tttagatcta gttaataggt tctatttaat ttgctacaac atttactgaa tggtggagtg
     5341 aaaaaactga tgcatactgg gaaatatcta ccatttttta aagataatgt taattaggaa
     5401 aagaacactt ttaaggaatt tatagcagtg atgaaatgaa ttcagttata tcagatacac
     5461 caaactgttg atggtattta aatgtgactt caagttagta tttctgtata tattattgat
     5521 tactggtttg tttttagata tgtaagtctg ttctaatcta cagttcacat atcgacagtt
     5581 actctggtaa taatagaatg ttagtgatga tcacttggtg gatgttgatt aagtgcctgt
     5641 gttttgtttc ctcctctgga taccaaatag gtgtatgcta cttttttggt gaacttattt
     5701 cttggaagat ttggctatgc tattcagggt ttttattctt atgtttttct tctaaattta
     5761 agtagcatcc tgctgctacc atattaaagc taaaatttaa cttttgctga agaatcagct
     5821 aattcaggta atccaaatat ttgtggaaaa acatctggat aatttattga acacattagt
     5881 attgtgttag acagctttga tcattcccat ttcataggtt tttattgtgg aatagtcaac
     5941 ttaatataga ttcactttca atttgcatgt ataaagtaat actcaataaa atttttttca
     6001 tttatttttc aacagtggtt attttttttc ttcctgtact atcagtaaaa tcctgactat
     6061 gagttttact tttgaagcta aaggataatg ctggtaatct aattatgtac ctcttacaga
     6121 aaccatatgc agcactttaa aaatctttat ttggtatatt attttaggtg gacaatgatt
     6181 taagactcaa agccatcata ttaaggtcta aatacattag tggtggggtt tctcgaataa
     6241 atgaggaagt gcacaaaagt tcagcctgac tgaaaatttt aattgtgttt taaaactaca
     6301 tgaataattt cttgattcaa aatcagaact cttataaact aaatctgatg gtgtccaaag
     6361 aatttcaggt ccttcaaagt ttgtaaaaga taagtagggg cctaggaata taaaaattta
     6421 gactttttta gtaaatggtt tacataacct tttgtcttaa tttgtcattc ttcatacaca
     6481 ggcacaagct aatcagtctt ctctacttct agaactctaa atcttctcag taatgtcata
     6541 caagtctaac aagaggaaaa gcatccttaa gtcagtctat ttagataaac tcttcaagtc
     6601 cctatataag gacgtattcc actagcaagc cagtaaattt ttccaaggtc acataatctt
     6661 acatgaaatg gaacctttca tcttagactt catcaaactc aattttttcc cttctagatt
     6721 cactttgtgt ttatgcatgc atgcacgcgt gcacacaatt ctatcagcag ctgtaaacta
     6781 cccacatatt ttcttaatct cattttttca gtttttcttc atctttaaaa gaggttacat
     6841 ttcattcctg gtcaactctt aaaaagaatt atgtaatgtt gggccttcat attaaagaga
     6901 gagactggtt ataagatcct ttacagtcca ttcattttat tctgatgtct aaccagatag
     6961 acactagcaa gcaaaacttc cctcttaatc ctggaccaaa tgcataattt tactgtcact
     7021 ttcaaaaatc tgttatgact gaatcaaaat ccttttaaag aaaggaaaaa gctccttttg
     7081 tgtcaaatag ttgaacaaca tgaaaacagt atgagccggt taaagataga ttgaattttt
     7141 actttacaca tatgaaaaac agtaagtttt gactgctgtg tatgttattc atgttaatat
     7201 gtgctcagtt attcactatt gttaatccac atataatcag ttgctatccc tggttagaca
     7261 cactatggaa cttgaaatgc acaatattta cattgttaga ggcttctatc caaatatctg
     7321 cattccttta aaatgtgaac tatttgctgt gattaaccaa aggtagatta tgtcatcagt
     7381 ggacatttta gctttatgga aacaaattat taagaaatga atagaaaggt gtctttttct
     7441 ttgtgtagtg caaaagccta aagctatcag tcaaaggcct aagaaatcca catttgaaaa
     7501 acgtaaatca tgattggtaa gaatacattc atctgatagt attgagaaaa gttgaaaaac
     7561 tgttagcctt ccataacaca ttaaacattt tatgtatgga tggctgaaag tattgagaaa
     7621 agctgaaaaa ctgttagcct tccataacac attaaacgtt ttgtgtatgg atggcttagg
     7681 acaataaaca acatcattaa agtaaaatta tgtcagtctg ttcatattaa cttatttaaa
     7741 tcaatgaaaa ttttgatgag atgactaaat ggatgctttg gaaatgcagg attataggag
     7801 gcctaaaagt gcatcttgtt tcttgtaacc cttttaaaac caatatgcct ggctaggtgc
     7861 agtggctcat gcctgtaata ccaacggggt aacacagggt tatgccgtct atacaaaaaa
     7921 ataaatgagc tgggcaagat ggcatgcacc tgtagtccca gctgcttggt aggctgaggg
     7981 ggaaggattg cttgagcctg ggaggtcgag actgcagtga gccaagatca caccactgca
     8041 ctccagcctg ggtgacagag caagactcta cctcaaaaat aaaaataatc aatatagttt
     8101 caatgaagca aagcatctca ggtaacaatt tgagcataac tttaaccata acttatgata
     8161 gcataataac attcattagt aattcagtag ccgtatgtgc caggctgtgt taggtgcttt
     8221 atatattgtt taatttttaa aaacttgtgg agtgtacaga ttggtaaggt gacattgtat
     8281 cacaaagcta gtctttgagt ccaaagtttt gtggttttat gttatgatat acttttatca
     8341 tggaattgtc ttattaaatg ttttgccagt ggttcttaaa gtgtgtttct gacaccagta
     8401 gcattgactt cacttagaaa cctgttagaa atacaaatta tttggcccca cccaacactt
     8461 gagtcacaaa ctttgcagat ggggctcaat ctgttttaac aagcgcttca tgtaattttg
     8521 atgcaggcct aagtttttga gccactgcag tatgcatttc tatttttaag caaagatctt
     8581 ggtctttctt tttggacatt gtagaaataa catgaacttg ttttttgttt gtttttgttt
     8641 tgttttgttt taagctcctg atctttgttg gttatgttgc aaaagattgt atcaggagaa
     8701 gcctcagcat ggacattggc atcctgacat aacccccatt aatttagtat tctttctgaa
     8761 actcaaatgg attctcaagt ccaagagact atggaataaa atcattgttt gtctgtgtta
     8821 agttttatct ctgttattgc ctgaagactt ttggtaacaa taatgcgctt tcatcaaact
     8881 tttaagactt gattggaaaa aataaatgta tgtttcatca gtta
//
