LOCUS       NM_014323               3895 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens POZ/BTB and AT hook containing zinc finger 1 (PATZ1),
            transcript variant 1, mRNA.
ACCESSION   NM_014323
VERSION     NM_014323.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3895)
  AUTHORS   Patel,S., Ganbold,K., Cho,C.H., Siddiqui,J., Yildiz,R., Sparman,N.,
            Sadeh,S., Nguyen,C.M., Wang,J., Whitelegge,J.P., Fried,S.K.,
            Waki,H., Villanueva,C.J., Seldin,M.M., Sakaguchi,S., Ellmeier,W.,
            Tontonoz,P. and Rajbhandari,P.
  TITLE     Transcription factor PATZ1 promotes adipogenesis by controlling
            promoter regulatory loci of adipogenic factors
  JOURNAL   Nat Commun 15 (1), 8533 (2024)
   PUBMED   39358382
  REMARK    GeneRIF: Transcription factor PATZ1 promotes adipogenesis by
            controlling promoter regulatory loci of adipogenic factors.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3895)
  AUTHORS   Huang,M., Liao,X., Wang,X., Qian,Y., Zhang,W., Chen,G. and Wu,Q.
  TITLE     POZ/BTB and AT hook containing zinc finger 1 (PATZ1) suppresses
            differentiation and regulates metabolism in human embryonic stem
            cells
  JOURNAL   Int J Biol Sci 20 (4), 1142-1159 (2024)
   PUBMED   38385086
  REMARK    GeneRIF: POZ/BTB and AT hook containing zinc finger 1 (PATZ1)
            suppresses differentiation and regulates metabolism in human
            embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3895)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 3895)
  AUTHORS   Alhalabi,K.T., Stichel,D., Sievers,P., Peterziel,H.,
            Sommerkamp,A.C., Sturm,D., Wittmann,A., Sill,M., Jager,N., Beck,P.,
            Pajtler,K.W., Snuderl,M., Jour,G., Delorenzo,M., Martin,A.M.,
            Levy,A., Dalvi,N., Hansford,J.R., Gottardo,N.G., Uro-Coste,E.,
            Maurage,C.A., Godfraind,C., Vandenbos,F., Pietsch,T., Kramm,C.,
            Filippidou,M., Kattamis,A., Jones,C., Ora,I., Mikkelsen,T.S.,
            Zapotocky,M., Sumerauer,D., Scheie,D., McCabe,M., Wesseling,P.,
            Tops,B.B.J., Kranendonk,M.E.G., Karajannis,M.A., Bouvier,N.,
            Papaemmanuil,E., Dohmen,H., Acker,T., von Hoff,K., Schmid,S.,
            Miele,E., Filipski,K., Kitanovski,L., Krskova,L., Gojo,J.,
            Haberler,C., Alvaro,F., Ecker,J., Selt,F., Milde,T., Witt,O.,
            Oehme,I., Kool,M., von Deimling,A., Korshunov,A., Pfister,S.M.,
            Sahm,F. and Jones,D.T.W.
  TITLE     PATZ1 fusions define a novel molecularly distinct neuroepithelial
            tumor entity with a broad histological spectrum
  JOURNAL   Acta Neuropathol 142 (5), 841-857 (2021)
   PUBMED   34417833
  REMARK    GeneRIF: PATZ1 fusions define a novel molecularly distinct
            neuroepithelial tumor entity with a broad histological spectrum.
REFERENCE   5  (bases 1 to 3895)
  AUTHORS   Rossi,S., Barresi,S., Giovannoni,I., Alesi,V., Ciolfi,A.,
            Colafati,G.S., Diomedi-Camassei,F., Miele,E., Cacchione,A.,
            Quacquarini,D., Carai,A., Tartaglia,M., Giannini,C.,
            Giangaspero,F., Mastronuzzi,A. and Alaggio,R.
  TITLE     Expanding the spectrum of EWSR1-PATZ1 rearranged CNS tumors: An
            infantile case with leptomeningeal dissemination
  JOURNAL   Brain Pathol 31 (3), e12934 (2021)
   PUBMED   33378126
  REMARK    GeneRIF: Expanding the spectrum of EWSR1-PATZ1 rearranged CNS
            tumors: An infantile case with leptomeningeal dissemination.
REFERENCE   6  (bases 1 to 3895)
  AUTHORS   Mitchelmore,C., Kjaerulff,K.M., Pedersen,H.C., Nielsen,J.V.,
            Rasmussen,T.E., Fisker,M.F., Finsen,B., Pedersen,K.M. and
            Jensen,N.A.
  TITLE     Characterization of two novel nuclear BTB/POZ domain zinc finger
            isoforms. Association with differentiation of hippocampal neurons,
            cerebellar granule cells, and macroglia
  JOURNAL   J Biol Chem 277 (9), 7598-7609 (2002)
   PUBMED   11744704
  REMARK    GeneRIF: We report here the isolation and characterization of two
            novel nuclear BTB/POZ domain zinc finger isoformsthat are
            specifically expressed in early hippocampal neurons, cerebellar
            granule cells, and gliogenic progenitors as well as in
            differentiated glia
REFERENCE   7  (bases 1 to 3895)
  AUTHORS   Pero,R., Lembo,F., Palmieri,E.A., Vitiello,C., Fedele,M., Fusco,A.,
            Bruni,C.B. and Chiariotti,L.
  TITLE     PATZ attenuates the RNF4-mediated enhancement of androgen
            receptor-dependent transcription
  JOURNAL   J Biol Chem 277 (5), 3280-3285 (2002)
   PUBMED   11719514
REFERENCE   8  (bases 1 to 3895)
  AUTHORS   Mastrangelo,T., Modena,P., Tornielli,S., Bullrich,F., Testi,M.A.,
            Mezzelani,A., Radice,P., Azzarelli,A., Pilotti,S., Croce,C.M.,
            Pierotti,M.A. and Sozzi,G.
  TITLE     A novel zinc finger gene is fused to EWS in small round cell tumor
  JOURNAL   Oncogene 19 (33), 3799-3804 (2000)
   PUBMED   10949935
  REMARK    GeneRIF: The short isoform of the Zinc finger Sarcoma Gene (ZSG)
            was isolated as a RNF4 interacting protein.
REFERENCE   9  (bases 1 to 3895)
  AUTHORS   Fedele,M., Benvenuto,G., Pero,R., Majello,B., Battista,S.,
            Lembo,F., Vollono,E., Day,P.M., Santoro,M., Lania,L., Bruni,C.B.,
            Fusco,A. and Chiariotti,L.
  TITLE     A novel member of the BTB/POZ family, PATZ, associates with the
            RNF4 RING finger protein and acts as a transcriptional repressor
  JOURNAL   J Biol Chem 275 (11), 7894-7901 (2000)
   PUBMED   10713105
REFERENCE   10 (bases 1 to 3895)
  AUTHORS   Kobayashi,A., Yamagiwa,H., Hoshino,H., Muto,A., Sato,K., Morita,M.,
            Hayashi,N., Yamamoto,M. and Igarashi,K.
  TITLE     A combinatorial code for gene expression generated by transcription
            factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ
            domain
  JOURNAL   Mol Cell Biol 20 (5), 1733-1746 (2000)
   PUBMED   10669750
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005003.2, AF119256.1,
            AF254085.1 and AL096880.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014323.2.
            
            Summary: The protein encoded by this gene contains an A-T hook DNA
            binding motif which usually binds to other DNA binding structures
            to play an important role in chromatin modeling and transcription
            regulation. Its Poz domain is thought to function as a site for
            protein-protein interaction and is required for transcriptional
            repression, and the zinc-fingers comprise the DNA binding domain.
            Since the encoded protein has typical features of a transcription
            factor, it is postulated to be a repressor of gene expression. In
            small round cell sarcoma, this gene is fused to EWS by a small
            inversion of 22q, then the hybrid is thought to be translocated
            (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves
            intron 8 of EWS and exon 1 of this gene creating a chimeric
            sequence containing the transactivation domain of EWS fused to zinc
            finger domain of this protein. This is a distinct example of an
            intra-chromosomal rearrangement of chromosome 22. Four
            alternatively spliced transcript variants are described for this
            gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (long C isoform).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.483050.1, AF254085.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266269.10/ ENSP00000266269.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC005003.2         39578-39660         c
            84-114              AF119256.1         1-31
            115-3890            AF254085.1         1-3776
            3891-3895           AL096880.1         3004-3008
FEATURES             Location/Qualifiers
     source          1..3895
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..3895
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /note="POZ/BTB and AT hook containing zinc finger 1"
                     /db_xref="GeneID:23598"
                     /db_xref="HGNC:HGNC:13071"
                     /db_xref="MIM:605165"
     exon            1..2015
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /inference="alignment:Splign:2.1.0"
     CDS             745..2808
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /note="isoform long C is encoded by transcript variant 1;
                     zinc finger protein 278; POZ-AT hook-zinc finger protein;
                     MAZ-related factor; POZ-, AT hook-, and zinc
                     finger-containing protein 1; BTB-POZ domain zinc finger
                     transcription factor; zinc finger sarcoma gene protein;
                     zinc finger and BTB domain-containing protein 19; protein
                     kinase A RI subunit alpha-associated protein"
                     /codon_start=1
                     /product="POZ-, AT hook-, and zinc finger-containing
                     protein 1 isoform long C"
                     /protein_id="NP_055138.2"
                     /db_xref="CCDS:CCDS13894.1"
                     /db_xref="GeneID:23598"
                     /db_xref="HGNC:HGNC:13071"
                     /db_xref="MIM:605165"
                     /translation="MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVL
                     LRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGATAAPGGGAGGSR
                     ELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSN
                     VQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEEEAARAAGA
                     AIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLL
                     DSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGEN
                     GLPISEDPDGPRKRSRTRKQVACEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRF
                     KRKDRMSYHVRSHDGSVGKPYICQSCGKGFSRPDHLNGHIKQVHTSERPHKCQTCNAS
                     FATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSAS
                     YLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDPIESSDSYG
                     DLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHI
                     QKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPM
                     GPEGK"
     exon            2016..2079
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2080..2251
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2389
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /inference="alignment:Splign:2.1.0"
     exon            2390..3895
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3870..3875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /note="hexamer: ATTAAA"
     polyA_site      3895
                     /gene="PATZ1"
                     /gene_synonym="dJ400N23; MAZR; PATZ; RIAZ; ZBTB19; ZNF278;
                     ZSG"
                     /note="major polyA site"
ORIGIN      
        1 gccatctttc ctccgctccg aacacacgga gcccggggcc gcacagccgc cgctccgccg
       61 ccgccttctc ccggcctgag gaagggccta ctctgccgcc gccgccgccc gcccgctcca
      121 gccgccgccg ccgccgccac cgccctccag gctccgggac ccggcccgcg ccaccgcccc
      181 cgtgcgcgcc ccgccgccgc cgccttcgcc ttcgcctttt gtttcctccg ctccggcgcc
      241 cccgccccgg ctcgcgcttt gcaggggacg cagcgcgcgc ccccagcggg cccgggaaaa
      301 gccgcggcgc gcgcgcgcgc ctgcgcggcg gacccctcct tctcctcccc gcgtgcgcgt
      361 gcccttcttg gctgcgcgcc ggcgccgcct ggcgggcggg aggggaggtg gcaggcgcgt
      421 ttgcaggagg ggcgcacctc ttcgctcgcg cacccccccg gaaggtagac cgggaagggg
      481 aggcgggcgg gcggagagga gagagtggcg cgcagtccag cgagggcggg ggttggctat
      541 gtggggggtg gtgcaccccg cagtctagac agtctgatcc gggctggggg cgtgtacact
      601 cggcgcacct gcgagactac agagcctcgg gccggcacgt gtggggagtg tggacacgtc
      661 tgctgcgccc cgcttctcgc tgctgagggg aagggagggg gcgggcaggt gcagcggccg
      721 ggctagtggg agggggcggc ggccatggag cgggtgaacg acgcttcgtg cggcccgtct
      781 ggctgctaca cataccaggt gagcagacac agcacggaga tgctgcacaa cctgaaccag
      841 cagcgcaaaa acggcgggcg cttctgcgac gtgctcttgc gggtaggcga cgagagcttc
      901 ccagcgcacc gcgccgtgct ggccgcctgc agcgagtact ttgagtcggt gttcagcgcc
      961 cagttgggcg acggcggagc tgcggacggg ggtccggctg atgtaggggg cgcgacggca
     1021 gcaccaggcg gcggggccgg gggcagccgg gagctggaga tgcacactat cagctccaag
     1081 gtatttgggg acattctgga cttcgcctac acttcccgca tcgtggtgcg cttggagagc
     1141 tttcccgaac tcatgacggc cgccaagttc ctgctgatga ggtcggttat cgagatctgc
     1201 caggaagtca tcaaacagtc caacgtacag atcctggtac cccctgcccg cgccgatata
     1261 atgctctttc gcccccctgg gacctcggac ttgggcttcc ctttggacat gaccaacggg
     1321 gcagccttgg cagccaacag caatggcatc gccggcagca tgcagccaga ggaggaggca
     1381 gctcgggcgg ctggtgcagc cattgcaggc caagcctctt tgcctgtgtt acctggggtg
     1441 gaccgcttgc ccatggtggc tggaccccta tccccccaac tgctgacttc cccattcccc
     1501 agtgtggcat ccagtgcccc tcccctgact ggcaagcgag gccggggccg cccaaggaag
     1561 gccaacctgc tggactcaat gtttgggtcc ccagggggcc tgagggaggc aggcatcctt
     1621 ccatgcggtc tatgtggtaa ggtgttcact gatgccaacc ggctccggca gcacgaggcc
     1681 cagcacggtg tcaccagcct ccagctgggc tacatcgacc ttcctcctcc gaggctgggt
     1741 gagaatgggc tacccatctc tgaagacccc gacggccccc gaaagaggag ccggaccagg
     1801 aagcaggtgg cttgtgagat ctgcggcaag atcttccgtg atgtgtatca tcttaaccgg
     1861 cacaagctgt cccactctgg ggagaagccc tactcctgcc ctgtgtgtgg gttgcggttc
     1921 aagagaaaag accgcatgtc ctaccatgtg cggtcccatg atgggtccgt gggcaagcct
     1981 tacatctgcc agagctgtgg gaaaggcttc tccaggcctg atcacttgaa cggacatatc
     2041 aagcaggtgc acacttctga gcggcctcac aagtgtcaga cctgcaatgc ttcttttgcc
     2101 acccgagacc gtctgcgctc ccacctggcc tgtcatgaag acaaggtgcc ctgccaggtg
     2161 tgtgggaagt acttgcgggc agcatacatg gcagaccacc tgaagaagca cagcgagggg
     2221 cccagcaact tctgcagtat ctgtaaccga ggtttctcct ctgcctccta cttaaaggtc
     2281 catgttaaaa cccaccacgg tgttcccctt ccccaggtct ccaggcacca ggagcccatc
     2341 ctgaatgggg gagcagcgtt ccactgcgcc aggacctatg gcaacaaaga aggccagaaa
     2401 tgctcacatc aggatccgat tgagagctct gactcctatg gtgacctctc agatgccagc
     2461 gacctgaaga cgccagagaa gcagagtgcc aatggctctt tctcctgcga catggcagtc
     2521 cccaaaaaca aaatggagtc tgatggggag aagaagtacc catgccctga atgtgggagc
     2581 ttcttccgct ctaagtccta cttgaacaaa cacatccaga aggtgcatgt ccgggctctc
     2641 gggggccccc tgggggacct gggccctgcc cttggctcac ctttctctcc tcagcagaac
     2701 atgtctctcc tcgagtcctt tgggtttcag attgttcagt cggcatttgc gtcatcttta
     2761 gtagatcctg aggttgacca gcagcccatg gggcctgaag ggaaatgagg cagctgctgt
     2821 gtccccacgg aaacaaccat ctggggactg ctgggaaatg ctgtgaatgc ggagggaagt
     2881 gatgtttggg ttctgtagct gagagatttt tattcatttt taactgcccc ccaaccccac
     2941 tccaactcct tctccaccac ccattctccc aatggtcttt agaaatagat tttcatctga
     3001 tattctgcag aaatatcaat gagacttggt atgggacagg ggcagaaaac actacatagg
     3061 cctccaaggc aaaaccagtc ccagtttctt taatgggaag aagctggaat tcctggtgct
     3121 caattcttag tgaccccaat cctataccca aatctatgat attctgggac ctcagtgatt
     3181 ttggtcccct cccacttctc tagttcgtca tcctcccttc ccatatcctt caaaagaacc
     3241 acactagggt ctccacctac ttatacaatg cggatgccca actgttttta aggaagccag
     3301 aagcatccca tggaccatgg ggtgagtgtc ctccaagagc cccctgagct cagccctctg
     3361 cctggagggc tccagacctt tctgagccct gcttggaggc gagcattttc actgctagga
     3421 caagctcagc tgttgaggac acccccaccc caaatttcag ttcttacgtg attttaacca
     3481 ttcaacatgc tgttgggttt taattctcta attattatta ttattgttat tattttttag
     3541 gaccagttgt agtgaattgc tactgaaagc tatcccaggt gatacagagc tctttgtaaa
     3601 ccgcagtcac acattagggt tagtattaaa ctttgtttag atgtaccata attaacttgg
     3661 ctagttgatt gtttgaagtc tatggaagaa atagttttat gcaaaatttt aaaaaatgcc
     3721 agtctggtca gggaagtagg gggtttcaat gctgttggga accaggaagg tgggacagcc
     3781 ggcaggtagg gacattgtgt acctcagttg tgtcacatgt gagcaagccc aggttgacct
     3841 tgtgatgtga attgatctga tcagactgta ttaaaaatgt tagtacatta ctcta
//
