LOCUS       NM_152716               4129 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens PAT1 homolog 1, processing body mRNA decay factor
            (PATL1), mRNA.
ACCESSION   NM_152716
VERSION     NM_152716.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4129)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4129)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   3  (bases 1 to 4129)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4129)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4129)
  AUTHORS   Peter,D., Ruscica,V., Bawankar,P., Weber,R., Helms,S., Valkov,E.,
            Igreja,C. and Izaurralde,E.
  TITLE     Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated
            translational repression
  JOURNAL   Genes Dev 33 (19-20), 1355-1360 (2019)
   PUBMED   31439631
REFERENCE   6  (bases 1 to 4129)
  AUTHORS   Marnef,A., Maldonado,M., Bugaut,A., Balasubramanian,S., Kress,M.,
            Weil,D. and Standart,N.
  TITLE     Distinct functions of maternal and somatic Pat1 protein paralogs
  JOURNAL   RNA 16 (11), 2094-2107 (2010)
   PUBMED   20826699
  REMARK    GeneRIF: hPat1b localizes to P-bodies, while mPat1a-GFP is either
            found weakly in P-bodies or disperses P-bodies in a
            dominant-negative fashion.
REFERENCE   7  (bases 1 to 4129)
  AUTHORS   Ozgur,S., Chekulaeva,M. and Stoecklin,G.
  TITLE     Human Pat1b connects deadenylation with mRNA decapping and controls
            the assembly of processing bodies
  JOURNAL   Mol Cell Biol 30 (17), 4308-4323 (2010)
   PUBMED   20584987
  REMARK    GeneRIF: By tethering Pat1b to a reporter mRNA, the study provides
            evidence that Pat1b is also functionally linked to both
            deadenylation and decapping.
REFERENCE   8  (bases 1 to 4129)
  AUTHORS   Braun,J.E., Tritschler,F., Haas,G., Igreja,C., Truffault,V.,
            Weichenrieder,O. and Izaurralde,E.
  TITLE     The C-terminal alpha-alpha superhelix of Pat is required for mRNA
            decapping in metazoa
  JOURNAL   EMBO J 29 (14), 2368-2380 (2010)
   PUBMED   20543818
  REMARK    GeneRIF: Data show that PatL1 is essential for the interaction with
            mRNA decapping factors (i.e. DCP2, EDC4 and LSm1-7), whereas the
            P-rich region and Mid domain have distinct functions in modulating
            these interactions.
REFERENCE   9  (bases 1 to 4129)
  AUTHORS   Scheller,N., Resa-Infante,P., de la Luna,S., Galao,R.P.,
            Albrecht,M., Kaestner,L., Lipp,P., Lengauer,T., Meyerhans,A. and
            Diez,J.
  TITLE     Identification of PatL1, a human homolog to yeast P body component
            Pat1
  JOURNAL   Biochim Biophys Acta 1773 (12), 1786-1792 (2007)
   PUBMED   17936923
  REMARK    GeneRIF: The identification of two human PAT1 genes is described
            and one of them, PATL1, codes for an open reading frame with
            similar features as the yeast PAT1.
REFERENCE   10 (bases 1 to 4129)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC409866.1 and BC111047.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152716.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.423178.1, AL831992.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300146.10/ ENSP00000300146.9
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               DC409866.1         2-338
            338-4129            BC111047.1         1-3792
FEATURES             Location/Qualifiers
     source          1..4129
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..4129
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /note="PAT1 homolog 1, processing body mRNA decay factor"
                     /db_xref="GeneID:219988"
                     /db_xref="HGNC:HGNC:26721"
                     /db_xref="MIM:614660"
     exon            1..157
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2455
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /note="PAT1-like protein 1; protein PAT1 homolog b;
                     protein associated with topoisomerase II homolog 1"
                     /codon_start=1
                     /product="protein PAT1 homolog 1"
                     /protein_id="NP_689929.2"
                     /db_xref="CCDS:CCDS44613.1"
                     /db_xref="GeneID:219988"
                     /db_xref="HGNC:HGNC:26721"
                     /db_xref="MIM:614660"
                     /translation="MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDD
                     DWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDP
                     AIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQ
                     GPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRP
                     PMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGR
                     MSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPP
                     GPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRSQHRNLNGAGDRGSHRSSH
                     QDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQ
                     GDGPKKERTKLITPQVAKLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDD
                     ETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMY
                     DNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLI
                     KKDAQDEVLPCLLSPFSLLLYHLPSVSITSLLRQLMNLPQSAATPALSNPHLTAVLQN
                     KFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIP
                     TNLVSLFSRYVDRQKLNLLETKLQLVQGIR"
     exon            158..269
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            270..487
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            488..568
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            569..763
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            764..865
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            866..955
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            956..1173
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1263
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1444
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1568
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1666
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1726
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1875
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2035
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2036..2191
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2283
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2433
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..4129
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4109..4114
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /note="hexamer: AACAAA"
     polyA_site      4129
                     /gene="PATL1"
                     /gene_synonym="hPat1b; Pat1b"
                     /note="major polyA site"
ORIGIN      
        1 cgtccccacg cacgctccgg cgtacggcgg cggccagggg tcgcgagccg gtggaggacc
       61 cgcgcgcgga ggagccgggg agtcagcgct tcttccctcc ctccccctct cccctccccg
      121 ctccctgccc ccctccccaa gaatgttccg ctacgagtct ttggaggatt gtcctctgga
      181 tgaagatgaa gatgcatttc agggactggg agaagaagat gaagagattg atcaattcaa
      241 tgatgataca tttgggtcag gtgcagttga tgatgattgg caggaagcac atgagcgcct
      301 ggctgaattg gaagaaaagc taccagtggc agttaatgaa caaacaggca atggagagag
      361 agatgaaatg gacttgttgg gtgaccatga ggagaatctg gcagaaaggc tcagtaagat
      421 ggtgattgaa aatgaactag aagatccagc tattatgagg gcagtgcaga ccaggccagt
      481 tttacaaccc caaccaggaa gtctgaattc cagtatctgg gatggatctg aagttctgag
      541 gcgaatccga ggaccactgc ttgctcagga aatgcctaca gtgtctgtat tagaatatgc
      601 tttgcctcag aggccccccc agggtccaga agatgatcgg gacctttctg aacgagcatt
      661 accaaggcgg tcaacttcac ctatcattgg cagtcctcct gttagagctg tccccatagg
      721 caccccacct aaacagatgg ctgtacccag cttcacccaa cagattctgt gtccgaagcc
      781 tgtccatgtt cggcccccaa tgccacctcg ttatcctgct ccctatggtg agaggatgtc
      841 tccaaaccag ctctgcagtg tcccgaactc ttccctcctg ggtcaccctt ttcctcctag
      901 tgttcctcct gttctcagcc ccctccagag agcacagctt cttggaggag cacagctaca
      961 gcctggacgg atgtctccca gccagtttgc acgggtccct ggatttgttg gtagtccact
     1021 tgctgccatg aatcccaagt tgctacaagg gcgagttggg cagatgcttc ccccagcacc
     1081 aggcttccgt gccttcttta gtgctccacc ctccgctaca ccacctccac agcagcaccc
     1141 tcctggccca ggaccccacc tgcaaaacct aagatctcag gccccaatgt ttagaccgga
     1201 cacaactcac ctccatccac agcaccgtcg actcttgcat cagagacagc aacagaatag
     1261 aagtcagcat cggaatctca atggtgcggg agatagagga agtcaccgga gcagtcatca
     1321 agatcatctc cgaaaggatc catatgccaa tctcatgttg cagcgggaaa aggattgggt
     1381 ctctaaaatc cagatgatgc aactgcaaag cactgatccc tacctggatg atttttatta
     1441 ccagaattac tttgaaaaac tggagaaact gtcagctgct gaagaaatac aaggtgatgg
     1501 ccctaagaag gagcgcacca agcttatcac ccctcaggtg gccaaactgg agcacgccta
     1561 taagccagtg caatttgagg gctctttggg aaagcttacc gtttctagtg tgaataatcc
     1621 ccgaaaaatg attgatgctg ttgtgacatc tcggagtgag gatgatgaga caaaagaaaa
     1681 acaagttcga gacaagagga gaaaaaccct tgttataatt gagaaaacct acagcttact
     1741 ccttgatgtg gaggactatg aaagacgtta tctcctaagt ctggaagaag agcgacctgc
     1801 cctaatggat gacagaaagc acaaaatttg tagcatgtat gacaacttaa gggggaaatt
     1861 gcctggacaa gagaggccta gtgatgacca ctttgtacag atcatgtgta tccgaaaagg
     1921 gaagagaatg gttgcccgta ttcttccttt cctctccaca gagcaagcag ctgacattct
     1981 catgacaaca gccaggaacc tccctttcct tatcaagaag gatgcacaag atgaggtgct
     2041 gccatgctta ctgagtccct tctctctcct tctctatcat cttccatcag tgagtatcac
     2101 cagccttttg cgacagctaa tgaacctacc tcaaagtgca gctacaccag cactctccaa
     2161 tcctcacctc actgctgtgc tccagaacaa gtttggcctg tcactgctcc tcatcctcct
     2221 gagccgtggt gaagacctac agagttcaga ccctgctaca gaatcaacac aaaataatca
     2281 gtggacggag gtgatgttca tggcaacacg agaacttctg cggattcccc aagcagccct
     2341 ggccaagcca atctctatac ctacaaacct agtgtccctc ttttctcgct atgttgaccg
     2401 gcagaaactg aacttgctgg agacaaaact gcagctagtt caggggatac gataaaagat
     2461 ctccaaatgt gtcctgtacc tccttttggc tgccacctgc actgctgcca tcaccaatgg
     2521 agtgttttta atgagggaag gaaggtagct ttttccccaa agcaaagtct tgtgggatcg
     2581 attcctgttt acaggggttg tctctctaaa tgtcagatat ttccccactg ctctatgaaa
     2641 tttggctggg tgatacttct gctggtttct ttaccttctg tgttacagtt ctgcatgtcc
     2701 tacttttact cagttctgtt ttgcattttc tttgccctag agacacaagt gtaatctctc
     2761 cctttatccc tccactactc cacctcagag tagattgtag cctgccaaag gattccttcc
     2821 ctcatcctat tgaagttgtt ttttcattgc cccatattaa tatgactata gaagagccaa
     2881 ttaagtagaa atcaagatat acacacacac atagatacac acacacacac cccatacatg
     2941 tatttatgtg gtcttcagag ggtccttaaa gaatgaattt tagattgaaa aatatttagt
     3001 tgtctcatta cctcttctaa acacaaacca gctgatgtat tttaatctgt ttctgttcta
     3061 tcttgtaatt aatttggtgg gttctacttg ttttaacata aataaagagt atgcagcacg
     3121 tttaataaaa tcagaactct taattggctt atgcccaggt ctaggctgag aagtcctttt
     3181 tcttcttccc acctttattt ccttagtttc tgtccacctt aatcgaaaca acacatggtt
     3241 atgtcttttt cctgctacaa ctacagggta cttgagcctt tcccctcaag tgcattcgaa
     3301 gtcacccagg atgatcctca ctagtagcct gctttggcag tgtggctttt tgcacacttg
     3361 ccctgtcttc ctgagactac ttcagtaagc catgcttcct tcttccccac ttttatttgg
     3421 tgtcatgaat agaaacttcc aaatgtaacc atggaagcta agtttggcct gctttgcttt
     3481 ttagtctcca caccatgggc agaactgctg tctttactac ttcatctcac ccaagtcccg
     3541 ttcccaggca gccaggggcc tgggtttgaa taattgcagg gccagcctgc catgatcttt
     3601 ctcacttact cctctcccat tcagcaatca accagactaa ggagttttga tccctagtga
     3661 ttacagccct gaagaaaatt aaatctgaat taattttaca tggccttcgt gatctttctg
     3721 ctgttcttac tttttcgaat gtagttgggg ggtgggaggg acaggttatg gtatttaaag
     3781 agaataaaca ttttgcacat acatgtattg tacaacagta agatcctctg ttaaaaccag
     3841 ctgtcctgtt ctccatctcc atttcttccc atgctgtaac cccaggctcc accagctgtt
     3901 ccccagtgat gttacctagc ttccctctac cgttgtctac tgaccatttc cactacatgc
     3961 ctttcctacc ttcccttcac aaccaatcaa gtgaatactt gattattatc tcttccttac
     4021 tgtgctttat cttttttgtt tggattggtt ctaattaatg aaaataaaag tttctaaatt
     4081 tacattttta tagggtattg taaataaaaa caaattgtat acttaaaaa
//
