LOCUS       NM_001350145            8621 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens PATJ crumbs cell polarity complex component (PATJ),
            transcript variant 2, mRNA.
ACCESSION   NM_001350145 XM_005270341
VERSION     NM_001350145.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8621)
  AUTHORS   Wu,D., Chapela,P.J., Barrows,C.M.L., Harrington,D.A., Carson,D.D.,
            Witt,R.L., Mohyuddin,N.G., Pradhan-Bhatt,S. and Farach-Carson,M.C.
  TITLE     MUC1 and Polarity Markers INADL and SCRIB Identify Salivary Ductal
            Cells
  JOURNAL   J Dent Res 101 (8), 983-991 (2022)
   PUBMED   35259994
  REMARK    GeneRIF: MUC1 and Polarity Markers INADL and SCRIB Identify
            Salivary Ductal Cells.
REFERENCE   2  (bases 1 to 8621)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 8621)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8621)
  AUTHORS   Mola-Caminal,M., Carrera,C., Soriano-Tarraga,C.,
            Giralt-Steinhauer,E., Diaz-Navarro,R.M., Tur,S., Jimenez,C.,
            Medina-Dols,A., Cullell,N., Torres-Aguila,N.P., Muino,E.,
            Rodriguez-Campello,A., Ois,A., Cuadrado-Godia,E.,
            Vivanco-Hidalgo,R.M., Hernandez-Guillamon,M., Sole,M., Delgado,P.,
            Bustamante,A., Garcia-Berrocoso,T., Mendioroz,M., Castellanos,M.,
            Serena,J., Marti-Fabregas,J., Segura,T., Serrano-Heras,G.,
            Obach,V., Ribo,M., Molina,C.A., Alvarez-Sabin,J., Palomeras,E.,
            Freijo,M., Font,M.A., Rosand,J., Rost,N.S., Gallego-Fabrega,C.,
            Lee,J.M., Heitsch,L., Ibanez,L., Cruchaga,C., Phuah,C.L.,
            Lemmens,R., Thijs,V., Lindgren,A., Maguire,J., Rannikmae,K.,
            Sudlow,C.L., Jern,C., Stanne,T.M., Lorentzen,E., Munoz-Narbona,L.,
            Davalos,A., Lopez-Cancio,E., Worrall,B.B., Woo,D., Kittner,S.J.,
            Mitchell,B.D., Montaner,J., Roquer,J., Krupinski,J., Estivill,X.,
            Rabionet,R., Vives-Bauza,C., Fernandez-Cadenas,I. and
            Jimenez-Conde,J.
  TITLE     PATJ Low Frequency Variants Are Associated With Worse Ischemic
            Stroke Functional Outcome
  JOURNAL   Circ Res 124 (1), 114-120 (2019)
   PUBMED   30582445
  REMARK    GeneRIF: Meta-analysis: Novel variants in PATJ (Pals1-associated
            tight junction) gene were associated with worse functional outcome
            at 3-month after stroke. The top variant was rs76221407 .
REFERENCE   5  (bases 1 to 8621)
  AUTHORS   Quinn,P.M., Pellissier,L.P. and Wijnholds,J.
  TITLE     The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene
            Therapy Strategy
  JOURNAL   Front Neurosci 11, 175 (2017)
   PUBMED   28424578
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8621)
  AUTHORS   Vaccaro,P., Brannetti,B., Montecchi-Palazzi,L., Philipp,S., Helmer
            Citterich,M., Cesareni,G. and Dente,L.
  TITLE     Distinct binding specificity of the multiple PDZ domains of INADL,
            a human protein with homology to INAD from Drosophila melanogaster
  JOURNAL   J Biol Chem 276 (45), 42122-42130 (2001)
   PUBMED   11509564
REFERENCE   7  (bases 1 to 8621)
  AUTHORS   Soejima,H., Kawamoto,S., Akai,J., Miyoshi,O., Arai,Y., Morohka,T.,
            Matsuo,S., Niikawa,N., Kimura,A., Okubo,K. and Mukai,T.
  TITLE     Isolation of novel heart-specific genes using the BodyMap database
  JOURNAL   Genomics 74 (1), 115-120 (2001)
   PUBMED   11374908
REFERENCE   8  (bases 1 to 8621)
  AUTHORS   Fanning,A.S. and Anderson,J.M.
  TITLE     PDZ domains: fundamental building blocks in the organization of
            protein complexes at the plasma membrane
  JOURNAL   J Clin Invest 103 (6), 767-772 (1999)
   PUBMED   10079096
  REMARK    Review article
REFERENCE   9  (bases 1 to 8621)
  AUTHORS   Kurschner,C., Mermelstein,P.G., Holden,W.T. and Surmeier,D.J.
  TITLE     CIPP, a novel multivalent PDZ domain protein, selectively interacts
            with Kir4.0 family members, NMDA receptor subunits, neurexins, and
            neuroligins
  JOURNAL   Mol Cell Neurosci 11 (3), 161-172 (1998)
   PUBMED   9647694
REFERENCE   10 (bases 1 to 8621)
  AUTHORS   Philipp,S. and Flockerzi,V.
  TITLE     Molecular characterization of a novel human PDZ domain protein with
            homology to INAD from Drosophila melanogaster
  JOURNAL   FEBS Lett 413 (2), 243-248 (1997)
   PUBMED   9280290
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097064.2, AL449143.18,
            AL353802.14, AL590374.4 and AL136458.16.
            
            On Jan 10, 2020 this sequence version replaced NM_001350145.2.
            
            Summary: This gene encodes a protein with multiple PDZ domains. PDZ
            domains mediate protein-protein interactions, and proteins with
            multiple PDZ domains often organize multimeric complexes at the
            plasma membrane. This protein localizes to tight junctions and to
            the apical membrane of epithelial cells. A similar protein in
            Drosophila is a scaffolding protein which tethers several members
            of a multimeric signaling complex in photoreceptors. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) includes an alternate
            penultimate exon, compared to variant 1, resulting in a novel 3'
            coding region and shorter 3' UTR. It encodes isoform 2 which has a
            longer and distinct C-terminus, compared to isoform 1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.216323.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000642238.2/ ENSP00000494277.1
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-76                AC097064.2         59471-59546
            77-133              AC097064.2         79849-79905
            134-300             AC097064.2         80004-80170
            301-495             AC097064.2         83270-83464
            496-635             AC097064.2         86274-86413
            636-831             AC097064.2         88422-88617
            832-960             AC097064.2         92197-92325
            961-1179            AC097064.2         104745-104963
            1180-1279           AC097064.2         108339-108438
            1280-1371           AC097064.2         112458-112549
            1372-1513           AC097064.2         114278-114419
            1514-1660           AC097064.2         118614-118760
            1661-1737           AC097064.2         122439-122515
            1738-1794           AL449143.18        611-667
            1795-1929           AL449143.18        15082-15216
            1930-2091           AL449143.18        19559-19720
            2092-2223           AL449143.18        25791-25922
            2224-2433           AL449143.18        48167-48376
            2434-2550           AL449143.18        53688-53804
            2551-2946           AL449143.18        56375-56770
            2947-3070           AL449143.18        67380-67503
            3071-3242           AL449143.18        76374-76545
            3243-3314           AL353802.14        6647-6718
            3315-3492           AL353802.14        8346-8523
            3493-3603           AL353802.14        15436-15546
            3604-3681           AL353802.14        21651-21728
            3682-3781           AL353802.14        34794-34893
            3782-3978           AL353802.14        97232-97428
            3979-4070           AL353802.14        124920-125011
            4071-4143           AL590374.4         3815-3887
            4144-4236           AL136458.16        9029-9121
            4237-4354           AL136458.16        37513-37630
            4355-4488           AL136458.16        42578-42711
            4489-4572           AL136458.16        66500-66583
            4573-4766           AL136458.16        72116-72309
            4767-4914           AL136458.16        74595-74742
            4915-5001           AL136458.16        75195-75281
            5002-5116           AL136458.16        79244-79358
            5117-5154           AL136458.16        81084-81121
            5155-5277           AL136458.16        86035-86157
            5278-5382           AL136458.16        86904-87008
            5383-5489           AL136458.16        106347-106453
            5490-5613           AL136458.16        111421-111544
            5614-8621           AL136458.16        118971-121978
FEATURES             Location/Qualifiers
     source          1..8621
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..8621
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /note="PATJ crumbs cell polarity complex component"
                     /db_xref="GeneID:10207"
                     /db_xref="HGNC:HGNC:28881"
                     /db_xref="MIM:603199"
     exon            1..76
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            77..133
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..5760
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /note="isoform 2 is encoded by transcript variant 2;
                     protein associated to tight junctions; PALS1-associated
                     tight junction protein; inactivation no after-potential
                     D-like protein; channel-interacting PDZ domain protein;
                     inactivation-no-afterpotential D-like; channel-interacting
                     PDZ domain-containing protein"
                     /codon_start=1
                     /product="inaD-like protein isoform 2"
                     /protein_id="NP_001337074.2"
                     /db_xref="CCDS:CCDS85980.1"
                     /db_xref="GeneID:10207"
                     /db_xref="HGNC:HGNC:28881"
                     /db_xref="MIM:603199"
                     /translation="MPENPATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKS
                     PLFNQILTLQQSIKQLKGQLNHIPSDCSANFDFSRKGLLVFTDGSITNGNVHRPSNNS
                     TVSGLFPWTPKLGNEDFNSVIQQMAQGRQIEYIDIERPSTGGLGFSVVALRSQNLGKV
                     DIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAIALLQQTTGSLRLIVA
                     REPVHTKSSTSSSLNDTTLPETVCWGHVEEVELINDGSGLGFGIVGGKTSGVVVRTIV
                     PGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAGDISV
                     TPPAPAALPVALPTVASKGPGSDSSLFETYNVELVRKDGQSLGIRIVGYVGTSHTGEA
                     SGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLV
                     RRKTSSSTSPLEPPSDRGTVVEPLKPPALFLTGAVETETNVDGEDEEIKERIDTLKND
                     NIQALEKLEKVPDSPENELKSRWENLLGPDYEVMVATLDTQIADDAELQKYSKLLPIH
                     TLRLGVEVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFL
                     KEVPPPFTLVCCRRLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSP
                     EVKIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSV
                     NEYCLDNTSLAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSG
                     TIHDINSSLILEAPKGFRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEF
                     LTPRLQEMDEEREILVDEEYELYQDPSPSMELYPLSHIQEATPVPSVNELHFGTQWLH
                     DNEPSESQEARTGRTVYSQEAQPYGYCPENVMKENFVMESLPSVPSTEGNSQQGRFDD
                     LENLNSLAKTSLDLGMIPNDVQGPSLLIDLPVVAQRREQEDLPLYQHQATRVISKASA
                     YTGMLSSRYATDTCELPEREEGEGEETPNFSHWGPPRIVEIFREPNVSLGISIVGGQT
                     VIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIK
                     NAGNPVVFIVQSLSSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPP
                     YKALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRM
                     SIFVVGINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFIR
                     NEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVS
                     QMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQAPLSVDPATCPIVPGQEM
                     IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLR
                     NSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGKR
                     NGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLE
                     IGRLRAGSWTSARTTSQNSQGSQQSAHSSCHPSFAPVITGLQNLVGTKRVSDPSQKNS
                     GTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDR
                     IVSINGQPLDGLSHADVVNLLKNAYGRIILQVVADTNISAIAAQLENMSTGYHLGSPT
                     AEHHPEDTETPPPKIITLEKGSEGLGFSIVGGYGSPHGDLPIYVKTVFAKGAAADDGR
                     LKRGDQILAVNGETLEGVTHEQAVAILKHQRGTVTLTVLS"
     exon            134..300
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            301..495
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            496..635
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            636..831
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            832..960
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1179
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1279
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1371
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1513
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1660
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1737
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1794
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1929
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2091
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            2092..2223
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2433
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2550
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2946
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            2947..3070
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3071..3242
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3314
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3315..3492
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3493..3603
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3604..3681
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3682..3781
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3782..3978
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            3979..4070
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4071..4143
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4144..4236
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4354
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4355..4488
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4489..4572
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4573..4766
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4767..4914
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            4915..5001
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5002..5116
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5117..5154
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5155..5277
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5278..5382
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5383..5489
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5490..5613
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     exon            5614..8621
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8192..8197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /note="hexamer: AATACA"
     polyA_site      8212
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /note="major polyA site"
     regulatory      8600..8605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
                     /note="hexamer: AATAAA"
     polyA_site      8621
                     /gene="PATJ"
                     /gene_synonym="Cipp; hINADL; InaD-like; INADL"
ORIGIN      
        1 acttccgccc aggtgaggca gggccgacac cgagcccgcc cgacccgggc tcccacctgc
       61 tcctccagcg caccaggtgt ctttaagagt gattgaagag aataattcaa aatgcctgaa
      121 aatcctgcta cagataaact gcaggtgctg caggtacttg atcgcctgaa aatgaaattg
      181 caggagaagg gtgacacgtc gcagaatgag aagttatcta tgttttatga gacactaaag
      241 agtcctctct tcaaccagat actcacactt cagcagtcca tcaagcaact gaagggtcaa
      301 ctcaaccata taccctcaga ttgttcagcc aactttgatt tttctaggaa aggtttgtta
      361 gtgttcacag atggttccat cactaatgga aatgtccaca ggccctctaa taactcgact
      421 gtatctgggt tatttccgtg gaccccgaag ttgggaaatg aagactttaa ctcagtcatt
      481 caacagatgg ctcagggccg gcaaattgaa tatatagata tagaacggcc ttcaactgga
      541 ggccttggat tcagtgtggt ggccctcaga agtcaaaatc tcggaaaagt tgatatcttc
      601 gtgaaggatg tccagccagg gagtgtagca gacagggatc aaagattaaa ggaaaatgat
      661 caaatattgg ccattaatca cacgccattg gatcagaaca tttcccatca gcaagcaatt
      721 gcattattac aacaaaccac tggatctttg agactgattg tggccaggga accagtccac
      781 acaaaaagca gtacttctag cagcctaaat gatacaactc tgcctgaaac agtttgttgg
      841 ggccatgttg aagaggttga gctcattaat gatggctctg gactaggttt tggaatagtt
      901 ggaggaaaaa caagtggcgt ggttgtgagg actatagttc ctggaggatt agcagatcga
      961 gatggaagac tccagacagg ggaccacatc ttgaagattg gtggcacaaa cgtgcaggga
     1021 atgaccagtg agcaagttgc acaagttcta aggaactgtg ggaattcagt caggatgctc
     1081 gttgctagag atccagctgg tgacatttca gtcacccccc ctgcccctgc agccttacct
     1141 gttgccctgc ctactgtagc cagcaagggc cctggttctg acagttctct ttttgaaact
     1201 tataatgttg agcttgtgag aaaagatggg cagagtcttg gaattagaat tgttggctat
     1261 gttggaacat ctcatacagg ggaagcttca gggatttatg tgaaaagtat aatacctggc
     1321 agtgctgcgt accacaatgg ccacattcaa gtgaatgaca aaatagttgc tgtcgatggc
     1381 gtgaacattc agggttttgc caaccatgat gttgttgaag tattacgaaa tgcagggcag
     1441 gtggtacacc taaccctagt tcgaaggaag acatcctcat ctacttctcc acttgaacca
     1501 ccttcagaca gaggaactgt tgtagaacca ctgaaaccac cagctctctt tctaactgga
     1561 gcagtggaaa ctgaaactaa tgtggatggt gaagatgagg aaattaaaga aagaattgat
     1621 actttaaaaa atgacaacat acaagcctta gaaaaattgg aaaaagtccc agactctcca
     1681 gaaaatgagc tgaaatccag atgggaaaac ctgttgggtc ctgattatga agtaatggtt
     1741 gctactttgg acacacagat tgcagatgat gctgagttac agaaatattc aaagctgctg
     1801 cctattcaca ctctgaggct tggtgtggaa gtggattcct ttgatgggca ccattatatt
     1861 tcttcaattg tttctggtgg tcctgttgat acattgggtc tcctacagcc agaagatgag
     1921 ctgcttgagg tcaatggcat gcagctttat ggaaaatctc gccgagaagc agtctccttt
     1981 cttaaagaag tgccaccccc ttttactttg gtttgctgtc ggaggttgtt tgatgatgaa
     2041 gcttctgtag atgaaccaag gcgcactgaa acctctcttc ctgagacaga ggttgaccac
     2101 aatatggatg tcaatactga agaagatgat gatggggaat tagcactgtg gtcccctgaa
     2161 gtcaagattg ttgaactagt aaaagattgt aaaggtttgg gattcagcat tttggattac
     2221 caggaccctt tagatcctac aagatcagtg attgtgatcc gctccctggt agcagatggt
     2281 gtagcagaaa gaagtggggg actattacct ggagaccgcc tggtctcagt caatgaatac
     2341 tgtttggaca acacctcact tgctgaagct gtggaaatat tgaaagctgt gccaccaggc
     2401 ctagtacacc ttggcatctg taagcctttg gtggaagata atgaagaaga aagttgttat
     2461 attttacatt caagcagtaa tgaagacaag actgaatttt caggaacaat tcatgatata
     2521 aattcatctt taatactcga agcacccaag ggatttagag atgaaccata ttttaaagaa
     2581 gaacttgtgg atgaaccatt tctagatctg ggaaagtctt tccattccca acaaaaagag
     2641 atagagcaaa gcaaggaggc ctgggagatg catgaatttc tgactcctag attgcaggaa
     2701 atggatgaag aaagagaaat tcttgttgat gaagaatatg agttatatca agatccctca
     2761 ccatccatgg agttgtatcc cttgtcgcac attcaagagg ccactcctgt gccctctgtg
     2821 aatgaacttc actttggtac acagtggttg catgataatg aaccatccga gtctcaagag
     2881 gcaagaaccg ggaggactgt ctattcccag gaggcacagc cgtatggcta ttgccctgaa
     2941 aatgtgatga aagaaaattt tgtcatggag tccctaccat ctgtaccatc aactgaagga
     3001 aacagtcaac aaggcagatt tgacgacctg gaaaatctta attcattagc aaaaactagt
     3061 ctggatttag gcatgatccc gaatgatgtc caaggtccta gcttgctcat tgaccttcct
     3121 gttgtggctc aaaggaggga gcaagaagat ttgcctttat atcaacacca agcgacacga
     3181 gttatttcca aggcctcagc atacacagga atgttgtctt ctagatatgc cactgataca
     3241 tgtgagttac ctgagagaga agaaggcgaa ggagaagaaa ctccaaattt tagccactgg
     3301 ggtccaccga gaattgttga gatttttaga gaacccaatg tgtctcttgg gatcagtatt
     3361 gttggtggac aaactgttat aaaacgtcta aagaatggag aggagcttaa aggtatattc
     3421 atcaaacaag ttttagaaga cagtccagca gggaagacga acgcacttaa aactggagat
     3481 aaaatacttg aggtgtctgg agtagatttg cagaatgcct cacacagcga agcagttgag
     3541 gccattaaga atgcaggaaa ccctgtggtg ttcattgttc agagtttgtc atccactcca
     3601 cgagtcattc ctaacgtaca taacaaggcc aacaaaatca ccggtaacca gaaccaggac
     3661 acccaagaaa agaaagaaaa gaggcaagga actgctccac cgccaatgaa acttcctcct
     3721 ccttataaag ctctgactga tgacagtgat gaaaatgaag aagaagatgc ctttaccgac
     3781 caaaaaatca gacaaagata tgcagatctg cctggagaac tgcacattat tgaacttgaa
     3841 aaagataaga atggacttgg actcagcctt gctggtaata aagaccgatc acgcatgagc
     3901 atatttgtgg tgggaattaa cccggaagga cctgctgccg cagatggacg aatgcgtatt
     3961 ggagatgaac tcttagagat aaacaatcag attctgtatg gaagaagtca ccaaaatgca
     4021 tctgccatta ttaagactgc cccatcaaag gtcaagctgg ttttcatcag aaacgaggat
     4081 gcagtcaatc agatggccgt tactcccttt ccagtgccat caagttctcc atcttctatt
     4141 gaggatcaga gcggcaccga acctattagt agtgaggaag atggcagcgt cgaagttggt
     4201 attaaacaat tgcctgaaag tgaaagcttc aaactggctg tcagccagat gaaacagcaa
     4261 aaatatccaa caaaagtctc cttcagttca caagagatac cattagcacc agcttcatca
     4321 taccattcaa cagatgcaga cttcacaggc tatggtggtt tccaggctcc tctgtcagtg
     4381 gaccccgcaa cgtgtcccat tgtccctgga caggaaatga ttatagaaat atccaaggga
     4441 cgttcagggc ttggtctcag cattgtggga ggaaaagaca cacccttgaa tgctatagtt
     4501 atccatgaag tctatgaaga aggggcagca gccagagatg gaagactttg ggctggtgac
     4561 cagatattag aggttaatgg ggttgacctg aggaactcca gccacgaaga agccatcaca
     4621 gccctgaggc agacccccca gaaggtgcgg ctggtggtgt atagagatga ggcacactac
     4681 cgggatgagg agaacttgga gattttccct gtggatctgc agaagaaagc tggccggggc
     4741 ctgggcctga gcatcgttgg gaaacgaaat ggaagcggag tgtttatttc tgacatcgtg
     4801 aaaggcggag ccgcagacct ggatgggaga ttgattcagg gagatcagat cttatctgtg
     4861 aatggggagg acatgagaaa tgcctcacag gagacagtgg ccaccatcct caagtgtgca
     4921 cagggacttg tgcagctaga gattggaaga ctccgagctg gttcctggac ctccgcaagg
     4981 acgacatcac agaacagtca gggtagtcag cagagtgcac acagcagctg tcatccctcc
     5041 ttcgctcctg tcatcactgg cctgcaaaac ctggttggca caaaaagagt ttcagatcct
     5101 tcccagaaaa attcaggcac agatatggaa ccaaggactg ttgagataaa cagggagctc
     5161 agtgatgccc ttggaatcag tattgctgga ggaagaggaa gtcccttagg agatatcccc
     5221 gtatttattg ccatgattca ggctagcgga gtggccgcac ggacacagaa gcttaaagtt
     5281 ggagatcgga ttgtcagcat taacgggcaa cctttggatg ggctgtctca cgcggatgtg
     5341 gttaatctgc tgaagaacgc ctacgggcgc attatcctgc aggttgtagc agataccaat
     5401 ataagcgcca tagcagctca gcttgaaaac atgtctacag gctaccacct tggttcgccc
     5461 actgctgaac accatccaga agacacagaa acacctccac ctaagattat tactttggag
     5521 aaaggctctg aaggcttggg gtttagtatt gtagggggtt atggaagtcc ccatggagac
     5581 ctgccaattt atgtcaagac tgtatttgca aagggagcag ctgcagatga cggccgatta
     5641 aaacgagggg atcagatttt agctgttaat ggcgagaccc tggaaggtgt tactcatgag
     5701 caagcagtcg ccattctaaa acaccagaga gggactgtaa ccttaactgt gctgtcatga
     5761 gcctcgggcc tgatcacaag atagatgttg ttgtttagaa tatccacagg cagatgaagt
     5821 tctgagtggg tatgaaaagc accctcaact aaaatgcacc ttcattctta tttcttgccc
     5881 tctctgctca ggagaaatgg ctgaggtttc atgtgaattt cccaaatcaa caatcatctc
     5941 ctaatgtttc ccagttcctg tcacctgttg gcgaggttga tttctaaaac ttaaatgagt
     6001 ctacctgttt tgcatttaat ttcagtgttc cgatttcttt tttttttttt tttttttttt
     6061 ttgagacgga gtctcactct gtcacccagg ctggagtgca atggcgcaat cttggctcac
     6121 tgcaacctcg gcctcccagg ttggagcgat tctcctgcct cagcctcccg agtagctggg
     6181 attacaggca tgcatcacca cactgggttt atttttgttt ttttagtaga gatggagctt
     6241 ccccatgtgg gccaggctgg tcttgaactt ctgacctcag gtgatctgcc tgccttggcc
     6301 tcccaaagtg ctgggattcc aggcgtgagc cactgcgccc agcccagtat tctgatttta
     6361 accaactggt tctgattata tttaccaaaa ctggagttaa cttctctttc cttatactct
     6421 tctctcccta tcccctactc acaccgaggc ttaacagcaa cctcagatct catccaatgg
     6481 acagaaacaa atgttaagca acttgtcatc tcactcatga tttacttatg ctaattgtct
     6541 cttcaagtaa gcaagaaaac attagcagtg taattaattt accagtgatc cccaagatga
     6601 aataccagat tctcctatgg gaaattactg tgctgtcttc tgtatgactt atggtcaaat
     6661 aagtctcaaa ttcatttctc tggatagatc tttatatgct agtcattggt gattttgatg
     6721 agtcaattta cagactgtaa tcttctaaaa attctgaaag actaattgtt ttctgtgcca
     6781 tataaatgca taccactgag caaatgaacc ttattctcag caggaacaac tagcatacat
     6841 gttctgaatt ctaacagtgc taaattacat tcaagtccag gaagatcacc tggaattaat
     6901 ggcatttcag ttggcaggca tcattcccac ccctcggtct taggaaaagg aggtagaagc
     6961 cccagaacca cacggcagag atcagcaagt tttgtctcaa gtcagacaag gtctaggtgg
     7021 ccttggcctt atgcaaagtg ggtgacatat ttgattatat ttccctttac ctccatagta
     7081 gtcaggccag cagcatggac tgcaagaacc taagggagca acatacttag ctgcaaagtg
     7141 agcaaatgaa ttgagcctag gaatatgtga tgaaaatgca tggctgatgt ttcctgatct
     7201 ccaaggagac tcccatttgc tgaagttttg catgctaaga aatcaactac agcagaaaat
     7261 acaagaatac ctttaagttg attattggca atcttattca tatattagca agaaaaaggg
     7321 agagatgctt actggtggat gctatagagt cctctgtttt taaaagtacc atggccgggt
     7381 gcagtggctc acgcctgtaa tcccagcact ttgggaggcc agggcaggcg aatcatgagg
     7441 tcaggagttc gagaccagcc tggccaatat ggtgaaaccc tgtctctact aaaaatacaa
     7501 aaattagctg ggtgcagtgg caggcgcctg taatcccagc tactccggag gttgaagcag
     7561 gaaaattgct tgaacctggg aggtggaggt tgcagtgagc caagttcgtg ccactccact
     7621 ccagcctggg tgacagagca agactctgtc tcgaaaaaga aaaaaaacca tgaaggatga
     7681 gtactagagt cagtaataga agtagttcag cattatttaa ctacaacaca atgctgcaaa
     7741 tatttcacag taattatcaa aatttaatgg gctctaattt aaaatgttat ttaataagta
     7801 tagattttaa ttgagaatta tctttgagta gatgtaatca caaagtgcat taactcttgt
     7861 tggaatattt tatggctatt ccaaagtata gagtgcctaa attttgtgtt gaaaatgtct
     7921 ttcatgacgg tattaagttt tctgaaatta cacatggctt ttaaaatttc taatgtatcc
     7981 aagatgtgca atgttgttag gatctcattc ttcagtgcat gaaaagctac taccctcaga
     8041 acattttgtg ttaattgtac ctgcaagaac acctcaggca agccaagaag aaatgaaacc
     8101 caaataaaac ttgaaaatgc accttaaaaa tatatataca tataatagtt ttgaaatggg
     8161 attctgcttt attttgatgg aatggccatt aaatacacat tttgagataa tacattgttg
     8221 tggtgtttct ttatacatta tccttttagg tcgtgctagt aaaagtatat tgatgaagga
     8281 attatgatgc tttatacttc ttactgcact aaattgatag aactagtact tgtcataatc
     8341 ggttctgtct ccgctcacat gactaatacg taattgcctt tccaaaaaga tatttttgcc
     8401 tcagaactta ctgacaagct gagaggctat gaagatggaa atttgtgaaa gaagtagtgc
     8461 tcttatattt ggcctcatca tttgggccat ttcagtatag taatgatatc actaatcgga
     8521 attagcatga gagggaagta agccaggaag aataaaactg ctgaatgttt gtatgtgtaa
     8581 gatatttcca aagattctaa ataaatgtag ttgcctacag a
//
