LOCUS       NM_212555               1666 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens prostate and testis expressed 2 (PATE2), mRNA.
ACCESSION   NM_212555
VERSION     NM_212555.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1666)
  AUTHORS   Margalit,M., Yogev,L., Yavetz,H., Lehavi,O., Hauser,R., Botchan,A.,
            Barda,S., Levitin,F., Weiss,M., Pastan,I., Wreschner,D.H., Paz,G.
            and Kleiman,S.E.
  TITLE     Involvement of the prostate and testis expression (PATE)-like
            proteins in sperm-oocyte interaction
  JOURNAL   Hum Reprod 27 (5), 1238-1248 (2012)
   PUBMED   22402205
  REMARK    GeneRIF: PATE proteins are involved in sperm-oolemma fusion and
            penetration but not sperm-zona binding.
REFERENCE   2  (bases 1 to 1666)
  AUTHORS   Levitin,F., Weiss,M., Hahn,Y., Stern,O., Papke,R.L., Matusik,R.,
            Nandana,S.R., Ziv,R., Pichinuk,E., Salame,S., Bera,T., Vincent,J.,
            Lee,B., Pastan,I. and Wreschner,D.H.
  TITLE     PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR
            proteins that are expressed in reproductive and neuron-rich tissues
            and possess neuromodulatory activity
  JOURNAL   J Biol Chem 283 (24), 16928-16939 (2008)
   PUBMED   18387948
  REMARK    GeneRIF: analysis of PATE, expressed primarily in prostate and less
            in testis, and additional PATE-like genes PATE-M, PATE-DJ, and
            PATE-B
REFERENCE   3  (bases 1 to 1666)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003087.2 and AY358105.1.
            
            On May 17, 2019 this sequence version replaced NM_212555.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq
            transcript is supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358105.1, SRR5189667.407643.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000358524.8/ ENSP00000351325.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AP003087.2         38487-38495         c
            10-552              AY358105.1         1-543
            553-1666            AP003087.2         35780-36893         c
FEATURES             Location/Qualifiers
     source          1..1666
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1666
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /note="prostate and testis expressed 2"
                     /db_xref="GeneID:399967"
                     /db_xref="HGNC:HGNC:32249"
     exon            1..107
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..397
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /note="prostate and testis expression M; prostate and
                     testis expressed protein 2; LVLF3112; PATE-like protein M"
                     /codon_start=1
                     /product="prostate and testis expressed protein 2
                     precursor"
                     /protein_id="NP_997720.1"
                     /db_xref="CCDS:CCDS8465.1"
                     /db_xref="GeneID:399967"
                     /db_xref="HGNC:HGNC:32249"
                     /translation="MLVLFLLGTVFLLCPYWGELHDPIKATEIMCYECKKYHLGLCYG
                     VMTSCSLKHKQSCAVENFYILTRKGQSMYHYSKLSCMTSCEDINFLGFTKRVELICCD
                     HSNYCNLPEGV"
     exon            108..131
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /inference="alignment:Splign:2.1.0"
     exon            132..260
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /inference="alignment:Splign:2.1.0"
     exon            261..1666
                     /gene="PATE2"
                     /gene_synonym="C11orf38; PATE-M; UNQ3112"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acaagagaac aacttgctcc ttccacagga agctgcacct gacagaagct ccaggatgct
       61 tgttctcttt ctcctgggca cagtctttct gctctgccca tattggggtg aacttcatga
      121 ccctataaaa gcgactgaaa taatgtgtta tgaatgtaaa aaatatcatc ttgggttatg
      181 ctatggtgtc atgacatcct gctccctgaa gcataaacag tcctgtgcag ttgagaactt
      241 ttacatcctt acaaggaaag ggcagagcat gtatcattat tcaaaactgt cgtgtatgac
      301 cagctgtgag gacatcaact tcctggggtt cacgaagagg gtagagctca tctgttgtga
      361 tcatagtaac tactgcaacc tccctgaggg agtttagttc tacgtctctc ctggattttg
      421 ggttcttttt caaccactac gctctttttc tcttccctga acctgaattt tgctctcctc
      481 ttctatgcat tggtagagag tgagaaagcc agctcatagt gaaaagacaa gcaggcataa
      541 ggagacgcag tgtggacagc ggagcctatt gatgatggag cactagactc actctttgca
      601 catccctgtc gctaacaggt gggaggggtt ttgctctcct tacgtgatac tgccatgaat
      661 aagctcagac ttggtcattt attatctcct gtatgaaaat gtgaacactt gggccataat
      721 aatctccaat ttgtactgag aattctgtga ctatcctcta tcctcatcta cacacacact
      781 cctctccgtt ggaattctct ttggattagc cctgacactt tctggcactg tccttttctg
      841 cccgtgggtt ctggagaggg ctaaccccag cttcccagtg tgttggcagc atgggccaag
      901 tctttctctg atagagctct tgggggaacc tcagggcaga aaaaaaaaaa ctgaacagac
      961 atagggatga gcatcaaaga aaacttcagg gggcatttca actggtaaaa actaagatct
     1021 gagaaataac ttgctgtggg tggaattggc ttgaattatc attgccctgg ctggccaggc
     1081 agccttgggc acatggttga actaggtgat tggattggga acagagtgtt tttttaagga
     1141 tggctagtca ggttcttctc atgggactga gcaaacaaaa tgctgataat gtggcaggtg
     1201 gtgtagtagt tgaagataat aggatgtaaa tagataccat gaggtagtgt tcaagtaaca
     1261 gagtgccctg tgtaagagga agttatgagt ttgcagaaag tgtgagaaag gtagcatata
     1321 tgggtaacag tggtgggaag agaagaagga agacacagaa acagatagga agagaaactg
     1381 agtagcattg atgttggagc acacctgtgg ccaaggtggc acattttcct tggatacaca
     1441 ctaaccctgg tgtttctgtc cttataaggc tgactgcacc ctagatgacg ggttgatggg
     1501 tgcagcaaac caccatggca catgtatacc tatgtaacaa acctgcatgc tgcactttct
     1561 ttcatgtatc ccagaactta aagtaaaata aaaaaataaa taaataaata aaggccagaa
     1621 aaattggcca aaaaatctga atagaaaaag atatacagat agtaaa
//
