LOCUS       NM_138294               1541 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens prostate and testis expressed 1 (PATE1), mRNA.
ACCESSION   NM_138294
VERSION     NM_138294.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1541)
  AUTHORS   Manfrevola,F., Ferraro,B., Sellitto,C., Rocco,D., Fasano,S.,
            Pierantoni,R. and Chianese,R.
  TITLE     CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic
            Semen
  JOURNAL   Cells 10 (8), 1956 (2021)
   PUBMED   34440724
  REMARK    GeneRIF: CRISP2, CATSPER1 and PATE1 Expression in Human
            Asthenozoospermic Semen.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1541)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1541)
  AUTHORS   Zhang,S., Wang,Q.M., Ding,X.P., Wang,T., Mu,X.M. and Chen,Z.Y.
  TITLE     Association of polymorphisms in PATE1 gene with idiopathic
            asthenozoospermia in Sichuan, China
  JOURNAL   J Reprod Immunol 118, 54-60 (2016)
   PUBMED   27636828
  REMARK    GeneRIF: these results show that PATE1 variant (A1423G) is probably
            one of the high risk genetic factors for idiopathic
            asthenozoospermia among males in China
REFERENCE   4  (bases 1 to 1541)
  AUTHORS   Liu,F.J., Liu,X., Han,J.L., Wang,Y.W., Jin,S.H., Liu,X.X., Liu,J.,
            Wang,W.T. and Wang,W.J.
  TITLE     Aged men share the sperm protein PATE1 defect with young
            asthenozoospermia patients
  JOURNAL   Hum Reprod 30 (4), 861-869 (2015)
   PUBMED   25637620
  REMARK    GeneRIF: PATE1 has a role in sperm-egg penetration and sperm
            motility
REFERENCE   5  (bases 1 to 1541)
  AUTHORS   Margalit,M., Yogev,L., Yavetz,H., Lehavi,O., Hauser,R., Botchan,A.,
            Barda,S., Levitin,F., Weiss,M., Pastan,I., Wreschner,D.H., Paz,G.
            and Kleiman,S.E.
  TITLE     Involvement of the prostate and testis expression (PATE)-like
            proteins in sperm-oocyte interaction
  JOURNAL   Hum Reprod 27 (5), 1238-1248 (2012)
   PUBMED   22402205
  REMARK    GeneRIF: PATE proteins are involved in sperm-oolemma fusion and
            penetration but not sperm-zona binding.
REFERENCE   6  (bases 1 to 1541)
  AUTHORS   Levitin,F., Weiss,M., Hahn,Y., Stern,O., Papke,R.L., Matusik,R.,
            Nandana,S.R., Ziv,R., Pichinuk,E., Salame,S., Bera,T., Vincent,J.,
            Lee,B., Pastan,I. and Wreschner,D.H.
  TITLE     PATE gene clusters code for multiple, secreted TFP/Ly-6/uPAR
            proteins that are expressed in reproductive and neuron-rich tissues
            and possess neuromodulatory activity
  JOURNAL   J Biol Chem 283 (24), 16928-16939 (2008)
   PUBMED   18387948
  REMARK    GeneRIF: analysis of PATE, expressed primarily in prostate and less
            in testis, and additional PATE-like genes PATE-M, PATE-DJ, and
            PATE-B
REFERENCE   7  (bases 1 to 1541)
  AUTHORS   Soler-Garcia,A.A., Maitra,R., Kumar,V., Ise,T., Nagata,S.,
            Beers,R., Bera,T.K. and Pastan,I.
  TITLE     The PATE gene is expressed in the accessory tissues of the human
            male genital tract and encodes a secreted sperm-associated protein
  JOURNAL   Reproduction 129 (4), 515-524 (2005)
   PUBMED   15798027
REFERENCE   8  (bases 1 to 1541)
  AUTHORS   Bera,T.K., Maitra,R., Iavarone,C., Salvatore,G., Kumar,V.,
            Vincent,J.J., Sathyanarayana,B.K., Duray,P., Lee,B.K. and Pastan,I.
  TITLE     PATE, a gene expressed in prostate cancer, normal prostate, and
            testis, identified by a functional genomic approach
  JOURNAL   Proc Natl Acad Sci U S A 99 (5), 3058-3063 (2002)
   PUBMED   11880645
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP003087.2, BC039863.1 and AF462605.1.
            
            On May 17, 2019 this sequence version replaced NM_138294.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF462605.1, BC039863.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465411 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305738.10/ ENSP00000307164.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AP003087.2         5946-5959
            15-507              BC039863.1         1-493
            508-1499            AF462605.1         490-1481
            1500-1522           BC039863.1         1481-1503
            1523-1541           AP003087.2         9516-9534
FEATURES             Location/Qualifiers
     source          1..1541
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1541
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /note="prostate and testis expressed 1"
                     /db_xref="GeneID:160065"
                     /db_xref="HGNC:HGNC:24664"
                     /db_xref="MIM:606861"
     exon            1..78
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..407
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /note="expressed in prostate and testis; prostate and
                     testis expressed protein 1"
                     /codon_start=1
                     /product="prostate and testis expressed protein 1
                     precursor"
                     /protein_id="NP_612151.1"
                     /db_xref="CCDS:CCDS8464.1"
                     /db_xref="GeneID:160065"
                     /db_xref="HGNC:HGNC:24664"
                     /db_xref="MIM:606861"
                     /translation="MDKSLLLELPILLCCFRALSGSLSMRNDAVNEIVAVKNNFPVIE
                     IVQCRMCHLQFPGEKCSRGRGICTATTEEACMVGRMFKRDGNPWLTFMGCLKNCADVK
                     GIRWSVYLVNFRCCRSHDLCNEDL"
     exon            79..114
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /inference="alignment:Splign:2.1.0"
     exon            115..150
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /inference="alignment:Splign:2.1.0"
     exon            151..273
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /inference="alignment:Splign:2.1.0"
     exon            274..1541
                     /gene="PATE1"
                     /gene_synonym="PATE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtagcctggc cctccctctt tccaaaatgg acaagtccct cttgctggaa ctccccatcc
       61 tgctctgctg ctttagggca ttatctggat cactttcaat gagaaatgat gcagtcaatg
      121 aaatagttgc tgtgaaaaac aattttcctg tgatagaaat tgttcagtgt aggatgtgcc
      181 acctccagtt cccaggagaa aagtgctcca gaggaagagg aatatgcaca gcaacaacag
      241 aagaggcctg catggttgga aggatgttca aaagggatgg taatccctgg ttaaccttca
      301 tgggctgcct aaagaactgt gctgatgtga aaggcataag gtggagtgtc tatttggtga
      361 acttcaggtg ctgcaggagc catgacctgt gcaatgaaga cctttagaag ttaatggttc
      421 ttctgtgact ccaatttctg ggtgaggttg ttgcctcagc ctcttcacaa tgactttcta
      481 aaaaaaatca cacacacaca cacacacact acagaagagg attgcaaaca catggctcca
      541 tcttctgcac acgaaaggaa agtccctctc cttttctaca gtctctgtca cgccccttaa
      601 aataagtaaa taaataacct tgagagaaag aacaagatca atatatcctg caggttgcta
      661 caaacccttg tgctttcact gtatagccag ttcattcaga aaaggaggaa agggtagttt
      721 aatttcaaaa aagaatccct tcctctttcc tctgctgctt tccttccttc tgtggcaggg
      781 tattttaata tatttttcaa atttttttcc tttctgtgtt atccttctta tcccactcca
      841 aagaaagcac ataactgtgg cctgaaggga tggggagtag caacataaaa agaagtggct
      901 caagtcttct tggagtttgt tcatgaatgc tgatcccagg gtgaggagaa gattgggaca
      961 tagaaaggaa actgcatcag aaacatgaac agagaaagat tgtctgcctt ctagaatcag
     1021 atctgtttgg ggctgggggt tggagaataa aagcaggaga agtctatggg attctagaaa
     1081 tagtacctgc atccagcttc cctgccaaac tcacaaggag acatcaacct ctagacaggg
     1141 aacagcttca ggatacttcc aggagacaga gccaccagca gcaaaacaaa tattcccatg
     1201 cctggagcat ggcatagagg aagctgagaa atgtggggtc tgaggaagcc atttgagtct
     1261 ggccactaga catctcatca gccacttgtg tgaagagatg ccccatgacc ccagatgcct
     1321 ctcccaccct tacctccatc tcacacactt gagcttgcca ctctgtataa ttctaacatc
     1381 ctggagaaaa atggcagttt gaccgaacct gttcacaagg gtagaggctg atttctaacg
     1441 aaacttgtag aatgaagcct ggaaagagtg atgaattata ttatattata taaaaataat
     1501 aataaaaata taaagaaagc tacctttctt ctatacccaa a
//
