LOCUS       NM_173493               3110 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens PAS domain containing repressor 1 (PASD1), mRNA.
ACCESSION   NM_173493
VERSION     NM_173493.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3110)
  AUTHORS   Soh,J.E., Abu,N., Sagap,I., Mazlan,L., Yahaya,A., Mustangin,M.,
            Khoo,T.S., Saidin,S., Ishak,M., Ab Mutalib,N.S. and Jamal,R.
  TITLE     Validation of immunogenic PASD1 peptides against HLA-A*24:02
            colorectal cancer
  JOURNAL   Immunotherapy 11 (14), 1205-1219 (2019)
   PUBMED   31478431
  REMARK    GeneRIF: Gene and protein expressions of PASD1 were detected in 20%
            and 17.3% of colorectal cancer samples, respectively. PASD1(4)
            peptide was shown to be immunogenic in colorectal cancer samples.
REFERENCE   2  (bases 1 to 3110)
  AUTHORS   Li,R., Guo,M. and Song,L.
  TITLE     PAS Domain Containing Repressor 1 (PASD1) Promotes Glioma Cell
            Proliferation Through Inhibiting Apoptosis In Vitro
  JOURNAL   Med Sci Monit 25, 6955-6964 (2019)
   PUBMED   31558691
  REMARK    GeneRIF: Findings suggested that PASD1 expression in glioma
            patients was extremely upregulated compared with that in normal
            tissue samples and cell lines.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3110)
  AUTHORS   Xu,Z.S., Zhang,H.X., Zhang,Y.L., Liu,T.T., Ran,Y., Chen,L.T.,
            Wang,Y.Y. and Shu,H.B.
  TITLE     PASD1 promotes STAT3 activity and tumor growth by inhibiting
            TC45-mediated dephosphorylation of STAT3 in the nucleus
  JOURNAL   J Mol Cell Biol 8 (3), 221-231 (2016)
   PUBMED   26892021
  REMARK    GeneRIF: PASD1 serves as a critical nuclear positive regulator of
            STAT3-mediated gene expression and tumorigenesis.
REFERENCE   4  (bases 1 to 3110)
  AUTHORS   Michael,A.K., Harvey,S.L., Sammons,P.J., Anderson,A.P.,
            Kopalle,H.M., Banham,A.H. and Partch,C.L.
  TITLE     Cancer/Testis Antigen PASD1 Silences the Circadian Clock
  JOURNAL   Mol Cell 58 (5), 743-754 (2015)
   PUBMED   25936801
  REMARK    GeneRIF: PASD1 is a circadian bHLH-PAS paralog repressor of CLOCK
            protein expression.
REFERENCE   5  (bases 1 to 3110)
  AUTHORS   Joseph-Pietras,D., Gao,Y., Zojer,N., Ait-Tahar,K., Banham,A.H.,
            Pulford,K., Rice,J., Savelyeva,N. and Sahota,S.S.
  TITLE     DNA vaccines to target the cancer testis antigen PASD1 in human
            multiple myeloma
  JOURNAL   Leukemia 24 (11), 1951-1959 (2010)
   PUBMED   20861911
  REMARK    GeneRIF: PASD1-derived epitopes are both efficiently and
            selectively processed and presented by native human multiple
            myeloma cells as cancer vaccines.
REFERENCE   6  (bases 1 to 3110)
  AUTHORS   Sahota,S.S., Goonewardena,C.M., Cooper,C.D., Liggins,A.P.,
            Ait-Tahar,K., Zojer,N., Stevenson,F.K., Banham,A.H. and Pulford,K.
  TITLE     PASD1 is a potential multiple myeloma-associated antigen
  JOURNAL   Blood 108 (12), 3953-3955 (2006)
   PUBMED   17114574
REFERENCE   7  (bases 1 to 3110)
  AUTHORS   Cooper,C.D., Liggins,A.P., Ait-Tahar,K., Roncador,G., Banham,A.H.
            and Pulford,K.
  TITLE     PASD1, a DLBCL-associated cancer testis antigen and candidate for
            lymphoma immunotherapy
  JOURNAL   Leukemia 20 (12), 2172-2174 (2006)
   PUBMED   17024112
REFERENCE   8  (bases 1 to 3110)
  AUTHORS   Guinn,B.A., Bland,E.A., Lodi,U., Liggins,A.P., Tobal,K.,
            Petters,S., Wells,J.W., Banham,A.H. and Mufti,G.J.
  TITLE     Humoral detection of leukaemia-associated antigens in presentation
            acute myeloid leukaemia
  JOURNAL   Biochem Biophys Res Commun 335 (4), 1293-1304 (2005)
   PUBMED   16112646
REFERENCE   9  (bases 1 to 3110)
  AUTHORS   Liggins,A.P., Brown,P.J., Asker,K., Pulford,K. and Banham,A.H.
  TITLE     A novel diffuse large B-cell lymphoma-associated cancer testis
            antigen encoding a PAS domain protein
  JOURNAL   Br J Cancer 91 (1), 141-149 (2004)
   PUBMED   15162151
REFERENCE   10 (bases 1 to 3110)
  AUTHORS   Liggins,A.P., Guinn,B.A., Hatton,C.S., Pulford,K. and Banham,A.H.
  TITLE     Serologic detection of diffuse large B-cell lymphoma-associated
            antigens
  JOURNAL   Int J Cancer 110 (4), 563-569 (2004)
   PUBMED   15122589
  REMARK    Erratum:[Int J Cancer. 2004 Jul 20;110(6):934]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK097552.1, BC040301.1,
            DB523527.1 and AF274854.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_173493.2.
            
            Summary: This gene encodes a protein that is thought to function as
            a transcription factor. The protein is a cancer-associated antigen
            that can stimulate autologous T-cell responses, and it is therefore
            considered to be a potential immunotherapeutic target for the
            treatment of various hematopoietic malignancies, including diffuse
            large B-cell lymphoma. [provided by RefSeq, May 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097552.1, BC040301.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370357.5/ ENSP00000359382.4
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-510               AK097552.1         54-563
            511-2879            BC040301.1         462-2830
            2880-3077           AK097552.1         2933-3130
            3078-3108           DB523527.1         405-435
            3109-3110           AF274854.4         102275-102276
FEATURES             Location/Qualifiers
     source          1..3110
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..3110
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /note="PAS domain containing repressor 1"
                     /db_xref="GeneID:139135"
                     /db_xref="HGNC:HGNC:20686"
                     /db_xref="MIM:300993"
     exon            1..165
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            166..220
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2514
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /note="cancer/testis antigen 63; PAS domain containing 1"
                     /codon_start=1
                     /product="circadian clock protein PASD1"
                     /protein_id="NP_775764.2"
                     /db_xref="CCDS:CCDS35431.1"
                     /db_xref="GeneID:139135"
                     /db_xref="HGNC:HGNC:20686"
                     /db_xref="MIM:300993"
                     /translation="MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGF
                     MITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNS
                     ETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAAC
                     VPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGH
                     TSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTM
                     PESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQ
                     AGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWLLH
                     DAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPK
                     DVKCFCGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRK
                     VQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQ
                     LQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGF
                     YQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSNSEAISSSSIPQFPITSDSTIST
                     LETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQ
                     AFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC"
     exon            221..309
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            310..399
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            400..499
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            500..610
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..738
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            739..821
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            822..909
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1033
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1263
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1422
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1629
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..2108
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2367
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..3110
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /note="hexamer: AAGAAA"
     polyA_site      2886
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
     regulatory      3087..3092
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /note="hexamer: AATAAA"
     polyA_site      3110
                     /gene="PASD1"
                     /gene_synonym="CT63; CT64; OXTES1"
                     /note="major polyA site"
ORIGIN      
        1 gcactctggg gcccacgcac ttccctgaag agtctagaag ctgctcctca tttccagact
       61 ttccgggcgc ccaccaggct cccgggctct caccggagac cacagggagg agcttcaagg
      121 taccccaagt ccctgcggcc tccagcagtg aagagttcca caagggagtc ttcctacgtc
      181 actgaataat gaatgaagat gagaggggaa aagagaagag acaaagtcaa tccaaaaagc
      241 tctcaaagga aattaaactg gattccatca tttcctacct atgattactt caaccaagtg
      301 acgctacagt tattagatgg ctttatgatt acactgagca cagatggagt gatcatttgt
      361 gtggctgaaa acatctcttc tcttcttgga catttaccag ctgagattgt gggcaaaaaa
      421 ttattaagcc ttctgcctga tgaagagaaa gatgaagtct accaaaagat tattctcaaa
      481 tttcctttac taaactcaga aacacatatt gaattttgct gtcatttaaa aagaggaaat
      541 gtcgaacatg gtgatagttc tgcttacgaa aacgtgaaat ttattgtgaa tgtaagagat
      601 atttgtaatg agtttcctgt ggtctttagt ggcttgtttt ccagccacct ctgtgctgac
      661 tttgctgcat gtgttcctca ggaggatcgg ctttatcttg tgggaaatgt ttgcattctc
      721 aggactcagc tcctgcagca actttacact tcaaaggcag tcagtgatga agctgtactt
      781 acacaagatt cagatgagga accttttgtg ggagagctca gtagctctca aggtcaaaga
      841 ggacacacta gcatgaaagc cgtgtacgtt gaacccgctg ctgctgctgc tgctgctgct
      901 atctcagacg accaaattga tattgcagag gttgagcagt atggaccaca agaaaacgtt
      961 cacatgtttg tagattctga ttcaacttat tgctccagta cagttttcct ggatactatg
     1021 cctgaatctc cagccttatc cttgcaagac tttcgaggtg agcctgaggt gaatccattg
     1081 tacagggcag acccagtgga cctggagttc tcggtggatc aggtggactc agtggaccag
     1141 gagggcccaa tggaccagca ggacccagag aacccagttg ccccgttgga ccaggcaggc
     1201 ctgatggatc cagtggatcc agaggactca gtggacctgg gggctgctgg cgcaagtgct
     1261 cagccattac agccatcatc accagttgca tatgacatca ttagccagga actggaactg
     1321 atgaagaagt tgaaggagca gctagaagag aggacttggt tgctgcatga tgccatccaa
     1381 aaccagcaga atgcattgga attgatgatg gatcaccttc agaagcagcc aaacacatta
     1441 cgccacgttg tcattcctga tctccaatct tcggaggcag tgcccaagaa acaacagaaa
     1501 caacacgctg ggcaagtgaa gcggcctctc ccacatccca aggacgtcaa gtgtttctgt
     1561 ggtttatctt tatccaactc tctcaaaaac actggggagc ttcaggagcc ttgtgttgcc
     1621 ttcaaccagc agcaactggt gcagcaagaa caacacctga aggagcagca gcggcagctg
     1681 cgggagcagc tgcaacagct gagagagcaa aggaaggtgc agaagcagaa gaagatgcag
     1741 gagaagaaga agctgcagga gcagaaaatg caggagaaga agaagctgca ggagcagagg
     1801 cggcaaaaga agaagaagct acaggagcgg aagaagtggc aggggcagat gctacagaaa
     1861 gagccagagg aggagcagca gaagcagcag ctgcaagagc agccactgaa gcataatgtc
     1921 atcgtgggga atgagagggt gcagatatgc ctgcaaaacc cacgtgacgt atctgtgccc
     1981 ctctgcaatc accctgttag atttttacag gcccaaccca ttgttcctgt ccagagagca
     2041 gctgaacaac agccctctgg cttctatcaa gatgaaaact gtgggcaaca ggaagatgag
     2101 agtcaaagtt tttatcctga ggcgtatcaa gggccccccg tgaaccagct gccattgata
     2161 gatacctcaa actctgaggc aatttcttct tccagcattc ctcagtttcc cataacttca
     2221 gactcaacca taagcaccct ggagacccca caggattaca tccggctttg gcaagagttg
     2281 tctgattcac tcggtcctgt tgtccaagtg aacacttggt cttgcgatga gcagggcacc
     2341 ctgcacggcc aacccaccta ccatcaggtg caagtttctg aggtaggagt cgagggacct
     2401 cctgatccac aggctttcca aggccctgct gcataccagc cagaccagat gagatctgcg
     2461 gagcagacca gattgatgcc tgcagagcaa cgtgactcaa ataagccgtg ctaacagtac
     2521 tttcatgacc agtgatgagg ggaaatgggg ggagggggca ggccaatgag gtctgcatgg
     2581 ccaggggacc ttcaaggtgc gtaaagtccc ttggggtagg gtttagtggg tagagactta
     2641 tttgtttcct gataggttat gtttgtaatt gtttgttaag cacagcctgt ttcttggaag
     2701 ttatgctgta gaggcagcct gtgatccgta gtatgctagg gtgtgacagc agccagccac
     2761 agctggatct gatgtcttgt ctgccccgcc cagctttgca tatccatgtt ctaccacagg
     2821 aaggtggcct gccaagagtc tgctcaaagt tttcaacata aagaataaag aaaaaaaaat
     2881 gccaaagtgc ttttcaatct agtaaatcta gagggttgtt ttgtcttagc cacaagaatt
     2941 ccgaggtctt gaccctgatg atcaacctgc ctcccctcca tagtcttgtt ggagaagccc
     3001 agagagaatg ggactccaac taagggaacc tgaaatcaac tcaatggagg cacttcagag
     3061 ctaaaataat tatggcttcc ttgcttaata aacattttcg ttcactgcaa
//
