LOCUS       NM_022141               3488 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens parvin gamma (PARVG), transcript variant 1, mRNA.
ACCESSION   NM_022141
VERSION     NM_022141.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3488)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 3488)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3488)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 3488)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3488)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3488)
  AUTHORS   Yoshimi,R., Yamaji,S., Suzuki,A., Mishima,W., Okamura,M., Obana,T.,
            Matsuda,C., Miwa,Y., Ohno,S. and Ishigatsubo,Y.
  TITLE     The gamma-parvin-integrin-linked kinase complex is critically
            involved in leukocyte-substrate interaction
  JOURNAL   J Immunol 176 (6), 3611-3624 (2006)
   PUBMED   16517730
  REMARK    GeneRIF: integrin-linked kinase-gamma-parvin complex is critically
            involved in the initial integrin signaling for leukocyte migration
REFERENCE   7  (bases 1 to 3488)
  AUTHORS   Alonso,M.E., Bello,M.J., de Campos,J.M., Isla,A., Vaquero,J.,
            Gutierrez,M., Sarasa,J.L. and Rey,J.A.
  TITLE     No evidence of INI1hSNF5 (SMARCB1) and PARVG point mutations in
            oligodendroglial neoplasms
  JOURNAL   Cancer Genet Cytogenet 160 (2), 169-173 (2005)
   PUBMED   15993274
  REMARK    GeneRIF: INI1hSNF5 and PARVG do not seem to be the tumor suppressor
            genes involved in oligodendroglioma development and progression
REFERENCE   8  (bases 1 to 3488)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   9  (bases 1 to 3488)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
  REMARK    GeneRIF: Mammalian parvins are likely to have arisen late in
            evolution from gene duplication as they share a remarkably similar
            exon/intron organization.
REFERENCE   10 (bases 1 to 3488)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA673498.1, BC034406.1, AL031595.4 and AI075834.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022141.6.
            
            Summary: Members of the parvin family, including PARVG, are
            actin-binding proteins associated with focal contacts.[supplied by
            OMIM, Aug 2004].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034406.1, SRR1163657.520574.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444313.8/ ENSP00000391583.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                DA673498.1         39-82
            45-1367             BC034406.1         1-1323
            1368-3067           AL031595.4         61044-62743
            3068-3488           AI075834.1         13-433              c
FEATURES             Location/Qualifiers
     source          1..3488
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..3488
                     /gene="PARVG"
                     /note="parvin gamma"
                     /db_xref="GeneID:64098"
                     /db_xref="HGNC:HGNC:14654"
                     /db_xref="MIM:608122"
     exon            1..261
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            262..437
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            438..528
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     CDS             450..1445
                     /gene="PARVG"
                     /codon_start=1
                     /product="gamma-parvin"
                     /protein_id="NP_071424.1"
                     /db_xref="CCDS:CCDS14057.1"
                     /db_xref="GeneID:64098"
                     /db_xref="HGNC:HGNC:14654"
                     /db_xref="MIM:608122"
                     /translation="MEPEFLYDLLQLPKGVEPPAEEELSKGGKKKYLPPTSRKDPKFE
                     ELQKVLMEWINATLLPEHIVVRSLEEDMFDGLILHHLFQRLAALKLEAEDIALTATSQ
                     KHKLTVVLEAVNRSLQLEEWQAKWSVESIFNKDLLSTLHLLVALAKRFQPDLSLPTNV
                     QVEVITIESTKSGLKSEKLVEQLTEYSTDKDEPPKDVFDELFKLAPEKVNAVKEAIVN
                     FVNQKLDRLGLSVQNLDTQFADGVILLLLIGQLEGFFLHLKEFYLTPNSPAEMLHNVT
                     LALELLKDEGLLSCPVSPEDIVNKDAKSTLRVLYGLFCKHTQKAHRDRTPHGAPN"
     exon            529..593
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            594..696
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            697..837
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            838..953
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1009
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1032
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1091
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1160
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1262
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1335
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..3488
                     /gene="PARVG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1652..1657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVG"
                     /note="hexamer: AATAAA"
     polyA_site      1674
                     /gene="PARVG"
                     /note="major polyA site"
     regulatory      3210..3215
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVG"
                     /note="hexamer: ATTAAA"
     polyA_site      3234
                     /gene="PARVG"
                     /note="major polyA site"
     regulatory      3468..3473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVG"
                     /note="hexamer: TATAAA"
     polyA_site      3488
                     /gene="PARVG"
ORIGIN      
        1 agcttgagag accagctcgg gtctgaagtg tttctctatc tactgtgctg agatctctcc
       61 ttctcgaacc ctgctatgcc tttgcatacg ctgttttctc cacctgccac gttctcaccc
      121 cttcttcttc cactgcaaac tcctatgcag ccgtcaaggc cccattctcc tctggaaagc
      181 cttcccgatc cccttggcaa caaccaccac caatatttat tcactgagcc cactttgtgc
      241 caagcattgt tctagacacg gagaggagga agctcctgcc ggctgagcgg gcctggagga
      301 agtgagcagc ggggctcctg cctcccggcc tggtccccga agaccccaga agaacccgga
      361 acttgcttcc attcggaatc cagggaccac cctttgcact cagtaggcct ttgttttcct
      421 gcgtggaaag cggttgggct tgggaggcga tggagccgga gttcttgtac gacctgctgc
      481 agctccccaa gggggtggag cccccagcgg aggaggagct ctcaaaagga ggaaagaaga
      541 aatacctgcc acccacttcc cggaaggacc ccaaatttga agaactgcag aaggtgttga
      601 tggagtggat caatgccact cttctccccg agcacattgt ggtccgcagc ctggaggagg
      661 acatgttcga cgggctcatc ctacaccacc tattccagag gctggcggcg ctcaagctgg
      721 aagcagagga catcgccctg acagccacaa gccagaagca caagctcaca gtggtgctgg
      781 aggccgtgaa ccggagtctg cagctggagg agtggcaggc caagtggagc gtggagagca
      841 tcttcaacaa ggacctgttg tctaccctgc acctccttgt ggccctggcc aagcgcttcc
      901 agcccgacct ctccctccca accaacgtcc aggtggaggt catcactatc gagagcacca
      961 aaagtggtct gaagtcagag aagttggtgg aacagctcac tgaatacagc acagacaagg
     1021 acgagcctcc aaaggacgtc tttgatgaat tatttaagct ggctccggag aaagtgaacg
     1081 cagtgaaaga ggccatcgtg aactttgtca accagaagct ggaccgcctg ggcctgtctg
     1141 tgcagaatct ggacacccag tttgcagatg gggtcatctt actcttgctg attggacaac
     1201 ttgaaggctt cttcctgcac ttaaaggaat tctacctcac tcccaactct cctgcagaaa
     1261 tgctgcacaa cgtcaccctg gcgctggagc tgctgaagga cgagggcctg ctcagctgcc
     1321 ctgtcagccc tgaagatatc gtgaacaagg atgccaagag cacactgagg gtgctctatg
     1381 gtctgttctg caagcacacg cagaaggcac acagggacag gacgccccat ggagccccga
     1441 attgaccctc actgcctcca aagcccagag cctgcctgtc agcccagctg gagggcccga
     1501 ggctgcaggg tgtcctccca cagtcccgct gtttcctgtg cattcgtgac ccgcttccct
     1561 cccaccctgt ctcctgtctc catcgttgga ttatctttga acccccttgt gtggatcatt
     1621 ttgagccgcc tggccttgct cagtttattt taataaaagt atttctggga gggattctgg
     1681 gaacttgaca gggtcctgag gagggccctt aaacctgcag cctccctccc atggggtgag
     1741 tgtgtgtcac atcagtctct catctctggg cccaggctag tgaccgccca gagaggtggc
     1801 atcactcagg gctggggact ctcagggaca gggcccacag ccccagaccc caccttttcc
     1861 agcccagctc cccacaccca cctgcttctc actcgggagg atgggcccca gagtcaccct
     1921 ccagggcagg agcccgaatg gctccatagc catgccccca cccaccggga gaagtggatt
     1981 cagtgactgt caaagcaacc cgggctgtgt cctgcagctg ccctcgtgag ttttgcccaa
     2041 aagtcacaaa gaagcaatct tcgtggttga ttagtgggtt caggtcatct ccagtctgtc
     2101 ctcgggagct gtgggttccc actcgctcca gtgagacttg gcattttctg cacataaaga
     2161 agagtcgtgt gggagaattg cacatagtca gtccagggca tccagagtgg ggcagagctg
     2221 atggctgatg ggaaccgggg aggaggctgg cggggagggg tgagattggt ggggagggct
     2281 ggggctggcc gggaggggtg ggactgatgg ggaggggtga ggctggcggg gaggggtgag
     2341 gctggcgggg aggggtggga ctggtgggga ggagtgaggc tagtgggcgg gtgaggctgg
     2401 cggggagggg agggtttgtg gggacgggtg aggctggcgg ggaggggtga ggctggtggg
     2461 gagggctggg gcctggtggg gaggagtggg acttgtgggg aggagtggga cttgtgggga
     2521 ggggtgaggc tggggagaag ggcaaccaca gccccaggct gctgctcctc cctggaccct
     2581 gaagaggcct ctgggtctgg ggttttcaca gtttgacagc tgaggccttg gggaggggct
     2641 ttagatgggg gttaggggct aggtcatcat tgacacccac tgggggcgcc taggcagatg
     2701 tccttcgggg gagcaagatg ggagccaggg acgcagtgcc aggtcagccc tgggagctgg
     2761 tgtctgggtg tgagaaggcc ttgaggggtc ttcccttcac ctagcctccc atctgcctgc
     2821 ccttctcagc tcccaattca cagggcaaac ccaagcccat aagcgtgttc cacgtgagca
     2881 ctcagatgca cccctcttca tggataccca ccctacttcc cggctgcctc tgggaaacgt
     2941 gcatcctccc acaccaggta cctggagccc agctccttcc acctgctcag gtgccccctc
     3001 cattgcgatg ccccctccag cacctcaaat cctctcctgg agcttctggg gacacaggct
     3061 cagcctctct cagctggctt catcccaaaa gcctgaaatc cagccccact tcctggggcc
     3121 tttgagtcct cacttgcttg ggccccatcc gctgcaggct ggctctgcct ggctgttcca
     3181 cgtcctcact cttgttctat ttgacagcaa ttaaaaaaaa agtgacttat ttaattactg
     3241 tagctttatt gaaaaataac ttcccagttt gaagtgtaca atttgatgag ttttgacaaa
     3301 tgcatgcagt catataacca ccaccatcgt tatccagaca tgggacattc ccatcaccat
     3361 gcaagtttct gcatctgtct gcagccagtt cccttctccc agcccctggc cctggggacc
     3421 actgatctgt tttctgtcac catcatttag acttgtctag aatttcttat aaactgtatc
     3481 ctatggta
//
