LOCUS       NM_013327               5394 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens parvin beta (PARVB), transcript variant 2, mRNA.
ACCESSION   NM_013327
VERSION     NM_013327.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Wu,G., Wang,K., Xue,Y., Song,G., Wang,Y., Sun,X., Zhong,L.,
            Zhou,C., Shen,B., Chen,J., Yu,Y., Tang,H., Peng,Z., Sun,P. and
            Wang,X.
  TITLE     Association of rs5764455 and rs6006473 polymorphisms in PARVB with
            liver damage of nonalcoholic fatty liver disease in Han Chinese
            population
  JOURNAL   Gene 575 (2 Pt 1), 270-275 (2016)
   PUBMED   26343796
  REMARK    GeneRIF: study found polymorphisms of rs5764455 and rs6006473 in
            PARVB gene in the Han Chinese population, and these polymorphisms
            were associated with the occurrence and progression of NAFLD.
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Kim,H.W., Lim,E.J., Jang,H.H., Cui,X., Kang,D.R., Lee,S.H.,
            Kim,H.R., Choe,J.S., Yang,Y.M., Kim,J.B. and Park,J.H.
  TITLE     24-Methylenecycloartanyl ferulate, a major compound of
            gamma-oryzanol, promotes parvin-beta expression through an
            interaction with peroxisome proliferator-activated receptor-gamma 2
            in human breast cancer cells
  JOURNAL   Biochem Biophys Res Commun 468 (4), 574-579 (2015)
   PUBMED   26549231
  REMARK    GeneRIF: Taken together, our results indicate that 24-MCF treatment
            increases parvin-beta expression, which may inhibit ILK downstream
            signaling.
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   4  (bases 1 to 5394)
  AUTHORS   Sepulveda,J.L. and Wu,C.
  TITLE     The parvins
  JOURNAL   Cell Mol Life Sci 63 (1), 25-35 (2006)
   PUBMED   16314921
  REMARK    Review article
REFERENCE   5  (bases 1 to 5394)
  AUTHORS   Mongroo,P.S., Johnstone,C.N., Naruszewicz,I., Leung-Hagesteijn,C.,
            Sung,R.K., Carnio,L., Rustgi,A.K. and Hannigan,G.E.
  TITLE     Beta-parvin inhibits integrin-linked kinase signaling and is
            downregulated in breast cancer
  JOURNAL   Oncogene 23 (55), 8959-8970 (2004)
   PUBMED   15467740
  REMARK    GeneRIF: loss of ParvB expression is a novel mechanism for
            upregulating ILK activity in tumors
REFERENCE   6  (bases 1 to 5394)
  AUTHORS   Rosenberger,G., Jantke,I., Gal,A. and Kutsche,K.
  TITLE     Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests
            an involvement of alphaPIX in integrin-mediated signaling
  JOURNAL   Hum Mol Genet 12 (2), 155-167 (2003)
   PUBMED   12499396
REFERENCE   7  (bases 1 to 5394)
  AUTHORS   Yamaji,S., Suzuki,A., Kanamori,H., Mishima,W., Takabayashi,M.,
            Fujimaki,K., Tomita,N., Fujisawa,S., Ohno,S. and Ishigatsubo,Y.
  TITLE     Possible role of ILK-affixin complex in integrin-cytoskeleton
            linkage during platelet aggregation
  JOURNAL   Biochem Biophys Res Commun 297 (5), 1324-1331 (2002)
   PUBMED   12372433
  REMARK    GeneRIF: the ILK-affixin complex has a role in
            integrin-cytoskeleton linkage during platelet aggregation [affixin]
REFERENCE   8  (bases 1 to 5394)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
  REMARK    GeneRIF: Mammalian parvins are likely to have arisen late in
            evolution from gene duplication as they share a remarkably similar
            exon/intron organization.
REFERENCE   9  (bases 1 to 5394)
  AUTHORS   Yamaji,S., Suzuki,A., Sugiyama,Y., Koide,Y., Yoshida,M.,
            Kanamori,H., Mohri,H., Ohno,S. and Ishigatsubo,Y.
  TITLE     A novel integrin-linked kinase-binding protein, affixin, is
            involved in the early stage of cell-substrate interaction
  JOURNAL   J Cell Biol 153 (6), 1251-1264 (2001)
   PUBMED   11402068
REFERENCE   10 (bases 1 to 5394)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP339885.1, AF237769.1,
            CA308417.1 and AL031595.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_013327.4.
            
            Summary: This gene encodes a member of the parvin family of
            actin-binding proteins, which play a role in cytoskeleton
            organization and cell adhesion. These proteins are associated with
            focal contacts and contain calponin homology domains that bind to
            actin filaments. This family member binds to alphaPIX and
            alpha-actinin, and it can inhibit the activity of integrin-linked
            kinase. This protein also functions in tumor suppression.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (2, also known as ParvB2) differs
            in the 5' UTR and 5' coding region, and uses an alternate start
            codon, compared to variant 1. The resulting isoform (b) has a
            distinct and shorter N-terminus, compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.18880.1, AK313957.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338758.12/ ENSP00000342492.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BP339885.1         27-55
            30-1681             AF237769.1         1-1652
            1682-1688           CA308417.1         13-19               c
            1689-5394           AL031595.4         23929-27634
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.31"
     gene            1..5394
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="parvin beta"
                     /db_xref="GeneID:29780"
                     /db_xref="HGNC:HGNC:14653"
                     /db_xref="MIM:608121"
     exon            1..150
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1133
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="isoform b is encoded by transcript variant 2;
                     affixin"
                     /codon_start=1
                     /product="beta-parvin isoform b"
                     /protein_id="NP_037459.2"
                     /db_xref="CCDS:CCDS14056.1"
                     /db_xref="GeneID:29780"
                     /db_xref="HGNC:HGNC:14653"
                     /db_xref="MIM:608121"
                     /translation="MSSAPRSPTPRPRRMKKDESFLGKLGGTLARKRRAREVSDLQEE
                     GKNAINSPMSPALVDVHPEDTQLEENEERTMIDPTSKEDPKFKELVKVLLDWINDVLV
                     EERIIVKQLEEDLYDGQVLQKLLEKLAGCKLNVAEVTQSEIGQKQKLQTVLEAVHDLL
                     RPRGWALRWSVDSIHGKNLVAILHLLVSLAMHFRAPIRLPEHVTVQVVVVRKREGLLH
                     SSHISEELTTTTEMMMGRFERDAFDTLFDHAPDKLSVVKKSLITFVNKHLNKLNLEVT
                     ELETQFADGVYLVLLMGLLEDYFVPLHHFYLTPESFDQKVHNVSFAFELMLDGGLKKP
                     KARPEDVVNLDLKSTLRVLYNLFTKYKNVE"
     exon            151..240
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            241..311
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            312..414
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            415..555
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            556..671
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            672..730
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            731..750
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            751..812
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            813..881
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            882..983
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1056
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..5394
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1379
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="major polyA site"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="hexamer: AATAAA"
     polyA_site      1681
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="major polyA site"
     regulatory      5376..5381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
                     /note="hexamer: AATAAA"
     polyA_site      5394
                     /gene="PARVB"
                     /gene_synonym="CGI-56"
ORIGIN      
        1 acacgcgctg cgcccgccgc cggccccacg cgcggcccat gtcctccgcg ccgcgctcgc
       61 ccaccccgcg gccccgcagg atgaagaagg acgagtcgtt cctgggcaag ctgggcggca
      121 ccctggccag gaagcggagg gcgcgcgagg tgagtgacct gcaggaagaa ggcaagaatg
      181 ccatcaactc accgatgtcc cccgccctgg tggatgttca ccctgaagac acccagcttg
      241 aggagaacga ggagcgcacg atgattgacc ccacttccaa ggaagacccc aagttcaagg
      301 aactggtcaa ggtcctcctc gactggatta atgacgtgct ggtggaggag aggatcattg
      361 tgaagcagct ggaggaagac ctgtatgacg gccaggtgct gcagaagctc ttggaaaaac
      421 tggcagggtg caagctgaat gtggctgagg tgacacagtc cgaaataggg cagaaacaga
      481 agctgcagac ggtgctggaa gcagtacatg acctgctgcg gccccgaggc tgggcgctcc
      541 ggtggagcgt ggactcaatt cacgggaaga acctggtggc catcctccac ctgctggtct
      601 ctctggccat gcacttcagg gcccccatcc gccttcctga gcatgtaacg gtgcaggtgg
      661 tggtcgtgcg gaaacgggaa ggcctgctgc attccagcca catctcggag gagctgacca
      721 caactacaga gatgatgatg ggccggttcg agcgggatgc cttcgacacg ctgttcgacc
      781 acgccccgga taagctcagc gtggtgaaga agtctctcat cacttttgtg aacaagcacc
      841 tgaacaagct gaatttggag gtgacggaac tggagaccca gtttgcagat ggcgtgtacc
      901 tggttctgct catgggcctt ctggaagact actttgttcc tctccaccac ttctacctga
      961 ctccggaaag cttcgatcag aaggtccaca atgtgtcctt cgcctttgag ctgatgctgg
     1021 acggaggcct caagaaaccc aaggctcgtc ctgaagacgt ggttaacttg gacctcaaat
     1081 ccaccctgag ggttctttac aacctgttca ccaagtacaa gaacgtggag tgacggggga
     1141 gctgtggatg gtggcaggag tgtcccagca agaaaggcgg catccgtctg tgccctgtgc
     1201 ctttccaggg agccaggcgc catgggcttc tggtccaagc tgtgttgact gtcatcccca
     1261 ccccacccct acctcacgcc tgccccaccc cctgcctctt ttggttgttg ttcttaatct
     1321 cctctccatg tagttcccag tgggcaagag cctttgaaaa tgcaggattc taaacactcg
     1381 tgcttgcgtt tgaagcctcg cgtcactcag tcgcgtggga tgatgagtcc gttgttgtct
     1441 gccttggccg aaagatgaaa aaaagcctga accccaaccc ccagctggtt gagagcaccc
     1501 tgcattctgc ctcatggtgc agttagcgat cacaggcctt cagaagtaca acatcagctc
     1561 agcaggaacg ccggctcccc gaggacccag gcttgacgat tcaccgggga tctcctgggc
     1621 tgggctctcc ttggaagtga ggccttttat taaaaataaa agggttttgc agtttgaaaa
     1681 actttaaagt cccagaagct tagatgtgac atgggtgtcc tccacccaca ttcctatcac
     1741 ttcttggtca ctcgttttaa tgtaggtttt gcacaaacat ccaagactca ggatggccca
     1801 gctcccacag tccttgaaag gagctgtctg ctggggacgt ttcttaattt cttgctgtgg
     1861 ttgaggggct gggtctggag atggctctaa ttgtgctgct tgagacagct tgggtcacag
     1921 ctttcccctt cagaggccct ttttgggaat gaatgcatct ttggaaactt taaaatgagg
     1981 ggggtgcatt ggttcactgg cactgtgtag taaagtgcca caggggagtg gctcagacat
     2041 cagagaatta catcctcagg cctttcgcct tggcttgtag atgccggctt ctccccgtgt
     2101 cttcacatgg tctcccctct gtgtgtctgt gtcctcaccg cctcttttat tttatttttt
     2161 atttttgttt ttattttttg agacagagtc tcgctctgtc accaggctgg agtgcagtgg
     2221 tgtgatctca gctcactgca acctctgcct cccaggttca agcgattctc ctgcctcagc
     2281 ctcccaagta gctggcatta caggcaggtg ccaccacacc tggctaattt ttgtattttt
     2341 agtagagacg gggtttcacc atgttggcca ggatggtctt gatctcctga cctcatgatc
     2401 tgcctgcctc agcctcccaa agtgttggga ttacaggcgt gagccactgt gcccagccta
     2461 tttttttttt tttttttgag acaagttctc actgtgtcac ccaggagtaa agtggtgcca
     2521 tctcagctca ctgcagcctt gatctcccag gctcaattga tcctcccacc tcagcctccc
     2581 aagtagcggg gaccacaagt gcacaccact aggcccatct aatttttgta ttttttgtag
     2641 agatggggtt tcaccatgtt gcccaggctg ttctcaaacc cctgggcttg agcgacccac
     2701 ccacctcagc ctcccaaagt gctgggatta taggcatgag cggacatgcc cagcctgcac
     2761 ccctcttttt agaagggctg cggtcctatt ggattagggc ccacttatat gacctcattt
     2821 aatcttgatt acctccataa agaccctgtc tccaaatacc atcacatcag aggtgctggg
     2881 gttaggactt cagcatgtgg atttgtgggg ggcataattt gccttgtacc gggaggatat
     2941 gaagtgttca tgttactctc cctgtagccc tgagagcatc tcccttagag tatcctataa
     3001 aaggagtcgc tgctcactca gttatgggtt gttcaccccc tcgctcaccc cagctctgca
     3061 gagaactggg gatcccatcg gccatgcttt ctgggctggc ctctggtcgc agtcagtccc
     3121 tcgctgtggc gcccccccct cccccagctc cttcccaggg tgatgacccg ctgaccccct
     3181 ggggtgcacc tgctgcaaag cagccccctt ccttggcatc tctcagcatt ctccgtagtg
     3241 agcctggcct ttctgatctt gttagctttt tgtcttcctg ccgcagatca gagctttgga
     3301 gtaagttttg atatgaaatc gaatgccaac accgaagttt tagaaaacag tttaatattc
     3361 cctctcagtt ccggctgttg ctaggctggg gatgggttca gaatagccat tttgatggag
     3421 gtgatttccc agcaggggaa agaaataatt aaaacagcat tacggtgtct cttgcgggat
     3481 gcagtgacat tcaaaagcca cactgacaaa aagcctgggg ctggaacgtt ctgtgctgcc
     3541 tgcatggcat gtacaggacc gcggccccct ggagctggtg gagtggccca gccttgccct
     3601 gctcacaggt ggacctggag agggcactgt gccttcccag ggattgggat ttgaaaagaa
     3661 cagagcttgg ccaggtgcgg tggctcacgc ctgtaatccc agcactttgg gaggctgagg
     3721 caggtggatc acttggggtc agaagttcga gaccagcctg gccaacatgg tgaaacccca
     3781 tgtctactaa aaatacaaaa attagccatg catggtatgt atgcctgtaa tcccagctat
     3841 tcgggaggct gaggcaggag aattgcatga acccaggagg tggaagttgc agtgagctga
     3901 gatcatgcca ctgcactcca gcctgagcaa cagagtgaga ctctgtctca aaaaaaaaaa
     3961 agaaagaaaa aagaaaaaga aaagaacaga gctgtgattt tcagccaaaa tgagcagccc
     4021 tggcccattc tgtgtcatca gaggggagag gacggttact gtgggagggg gcttcagctt
     4081 ctcagggagg tcctggcggc ccccatctag taaaccagta aacccatgcc tatcctcatg
     4141 cccacgtcac actcttgtgg gtttcaagtc gaacagtaaa aggaatcata agatctgtgg
     4201 ggaagctaca tgggcacttg tgtttcacaa cagggaccct taaaggcgat gtttccagca
     4261 aaggatgtga tttttttttt tttttttttt gagataagtt ctcactgcgt tgcccaggct
     4321 ggagtgcagt ggtcattcac agacacacac atagcagact acagactaca gccttgaact
     4381 cctgggctca agtgatccac ccacttctgt atcctgagtc cctggaacgg caggtgcaca
     4441 ccaccgcacc cggcttggat gtgatctttt gtccacattc ttttccaatt ggttcaaagg
     4501 tgtaggtgtg ccttttgcat acctgggaag ggccccatta ggctcgactc ctcatttttc
     4561 tccattcacc atcagtttga gtctgaattc atagcatggc ctggacagat gcagcaaggg
     4621 gccagttcca aggcagaatt cagggtgaac tcgattccta taggcttggg atgaatggct
     4681 gctgggacat gaggcttggg tgtgagatgc cccgtctgct gctgctcttg gttcttagtt
     4741 cagagaaatt ctgggaccct tcctcctccc ggcaccacgt tttcagtgaa tggttctttg
     4801 aagaggaacc ctggtccata ggaactgagt gaaagcaagg ccaagtatgt ccacccatgg
     4861 ggacaaacgt cccagcacaa aggggtctca ggcctgcaag gcccaagtgg acgctcggac
     4921 aagggcagga aggtatttgc tgattctcct tctccatgtg acgtgtctct caacccacac
     4981 cagctagggg agcctcccgc agcttcagtt cccctttgac gcccacacag tgttatgcaa
     5041 gcaccgagcc cagagtcccg ctgggccgtg gtgtcctaat tgtcttggtg acaaagagca
     5101 attttatttt aaagcaactg aatcctttcc ccctgttttg tgtgccagta ttttactgtc
     5161 ttcttaattg ttttaagcaa tgtttacttt ggatttctgg atgttatata aaagccacga
     5221 aaaccctggc catgctgttt gtcaggccca cctggctgag tgcaggaagc aagcgctttt
     5281 caggagctca ctgcaacacc gggcaaacac ttcttccgcc agggatgcgg ttaggacaat
     5341 gccacgtggc gtcacagtat gctgttattt attccaataa agacctcgtg agca
//
