LOCUS       NM_018222               8627 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens parvin alpha (PARVA), mRNA.
ACCESSION   NM_018222
VERSION     NM_018222.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8627)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8627)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 8627)
  AUTHORS   Yang,H., Lin,L., Sun,K., Zhang,T., Chen,W., Li,L., Xie,Y., Wu,C.,
            Wei,Z. and Yu,C.
  TITLE     Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism
            of the ILK/PINCH/Parvin complex for F-actin dynamics
  JOURNAL   Elife 10, e64395 (2021)
   PUBMED   33587032
  REMARK    GeneRIF: Complex structures of Rsu1 and PINCH1 reveal a regulatory
            mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8627)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 8627)
  AUTHORS   Fukuda,T., Guo,L., Shi,X. and Wu,C.
  TITLE     CH-ILKBP regulates cell survival by facilitating the membrane
            translocation of protein kinase B/Akt
  JOURNAL   J Cell Biol 160 (7), 1001-1008 (2003)
   PUBMED   12654898
REFERENCE   6  (bases 1 to 8627)
  AUTHORS   Zhang,Y., Chen,K., Tu,Y., Velyvis,A., Yang,Y., Qin,J. and Wu,C.
  TITLE     Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is
            essential for localization of each component to cell-matrix
            adhesion sites
  JOURNAL   J Cell Sci 115 (Pt 24), 4777-4786 (2002)
   PUBMED   12432066
REFERENCE   7  (bases 1 to 8627)
  AUTHORS   Nikolopoulos,S.N. and Turner,C.E.
  TITLE     Molecular dissection of actopaxin-integrin-linked kinase-Paxillin
            interactions and their role in subcellular localization
  JOURNAL   J Biol Chem 277 (2), 1568-1575 (2002)
   PUBMED   11694518
REFERENCE   8  (bases 1 to 8627)
  AUTHORS   Korenbaum,E., Olski,T.M. and Noegel,A.A.
  TITLE     Genomic organization and expression profile of the parvin family of
            focal adhesion proteins in mice and humans
  JOURNAL   Gene 279 (1), 69-79 (2001)
   PUBMED   11722847
  REMARK    GeneRIF: Mammalian parvins are likely to have arisen late in
            evolution from gene duplication as they share a remarkably similar
            exon/intron organization.
REFERENCE   9  (bases 1 to 8627)
  AUTHORS   Tu,Y., Huang,Y., Zhang,Y., Hua,Y. and Wu,C.
  TITLE     A new focal adhesion protein that interacts with integrin-linked
            kinase and regulates cell adhesion and spreading
  JOURNAL   J Cell Biol 153 (3), 585-598 (2001)
   PUBMED   11331308
REFERENCE   10 (bases 1 to 8627)
  AUTHORS   Olski,T.M., Noegel,A.A. and Korenbaum,E.
  TITLE     Parvin, a 42 kDa focal adhesion protein, related to the
            alpha-actinin superfamily
  JOURNAL   J Cell Sci 114 (Pt 3), 525-538 (2001)
   PUBMED   11171322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC344546.1, AK001655.1,
            AC009806.9 and CA444306.1.
            
            On Jan 31, 2018 this sequence version replaced NM_018222.4.
            
            Summary: This gene encodes a member of the parvin family of
            actin-binding proteins. Parvins are associated with focal contacts
            and contain calponin homology domains that bind to actin filaments.
            The encoded protein is part of the integrin-linked kinase signaling
            complex and plays a role in cell adhesion, motility and survival.
            [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.102228.1, AF237771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334956.15/ ENSP00000334008.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                DC344546.1         86-113
            29-3134             AK001655.1         1-3106
            3135-7924           AC009806.9         30994-35783         c
            7925-8627           CA444306.1         18-720              c
FEATURES             Location/Qualifiers
     source          1..8627
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.3"
     gene            1..8627
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="parvin alpha"
                     /db_xref="GeneID:55742"
                     /db_xref="HGNC:HGNC:14652"
                     /db_xref="MIM:608120"
     exon            1..213
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1196
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="actopaxin; matrix-remodeling-associated protein 2;
                     calponin-like integrin-linked kinase-binding protein"
                     /codon_start=1
                     /product="alpha-parvin"
                     /protein_id="NP_060692.3"
                     /db_xref="CCDS:CCDS44541.3"
                     /db_xref="GeneID:55742"
                     /db_xref="HGNC:HGNC:14652"
                     /db_xref="MIM:608120"
                     /translation="MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAK
                     EVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLI
                     DWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTV
                     LEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVV
                     QKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHL
                     NKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELM
                     QDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE"
     exon            214..303
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            304..374
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            375..477
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..618
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            619..734
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            735..793
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            794..813
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            814..875
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            876..944
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1046
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1119
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..8627
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1514..1519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="hexamer: AATAAA"
     polyA_site      1539
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="major polyA site"
     regulatory      4037..4042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="hexamer: ATTAAA"
     polyA_site      4069
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
     regulatory      7785..7790
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="hexamer: GATAAA"
     polyA_site      7808
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
     regulatory      8578..8583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="hexamer: ATTAAA"
     polyA_site      8600
                     /gene="PARVA"
                     /gene_synonym="CH-ILKBP; MXRA2"
                     /note="major polyA site"
ORIGIN      
        1 agtcccgccg ccgcccgctg cgtccgccca gcgccagctc cgcgtcccga ccggcccgcg
       61 gcagcctgcg ccgcgccatg gccacctccc cgcagaagtc gccttctgtc cccaagtctc
      121 ccactcccaa gtcgcccccg tcccgcaaga aagatgattc cttcttgggg aaactcggag
      181 ggaccctggc ccggaggaag aaagccaagg aggtgtccga gctgcaggag gagggaatga
      241 acgccatcaa cctgcccctc agcccaattc cctttgagct ggaccccgag gacacgatgc
      301 tggaggagaa tgaggtgcga acaatggtgg atccaaactc acgcagtgac cccaagcttc
      361 aagaactgat gaaggtatta attgactgga ttaatgatgt gttggttgga gaaagaatca
      421 ttgtgaaaga cctagctgaa gatttgtatg atggacaagt cctgcagaag cttttcgaga
      481 aactggagag tgagaagcta aatgtggctg aggtcaccca gtcagagatt gctcagaagc
      541 aaaaactgca gactgtcctg gagaagatca atgaaaccct gaaacttcct cccaggagca
      601 tcaagtggaa tgtggattct gttcatgcca agagcctggt ggccatctta cacctgctcg
      661 ttgctctgtc tcagtatttc cgcgcaccaa ttcgactccc agaccatgtt tccatccaag
      721 tggttgtggt ccagaaacga gaaggaatcc tccagtctcg gcaaatccaa gaggaaataa
      781 ctggtaacac agaggctctt tccgggaggc atgaacgtga tgcctttgac accttgttcg
      841 accatgcccc agacaagctg aatgtggtga aaaagacact catcactttc gtgaacaagc
      901 acctgaataa actgaacctg gaggtcacag aactggaaac ccagtttgca gatggggtgt
      961 acctggtgct gctcatgggg ctcctggagg gctactttgt gcccctgcac agcttcttcc
     1021 tgaccccgga cagctttgaa cagaaggtct tgaatgtctc ctttgccttt gagctcatgc
     1081 aagatggagg gttggaaaag ccaaaaccgc ggccagaaga catagtcaac tgtgacctga
     1141 aatctacact acgagtgttg tacaacctct tcaccaagta ccgtaacgtg gagtgagggg
     1201 ctgccctggg cccaccactg cccaagagtt cttgctgttg gcgtactgga ccctcctccg
     1261 aactgcctta ccctgcttat tcctgtctct tgcactgtgc tctcccacaa gtccagctgc
     1321 aacccagaga tagtggaaac tgaaattagg aaggaaatca tcaataactc agtgggctga
     1381 cccatccctc ccaggcgctg gggaccaacc tagcaatgaa ggttgggaag gttgttccct
     1441 tcccggtgcc aggtccagat ttccctccat gatttgggaa ccagcttagg caaaagagtc
     1501 cccacaagat gaaaataaag atcctagtta ccattcaaag gatgctaact gtgtgtcagg
     1561 ccccacacta agtgctctgc tctgatatac tcaaggccat taatcttcag gactcccatt
     1621 gacgtaggtg tttcattccc cttttacaga tgaggaaact aaggcttgga ggttaaatga
     1681 cttgccagaa gttggaattt ttttcctctt tgaacataac ctctcccttc tccctaaagg
     1741 taaccactat tctgagtcca atcatcaagg ttttgctttt ctttttagct aagtatgcat
     1801 tcctcaatag tagacagtac aacatgttta taacaagcca attacattat gttctttgca
     1861 tgttctaaag ttgtgtatgt gtgtgcacat ctgagcacgt gcacatgtac acctgagcca
     1921 aaaacacgag aacccactga tctcaccact ggggcaagct aggtcagagc ttagtgattc
     1981 acactgaaat tggcaaattg gatttaaccc aattaatagt gtgtgtgtgg caggagtcat
     2041 gtccctcaca tcctttgtac aaatgaaaat tactcttaat tccttcagat ttataataac
     2101 tctgtacttt ggtttcaggg tgacatttgg gaaggatttt gtttagaatt aatggagtgg
     2161 cacattttgc agcctttttg cttgattgca tgtaatggaa atgccctata ttttcctgca
     2221 aaataagtac taaattcatt atcgttaagc aaatgtacaa tatgctcagg caccgcagag
     2281 agctgggcac gggcccatgt gagcatcact ttggaagtag ggctcttcaa cagggaccct
     2341 tgaactttaa agaaaggaac ttctttttgc cttctaattg atcatttaga ctattctggc
     2401 taagtctgcc cacatgtaat taccggctaa ttcaagcgag gaaaaatgta agtcatttag
     2461 accaaagcca agcagtttct ttgcgtgggt tactcaaggg cttgtggtta cttgtatctc
     2521 ctctatgtga acttgacttt gaaagacaga gctctagtgt gccagcctgc taagtcctgt
     2581 aagaataggg aagggcggag gggggtgggc agtgactagg ggacgagaag catggggaaa
     2641 atatttgcac tctaaacata cagagataga ggtggggctt gtggtactta acacttgtag
     2701 ccatcaactg actgagacct tgggctaaat aatcaattgt gctgatatta catctcgtta
     2761 tggaatgttc ctaaatatgc caggtagaca ccagcccaag taccctcctc cagaagtctg
     2821 tgactacctt gtcactactt taggcccatt ccacaaagcc catctctggt ttgagaattc
     2881 attttgatct gtatctacac cacccaaagt taggcctcct ataatgtcca aaacattcct
     2941 ttcagccttt ttatttctta ctgtactgtc tcttactgta ctgtctatct gcagtaattg
     3001 aggacccata aaatttagat aactacatgt ctttgctctt agaattgtca ctcagcataa
     3061 tgagcattta acatacaaag gcaatgtact gttttgtgtt gatctatgta aaagaataca
     3121 attctttttt acataattag tgaaatttta ttttttatta ggaaacacta aatagtgtaa
     3181 tatttctttt gcttttaaaa aaattcctgg tagcaaatca agataaataa ttgcttcatt
     3241 ttcttgagca atactgaagc aggatgaagt aagaggaatg cattcattta aacatgcttt
     3301 gctttatgaa ttttgtctct tttttggtct ctttttctta tattcaagtt acaaatgtac
     3361 aagtatcctt actaagagtg ctccttttgt attttacata tatacagtat gaaaatacat
     3421 tggaacacta ggaaagtttt taaataacag ttctaattta tcagaaaatt gtgttttggg
     3481 attgagttct ttgtctcagc ccagaatccc aggtcctggg cctggttttc taatgctgtc
     3541 atctcagttc gatattttac tttagaacct ggaatctcct acttaatata tgaccatgac
     3601 tttgaaaggc aaaagaggaa tcaagaataa ataaaacaaa cttaatcttc atctttaaaa
     3661 aaaagaaaaa agaaaccaaa atgagaatca acacttcata ggctcactgg gttttctttt
     3721 cttttctgtt aatttaaact cagttatttt taatgcttaa tacatacatg gtgcaaaatt
     3781 taaaaagcgc aaataggtat ctagtggaaa acctaagcct ccctctctcc tccggcaccc
     3841 attacctctc cctggaggca actgttttga tccatttctt acacacactg ccagagatac
     3901 tctaggcatg taaagcacaa acatacatat aaaatctgcg ggcttcaaaa aatataagta
     3961 ggatgtcatc tatactgtca tacactttgt tttttatcac ttaatgttat atcttggata
     4021 ttgtattacc ctgggtatta aaaagaactc ctttcacatt ttaaaataac aatctgagca
     4081 cttcataaat ccaaatgcgt atctccagtc tgctcgagct aggaaaggaa aaaagcccta
     4141 gccgaaggag gaaaggctgc ctagacaatg atttcaaaag tagagtctaa aacctatggg
     4201 gtgcaggacc agaggctggg gcacattatc agaggcatcc tcatgtgcct cgaaccgaat
     4261 gtttttaagt cctcttttgg aaccttatgg tgaattgtat gcagattgat gaaggtttca
     4321 tttttatata ttaccaggac tacgaatttg taatccacta agcatcacaa aggttactac
     4381 atacgctata atactgtact ataaagtcta gctgccagca atgcagtgct cgcctgctat
     4441 attagaaggc tccagtttca catgtgcagg cacagagatg acatttcccg atctgggaga
     4501 aggcttcttt atcagcacat catcagtgtt gcctcgagtt ggttgcaatt ttcaattgct
     4561 gctattggtg ctttttaatt atgaattact gttagcttgc attatcatca gtttgttttg
     4621 ttgtgggttg cttggttaac cctacagagt atacttgaag cttatttgca tcaacagtat
     4681 tctggagctg taatttttca ataactagac tctgagacat gtatacattg tggttcaaat
     4741 aggaatcatc catagtccag tgctagaaca aatgtataca taatccactc cccacaaatt
     4801 atcactcatt tatttttcca ctggaaaata agactagatg gagtcggtag gtgaaacagt
     4861 tttgccgtgc ctaagtggag gctgatcaaa actaatttga gatccgctgc ctttaataga
     4921 gctccacctc aggaatctta cctttataat acatcctaga taggcaagag ggatatgtcc
     4981 tgaaatcttc actaattcca agattgcgtg tcatttcccc caaaaatttg cttaactcta
     5041 ttggaaaatc caagagaatt gctgcagctg ctgaaaacaa gagagctgca ttaagctgca
     5101 aggccgggta gggtaggtag actgactcac cacctatggg acctgcctcc acacatcagc
     5161 ttcccaaata cttgcagatt tgggtcttac caaaagaaaa gtcagtatga gttactcaca
     5221 atcctaacta caaaggctac atttacaaat accagagttt cgactgtgtt tttactctct
     5281 gctccctgaa aactgtaacc ccaggctagc tccaaactct gcttatagcc catgctttac
     5341 tacagtggtg gtcgcatatg tgaacgtgtg catgcgtgtt cacgtgttca tgacaacagc
     5401 aatgcagcca tgagggtgct gcccccaaac caagcctgat gaccttgaga acctcaggct
     5461 tcccagtagg atcctgcaag aaagcatctc ttaaaaataa attctacagg atattagtaa
     5521 atgttagatg aaaaaaaaag tcacgtttaa atatgtttag gaaacatgag gtgaagaaag
     5581 ttagcttact gacgcttttt gttttctagt tggagcgcac ctcagagtcc cctacataat
     5641 gcgtattagg actttctaag ggaagacggg gtacgatggg tcccaatctt gtttgatcac
     5701 aggatgtatc tgtcccctga gaaatttcta ggatgagtac tctgaactca ggacttcatt
     5761 tagtcatata ttcggcaagt atgtgttgag tgcagcatgt ccaagggtga gtgagagatt
     5821 atagctagca ggggagacag atgaaaaata actatgaatc gacgttagtt acaaattgtg
     5881 actgtcgcga tggagaagta ctaaaatcta tgaaagagtt ctaatgtaga tttaaggtca
     5941 tgagaagtct ccggcaaagt ggcattttaa agtaatccct cagtcgtgga gctactccaa
     6001 tgagaagcct gccactccag ggcgcaccac ggaggaggat ccccagacaa gaagacctgg
     6061 ctccccagag gagtgcggaa agccagcatg gctagaggac acagaatgag ggagaagacg
     6121 gatccgatcg caggcatcgg gagtgctgat ttttctcctt tgaaaaacag gttgccatct
     6181 acctttttaa atgtcccact gtgtaggaaa actctgggga aagctacgtc agcaatatgg
     6241 agtctggggt tgcctttctc atgtcatacc atggtcctgg ctggggagcg gaggagacca
     6301 ggagaggaga tcagacctct gcccacccca acaccaatct ggtcttagca acctctgggc
     6361 atcccatagc tcctcctaac ctgctgctgc tgatggacag gaactcctgg actaccccca
     6421 gcctctccac aatgtgtcct gagaagagct aggggaactg gacagagtgg acgaggctgc
     6481 atgtgtggag ggaatgaaat aaggggccta ccaggccaga acgctgatcc atggagacca
     6541 gtgcttccag ccctctcacc tcggaggagg actcctgttt taccaacggc aggagcagga
     6601 atcccaccat tcagcctgtg ggcttgacaa actataagca agcctcctgg atgtggaata
     6661 atacattttc aaaattcata ctaatcagca tgaactataa ctgctccaat gcccaccaca
     6721 ttatataaaa tctaccaaaa gggggtcact taatgtttca caatgtttgg tgaaacaact
     6781 ttcatatgaa agtacggttg atccttgaat gatatgggca ccgacccctg agcagctgaa
     6841 aatttgcatg taacttgact cccccaaaac gtaactataa tactaatagc cttactgaac
     6901 acggtcaatt aacacatagc tagtatgtta tgtgcattat atactatatc cttaccatac
     6961 ggtaagctag agaaaaaatg ttactaagaa aaacataagc aagagaaaat atatttacta
     7021 ttaagtgaaa gcaggtcatc ataaagtcct catcctcatg gtcatcacat tgagtaggcg
     7081 gaggaggagg aggaggagga ggagtagggg ttggtcttgc tgtctgaggg gtggcagagg
     7141 cagaaaaaaa atccatgggc cgagcacggt ggctcacacc tgtaatccca gcactttggg
     7201 aggccgagac ggacagatca caaggtcagg agattgagac tatcctggct aatatggtga
     7261 aaccccgtct gtactaaaaa tacaaaaaat tagccaggtg tggtggtgcg tgcctgtaat
     7321 cccagctact cagggggctg aggcagaagt attgcttgaa cccaggaggc agaggttgca
     7381 atgagctgag atcgcatcac tgcactcaag cctgggcaac agagcaagac tgcgtctcaa
     7441 aaaaacaaaa caaaacaaaa caaaaatcca tgaacaagtg gacctgccca gttcaaatca
     7501 ttgttgttca agggtcaatt gtatattatt ttcactggaa gttttgaaat tccagaaata
     7561 tgcttggaaa tccccgcttg aaatctcctt ggttggaaac cagtccagtg ggtgactggc
     7621 ccagaatgat gcttctcctc ggtggacccc ctgggctgag cagcctgtgt tcctgcctca
     7681 actcccctga accctcctga actttctaca cacatgtggg cactggcttt gatactggca
     7741 tttggaaggg cacttgggaa attcagagaa gtacccatta ttaagataaa tgatgtttta
     7801 tcaatgaagc agacttttca tttcttttta ttgatcttca tgttttcaca tcttgagatg
     7861 caatttgtta gcacaggctg tcattccaag acacacaaat gtcattaagg caaccgctta
     7921 aaggagtgtg atattttatt gaggtagaca ggacaataga taaatattta atctgttaca
     7981 tgtttgctct gtgtggagcc agggttgggg ctgcacaact ctctggctgc tatgtgtctt
     8041 cctggaaacc ctgtcaaagg ccttaccgcc tgcctggaga aacacagtgc ctgcccttgg
     8101 caaatatatg ttggtgtatc tgaaaaacag ctcctggaag ctttttctca ttcaggcttt
     8161 aggggttacc ccatctttcc ttatgtgtgt aatattggag aatgtacact ctcactgaac
     8221 tggggatgtt tgacttaaaa tgatggacaa taagatagtg agcagtaagt gtgctctagg
     8281 ctaggctacg agaggccatg agctcctcat ctcttctctg ttctgagctc tctgatccac
     8341 tgcacttggg gcagggggtg cattctctgt gcctctcctg agtctacttt ctgcatcatt
     8401 ggttctccca gctcacttcc ataatgtcct cctaggctgc attggaattg tgtgttgtct
     8461 agacccatgg ccaagactgt cattgcctgt gagggagacc aagctcacca ccaagggctt
     8521 ttgccagatt gctttcattt acagaatttg cccattcatg tgtctttgtg tttatggatt
     8581 aaatggcttt ctgaccagca tccctttggt gtgctttgtc aataaga
//
