LOCUS       NM_017915               3076 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens PARP1 binding protein (PARPBP), transcript variant 2,
            mRNA.
ACCESSION   NM_017915
VERSION     NM_017915.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Chen,S., Li,Q.H., Chen,X., Bao,H.J., Wu,W., Shen,F., Lu,B.F.,
            Jiang,R.Q., Zong,Z.H. and Zhao,Y.
  TITLE     SNORA70E promotes the occurrence and development of ovarian cancer
            through pseudouridylation modification of RAP1B and alternative
            splicing of PARPBP
  JOURNAL   J Cell Mol Med 26 (20), 5150-5164 (2022)
   PUBMED   36056690
  REMARK    GeneRIF: SNORA70E promotes the occurrence and development of
            ovarian cancer through pseudouridylation modification of RAP1B and
            alternative splicing of PARPBP.
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Yu,B., Ding,Y., Liao,X., Wang,C., Wang,B. and Chen,X.
  TITLE     Overexpression of PARPBP Correlates with Tumor Progression and Poor
            Prognosis in Hepatocellular Carcinoma
  JOURNAL   Dig Dis Sci 64 (10), 2878-2892 (2019)
   PUBMED   30949905
  REMARK    GeneRIF: PARP1-binding protein was significantly upregulated in
            Hepatocellular Carcinoma tissues compared with normal liver. High
            PARPBP expression was associated with elevated serum AFP level,
            vascular invasion, poor tumor differentiation, and advanced TNM
            stage.
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Xu,D., Tao,Z., Tang,X. and He,J.K.
  TITLE     Poly (ADP-ribose) polymerase-1 Binding Protein Facilitates Lung
            Adenocarcinoma Cell Proliferation and Correlates with Poor
            Prognosis
  JOURNAL   Ann Clin Lab Sci 49 (5), 574-580 (2019)
   PUBMED   31611199
  REMARK    GeneRIF: PARPBP expression is enhanced in lung adenocarcinoma
            tissues and is a potential factor in the progression of lung
            adenocarcinoma.
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Nicolae,C.M., O'Connor,M.J., Schleicher,E.M., Song,C., Gowda,R.,
            Robertson,G., Dovat,S. and Moldovan,G.L.
  TITLE     PARI (PARPBP) suppresses replication stress-induced myeloid
            differentiation in leukemia cells
  JOURNAL   Oncogene 38 (27), 5530-5540 (2019)
   PUBMED   30967629
  REMARK    GeneRIF: show that PARI expression negatively correlates with
            expression of differentiation markers in clinical myeloid leukemia
            samples, suggesting that targeting PARI may restore differentiation
            ability of leukemia cells and antagonize their proliferation
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Zhang,Y., Ye,X., Chen,L., Wu,Q., Gao,Y. and Li,Y.
  TITLE     PARI functions as a new transcriptional target of FOXM1 involved in
            gastric cancer development
  JOURNAL   Int J Biol Sci 14 (5), 531-541 (2018)
   PUBMED   29805304
  REMARK    GeneRIF: PARI plays potential oncogenic roles and functions as a
            transcriptional target and effector of FOXM1 in gastric cancer
            development
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3076)
  AUTHORS   Burkovics,P., Dome,L., Juhasz,S., Altmannova,V., Sebesta,M.,
            Pacesa,M., Fugger,K., Sorensen,C.S., Lee,M.Y., Haracska,L. and
            Krejci,L.
  TITLE     The PCNA-associated protein PARI negatively regulates homologous
            recombination via the inhibition of DNA repair synthesis
  JOURNAL   Nucleic Acids Res 44 (7), 3176-3189 (2016)
   PUBMED   26792895
  REMARK    GeneRIF: PARI inhibits homologous recombination in vivo, and its
            knockdown suppresses the UV sensitivity of RAD18-depleted cells
REFERENCE   7  (bases 1 to 3076)
  AUTHORS   O'Connor,K.W., Dejsuphong,D., Park,E., Nicolae,C.M.,
            Kimmelman,A.C., D'Andrea,A.D. and Moldovan,G.L.
  TITLE     PARI overexpression promotes genomic instability and pancreatic
            tumorigenesis
  JOURNAL   Cancer Res 73 (8), 2529-2539 (2013)
   PUBMED   23436799
  REMARK    GeneRIF: PARI overexpression promotes genomic instability and
            pancreatic tumorigenesis.
REFERENCE   8  (bases 1 to 3076)
  AUTHORS   Varisli,L.
  TITLE     Meta-analysis of the cell cycle related C12orf48
  JOURNAL   Biocell 37 (1), 11-16 (2013)
   PUBMED   24396997
REFERENCE   9  (bases 1 to 3076)
  AUTHORS   Moldovan,G.L., Dejsuphong,D., Petalcorin,M.I., Hofmann,K.,
            Takeda,S., Boulton,S.J. and D'Andrea,A.D.
  TITLE     Inhibition of homologous recombination by the PCNA-interacting
            protein PARI
  JOURNAL   Mol Cell 45 (1), 75-86 (2012)
   PUBMED   22153967
  REMARK    GeneRIF: PARI suppresses inappropriate recombination events at
            mammalian replication forks.
REFERENCE   10 (bases 1 to 3076)
  AUTHORS   Piao,L., Nakagawa,H., Ueda,K., Chung,S., Kashiwaya,K., Eguchi,H.,
            Ohigashi,H., Ishikawa,O., Daigo,Y., Matsuda,K. and Nakamura,Y.
  TITLE     C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose)
            polymerase-1 (PARP-1) activity and protects pancreatic cancer cells
            from DNA damage
  JOURNAL   Genes Chromosomes Cancer 50 (1), 13-24 (2011)
   PUBMED   20931645
  REMARK    GeneRIF: Demonstrated that C12orf48 protein could directly interact
            with Poly(ADP-ribose) Polymerase-1 (PARP-1). Knockdown of C12orf48
            by siRNA in PDAC cells significantly suppressed their growth.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC079907.25 and AC087882.17.
            
            On May 20, 2020 this sequence version replaced NM_017915.4.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            splice site compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.1990347.1,
                                           SRR14038192.1407267.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327680.7/ ENSP00000332915.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC079907.25        500-603             c
            105-260             AC087882.17        92179-92334         c
            261-494             AC087882.17        67757-67990         c
            495-602             AC087882.17        62244-62351         c
            603-773             AC087882.17        51612-51782         c
            774-928             AC087882.17        50337-50491         c
            929-1112            AC087882.17        40554-40737         c
            1113-1291           AC087882.17        37450-37628         c
            1292-1370           AC087882.17        33593-33671         c
            1371-1506           AC087882.17        20773-20908         c
            1507-3076           AC087882.17        18700-20269         c
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q23.2"
     gene            1..3076
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /note="PARP1 binding protein"
                     /db_xref="GeneID:55010"
                     /db_xref="HGNC:HGNC:26074"
                     /db_xref="MIM:613687"
     exon            1..104
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            105..260
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1847
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /note="isoform 2 is encoded by transcript variant 2;
                     PCNA-interacting partner"
                     /codon_start=1
                     /product="PCNA-interacting partner isoform 2"
                     /protein_id="NP_060385.3"
                     /db_xref="CCDS:CCDS9090.2"
                     /db_xref="GeneID:55010"
                     /db_xref="HGNC:HGNC:26074"
                     /db_xref="MIM:613687"
                     /translation="MAVFNQKSVSDMIKEFRKNWRALCNSERTTLCGADSMLLALQLS
                     MAENNKQHSGEFTVSLSDVLLTWKYLLHEKLNLPVENMDVTDHYEDVRKIYDDFLKNS
                     NMLDLIDVYQKCRALTSNCENYNTVSPSQLLDFLSGKQYAVGDETDLSIPTSPTSKYN
                     RDNEKVQLLARKIIFSYLNLLVNSKNDLAVAYILNIPDRGLGREAFTDLKHAAREKQM
                     SIFLVATSFIRTIELGGKGYAPPPSDPLRTHVKGLSNFINFIDKLDEILGEIPNPSIA
                     GGQILSVIKMQLIKGQNSRDPFCKAIEEVAQDLDLRIKNIINSQEGVVALSTTDISPA
                     RPKSHAINHGTAYCGRDTVKALLVLLDEEAANAPTKNKAELLYDEENTIHHHGTSILT
                     LFRSPTQVNNSIKPLRERICVSMQEKKIKMKQTLIRSQFACTYKDDYMISKDNWNNVN
                     LASKPLCVLYMENDLSEGVNPSVGRSTIGTSFGNVHLDRSKNEKVSRKSTSQTGNKSS
                     KRKQVDLDGENILCDNRNEPPQHKNAKIPKKSNDSQNRLYGKLAKVAKSNKCTAKDKL
                     ISGQAKLTQFFRL"
     exon            261..494
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            495..602
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            603..773
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            774..928
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1112
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1291
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1370
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1506
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..3076
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3049..3054
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="PARPBP"
                     /gene_synonym="AROM; C12orf48; PARI"
                     /note="major polyA site"
ORIGIN      
        1 gtattcagcg gcgacagcgg cgactgcggc ggccgcggga gggcatcccg ttggggatcc
       61 ttccgcacac tgaagagtac gtcttcgggt ctacccctaa tcacataatg gctgtgttta
      121 atcagaagtc tgtctcggat atgattaaag agtttcgaaa aaattggcgt gctctttgta
      181 actctgagag aactactcta tgtggtgcag actccatgct cttggcattg cagctttcta
      241 tggcggagaa caacaaacag cacagtggag aatttacagt ctctctcagt gatgttttat
      301 tgacatggaa atacttgctc catgagaaat tgaacttacc agttgaaaac atggacgtga
      361 ctgaccatta tgaggacgtt aggaagattt atgatgattt cttgaagaac agtaatatgt
      421 tagatctgat tgatgtttat caaaaatgta gggctttgac ttctaattgt gaaaattata
      481 acacagtatc tcctagtcaa ctactggatt ttctgtctgg caaacagtat gcagtaggtg
      541 atgaaactga tctttctata ccaacatcac caacaagtaa atacaaccgt gataatgaaa
      601 aggtgcagct gctagcaagg aaaattatct tttcatattt aaatctgcta gtgaattcaa
      661 agaatgacct ggctgtggct tatattctca atattcctga tagaggacta ggaagagaag
      721 ccttcactga tttgaaacat gctgctcgag agaaacaaat gtctatcttt ttggtggcca
      781 cgtcttttat tagaacaata gagcttggag ggaaaggata tgcaccacca ccatcagatc
      841 ctttaaggac acatgtaaag ggattgtcta attttattaa tttcattgac aaattagatg
      901 agattcttgg agaaatacca aacccaagca ttgcaggggg tcaaatactg tcagtgataa
      961 agatgcaact gattaaaggc caaaacagca gggatccttt ttgcaaagca atagaggaag
     1021 ttgctcagga tttggatttg aggattaaaa atattatcaa ttctcaagaa ggtgttgtag
     1081 ctcttagcac cactgacatc agtcctgctc ggccaaaatc tcatgccata aaccatggta
     1141 ctgcatactg tggcagagat actgtgaaag ccttattagt tcttttggac gaagaagcag
     1201 ctaatgctcc taccaaaaac aaagcagagc ttttatatga tgaggaaaac acaatccatc
     1261 atcatggaac gtctattctt acacttttta ggtctcccac acaggtgaat aattcgataa
     1321 aacccctaag agaacgcatc tgtgtgtcaa tgcaagagaa aaaaattaag atgaagcaaa
     1381 ctttaattag atcccaattt gcttgtactt ataaagatga ctacatgata agcaaggata
     1441 attggaataa tgttaattta gcatcaaagc ctttgtgtgt tctttacatg gaaaatgacc
     1501 tttctgaggg tgtaaatcca tctgttggaa gatcaacaat tggaacgagt tttggaaatg
     1561 ttcatctgga cagaagtaaa aatgaaaaag tatcaagaaa atcaaccagt cagacaggaa
     1621 ataaaagctc aaaaaggaaa caggtggatt tggatggtga aaatattctc tgtgataata
     1681 gaaatgaacc acctcaacat aaaaatgcta aaatacctaa gaaatcaaat gattcacaga
     1741 atagattgta cggcaaacta gctaaagtag caaaaagtaa taaatgtact gccaaggaca
     1801 agttgatttc tggccaggca aagttaactc agttttttag actataaatt tgtgtcttat
     1861 atgctttagg tttatgtatc tataaaccat tcaccaaaga catgcttaat ttttaagaga
     1921 tcaaggtgta aattatgatg atttattatt ttggtctaca gtgtatgtaa ggttagtatg
     1981 ttaagcattg tttaaaaata ctagtaagtc ataattatgc agaattttca caaagtttaa
     2041 tgcacagaga aagcatatca tttcagttac tgatacatct taacactact ttcttttaaa
     2101 acagacattt aacatacaca agttatagta gcagtatggg cttctcctcc cattggcaat
     2161 taaatgcttt tattttcttc tgaaaagatg atgtggacca acaggtatca gacttgccaa
     2221 caaggtcggt agactcttcc cagcatacat ctgagcactg aaggaagaag aaagtttaaa
     2281 ttgtttaaag gactataatt atcacacaaa atttattaag aaaaaaagaa tggatctagt
     2341 ataactaatt ctgagtaaac caaaatgata ataattaatt gttgctattt aatcccacat
     2401 ttttggcagg tgtaattgag ccatggtctt atttgatttt gttatgattg catccaaatt
     2461 cactttaact cagagttctg tttaatggtg gtaggatgta agaattgaat tttgaaaaga
     2521 ctactcactg tcaaaatctc tccttcctat aggaaattta gctgagtttt cttcatcccc
     2581 aatttctctc ttttcttgtg ttgattcagt attctgaact ccattctcag ctgggaaagc
     2641 tacagatcct tttagtgcaa gataaggttt tatagccaga ttcagtggca gaccatgatt
     2701 taagaaatta tgtttggagc ctgtgttctg taaagagaag gttgatttgg tttttagcta
     2761 tcgtattcgg agtggaacta taatacaatt gtataatatt cttgttgatc aattcaaagt
     2821 tactctgcac tgtttttgac tttttaaaaa taccttagat gcaaatttat aggagaaaaa
     2881 acactttcag ataagaggtg tttgctggga tggaagaact acctggcatg taagaaatat
     2941 cgtcagtcgt cctaatgcat attgtgactg tttgcatata cttctgttta taaaagtatc
     3001 agttttactt ttcagaggat ttgtaagaat catttaaatt ttcattgaaa taaacgacaa
     3061 gtcacattgc cactta
//
