LOCUS       NM_001387882            3183 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 9 (PARP9),
            transcript variant 21, mRNA.
ACCESSION   NM_001387882
VERSION     NM_001387882.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3183)
  AUTHORS   Pandi,K., Angabo,S., Makkawi,H., Benyamini,H., Elgavish,S. and
            Nussbaum,G.
  TITLE     P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association
            with PARP9
  JOURNAL   J Dent Res 103 (3), 329-338 (2024)
   PUBMED   38344758
  REMARK    GeneRIF: P. gingivalis-Induced TLR2 Interactome Analysis Reveals
            Association with PARP9.
REFERENCE   2  (bases 1 to 3183)
  AUTHORS   Thirunavukkarasu,S., Ahmed,M., Rosa,B.A., Boothby,M., Cho,S.H.,
            Rangel-Moreno,J., Mbandi,S.K., Schreiber,V., Gupta,A., Zuniga,J.,
            Mitreva,M., Kaushal,D., Scriba,T.J. and Khader,S.A.
  TITLE     Poly(ADP-ribose) polymerase 9 mediates early protection against
            Mycobacterium tuberculosis infection by regulating type I IFN
            production
  JOURNAL   J Clin Invest 133 (12), e158630 (2023)
   PUBMED   37200107
  REMARK    GeneRIF: Poly(ADP-ribose) polymerase 9 mediates early protection
            against Mycobacterium tuberculosis infection by regulating type I
            IFN production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3183)
  AUTHORS   Russo,L.C., Tomasin,R., Matos,I.A., Manucci,A.C., Sowa,S.T.,
            Dale,K., Caldecott,K.W., Lehtio,L., Schechtman,D., Meotti,F.C.,
            Bruni-Cardoso,A. and Hoch,N.C.
  TITLE     The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent
            ADP-ribosylation induced by interferon signaling
  JOURNAL   J Biol Chem 297 (3), 101041 (2021)
   PUBMED   34358560
  REMARK    GeneRIF: The SARS-CoV-2 Nsp3 macrodomain reverses
            PARP9/DTX3L-dependent ADP-ribosylation induced by interferon
            signaling.
REFERENCE   4  (bases 1 to 3183)
  AUTHORS   Xing,J., Zhang,A., Du,Y., Fang,M., Minze,L.J., Liu,Y.J., Li,X.C.
            and Zhang,Z.
  TITLE     Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a
            noncanonical sensor for RNA virus in dendritic cells
  JOURNAL   Nat Commun 12 (1), 2681 (2021)
   PUBMED   33976210
  REMARK    GeneRIF: Identification of poly(ADP-ribose) polymerase 9 (PARP9) as
            a noncanonical sensor for RNA virus in dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3183)
  AUTHORS   Yang,C.S., Jividen,K., Kamata,T., Dworak,N., Oostdyk,L.,
            Remlein,B., Pourfarjam,Y., Kim,I.K., Du,K.P., Abbas,T.,
            Sherman,N.E., Wotton,D. and Paschal,B.M.
  TITLE     Androgen signaling uses a writer and a reader of ADP-ribosylation
            to regulate protein complex assembly
  JOURNAL   Nat Commun 12 (1), 2705 (2021)
   PUBMED   33976187
  REMARK    GeneRIF: Androgen signaling uses a writer and a reader of
            ADP-ribosylation to regulate protein complex assembly.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3183)
  AUTHORS   Jha,R., Agarwal,A., Mahfouz,R., Paasch,U., Grunewald,S.,
            Sabanegh,E., Yadav,S.P. and Sharma,R.
  TITLE     Determination of Poly (ADP-ribose) polymerase (PARP) homologues in
            human ejaculated sperm and its correlation with sperm maturation
  JOURNAL   Fertil Steril 91 (3), 782-790 (2009)
   PUBMED   18339380
  REMARK    GeneRIF: Determination of Poly (ADP-ribose) polymerase (PARP)
            homologues in human ejaculated sperm and its correlation with sperm
            maturation.
REFERENCE   7  (bases 1 to 3183)
  AUTHORS   Juszczynski,P., Kutok,J.L., Li,C., Mitra,J., Aguiar,R.C. and
            Shipp,M.A.
  TITLE     BAL1 and BBAP are regulated by a gamma interferon-responsive
            bidirectional promoter and are overexpressed in diffuse large
            B-cell lymphomas with a prominent inflammatory infiltrate
  JOURNAL   Mol Cell Biol 26 (14), 5348-5359 (2006)
   PUBMED   16809771
  REMARK    GeneRIF: BAL1 and BBAP are located on chromosome 3q21 in a
            head-to-head orientation and are regulated by a
            IFN-gamma-responsive bidirectional promoter.
REFERENCE   8  (bases 1 to 3183)
  AUTHORS   Aguiar,R.C., Takeyama,K., He,C., Kreinbrink,K. and Shipp,M.A.
  TITLE     B-aggressive lymphoma family proteins have unique domains that
            modulate transcription and exhibit poly(ADP-ribose) polymerase
            activity
  JOURNAL   J Biol Chem 280 (40), 33756-33765 (2005)
   PUBMED   16061477
REFERENCE   9  (bases 1 to 3183)
  AUTHORS   Takeyama,K., Aguiar,R.C., Gu,L., He,C., Freeman,G.J., Kutok,J.L.,
            Aster,J.C. and Shipp,M.A.
  TITLE     The BAL-binding protein BBAP and related Deltex family members
            exhibit ubiquitin-protein isopeptide ligase activity
  JOURNAL   J Biol Chem 278 (24), 21930-21937 (2003)
   PUBMED   12670957
REFERENCE   10 (bases 1 to 3183)
  AUTHORS   Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Salgia,R., Fletcher,J.A.
            and Shipp,M.A.
  TITLE     BAL is a novel risk-related gene in diffuse large B-cell lymphomas
            that enhances cellular migration
  JOURNAL   Blood 96 (13), 4328-4334 (2000)
   PUBMED   11110709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC092908.9 and AC096861.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                AC092908.9         135916-135971
            57-157              AC092908.9         140510-140610
            158-191             AC092908.9         141749-141782
            192-1027            AC092908.9         144095-144930
            1028-1249           AC092908.9         147577-147798
            1250-1468           AC092908.9         149414-149632
            1469-1526           AC092908.9         154727-154784
            1527-1907           AC092908.9         159364-159744
            1908-2047           AC092908.9         163143-163282
            2048-2222           AC092908.9         163874-164048
            2223-2363           AC092908.9         169321-169461
            2364-3146           AC092908.9         171473-172255
            3147-3183           AC096861.5         99143-99179         c
FEATURES             Location/Qualifiers
     source          1..3183
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..3183
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="poly(ADP-ribose) polymerase family member 9"
                     /db_xref="GeneID:83666"
                     /db_xref="HGNC:HGNC:24118"
                     /db_xref="MIM:612065"
     exon            1..56
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            57..157
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..2344
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /EC_number="2.4.2.30"
                     /note="isoform g is encoded by transcript variant 21; poly
                     [ADP-ribose] polymerase 9; poly (ADP-ribose) polymerase 9;
                     PARP-9; b aggressive lymphoma protein;
                     ADP-ribosyltransferase diphtheria toxin-like 9; protein
                     mono-ADP-ribosyltransferase PARP9"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP9
                     isoform g"
                     /protein_id="NP_001374811.1"
                     /db_xref="GeneID:83666"
                     /db_xref="HGNC:HGNC:24118"
                     /db_xref="MIM:612065"
                     /translation="MDFSMVAGAAAYNEKSETGALGENYSWQIPINHNDFKILKNNER
                     QLCEVLQNKFGCISTLVSPVQEGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVN
                     AANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIH
                     AVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTK
                     TIVETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFKAASEFILGKSELGQETTPSFNA
                     MVVNNLTLQIVQGHIEWQTADVIVNSVNPHDITVGPVAKSILQQAGVEMKSEFLATKA
                     KQFQRSQLVLVTKGFNLFCKYIYHVLWHSEFPKPQILKHAMKECLEKCIEQNITSISF
                     PALGTGNMEIKKETAAEILFDEVLTFAKDHVKHQLTVKFVIFPTDLEIYKAFSSEMAK
                     RSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNVEEMYEAHAWIQRILSLQNH
                     HIIENNHILYLGRKEHDILSQLQKTSSVSITEIISPGRTELEIEGARADLIEVVMNIE
                     DMLCKVQEEMARKKERGLWRSLGQWTIQQQKTQDEMKENIIFLKCPVPPTQELLDQKK
                     QFEKCGLQVLKVEKIDNEVLMAAFQRKKKMMEEKLHRQPVSHRLFQQVPYQFCNVVCR
                     VGFQRMYSTPCEIGSHCVAQASLKLLTSTNPPALASQSAGITDMSHSAWKF"
     exon            158..191
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            192..1027
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1249
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1468
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1526
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1907
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2047
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            2048..2222
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2363
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..3183
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3160..3165
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="hexamer: AATAAA"
     polyA_site      3183
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="major polyA site"
ORIGIN      
        1 agagccgctt ccccctcctc cctgtgctgt ctgcaccgag gagagcggcc tgccggtggg
       61 ccaccatatc tggaaactac agtctatgct ttgaagcgca aaagggaata aacatttaaa
      121 gactcccccg gggacctgga ggatggactt ttccatggtg gccggagcag cagcttacaa
      181 tgaaaaatca gagactggtg ctcttggaga aaactatagt tggcaaattc ccattaacca
      241 caatgacttc aaaattttaa aaaataatga gcgtcagctg tgtgaagtcc tccagaataa
      301 gtttggctgt atctctaccc tggtctctcc agttcaggaa ggcaacagca aatctctgca
      361 agtgttcaga aaaatgctga ctcctaggat agagttatca gtctggaaag atgacctcac
      421 cacacatgct gttgatgctg tggtgaatgc agccaatgaa gatcttctgc atgggggagg
      481 cctggccctg gccctggtaa aagctggtgg atttgaaatc caagaagaga gcaaacagtt
      541 tgttgccaga tatggtaaag tgtcagctgg tgagatagct gtcacgggag cagggaggct
      601 tccctgcaaa cagatcatcc atgctgttgg gcctcggtgg atggaatggg ataaacaggg
      661 atgtactgga aagctgcaga gggccattgt aagtattctg aattatgtca tctataaaaa
      721 tactcacatt aagacagtag caattccagc cttgagctct gggatttttc agttccctct
      781 gaatttgtgt acaaagacta ttgtagagac tatccgggtt agtttgcaag ggaagccaat
      841 gatgagtaat ttgaaagaaa ttcacctggt gagcaatgag gaccctactg ttgctgcctt
      901 taaagctgct tcagaattca tcctagggaa gagtgagctg ggacaagaaa ccaccccttc
      961 tttcaatgca atggtcgtga acaacctgac cctccagatt gtccagggcc acattgaatg
     1021 gcagacggca gatgtaattg ttaattctgt aaacccacat gatattacag ttggacctgt
     1081 ggcaaagtca attctacaac aagcaggagt tgaaatgaaa tcggaatttc ttgccacaaa
     1141 ggctaaacag tttcaacggt cccagttggt actggtcaca aaaggattta acttgttctg
     1201 taaatatata taccatgtac tgtggcattc agaatttcct aaacctcaga tattaaaaca
     1261 tgcaatgaag gagtgtttgg aaaaatgcat tgagcaaaat ataacttcca tttcctttcc
     1321 tgcccttggg actggaaaca tggaaataaa gaaggaaaca gcagcagaga ttttgtttga
     1381 tgaagtttta acatttgcca aagaccatgt aaaacaccag ttaactgtaa aatttgtgat
     1441 ctttccaaca gatttggaga tatataaggc tttcagttct gaaatggcaa agaggtccaa
     1501 gatgctgagt ttgaacaatt acagtgtccc ccagtcaacc agagaggaga aaagagaaaa
     1561 tgggcttgaa gctagatctc ctgccatcaa tctgatggga ttcaacgtgg aagagatgta
     1621 tgaggcccac gcatggatcc aaagaatcct gagtctccag aaccaccaca tcattgagaa
     1681 taatcatatt ctgtaccttg ggagaaagga acatgacatt ttgtctcagc ttcagaaaac
     1741 ttcaagtgtc tccatcacag aaattatcag cccaggaagg acagagttag agattgaagg
     1801 agcccgggct gacctcattg aggtggttat gaacattgaa gatatgcttt gtaaagtaca
     1861 ggaggaaatg gcaaggaaaa aggagcgagg cctttggcgc tcgttaggac agtggactat
     1921 tcagcaacaa aaaacccaag acgaaatgaa agaaaatatc atatttctga aatgtcctgt
     1981 gcctccaact caagagcttc tagatcaaaa gaaacagttt gaaaaatgtg gtttgcaggt
     2041 tctaaaggtg gagaagatag acaatgaggt ccttatggct gcctttcaaa gaaagaagaa
     2101 aatgatggaa gaaaaactgc acaggcaacc tgtgagccat aggctgtttc agcaagtccc
     2161 ataccagttc tgcaatgtgg tatgcagagt tggctttcaa agaatgtact cgacaccttg
     2221 cgagattggg tctcactgtg ttgcccaggc tagtctcaaa ctcctgacct ccaccaatcc
     2281 tcctgccttg gcctcccaaa gtgctgggat tacagacatg agccactcag cctggaagtt
     2341 ttaaacgaca tgtgtgactc ataatccaaa atacggagct ggcatatact tcaccaagaa
     2401 cctcaaaaac ctggcagaga aggccaagaa aatctctgct gcagataagc tgatctatgt
     2461 gtttgaggct gaagtactca caggcttctt ctgccaggga catccgttaa atattgttcc
     2521 cccaccactg agtcctggag ctatagatgg tcatgacagt gtggttgaca atgtctccag
     2581 ccctgaaacc tttgttattt ttagtggcat gcaggctata cctcagtatt tgtggacatg
     2641 cacccaggaa tatgtacagt cacaagatta ctcatcagga ccaatgagac cctttgcaca
     2701 gcatccttgg aggggattcg caagtggcag ccctgttgat taatctctac atcattttaa
     2761 cagctggtat ggccttacct tgggtgaact aaccaaataa tgaccatcga tggctcaaag
     2821 agtggcttga atatatccca tgggttatct gtatggactg actgggttat tgaaaggact
     2881 agccacatac tagcatctta gtgcctttat ctgtctttat gtcttggggt tggggtaggt
     2941 agataccaaa tgaaacactt tcaggacctt ccttcctctt gcagttgttc tttaatctcc
     3001 tttactagag gagataaata ttttgcatat aatgaagaaa tttttctagt atataacgca
     3061 ggccttttat tttctaaaat gatgatagta taaaaatgtt aggataacag aatgatttta
     3121 gattttccag agaatattat aaagtgcttt aggtatgaaa ataaatcatc tttgtctgat
     3181 taa
//
