LOCUS       NM_001146105            3045 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 9 (PARP9),
            transcript variant 5, mRNA.
ACCESSION   NM_001146105
VERSION     NM_001146105.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3045)
  AUTHORS   Pandi,K., Angabo,S., Makkawi,H., Benyamini,H., Elgavish,S. and
            Nussbaum,G.
  TITLE     P. gingivalis-Induced TLR2 Interactome Analysis Reveals Association
            with PARP9
  JOURNAL   J Dent Res 103 (3), 329-338 (2024)
   PUBMED   38344758
  REMARK    GeneRIF: P. gingivalis-Induced TLR2 Interactome Analysis Reveals
            Association with PARP9.
REFERENCE   2  (bases 1 to 3045)
  AUTHORS   Thirunavukkarasu,S., Ahmed,M., Rosa,B.A., Boothby,M., Cho,S.H.,
            Rangel-Moreno,J., Mbandi,S.K., Schreiber,V., Gupta,A., Zuniga,J.,
            Mitreva,M., Kaushal,D., Scriba,T.J. and Khader,S.A.
  TITLE     Poly(ADP-ribose) polymerase 9 mediates early protection against
            Mycobacterium tuberculosis infection by regulating type I IFN
            production
  JOURNAL   J Clin Invest 133 (12), e158630 (2023)
   PUBMED   37200107
  REMARK    GeneRIF: Poly(ADP-ribose) polymerase 9 mediates early protection
            against Mycobacterium tuberculosis infection by regulating type I
            IFN production.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3045)
  AUTHORS   Russo,L.C., Tomasin,R., Matos,I.A., Manucci,A.C., Sowa,S.T.,
            Dale,K., Caldecott,K.W., Lehtio,L., Schechtman,D., Meotti,F.C.,
            Bruni-Cardoso,A. and Hoch,N.C.
  TITLE     The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent
            ADP-ribosylation induced by interferon signaling
  JOURNAL   J Biol Chem 297 (3), 101041 (2021)
   PUBMED   34358560
  REMARK    GeneRIF: The SARS-CoV-2 Nsp3 macrodomain reverses
            PARP9/DTX3L-dependent ADP-ribosylation induced by interferon
            signaling.
REFERENCE   4  (bases 1 to 3045)
  AUTHORS   Xing,J., Zhang,A., Du,Y., Fang,M., Minze,L.J., Liu,Y.J., Li,X.C.
            and Zhang,Z.
  TITLE     Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a
            noncanonical sensor for RNA virus in dendritic cells
  JOURNAL   Nat Commun 12 (1), 2681 (2021)
   PUBMED   33976210
  REMARK    GeneRIF: Identification of poly(ADP-ribose) polymerase 9 (PARP9) as
            a noncanonical sensor for RNA virus in dendritic cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3045)
  AUTHORS   Yang,C.S., Jividen,K., Kamata,T., Dworak,N., Oostdyk,L.,
            Remlein,B., Pourfarjam,Y., Kim,I.K., Du,K.P., Abbas,T.,
            Sherman,N.E., Wotton,D. and Paschal,B.M.
  TITLE     Androgen signaling uses a writer and a reader of ADP-ribosylation
            to regulate protein complex assembly
  JOURNAL   Nat Commun 12 (1), 2705 (2021)
   PUBMED   33976187
  REMARK    GeneRIF: Androgen signaling uses a writer and a reader of
            ADP-ribosylation to regulate protein complex assembly.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3045)
  AUTHORS   Jha,R., Agarwal,A., Mahfouz,R., Paasch,U., Grunewald,S.,
            Sabanegh,E., Yadav,S.P. and Sharma,R.
  TITLE     Determination of Poly (ADP-ribose) polymerase (PARP) homologues in
            human ejaculated sperm and its correlation with sperm maturation
  JOURNAL   Fertil Steril 91 (3), 782-790 (2009)
   PUBMED   18339380
  REMARK    GeneRIF: Determination of Poly (ADP-ribose) polymerase (PARP)
            homologues in human ejaculated sperm and its correlation with sperm
            maturation.
REFERENCE   7  (bases 1 to 3045)
  AUTHORS   Juszczynski,P., Kutok,J.L., Li,C., Mitra,J., Aguiar,R.C. and
            Shipp,M.A.
  TITLE     BAL1 and BBAP are regulated by a gamma interferon-responsive
            bidirectional promoter and are overexpressed in diffuse large
            B-cell lymphomas with a prominent inflammatory infiltrate
  JOURNAL   Mol Cell Biol 26 (14), 5348-5359 (2006)
   PUBMED   16809771
  REMARK    GeneRIF: BAL1 and BBAP are located on chromosome 3q21 in a
            head-to-head orientation and are regulated by a
            IFN-gamma-responsive bidirectional promoter.
REFERENCE   8  (bases 1 to 3045)
  AUTHORS   Aguiar,R.C., Takeyama,K., He,C., Kreinbrink,K. and Shipp,M.A.
  TITLE     B-aggressive lymphoma family proteins have unique domains that
            modulate transcription and exhibit poly(ADP-ribose) polymerase
            activity
  JOURNAL   J Biol Chem 280 (40), 33756-33765 (2005)
   PUBMED   16061477
REFERENCE   9  (bases 1 to 3045)
  AUTHORS   Takeyama,K., Aguiar,R.C., Gu,L., He,C., Freeman,G.J., Kutok,J.L.,
            Aster,J.C. and Shipp,M.A.
  TITLE     The BAL-binding protein BBAP and related Deltex family members
            exhibit ubiquitin-protein isopeptide ligase activity
  JOURNAL   J Biol Chem 278 (24), 21930-21937 (2003)
   PUBMED   12670957
REFERENCE   10 (bases 1 to 3045)
  AUTHORS   Aguiar,R.C., Yakushijin,Y., Kharbanda,S., Salgia,R., Fletcher,J.A.
            and Shipp,M.A.
  TITLE     BAL is a novel risk-related gene in diffuse large B-cell lymphomas
            that enhances cellular migration
  JOURNAL   Blood 96 (13), 4328-4334 (2000)
   PUBMED   11110709
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC368112.1 and BC039580.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001146105.1.
            
            Transcript Variant: This variant (5) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 5' coding region, compared
            to variant 1. This results in a shorter protein (isoform b),
            compared to isoform a. Variants 3, 4 and 5 encode the same isoform
            (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039580.1, DRR138522.1371034.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682323.1/ ENSP00000507390.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                DC368112.1         1-42
            43-3045             BC039580.1         1-3003
FEATURES             Location/Qualifiers
     source          1..3045
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..3045
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="poly(ADP-ribose) polymerase family member 9"
                     /db_xref="GeneID:83666"
                     /db_xref="HGNC:HGNC:24118"
                     /db_xref="MIM:612065"
     exon            1..56
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            57..160
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     CDS             146..2605
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /EC_number="2.4.2.30"
                     /note="isoform b is encoded by transcript variant 5; poly
                     [ADP-ribose] polymerase 9; poly (ADP-ribose) polymerase 9;
                     PARP-9; b aggressive lymphoma protein;
                     ADP-ribosyltransferase diphtheria toxin-like 9; protein
                     mono-ADP-ribosyltransferase PARP9"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP9
                     isoform b"
                     /protein_id="NP_001139577.1"
                     /db_xref="CCDS:CCDS54634.1"
                     /db_xref="GeneID:83666"
                     /db_xref="HGNC:HGNC:24118"
                     /db_xref="MIM:612065"
                     /translation="MDFSMVAGAAAYNEKSETGALGENYSWQIPINHNDFKILKNNER
                     QLCEVLQNKFGCISTLVSPVQEGNSKSLQVFRKMLTPRIELSVWKDDLTTHAVDAVVN
                     AANEDLLHGGGLALALVKAGGFEIQEESKQFVARYGKVSAGEIAVTGAGRLPCKQIIH
                     AVGPRWMEWDKQGCTGKLQRAIVSILNYVIYKNTHIKTVAIPALSSGIFQFPLNLCTK
                     TIVETIRVSLQGKPMMSNLKEIHLVSNEDPTVAAFKAASEFILGKSELGQETTPSFNA
                     MVVNNLTLQIVQGHIEWQTADVIVNSVNPHDITVGPVAKSILQQAGVEMKSEFLATKA
                     KQFQRSQLVLVTKGFNLFCKYIYHVLWHSEFPKPQILKHAMKECLEKCIEQNITSISF
                     PALGTGNMEIKKETAAEILFDEVLTFAKDHVKHQLTVKFVIFPTDLEIYKAFSSEMAK
                     RSKMLSLNNYSVPQSTREEKRENGLEARSPAINLMGFNVEEMYEAHAWIQRILSLQNH
                     HIIENNHILYLGRKEHDILSQLQKTSSVSITEIISPGRTELEIEGARADLIEVVMNIE
                     DMLCKVQEEMARKKERGLWRSLGQWTIQQQKTQDEMKENIIFLKCPVPPTQELLDQKK
                     QFEKCGLQVLKVEKIDNEVLMAAFQRKKKMMEEKLHRQPVSHRLFQQVPYQFCNVVCR
                     VGFQRMYSTPCDPKYGAGIYFTKNLKNLAEKAKKISAADKLIYVFEAEVLTGFFCQGH
                     PLNIVPPPLSPGAIDGHDSVVDNVSSPETFVIFSGMQAIPQYLWTCTQEYVQSQDYSS
                     GPMRPFAQHPWRGFASGSPVD"
     exon            161..194
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            195..1030
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1252
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1471
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1529
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1910
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2050
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2225
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..3045
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3022..3027
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="hexamer: AATAAA"
     polyA_site      3045
                     /gene="PARP9"
                     /gene_synonym="ARTD9; BAL; BAL1; MGC:7868"
                     /note="major polyA site"
ORIGIN      
        1 agagccgctt ccccctcctc cctgtgctgt ctgcaccgag gagagcggcc tgccggaagt
       61 gggccaccat atctggaaac tacagtctat gctttgaagc gcaaaaggga ataaacattt
      121 aaagactccc ccggggacct ggaggatgga cttttccatg gtggccggag cagcagctta
      181 caatgaaaaa tcagagactg gtgctcttgg agaaaactat agttggcaaa ttcccattaa
      241 ccacaatgac ttcaaaattt taaaaaataa tgagcgtcag ctgtgtgaag tcctccagaa
      301 taagtttggc tgtatctcta ccctggtctc tccagttcag gaaggcaaca gcaaatctct
      361 gcaagtgttc agaaaaatgc tgactcctag gatagagtta tcagtctgga aagatgacct
      421 caccacacat gctgttgatg ctgtggtgaa tgcagccaat gaagatcttc tgcatggggg
      481 aggcctggcc ctggccctgg taaaagctgg tggatttgaa atccaagaag agagcaaaca
      541 gtttgttgcc agatatggta aagtgtcagc tggtgagata gctgtcacgg gagcagggag
      601 gcttccctgc aaacagatca tccatgctgt tgggcctcgg tggatggaat gggataaaca
      661 gggatgtact ggaaagctgc agagggccat tgtaagtatt ctgaattatg tcatctataa
      721 aaatactcac attaagacag tagcaattcc agccttgagc tctgggattt ttcagttccc
      781 tctgaatttg tgtacaaaga ctattgtaga gactatccgg gttagtttgc aagggaagcc
      841 aatgatgagt aatttgaaag aaattcacct ggtgagcaat gaggacccta ctgttgctgc
      901 ctttaaagct gcttcagaat tcatcctagg gaagagtgag ctgggacaag aaaccacccc
      961 ttctttcaat gcaatggtcg tgaacaacct gaccctccag attgtccagg gccacattga
     1021 atggcagacg gcagatgtaa ttgttaattc tgtaaaccca catgatatta cagttggacc
     1081 tgtggcaaag tcaattctac aacaagcagg agttgaaatg aaatcggaat ttcttgccac
     1141 aaaggctaaa cagtttcaac ggtcccagtt ggtactggtc acaaaaggat ttaacttgtt
     1201 ctgtaaatat atataccatg tactgtggca ttcagaattt cctaaacctc agatattaaa
     1261 acatgcaatg aaggagtgtt tggaaaaatg cattgagcaa aatataactt ccatttcctt
     1321 tcctgccctt gggactggaa acatggaaat aaagaaggaa acagcagcag agattttgtt
     1381 tgatgaagtt ttaacatttg ccaaagacca tgtaaaacac cagttaactg taaaatttgt
     1441 gatctttcca acagatttgg agatatataa ggctttcagt tctgaaatgg caaagaggtc
     1501 caagatgctg agtttgaaca attacagtgt cccccagtca accagagagg agaaaagaga
     1561 aaatgggctt gaagctagat ctcctgccat caatctgatg ggattcaacg tggaagagat
     1621 gtatgaggcc cacgcatgga tccaaagaat cctgagtctc cagaaccacc acatcattga
     1681 gaataatcat attctgtacc ttgggagaaa ggaacatgac attttgtctc agcttcagaa
     1741 aacttcaagt gtctccatca cagaaattat cagcccagga aggacagagt tagagattga
     1801 aggagcccgg gctgacctca ttgaggtggt tatgaacatt gaagatatgc tttgtaaagt
     1861 acaggaggaa atggcaagga aaaaggagcg aggcctttgg cgctcgttag gacagtggac
     1921 tattcagcaa caaaaaaccc aagacgaaat gaaagaaaat atcatatttc tgaaatgtcc
     1981 tgtgcctcca actcaagagc ttctagatca aaagaaacag tttgaaaaat gtggtttgca
     2041 ggttctaaag gtggagaaga tagacaatga ggtccttatg gctgcctttc aaagaaagaa
     2101 gaaaatgatg gaagaaaaac tgcacaggca acctgtgagc cataggctgt ttcagcaagt
     2161 cccataccag ttctgcaatg tggtatgcag agttggcttt caaagaatgt actcgacacc
     2221 ttgcgatcca aaatacggag ctggcatata cttcaccaag aacctcaaaa acctggcaga
     2281 gaaggccaag aaaatctctg ctgcagataa gctgatctat gtgtttgagg ctgaagtact
     2341 cacaggcttc ttctgccagg gacatccgtt aaatattgtt cccccaccac tgagtcctgg
     2401 agctatagat ggtcatgaca gtgtggttga caatgtctcc agccctgaaa cctttgttat
     2461 ttttagtggc atgcaggcta tacctcagta tttgtggaca tgcacccagg aatatgtaca
     2521 gtcacaagat tactcatcag gaccaatgag accctttgca cagcatcctt ggaggggatt
     2581 cgcaagtggc agccctgttg attaatctct acatcatttt aacagctggt atggccttac
     2641 cttgggtgaa ctaaccaaat aatgaccatc gatggctcaa agagtggctt gaatatatcc
     2701 catgggttat ctgtatggac tgactgggtt attgaaagga ctagccacat actagcatct
     2761 tagtgccttt atctgtcttt atgtcttggg gttggggtag gtagatacca aatgaaacac
     2821 tttcaggacc ttccttcctc ttgcagttgt tctttaatct cctttactag aggagataaa
     2881 tattttgcat ataatgaaga aatttttcta gtatataacg caggcctttt attttctaaa
     2941 atgatgatag tataaaaatg ttaggataac agaatgattt tagattttcc agagaatatt
     3001 ataaagtgct ttaggtatga aaataaatca tctttgtctg attaa
//
