LOCUS       NM_001178056            7349 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 8 (PARP8),
            transcript variant 3, mRNA.
ACCESSION   NM_001178056
VERSION     NM_001178056.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7349)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7349)
  AUTHORS   Viding,E., Price,T.S., Jaffee,S.R., Trzaskowski,M., Davis,O.S.,
            Meaburn,E.L., Haworth,C.M. and Plomin,R.
  TITLE     Genetics of callous-unemotional behavior in children
  JOURNAL   PLoS One 8 (7), e65789 (2013)
   PUBMED   23874384
  REMARK    Erratum:[PLoS One. 2013;8(7). doi:
            10.1371/annotation/0b16418f-ceb5-41b2-be2a-a20f0c56f9a6]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7349)
  AUTHORS   Fan,Q., Barathi,V.A., Cheng,C.Y., Zhou,X., Meguro,A., Nakata,I.,
            Khor,C.C., Goh,L.K., Li,Y.J., Lim,W., Ho,C.E., Hawthorne,F.,
            Zheng,Y., Chua,D., Inoko,H., Yamashiro,K., Ohno-Matsui,K.,
            Matsuo,K., Matsuda,F., Vithana,E., Seielstad,M., Mizuki,N.,
            Beuerman,R.W., Tai,E.S., Yoshimura,N., Aung,T., Young,T.L.,
            Wong,T.Y., Teo,Y.Y. and Saw,S.M.
  TITLE     Genetic variants on chromosome 1q41 influence ocular axial length
            and high myopia
  JOURNAL   PLoS Genet 8 (6), e1002753 (2012)
   PUBMED   22685421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112187.2, DC417471.1, DC429180.1, BC075801.1 and AC022441.5.
            
            On May 31, 2019 this sequence version replaced NM_001178056.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            lacks an exon in the 3' coding region compared to variant 1. The
            resulting protein (isoform 2) is shorter but has the same N- and
            C-termini compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC075801.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-301               AC112187.2         90454-90754
            302-847             DC417471.1         1-546
            848-921             DC429180.1         519-592
            922-3171            BC075801.1         580-2829
            3172-7349           AC022441.5         115431-119608       c
FEATURES             Location/Qualifiers
     source          1..7349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.1"
     gene            1..7349
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="poly(ADP-ribose) polymerase family member 8"
                     /db_xref="GeneID:79668"
                     /db_xref="HGNC:HGNC:26124"
     exon            1..550
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     CDS             460..2898
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /EC_number="2.4.2.30"
                     /note="isoform 2 is encoded by transcript variant 3;
                     ADP-ribosyltransferase diphtheria toxin-like 16; protein
                     mono-ADP-ribosyltransferase PARP8"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP8
                     isoform 2"
                     /protein_id="NP_001171527.1"
                     /db_xref="CCDS:CCDS54849.1"
                     /db_xref="GeneID:79668"
                     /db_xref="HGNC:HGNC:26124"
                     /translation="MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYV
                     GGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCC
                     LSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSA
                     VREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQ
                     YLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKV
                     KSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVT
                     KSHRTFGRSLSSDPRAEQAMTAIKSHKLLNRPCPAAVKSEECLTLKSHRLLTRSCSGD
                     PRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNA
                     EGRRLSLTSGLIGILTPSSSSSSQLAPNGAKCIPVRDRGFLVQTIEFAEQRIPVLNEY
                     CVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQKKNYDRVMKA
                     LDSITSIREMTQAPYLEIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHT
                     PHQFLLLSSPPAKESNFRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHG
                     AMYGSGIYLSPMSSISFGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFLQS
                     RNLKCIALCEVITSSDLHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIH
                     KEILRVIGNQTATG"
     exon            551..605
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            606..643
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            644..733
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            734..804
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            805..882
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            883..977
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1038
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1129
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1196
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1322
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1887
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..1938
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2034
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2127
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2193
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2261
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2262..2310
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2311..2423
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2496
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2497..2566
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2640
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2710
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2795
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..7349
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="hexamer: AATAAA"
     polyA_site      3171
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="major polyA site"
     regulatory      7326..7331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="hexamer: AATAAA"
     polyA_site      7349
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="major polyA site"
ORIGIN      
        1 gtggaaggcc ggcgtgcgag ccgtgagggg tgtgcgcgcg tgagccggag cggggctcgc
       61 ccctcgccgg cgcccgccgc ccagccggtg attgctctct ggctgtcccc ggcacctcgg
      121 cccccacggc cgttggtccg ggcgggtgag ggagaaagtg agacttggtg tcatcaccat
      181 ccattgtcag aaggggagga aattggaatc cagcagcggc gagcagcagc tgggcggtca
      241 catctgggaa tgcaaagccg acctccccct cctcctcctc ctccccctcc tcctcctcct
      301 cttctctcac ccaggatcac ttccgaaacc acttcgcctt cagcccctgc ctcggccaga
      361 ggtttcattt ttaactgaat atttacgaaa gctggaagcg tgcgaggggg gtggggtggg
      421 gtggaaatag cggctgcttc ttttccaggg atttatttaa tggggatgtg ttcaaggcaa
      481 gagcgaattc agaaggatat cgacgtcgtg atccagaagt ccagagctga gaaggactgc
      541 ctgtttgcag atttcagata ctctgactcc acctttactt ttacctacgt tggcggcccc
      601 agaagtgtat cctactcagt acatgtatct gaagattacc cagataatac atatgtgtca
      661 agttcagaga atgatgaaga tgtgctagtt actacagagc caataccagt aatttttcat
      721 agaatagcaa cagaattaag aaaaacaaat gacattaact gttgcttatc cataaaatcc
      781 aaattacaaa aggaaaatgg ggaggaatca agacagaata gtacagtgga ggaagattct
      841 gaaggtgaca atgattccga agaattttat tacggagggc aggtgaacta tgatggggaa
      901 ctgcacaagc acccacaact ggaagctgat ttgtcagcag ttagagagat atatgggcca
      961 catgcagttt ctctcaggga atatggagcc attgatgatg tagatattga tctgcatatc
     1021 gatgttagct ttcttgatga ggagattgct gtggcttggg aagtaattcg aacagaacct
     1081 ataattgttc gactacactg ttcacttaca cagtatttaa atggcccagt gcccactgtt
     1141 gatgtctttc agatttccac aaaagagcga tttggattgg gacatcagct gaaaaaaatc
     1201 atgcagacat ttgttacaca gcagtggaaa cagagcaaag aaaaatccaa ttgcctgcac
     1261 aataaaaagt tgtcagagaa gaaagtgaag tctcccctgc atttattttc tactttgcgc
     1321 aggtcgccaa gttatcctcc ccctggttgt ggcaaaagca aatccaaact gaaatctgag
     1381 caggacggaa tctccaaaac gcataagctg ctgcggagga cttgttccag cacagtcaag
     1441 actgatgatg tgtgtgtcac aaagtcacac aggacctttg gccgctcctt gtccagcgat
     1501 cccagggcgg agcaggctat gacagcaatt aaatcgcaca aacttttgaa ccgtccttgc
     1561 cctgcagctg ttaagtcaga ggaatgccta actctaaagt cgcatagact attgactcga
     1621 tcttgttctg gagatccacg atgtgagcac aacacaaact tgaagcccca taaactgtta
     1681 agcaggtctt actctagtaa tctcagaatg gaagaattat atggactgaa aaatcacaaa
     1741 ttgctcagca agtcctactc cagtgccccc aagtcatcca aaactgagct tttcaaggaa
     1801 cctaacgcag agggcaggag gctctctctt acctcagggc ttattggtat cctaacacca
     1861 tcttcatctt catcttctca gcttgctcca aatggtgcaa aatgcattcc agtacgagac
     1921 cgtggcttcc tggtgcagac aattgagttt gctgaacagc ggatccctgt attaaatgaa
     1981 tattgtgtgg tttgtgatga gccacatgtg tttcaaaatg gccctatgct taggcctacc
     2041 gtatgtgaac gggagctgtg tgtgtttgct tttcaaaccc tgggagtaat gaatgaagct
     2101 gctgatgaaa tagcaactgg agctcagaaa aagaactatg atcgagtaat gaaagcactg
     2161 gatagcataa cttctatcag agaaatgaca caagcaccat atctggaaat caagaagcaa
     2221 atggataaac aggaccccct tgctcatccc ttactgcaat gggttatatc aagtaataga
     2281 tcacatattg tgaaactgcc agttaacagg caattgaagt ttatgcatac tccacatcag
     2341 ttccttcttc tcagcagtcc accagccaaa gaatccaatt ttagagctgc taaaaaactc
     2401 tttggaagca cctttgcatt tcatggctca cacattgaaa actggcactc catcctgagg
     2461 aatggtctgg ttgttgcttc taatacacga ttgcagctcc atggtgcaat gtatggaagt
     2521 ggaatctatc ttagtccaat gtcaagcata tcatttggtt actcagggat gaacaagaaa
     2581 cagaaggtgt cagccaagga cgagccagct tcaagcagta aaagcagcaa tacatcacag
     2641 tcacagaaaa aaggacagca atcccaattc ctgcaaagcc gtaacttaaa atgcatagcc
     2701 ttatgtgaag tgatcacctc atctgacctg cacaaacatg gagagatatg ggttgtcccc
     2761 aatactgacc atgtctgcac acgattcttt ttcgtctatg aagacggcca agtgggagat
     2821 gcaaatatta atacacaaga aggaggcatt cacaaagaga tcctccgagt aattggtaat
     2881 caaactgcta ctggttaaag gaccaccatt taattaacat gattcgaaag ccttcctcgg
     2941 gttcaaagct ggattttgaa ctgaagaaga ttataaaatt atttattgtt attataaaca
     3001 aaattaaccc tttgaatact gatttttttt cttagtattt ctaagtatct cattaaatac
     3061 ctaaaatggt ataagattta tcaattgtag ggttatggaa tctagtaata aaatttcaac
     3121 agcacttaaa ctgaagtttg ggttgctcat acaataaaca gattgaaaaa actgttttgt
     3181 gctgatattt ttatactaaa ctctttaact ggatatttgg tattatatac cgacatttta
     3241 ggttaccaaa atagaattga gaacatttta taatggcatc taaatctatc agatactttg
     3301 caataagtat actgtttgca cattctgatg tgctatatca ttagtagtat gggcattcta
     3361 atgttttgga aggggtgttc cctattctat ttttcttcat aaaaaaagaa gtaggtctta
     3421 gaagcagtgc tttgccaaaa agtatgtaat atacacatct atacattcat gcatcaaaat
     3481 gtgtggttgt gaatatattt gtgtatattc acacgtatgt tttgacaaga aagatggctt
     3541 agcttcacaa ttctatcctc gtttaatgga aagaagataa tatttagtaa gcaataaatt
     3601 tggacataaa tcaagatatg agccagattt accaccattc attcactgaa aatatttgca
     3661 gacaattttt ctgtttgtct gaagaaattc agccctttta aaatgttatc taaaagtcat
     3721 aatttgggga acatacatgg cctggtagac cgaatctata ttcaaatgat tatgtattta
     3781 aaagaaagac ctcagaattt aaagaaacca tatatatttt ttatttacta caaaaaaatt
     3841 atacaatttt atttatgcca caccagcatt tttatatttg ttcatctaat atctctgctt
     3901 atttttttca tattgagaaa gaacacaaac ttgatgcttc ttttatatta aaagaccaca
     3961 aataagttta tagagaacag taacaccagc tctcagcatt tccttttcaa gagtcataat
     4021 ttcatcaaaa tcatttctta ttctttgagt cctagagttc ttattcatca agttttaatt
     4081 gacagtgttt attttcccac atgttgtctt tggaataagg ccattcatga aagcagttta
     4141 attagtgagt ctgccactct attcaaaccc tgaatcaagg ctctatctga ttttaattta
     4201 tgtaaaaaaa aataaaaatg tatagtcatt tgcaagtata atgtgataac tgctgtgttt
     4261 atttcctttg tctggcataa aaggtgagaa aaaggtcata catgttgtta agggtagcag
     4321 tttaggaagt gttttctaat aatttgtttt gttatattgc aaataattga tatgccactt
     4381 atttctgcaa gaaaaatagg cttgaagtgg ttgggatatt aatcattttg atagtatcta
     4441 cttaaagcat tgatctgttt tgacttgtgg ctctgaaccc tgggctaggc tgagggataa
     4501 tagtagtgga gtagggcaaa gatataatat cctatccagt gttttgtgac cacttatttg
     4561 aagattagtg tgggacatga ggaccttgct acttttttgc caagatgctg caagtctccc
     4621 aaatcacttc aactgtgttt ttaaaacatg tttaagcaac agaattattt ttttgaaatt
     4681 agtctatacg ttagacagtc tatacatgac aaacatgaag atctaatatc aagatttggg
     4741 agacgggatc ttggaactcc acctgtttga ccactaggac cactgaggca cctccaataa
     4801 gctctgtaga gtgcctccag cataattcaa aatccactga cctaatccat tatggcttta
     4861 cttaacattg gagtgatccg taaagaatat agtattggag tctgaactgg aacggtaact
     4921 cgtaagactc aagaaagacc gtttaaggaa aattggcata atacaaactg ttcctgttga
     4981 cttaagaata acagtaggtt cacctatctg aggaaattaa gtagttgata gtttaatgct
     5041 aggcatcttt tatgataata aagtaagatg tcttcttatg acagttaatt gagttgtatc
     5101 atgatacaga atgacagatt ttgtttcaaa caattgcgtc agaacctttg taagcaaata
     5161 ttctaaggag aatcaatctt attttttaat tgaacttttt gaaattaggg atactataat
     5221 aactgataaa gatgaatttc tgtgtttcta aagaatctaa tttcaattac taccattaac
     5281 atataaatgt gcttccaaaa tccaagcagg tccatacaat ttagagattt gaacactgtt
     5341 atcatgcttt aattcagtca ttcattaaaa tattatctat tcacttattt gatgattcca
     5401 aacatttgat attgtattgt gtttttataa ttatttgaaa tctgttcacc aatgctttgt
     5461 aatggtttta ttaattgtgt agccattgct acttagatag taacccactg agcaaaggca
     5521 gtcatttatt ttcatccttg aagtagggga agaaaattat taatttatta gttctacttt
     5581 ttcctgcatt gcttattttg taaacatttt actatgaata atctgttctc tttcactgta
     5641 ttaaaaggag aagaaaatga acatttgaga atggaaaaaa gtaataatat acaaataatc
     5701 tagtgctata aaatgcatta tagtaagaca cttttggtgt cttcgagtgc actatgttgg
     5761 aataaatttt atacttgttg cttagtaaat ctcagtcata cgtttggttt gaagctgttt
     5821 ttttttttaa tttgaagttt aattttaaaa gtgccacatt gtaaaagtta ccgttaaata
     5881 ctatgtagta taaaaaacca acccaagcta ttgttaatgc tctgaatgtt tttctttgaa
     5941 aatttaagtt tagagaagaa attccttcat ttttctcccc tttgctaaaa gaaagaaaat
     6001 ctataatatg taagtctatg aatctttaaa taactgaagg aattttagca gtactttgta
     6061 taataaaaat attttttaaa ctataacttg ccttagagca tggggtttca gaaagttttg
     6121 acgaaaaact catcttcatt aaagagtctg gataacttca tcagatggta atttaatatg
     6181 tcatgaaggg gacactcaac attgggtcat ctaccgtcta aataaatacg gatttcatgg
     6241 tggcatttga agcacatttt gcaaacatta tgatgttcta ttgtcttgct gaattcttta
     6301 ttataacact acctcaagac aaatgataga ctgttggtaa ggtaaattgg gttttcaatg
     6361 tcaggaacaa ataaaatttt gcaaatagaa gtcatcaaat aattcaacag gaagaccata
     6421 ctggacacag atgttgtcag ttacttctgg acaatgtggt aacatggata tttcagtcac
     6481 tggtaacaat gtcagggtta acacccaatg aattatttga aacaatttgg gttgcaaaat
     6541 ttgaaattaa ttagtctatt ttgagattga ttttctacgt gggccaattt tatgtccatt
     6601 acctaaagcc acaatctccc gctctaagga gttaaaggat gaaaacaccc aactgctaca
     6661 ctggaatggc agactggata ttcaagcatt ttggcattta atgcctgcta aatttttgtc
     6721 cgattatata tagatttgat gtatattatt acccagtaaa ttcttcttgg gaattttgta
     6781 tacattatgg aatattagga taagtttttg taggtcagaa gaatttcaag tagtttttag
     6841 acaaaacata tccatgagtg tgaaaaaagc tgtgttgacg aatagattac atttcacatt
     6901 taccagcaag tcagtaaaaa atagtgctta tttacatagt caatataatt taatgttcta
     6961 aaaataatat cttcgatctg cccaatattt aatgtatcat ttgagatttt taaaaatgca
     7021 tccgctccat tatgtaaaca ttaagatatg cctatgtttc tttaactata cagcctcttt
     7081 acaataaatt tcttgatttt tgtgcacagg atagtattgc aacctgctat ttagcctttg
     7141 gtgccttaga attattataa atatttaaca atatgtacat aatgtaaata ctgccaagag
     7201 atcagtaagg ccaaatattt tctctattca ctttttattg ctcttgcttt ctattgctac
     7261 taaagcctct tttatccagc tttgtaatag ttccaacatt gtagcgaatg taaatgttta
     7321 ctttcaataa atctgaactt gttcaacaa
//
