LOCUS       NM_001178055            7166 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 8 (PARP8),
            transcript variant 1, mRNA.
ACCESSION   NM_001178055
VERSION     NM_001178055.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7166)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7166)
  AUTHORS   Viding,E., Price,T.S., Jaffee,S.R., Trzaskowski,M., Davis,O.S.,
            Meaburn,E.L., Haworth,C.M. and Plomin,R.
  TITLE     Genetics of callous-unemotional behavior in children
  JOURNAL   PLoS One 8 (7), e65789 (2013)
   PUBMED   23874384
  REMARK    Erratum:[PLoS One. 2013;8(7). doi:
            10.1371/annotation/0b16418f-ceb5-41b2-be2a-a20f0c56f9a6]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7166)
  AUTHORS   Fan,Q., Barathi,V.A., Cheng,C.Y., Zhou,X., Meguro,A., Nakata,I.,
            Khor,C.C., Goh,L.K., Li,Y.J., Lim,W., Ho,C.E., Hawthorne,F.,
            Zheng,Y., Chua,D., Inoko,H., Yamashiro,K., Ohno-Matsui,K.,
            Matsuo,K., Matsuda,F., Vithana,E., Seielstad,M., Mizuki,N.,
            Beuerman,R.W., Tai,E.S., Yoshimura,N., Aung,T., Young,T.L.,
            Wong,T.Y., Teo,Y.Y. and Saw,S.M.
  TITLE     Genetic variants on chromosome 1q41 influence ocular axial length
            and high myopia
  JOURNAL   PLoS Genet 8 (6), e1002753 (2012)
   PUBMED   22685421
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK314466.1, DC429180.1, AL834477.1 and AC022441.5.
            
            On Jun 1, 2019 this sequence version replaced NM_001178055.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314466.1, SRR1803617.94903.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-569               AK314466.1         33-601
            570-612             DC429180.1         550-592
            613-2989            AL834477.1         580-2956
            2990-7166           AC022441.5         115431-119607       c
FEATURES             Location/Qualifiers
     source          1..7166
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.1"
     gene            1..7166
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="poly(ADP-ribose) polymerase family member 8"
                     /db_xref="GeneID:79668"
                     /db_xref="HGNC:HGNC:26124"
     exon            1..139
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            140..241
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2715
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /EC_number="2.4.2.30"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ADP-ribosyltransferase diphtheria toxin-like 16; protein
                     mono-ADP-ribosyltransferase PARP8"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP8
                     isoform 1"
                     /protein_id="NP_001171526.1"
                     /db_xref="CCDS:CCDS3954.1"
                     /db_xref="GeneID:79668"
                     /db_xref="HGNC:HGNC:26124"
                     /translation="MGMCSRQERIQKDIDVVIQKSRAEKDCLFADFRYSDSTFTFTYV
                     GGPRSVSYSVHVSEDYPDNTYVSSSENDEDVLVTTEPIPVIFHRIATELRKTNDINCC
                     LSIKSKLQKENGEESRQNSTVEEDSEGDNDSEEFYYGGQVNYDGELHKHPQLEADLSA
                     VREIYGPHAVSLREYGAIDDVDIDLHIDVSFLDEEIAVAWEVIRTEPIIVRLHCSLTQ
                     YLNGPVPTVDVFQISTKERFGLGHQLKKIMQTFVTQQWKQSKEKSNCLHNKKLSEKKV
                     KSPLHLFSTLRRSPSYPPPGCGKSKSKLKSEQDGISKTHKLLRRTCSSTVKTDDVCVT
                     KSHRTFGRSLSSDPRAEQAMTAIKSHKLLNRPCPAAVKSEECLTLKSHRLLTRSCSGD
                     PRCEHNTNLKPHKLLSRSYSSNLRMEELYGLKNHKLLSKSYSSAPKSSKTELFKEPNA
                     EGRRLSLTSGLIGILTPSSSSSSQLAPNGAKCIPVRDRGFLVQTIEFAEQRIPVLNEY
                     CVVCDEPHVFQNGPMLRPTVCERELCVFAFQTLGVMNEAADEIATGAQVVDLLVSMCR
                     SALESPRKVVIFEPYPSVVDPNDPQMLAFNPRKKNYDRVMKALDSITSIREMTQAPYL
                     EIKKQMDKQDPLAHPLLQWVISSNRSHIVKLPVNRQLKFMHTPHQFLLLSSPPAKESN
                     FRAAKKLFGSTFAFHGSHIENWHSILRNGLVVASNTRLQLHGAMYGSGIYLSPMSSIS
                     FGYSGMNKKQKVSAKDEPASSSKSSNTSQSQKKGQQSQFLQSRNLKCIALCEVITSSD
                     LHKHGEIWVVPNTDHVCTRFFFVYEDGQVGDANINTQEGGIHKEILRVIGNQTATG"
     exon            242..296
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            297..334
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            335..424
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            425..495
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            496..573
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            574..668
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            669..729
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            730..820
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            821..887
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1013
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1578
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1629
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1725
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1818
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1944
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2010
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2078
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2127
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2240
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2241..2313
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2383
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2384..2457
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2458..2527
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2612
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     exon            2613..7166
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2970..2975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="hexamer: AATAAA"
     polyA_site      2988
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="major polyA site"
     regulatory      7143..7148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="hexamer: AATAAA"
     polyA_site      7166
                     /gene="PARP8"
                     /gene_synonym="ARTD16; pART16"
                     /note="major polyA site"
ORIGIN      
        1 gtagctttcc cttgactgtc aaaggaggtg gttttaaaaa tcaagccaaa caggtttcca
       61 tcttttagga agaccctgga acgtgccagt tgattctgac catttctcat gaacagaaac
      121 acctaggaag ggagaactgg gatttattta atggggatgt gttcaaggca agagcgaatt
      181 cagaaggata tcgacgtcgt gatccagaag tccagagctg agaaggactg cctgtttgca
      241 gatttcagat actctgactc cacctttact tttacctacg ttggcggccc cagaagtgta
      301 tcctactcag tacatgtatc tgaagattac ccagataata catatgtgtc aagttcagag
      361 aatgatgaag atgtgctagt tactacagag ccaataccag taatttttca tagaatagca
      421 acagaattaa gaaaaacaaa tgacattaac tgttgcttat ccataaaatc caaattacaa
      481 aaggaaaatg gggaggaatc aagacagaat agtacagtgg aggaagattc tgaaggtgac
      541 aatgattccg aagaatttta ttacggaggg caggtgaact atgatgggga actgcacaag
      601 cacccacaac tggaagctga tttgtcagca gttagagaga tatatgggcc acatgcagtt
      661 tctctcaggg aatatggagc cattgatgat gtagatattg atctgcatat cgatgttagc
      721 tttcttgatg aggagattgc tgtggcttgg gaagtaattc gaacagaacc tataattgtt
      781 cgactacact gttcacttac acagtattta aatggcccag tgcccactgt tgatgtcttt
      841 cagatttcca caaaagagcg atttggattg ggacatcagc tgaaaaaaat catgcagaca
      901 tttgttacac agcagtggaa acagagcaaa gaaaaatcca attgcctgca caataaaaag
      961 ttgtcagaga agaaagtgaa gtctcccctg catttatttt ctactttgcg caggtcgcca
     1021 agttatcctc cccctggttg tggcaaaagc aaatccaaac tgaaatctga gcaggacgga
     1081 atctccaaaa cgcataagct gctgcggagg acttgttcca gcacagtcaa gactgatgat
     1141 gtgtgtgtca caaagtcaca caggaccttt ggccgctcct tgtccagcga tcccagggcg
     1201 gagcaggcta tgacagcaat taaatcgcac aaacttttga accgtccttg ccctgcagct
     1261 gttaagtcag aggaatgcct aactctaaag tcgcatagac tattgactcg atcttgttct
     1321 ggagatccac gatgtgagca caacacaaac ttgaagcccc ataaactgtt aagcaggtct
     1381 tactctagta atctcagaat ggaagaatta tatggactga aaaatcacaa attgctcagc
     1441 aagtcctact ccagtgcccc caagtcatcc aaaactgagc ttttcaagga acctaacgca
     1501 gagggcagga ggctctctct tacctcaggg cttattggta tcctaacacc atcttcatct
     1561 tcatcttctc agcttgctcc aaatggtgca aaatgcattc cagtacgaga ccgtggcttc
     1621 ctggtgcaga caattgagtt tgctgaacag cggatccctg tattaaatga atattgtgtg
     1681 gtttgtgatg agccacatgt gtttcaaaat ggccctatgc ttaggcctac cgtatgtgaa
     1741 cgggagctgt gtgtgtttgc ttttcaaacc ctgggagtaa tgaatgaagc tgctgatgaa
     1801 atagcaactg gagctcaggt ggtagatcta ctagtatcca tgtgtaggtc tgcgttggaa
     1861 tctcctagaa aagttgtgat tttcgagcca tatccttctg tggtagatcc taatgatcct
     1921 cagatgttgg ccttcaaccc caggaaaaag aactatgatc gagtaatgaa agcactggat
     1981 agcataactt ctatcagaga aatgacacaa gcaccatatc tggaaatcaa gaagcaaatg
     2041 gataaacagg acccccttgc tcatccctta ctgcaatggg ttatatcaag taatagatca
     2101 catattgtga aactgccagt taacaggcaa ttgaagttta tgcatactcc acatcagttc
     2161 cttcttctca gcagtccacc agccaaagaa tccaatttta gagctgctaa aaaactcttt
     2221 ggaagcacct ttgcatttca tggctcacac attgaaaact ggcactccat cctgaggaat
     2281 ggtctggttg ttgcttctaa tacacgattg cagctccatg gtgcaatgta tggaagtgga
     2341 atctatctta gtccaatgtc aagcatatca tttggttact cagggatgaa caagaaacag
     2401 aaggtgtcag ccaaggacga gccagcttca agcagtaaaa gcagcaatac atcacagtca
     2461 cagaaaaaag gacagcaatc ccaattcctg caaagccgta acttaaaatg catagcctta
     2521 tgtgaagtga tcacctcatc tgacctgcac aaacatggag agatatgggt tgtccccaat
     2581 actgaccatg tctgcacacg attctttttc gtctatgaag acggccaagt gggagatgca
     2641 aatattaata cacaagaagg aggcattcac aaagagatcc tccgagtaat tggtaatcaa
     2701 actgctactg gttaaaggac caccatttaa ttaacatgat tcgaaagcct tcctcgggtt
     2761 caaagctgga ttttgaactg aagaagatta taaaattatt tattgttatt ataaacaaaa
     2821 ttaacccttt gaatactgat tttttttctt agtatttcta agtatctcat taaataccta
     2881 aaatggtata agatttatca attgtagggt tatggaatct agtaataaaa tttcaacagc
     2941 acttaaactg aagtttgggt tgctcataca ataaacagat tgaaaaaact gttttgtgct
     3001 gatattttta tactaaactc tttaactgga tatttggtat tatataccga cattttaggt
     3061 taccaaaata gaattgagaa cattttataa tggcatctaa atctatcaga tactttgcaa
     3121 taagtatact gtttgcacat tctgatgtgc tatatcatta gtagtatggg cattctaatg
     3181 ttttggaagg ggtgttccct attctatttt tcttcataaa aaaagaagta ggtcttagaa
     3241 gcagtgcttt gccaaaaagt atgtaatata cacatctata cattcatgca tcaaaatgtg
     3301 tggttgtgaa tatatttgtg tatattcaca cgtatgtttt gacaagaaag atggcttagc
     3361 ttcacaattc tatcctcgtt taatggaaag aagataatat ttagtaagca ataaatttgg
     3421 acataaatca agatatgagc cagatttacc accattcatt cactgaaaat atttgcagac
     3481 aatttttctg tttgtctgaa gaaattcagc ccttttaaaa tgttatctaa aagtcataat
     3541 ttggggaaca tacatggcct ggtagaccga atctatattc aaatgattat gtatttaaaa
     3601 gaaagacctc agaatttaaa gaaaccatat atatttttta tttactacaa aaaaattata
     3661 caattttatt tatgccacac cagcattttt atatttgttc atctaatatc tctgcttatt
     3721 tttttcatat tgagaaagaa cacaaacttg atgcttcttt tatattaaaa gaccacaaat
     3781 aagtttatag agaacagtaa caccagctct cagcatttcc ttttcaagag tcataatttc
     3841 atcaaaatca tttcttattc tttgagtcct agagttctta ttcatcaagt tttaattgac
     3901 agtgtttatt ttcccacatg ttgtctttgg aataaggcca ttcatgaaag cagtttaatt
     3961 agtgagtctg ccactctatt caaaccctga atcaaggctc tatctgattt taatttatgt
     4021 aaaaaaaaat aaaaatgtat agtcatttgc aagtataatg tgataactgc tgtgtttatt
     4081 tcctttgtct ggcataaaag gtgagaaaaa ggtcatacat gttgttaagg gtagcagttt
     4141 aggaagtgtt ttctaataat ttgttttgtt atattgcaaa taattgatat gccacttatt
     4201 tctgcaagaa aaataggctt gaagtggttg ggatattaat cattttgata gtatctactt
     4261 aaagcattga tctgttttga cttgtggctc tgaaccctgg gctaggctga gggataatag
     4321 tagtggagta gggcaaagat ataatatcct atccagtgtt ttgtgaccac ttatttgaag
     4381 attagtgtgg gacatgagga ccttgctact tttttgccaa gatgctgcaa gtctcccaaa
     4441 tcacttcaac tgtgttttta aaacatgttt aagcaacaga attatttttt tgaaattagt
     4501 ctatacgtta gacagtctat acatgacaaa catgaagatc taatatcaag atttgggaga
     4561 cgggatcttg gaactccacc tgtttgacca ctaggaccac tgaggcacct ccaataagct
     4621 ctgtagagtg cctccagcat aattcaaaat ccactgacct aatccattat ggctttactt
     4681 aacattggag tgatccgtaa agaatatagt attggagtct gaactggaac ggtaactcgt
     4741 aagactcaag aaagaccgtt taaggaaaat tggcataata caaactgttc ctgttgactt
     4801 aagaataaca gtaggttcac ctatctgagg aaattaagta gttgatagtt taatgctagg
     4861 catcttttat gataataaag taagatgtct tcttatgaca gttaattgag ttgtatcatg
     4921 atacagaatg acagattttg tttcaaacaa ttgcgtcaga acctttgtaa gcaaatattc
     4981 taaggagaat caatcttatt ttttaattga actttttgaa attagggata ctataataac
     5041 tgataaagat gaatttctgt gtttctaaag aatctaattt caattactac cattaacata
     5101 taaatgtgct tccaaaatcc aagcaggtcc atacaattta gagatttgaa cactgttatc
     5161 atgctttaat tcagtcattc attaaaatat tatctattca cttatttgat gattccaaac
     5221 atttgatatt gtattgtgtt tttataatta tttgaaatct gttcaccaat gctttgtaat
     5281 ggttttatta attgtgtagc cattgctact tagatagtaa cccactgagc aaaggcagtc
     5341 atttattttc atccttgaag taggggaaga aaattattaa tttattagtt ctactttttc
     5401 ctgcattgct tattttgtaa acattttact atgaataatc tgttctcttt cactgtatta
     5461 aaaggagaag aaaatgaaca tttgagaatg gaaaaaagta ataatataca aataatctag
     5521 tgctataaaa tgcattatag taagacactt ttggtgtctt cgagtgcact atgttggaat
     5581 aaattttata cttgttgctt agtaaatctc agtcatacgt ttggtttgaa gctgtttttt
     5641 tttttaattt gaagtttaat tttaaaagtg ccacattgta aaagttaccg ttaaatacta
     5701 tgtagtataa aaaaccaacc caagctattg ttaatgctct gaatgttttt ctttgaaaat
     5761 ttaagtttag agaagaaatt ccttcatttt tctccccttt gctaaaagaa agaaaatcta
     5821 taatatgtaa gtctatgaat ctttaaataa ctgaaggaat tttagcagta ctttgtataa
     5881 taaaaatatt ttttaaacta taacttgcct tagagcatgg ggtttcagaa agttttgacg
     5941 aaaaactcat cttcattaaa gagtctggat aacttcatca gatggtaatt taatatgtca
     6001 tgaaggggac actcaacatt gggtcatcta ccgtctaaat aaatacggat ttcatggtgg
     6061 catttgaagc acattttgca aacattatga tgttctattg tcttgctgaa ttctttatta
     6121 taacactacc tcaagacaaa tgatagactg ttggtaaggt aaattgggtt ttcaatgtca
     6181 ggaacaaata aaattttgca aatagaagtc atcaaataat tcaacaggaa gaccatactg
     6241 gacacagatg ttgtcagtta cttctggaca atgtggtaac atggatattt cagtcactgg
     6301 taacaatgtc agggttaaca cccaatgaat tatttgaaac aatttgggtt gcaaaatttg
     6361 aaattaatta gtctattttg agattgattt tctacgtggg ccaattttat gtccattacc
     6421 taaagccaca atctcccgct ctaaggagtt aaaggatgaa aacacccaac tgctacactg
     6481 gaatggcaga ctggatattc aagcattttg gcatttaatg cctgctaaat ttttgtccga
     6541 ttatatatag atttgatgta tattattacc cagtaaattc ttcttgggaa ttttgtatac
     6601 attatggaat attaggataa gtttttgtag gtcagaagaa tttcaagtag tttttagaca
     6661 aaacatatcc atgagtgtga aaaaagctgt gttgacgaat agattacatt tcacatttac
     6721 cagcaagtca gtaaaaaata gtgcttattt acatagtcaa tataatttaa tgttctaaaa
     6781 ataatatctt cgatctgccc aatatttaat gtatcatttg agatttttaa aaatgcatcc
     6841 gctccattat gtaaacatta agatatgcct atgtttcttt aactatacag cctctttaca
     6901 ataaatttct tgatttttgt gcacaggata gtattgcaac ctgctattta gcctttggtg
     6961 ccttagaatt attataaata tttaacaata tgtacataat gtaaatactg ccaagagatc
     7021 agtaaggcca aatattttct ctattcactt tttattgctc ttgctttcta ttgctactaa
     7081 agcctctttt atccagcttt gtaatagttc caacattgta gcgaatgtaa atgtttactt
     7141 tcaataaatc tgaacttgtt caacaa
//
