LOCUS       NM_001323532            2788 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 6 (PARP6),
            transcript variant 14, mRNA.
ACCESSION   NM_001323532
VERSION     NM_001323532.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   Vermehren-Schmaedick,A., Huang,J.Y., Levinson,M., Pomaville,M.B.,
            Reed,S., Bellus,G.A., Gilbert,F., Keren,B., Heron,D., Haye,D.,
            Janello,C., Makowski,C., Danhauser,K., Fedorov,L.M., Haack,T.B.,
            Wright,K.M. and Cohen,M.S.
  TITLE     Characterization of PARP6 Function in Knockout Mice and Patients
            with Developmental Delay
  JOURNAL   Cells 10 (6), 1289 (2021)
   PUBMED   34067418
  REMARK    GeneRIF: Characterization of PARP6 Function in Knockout Mice and
            Patients with Developmental Delay.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Wang,H., Li,S., Luo,X., Song,Z., Long,X. and Zhu,X.
  TITLE     Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits
            cell invasion of colorectal adenocarcinoma cells
  JOURNAL   Oncol Rep 37 (4), 2245-2251 (2017)
   PUBMED   28260087
  REMARK    GeneRIF: Results showed that both PARP6 and survivin exhibited
            higher expression in colorectal adenocarcinoma tissues and cell
            lines.  knockdown of either PARP6 or survivin promotes cell
            apoptosis and inhibits the cell invasion of colorectal
            adenocarcinoma cells suggesting a significant correlation between
            theses 2 proteins.
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Qi,G., Kudo,Y., Tang,B., Liu,T., Jin,S., Liu,J., Zuo,X., Mi,S.,
            Shao,W., Ma,X., Tsunematsu,T., Ishimaru,N., Zeng,S., Tatsuka,M. and
            Shimamoto,F.
  TITLE     PARP6 acts as a tumor suppressor via downregulating Survivin
            expression in colorectal cancer
  JOURNAL   Oncotarget 7 (14), 18812-18824 (2016)
   PUBMED   26934315
  REMARK    GeneRIF: PARP6 acts as a tumor suppressor via downregulating
            Survivin expression in CRC. PARP6 can be a novel diagnostic and
            therapeutic target together with Survivin for CRC.
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Tuncel,H., Tanaka,S., Oka,S., Nakai,S., Fukutomi,R., Okamoto,M.,
            Ota,T., Kaneko,H., Tatsuka,M. and Shimamoto,F.
  TITLE     PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of
            cell proliferation, is involved in colorectal cancer development
  JOURNAL   Int J Oncol 41 (6), 2079-2086 (2012)
   PUBMED   23042038
  REMARK    GeneRIF: PARP6, a mono(ADP-ribosyl) transferase and a negative
            regulator of cell proliferation, is involved in colorectal cancer
            development, PARP6-positive colorectal cancer had a good prognosis.
REFERENCE   6  (bases 1 to 2788)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009690.17.
            
            On Nov 23, 2018 this sequence version replaced NM_001323532.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.244764.1,
                                           SRR1660809.205530.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000569795.6/ ENSP00000456348.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-162               AC009690.17        56304-56465         c
            163-427             AC009690.17        54934-55198         c
            428-624             AC009690.17        51386-51582         c
            625-702             AC009690.17        50656-50733         c
            703-797             AC009690.17        49808-49902         c
            798-858             AC009690.17        49324-49384         c
            859-949             AC009690.17        48992-49082         c
            950-1016            AC009690.17        48466-48532         c
            1017-1166           AC009690.17        45469-45618         c
            1167-1377           AC009690.17        44389-44599         c
            1378-1431           AC009690.17        43519-43572         c
            1432-1527           AC009690.17        41948-42043         c
            1528-1620           AC009690.17        41259-41351         c
            1621-1746           AC009690.17        40376-40501         c
            1747-1812           AC009690.17        38366-38431         c
            1813-1880           AC009690.17        37348-37415         c
            1881-1929           AC009690.17        35118-35166         c
            1930-2039           AC009690.17        34756-34865         c
            2040-2112           AC009690.17        33931-34003         c
            2113-2182           AC009690.17        33156-33225         c
            2183-2262           AC009690.17        26531-26610         c
            2263-2326           AC009690.17        26068-26131         c
            2327-2411           AC009690.17        25812-25896         c
            2412-2788           AC009690.17        25092-25468         c
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..2788
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /note="poly(ADP-ribose) polymerase family member 6"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
     exon            1..162
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            163..427
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            428..624
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..2514
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /EC_number="2.4.2.30"
                     /note="isoform 1 is encoded by transcript variant 14; poly
                     [ADP-ribose] polymerase 6; PARP-6; ADP-ribosyltransferase
                     diphtheria toxin-like 17; protein
                     mono-ADP-ribosyltransferase PARP6; MIEREN, class II"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP6
                     isoform 1"
                     /protein_id="NP_001310461.1"
                     /db_xref="CCDS:CCDS10241.2"
                     /db_xref="GeneID:56965"
                     /db_xref="HGNC:HGNC:26921"
                     /db_xref="MIM:619439"
                     /translation="MDIKGQFWNDDDSEGDNESEEFLYGVQGSCAADLYRHPQLDADI
                     EAVKEIYSENSVSIREYGTIDDVDIDLHINISFLDEEVSTAWKVLRTEPIVLRLRFSL
                     SQYLDGPEPSIEVFQPSNKEGFGLGLQLKKILGMFTSQQWKHLSNDFLKTQQEKRHSW
                     FKASGTIKKFRAGLSIFSPIPKSPSFPIIQDSMLKGKLGVPELRVGRLMNRSISCTMK
                     NPKVEVFGYPPSPQAGLLCPQHVGLPPPARTSPLVSGHCKNIPTLEYGFLVQIMKYAE
                     QRIPTLNEYCVVCDEQHVFQNGSMLKPAVCTRELCVFSFYTLGVMSGAAEEVATGAEV
                     VDLLVAMCRAALESPRKSIIFEPYPSVVDPTDPKTLAFNPKKKNYERLQKALDSVMSI
                     REMTQGSYLEIKKQMDKLDPLAHPLLQWIISSNRSHIVKLPLSRLKFMHTSHQFLLLS
                     SPPAKEARFRTAKKLYGSTFAFHGSHIENWHSILRNGLVNASYTKLQLHGAAYGKGIY
                     LSPISSISFGYSGMGKGQHRMPSKDELVQRYNRMNTIPQTRSIQSRFLQSRNLNCIAL
                     CEVITSKDLQKHGNIWVCPVSDHVCTRFFFVYEDGQVGDANINTQDPKIQKEIMRVIG
                     TQVYTN"
     exon            625..702
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            703..797
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            798..858
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            859..949
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1016
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1166
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1377
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1431
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1527
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1620
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1746
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1812
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1880
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1929
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2039
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2112
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2182
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2262
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2263..2326
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2327..2411
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     exon            2412..2788
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2753..2758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /note="hexamer: AATAAA"
     polyA_site      2788
                     /gene="PARP6"
                     /gene_synonym="ARTD17; PARP-6-B1; PARP-6-C; pART17"
                     /note="major polyA site"
ORIGIN      
        1 gtcccgggcc gctcgtcccg tcggctgcgg ccgcgcgcgg cccggggtcg ccgtgagtac
       61 tcgccaggct ggcctgtgtg gccgccacca cgggcacagg gcggtgcggc cgggccacgg
      121 gaagggtgcg gggctcgccc cgtctccgca ggggtggacg aacaacagaa accaagcagc
      181 aacagccctt ggaaagaggc taaatttttc ttgacttctg cagcaacaaa gaccgtgaaa
      241 agttggcact tctggcctaa cgctgccgtc atcctacccc tcaccccagg gcaacccagg
      301 ctggacattt agtgcctccc tctttattcc tctgtgatca tccagatcag cacttgactg
      361 tttattttca aatctcacga acctcacccc aagatcttca cattctggat ctcagctgct
      421 cttgaaggac agtgacttgt taccaccgca acagcagagc ctgccatccc caacagatca
      481 ccagttgtcc ctgacatcgt gccctacctt gtctcccttt gtggtctcct aaatgcccat
      541 ctcgttggcc ttggttcggc tagtggtatg gaggggtgct gcctagcact gacctgagag
      601 tgtgtgtgac ccactgaccc aatggacatc aaaggccagt tctggaatga tgacgactcg
      661 gagggagata atgaatcaga ggaatttctc tatggcgttc aggggagctg tgcagctgac
      721 ctgtatcgac acccacagct tgatgcagac attgaagccg tgaaggagat ctacagtgag
      781 aactctgtat ccatcagaga atatggaact atcgatgacg tggacattga cctccacatc
      841 aacatcagct tcctcgatga ggaagtctct acagcctgga aggtcctccg gacagaacct
      901 attgtgttga ggctgcgatt ttctctctcc cagtacctag atggaccaga accatccatt
      961 gaggttttcc agccatcaaa taaggaagga tttgggctgg gtcttcagtt gaaaaagatc
     1021 ctgggtatgt ttacatccca acaatggaaa catctgagca atgatttctt gaagacccag
     1081 caggagaaga ggcacagttg gttcaaggca agtggtacca tcaagaagtt ccgagctggc
     1141 ctcagcatct tttcacccat ccccaagtct cccagtttcc ctatcataca ggactccatg
     1201 ctgaaaggca aactaggtgt accagagctt cgggttgggc gcctcatgaa ccgttccatc
     1261 tcctgtacca tgaagaaccc caaagtggaa gtgtttggct accctcccag cccccaggca
     1321 ggtctcctgt gccctcagca cgtgggcctc cctcccccag cacggacctc tcctttggtc
     1381 agtggtcact gcaagaacat tcccactctg gagtatggat tcctcgttca gatcatgaag
     1441 tatgcagaac agaggattcc aacattgaat gagtactgtg tggtgtgtga tgagcagcat
     1501 gtcttccaaa atggatctat gctgaagcca gctgtctgta ctcgtgaact atgcgttttc
     1561 tccttctaca cactgggcgt catgtctgga gctgcagagg aggtggccac tggagcagag
     1621 gtggtggatc tgctggtggc catgtgtagg gcagctttag agtcccctag aaagagcatc
     1681 atctttgagc cttatccctc tgtggtggac cccactgatc ccaagactct ggcctttaac
     1741 cctaagaaga agaattatga gcggcttcag aaagctctgg atagtgtgat gtctattcgg
     1801 gagatgaccc agggctcata tttggaaatc aagaaacaga tggacaagtt ggatcccctg
     1861 gcccatcctc tcctgcagtg gatcatctct agcaacaggt cacacattgt caaactacct
     1921 ctcagcaggc tgaagttcat gcacacctca caccagttcc tcctgctgag cagccctcct
     1981 gccaaggagg ctcggttccg gaccgccaag aagctctatg gcagcacctt tgccttccat
     2041 gggtcccaca ttgagaactg gcattcgatc ctgcgcaatg ggctggtcaa tgcatcctac
     2101 accaaactgc agctgcatgg agcagcctat ggcaaaggca tctacctgag ccccatctcc
     2161 agtatttcct ttggatactc aggaatggga aaaggacagc acaggatgcc ctccaaggat
     2221 gagctggtcc agagatacaa caggatgaat accatccccc agacccgatc cattcagtca
     2281 cggttcctgc agagtcggaa tctaaactgt atagcacttt gtgaagtgat tacatctaag
     2341 gacctccaga agcatgggaa catctgggtg tgccctgtgt ccgaccatgt ctgcacaaga
     2401 ttcttctttg tatatgagga tggtcaggtg ggcgatgcca acattaatac tcaggacccc
     2461 aagatacaga aggaaatcat gcgtgtgatc ggaactcagg tttacacaaa ctgagggggc
     2521 cccagccctc gtaccacccc tgttacccca ggatccatct gccctcataa aagtgttcag
     2581 gtacagcagc tgaggctgcc ctgaggaatc aaggggccat taccaagggg caggaaaagg
     2641 atatgtaaga ggtggccttc atggtagagc ttgacccaag aactactcca cattcggatg
     2701 gcccagactg actccatccc ctgactttcc ctttgacttc accctgtttg taaataaaac
     2761 aataaaatgg aaggtgctgt ggactgga
//
