LOCUS       NM_006437               5437 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 4 (PARP4),
            mRNA.
ACCESSION   NM_006437
VERSION     NM_006437.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5437)
  AUTHORS   Lee,Y.F., Phua,C.Z.J., Yuan,J., Zhang,B., Lee,M.Y., Kannan,S.,
            Chiu,Y.H.J., Koh,C.W.Q., Yap,C.K., Lim,E.K.H., Chen,J., Lim,Y.,
            Lee,J.J.H., Skanderup,A.J., Wang,Z., Zhai,W., Tan,N.S., Verma,C.S.,
            Tay,Y., Tan,D.S.W. and Tam,W.L.
  TITLE     PARP4 interacts with hnRNPM to regulate splicing during lung cancer
            progression
  JOURNAL   Genome Med 16 (1), 91 (2024)
   PUBMED   39034402
  REMARK    GeneRIF: PARP4 interacts with hnRNPM to regulate splicing during
            lung cancer progression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5437)
  AUTHORS   Frigon,L. and Pascal,J.M.
  TITLE     Structural and biochemical analysis of the PARP1-homology region of
            PARP4/vault PARP
  JOURNAL   Nucleic Acids Res 51 (22), 12492-12507 (2023)
   PUBMED   37971310
  REMARK    GeneRIF: Structural and biochemical analysis of the PARP1-homology
            region of PARP4/vault PARP.
REFERENCE   3  (bases 1 to 5437)
  AUTHORS   Sung,H.Y., Han,J., Chae,Y.J., Ju,W., Lee Kang,J., Park,A.K. and
            Ahn,J.H.
  TITLE     Identification of a novel PARP4 gene promoter CpG locus associated
            with cisplatin chemoresistance
  JOURNAL   BMB Rep 56 (6), 347-352 (2023)
   PUBMED   37013346
  REMARK    GeneRIF: Identification of a novel PARP4 gene promoter CpG locus
            associated with cisplatin chemoresistance.
REFERENCE   4  (bases 1 to 5437)
  AUTHORS   Kim,J.H., Lee,S. and Hong,Y.C.
  TITLE     Modification Effect of PARP4 and ERCC1 Gene Polymorphisms on the
            Relationship between Particulate Matter Exposure and Fasting
            Glucose Level
  JOURNAL   Int J Environ Res Public Health 19 (10), 6241 (2022)
   PUBMED   35627777
  REMARK    GeneRIF: Modification Effect of PARP4 and ERCC1 Gene Polymorphisms
            on the Relationship between Particulate Matter Exposure and Fasting
            Glucose Level.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5437)
  AUTHORS   Pietras,P., Lesniczak-Staszak,M., Kasprzak,A., Andrzejewska,M.,
            Jopek,K., Sowinski,M., Rucinski,M., Lyons,S.M., Ivanov,P. and
            Szaflarski,W.
  TITLE     MVP Expression Facilitates Tumor Cell Proliferation and Migration
            Supporting the Metastasis of Colorectal Cancer Cells
  JOURNAL   Int J Mol Sci 22 (22), 12121 (2021)
   PUBMED   34829999
  REMARK    GeneRIF: MVP Expression Facilitates Tumor Cell Proliferation and
            Migration Supporting the Metastasis of Colorectal Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5437)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     Identification of a novel gene (ADPRTL1) encoding a potential
            Poly(ADP-ribosyl)transferase protein
  JOURNAL   Genomics 62 (3), 533-536 (1999)
   PUBMED   10644454
REFERENCE   7  (bases 1 to 5437)
  AUTHORS   Kickhoefer,V.A., Stephen,A.G., Harrington,L., Robinson,M.O. and
            Rome,L.H.
  TITLE     Vaults and telomerase share a common subunit, TEP1
  JOURNAL   J Biol Chem 274 (46), 32712-32717 (1999)
   PUBMED   10551828
REFERENCE   8  (bases 1 to 5437)
  AUTHORS   Kickhoefer,V.A., Siva,A.C., Kedersha,N.L., Inman,E.M., Ruland,C.,
            Streuli,M. and Rome,L.H.
  TITLE     The 193-kD vault protein, VPARP, is a novel poly(ADP-ribose)
            polymerase
  JOURNAL   J Cell Biol 146 (5), 917-928 (1999)
   PUBMED   10477748
REFERENCE   9  (bases 1 to 5437)
  AUTHORS   Jean,L., Risler,J.L., Nagase,T., Coulouarn,C., Nomura,N. and
            Salier,J.P.
  TITLE     The nuclear protein PH5P of the inter-alpha-inhibitor superfamily:
            a missing link between poly(ADP-ribose)polymerase and the
            inter-alpha-inhibitor family and a novel actor of DNA repair?
  JOURNAL   FEBS Lett 446 (1), 6-8 (1999)
   PUBMED   10100603
  REMARK    Review article
REFERENCE   10 (bases 1 to 5437)
  AUTHORS   Soares,M.B., Bonaldo,M.F., Jelene,P., Su,L., Lawton,L. and
            Efstratiadis,A.
  TITLE     Construction and characterization of a normalized cDNA library
  JOURNAL   Proc Natl Acad Sci U S A 91 (20), 9228-9232 (1994)
   PUBMED   7937745
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359763.9, DB238428.1,
            AF158255.1, BX479127.1, T10289.1, CV574448.1 and CA308288.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006437.3.
            
            Summary: This gene encodes poly(ADP-ribosyl)transferase-like 1
            protein, which is capable of catalyzing a poly(ADP-ribosyl)ation
            reaction. This protein has a catalytic domain which is homologous
            to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal
            DNA binding domain which activates the C-terminal catalytic domain
            of poly (ADP-ribosyl) transferase. Since this protein is not
            capable of binding DNA directly, its transferase activity may be
            activated by other factors such as protein-protein interaction
            mediated by the extensive carboxyl terminus. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF158255.1, SRR18074968.1484437.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381989.4/ ENSP00000371419.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AL359763.9         181036-181108       c
            74-587              DB238428.1         74-587
            588-1522            AF158255.1         620-1554
            1523-1774           BX479127.1         225-476
            1775-2636           AF158255.1         1807-2668
            2637-2832           AL359763.9         123347-123542       c
            2833-3088           T10289.1           12-267
            3089-3188           AL359763.9         118048-118147       c
            3189-3359           AL359763.9         115346-115516       c
            3360-3440           AL359763.9         115011-115091       c
            3441-3740           CV574448.1         262-561
            3741-4820           AL359763.9         102725-103804       c
            4821-5437           CA308288.1         18-634              c
FEATURES             Location/Qualifiers
     source          1..5437
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..5437
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /note="poly(ADP-ribose) polymerase family member 4"
                     /db_xref="GeneID:143"
                     /db_xref="HGNC:HGNC:271"
                     /db_xref="MIM:607519"
     exon            1..73
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            74..206
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..5249
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /EC_number="2.4.2.30"
                     /note="vault protein, 193-kDa; poly(ADP-ribose)
                     synthetase; ADP-ribosyltransferase (NAD+; poly
                     (ADP-ribose) polymerase)-like 1; von Willebrand factor A
                     domain containing 5C; PARP-related; I-alpha-I-related;
                     poly(ADP-ribosyl)transferase-like 1; H5 proline-rich; poly
                     [ADP-ribose] polymerase 4; ADP-ribosyltransferase
                     diphtheria toxin-like 4; 193 kDa vault protein; vault
                     poly(ADP-ribose) polymerase; PARP-related/IalphaI-related
                     H5/proline-rich"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP4"
                     /protein_id="NP_006428.2"
                     /db_xref="CCDS:CCDS9307.1"
                     /db_xref="GeneID:143"
                     /db_xref="HGNC:HGNC:271"
                     /db_xref="MIM:607519"
                     /translation="MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQ
                     CTHIILDNADVLSQYQLNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITP
                     PPDQKASSSEVKTEGLCPDSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKV
                     GMEGGQEAVVVELQCSRDSRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENY
                     IEELKKQGFLLREHFTPEATQLASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALG
                     HLEHMLLKPVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTM
                     PKEVNLGLLAKKADLCQLIRDMVNVCETNLSKPNPPSLAKYRALRCKIEHVEQNTEEF
                     LRVRKEVLQNHHSKSPVDVLQIFRVGRVNETTEFLSKLGNVRPLLHGSPVQNIVGILC
                     RGLLLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLICDVALG
                     KCMDLHEKDFSLTEAPPGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSM
                     PGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQLPDAKTSSSTKAGLQDASGNLVPLE
                     DVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGE
                     IKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGNLPPKAKVLIKITYITELSIL
                     GTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEFI
                     FSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEKHPEKESEAC
                     MLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQKVNI
                     IQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYLSLLYPARGSRNI
                     LLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCGAGVFEYFNAK
                     SKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFLNDRLLVYG
                     FIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGILHENET
                     SHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAKEDVD
                     FLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSEDFE
                     EDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
                     PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIP
                     QSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQ
                     LHFSLPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTT
                     PVDLCLLEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCF
                     LEVKEEDEIVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQK
                     GIQSLGVKGRECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEA
                     IKQASEWVRRTEGQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG"
     exon            207..408
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            409..475
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            476..551
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            552..665
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            666..815
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            816..953
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1127
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1288
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1426
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1522
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1706
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1707..1863
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1988
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            1989..2120
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2207
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2372
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2373..2419
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2498
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..2636
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2637..2832
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2833..2900
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            2901..3088
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3089..3188
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3359
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3440
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3441..3521
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3522..3617
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3618..3740
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            3741..4820
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4821..4920
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            4921..5053
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     exon            5054..5437
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5417..5422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /note="hexamer: AATAAA"
     polyA_site      5437
                     /gene="PARP4"
                     /gene_synonym="ADPRTL1; ARTD4; p193; PARP-4; PARPL; PH5P;
                     VAULT3; VPARP; VWA5C"
                     /note="major polyA site"
ORIGIN      
        1 agattacgga agtaccgcga gcaaggagcg cggaatcggg gagcgtccgg agctagctgg
       61 atcctctagg caggatggtg atgggaatct ttgcaaattg tatcttctgt ttgaaagtga
      121 agtacttacc tcagcagcag aagaaaaagc tacaaactga cattaaggaa aatggcggaa
      181 agttttcctt ttcgttaaat cctcagtgca cacatataat cttagataat gctgatgttc
      241 tgagtcagta ccaactgaat tctatccaaa agaaccacgt tcatattgca aacccagatt
      301 ttatatggaa atctatcagg gaaaagagac tcttggatgt aaagaattat gatccttata
      361 agcccctgga catcacacca cctcctgatc agaaggcgag cagttctgaa gtgaaaacag
      421 aaggtctatg cccggacagt gccacagagg aggaagacac tgtggaactc actgagtttg
      481 gtatgcagaa tgttgaaatt cctcatcttc ctcaagattt tgaagttgca aaatataaca
      541 ccttggagaa agtgggaatg gagggaggcc aggaagctgt ggtggtggag cttcagtgtt
      601 cgcgggactc cagggactgt cctttcctga tatcctcaca cttcctcctg gatgatggca
      661 tggagactag aagacagttt gctataaaga aaacctctga agatgcaagt gaatactttg
      721 aaaattacat tgaagaactg aagaaacaag gatttctact aagagaacat ttcacacctg
      781 aagcaaccca attagcatct gaacaattgc aagcattgct tttggaggaa gtcatgaatt
      841 caagcactct gagccaagag gtgagcgatt tagtagagat gatttgggca gaggccctgg
      901 gccacctgga acacatgctt ctcaagccag tgaacaggat tagcctcaac gatgtgagca
      961 aggcagaggg gattctcctt ctagtaaagg cagcactgaa aaatggagaa acagcagagc
     1021 aattgcaaaa gatgatgaca gagttttaca gactgatacc tcacaaaggc acaatgccca
     1081 aagaagtgaa cctgggacta ttggctaaga aagcagacct ctgccagcta ataagagaca
     1141 tggttaatgt ctgtgaaact aatttgtcca aacccaaccc accatccctg gccaaatacc
     1201 gagctttgag gtgcaaaatt gagcatgttg aacagaatac tgaagaattt ctcagggtta
     1261 gaaaagaggt tttgcagaat catcacagta agagcccagt ggatgtcttg cagatattta
     1321 gagttggcag agtgaatgaa accacagagt ttttgagcaa acttggtaat gtgaggccct
     1381 tgttgcatgg ttctcctgta caaaacatcg tgggaatctt gtgtcgaggg ttgcttttac
     1441 ccaaagtagt ggaagatcgt ggtgtgcaaa gaacagacgt cggaaacctt ggaagtggga
     1501 tttatttcag tgattcgctc agtacaagta tcaagtactc acacccggga gagacagatg
     1561 gcaccagact cctgctcatt tgtgacgtag ccctcggaaa gtgtatggac ttacatgaga
     1621 aggacttttc cttaactgaa gcaccaccag gctacgacag tgtgcatgga gtttcgcaaa
     1681 cagcctctgt caccacagac tttgaggatg atgaatttgt tgtctataaa accaatcagg
     1741 ttaaaatgaa atatattatt aaattttcca tgcctggaga tcagataaag gactttcatc
     1801 ctagtgatca tactgaatta gaggaataca gacctgagtt ttcaaatttt tcaaaggttg
     1861 aagattacca gttaccagat gccaaaactt ccagcagcac caaggccggc ctccaggatg
     1921 cctctgggaa cttggttcct ctggaggatg tccacatcaa agggagaatc atagacactg
     1981 tagcccaggt cattgttttt cagacataca caaataaaag tcacgtgccc attgaggcaa
     2041 aatatatctt tcctttggat gacaaggccg ctgtgtgtgg cttcgaagcc ttcatcaatg
     2101 ggaagcacat agttggagag attaaagaga aggaagaagc ccagcaagag tacctagaag
     2161 ccgtgaccca gggccatggc gcttacctga tgagtcagga tgctccggac gtttttactg
     2221 taagtgttgg aaacttaccc cctaaggcta aggttcttat aaaaattacc tacatcacag
     2281 aactcagcat cctgggcact gttggtgtct ttttcatgcc cgccaccgta gcaccctggc
     2341 aacaggacaa ggctttgaat gaaaaccttc aggatacagt agagaagatt tgtataaaag
     2401 aaataggaac aaagcaaagc ttctctttga ctatgtctat tgagatgccg tatgtgattg
     2461 aattcatttt cagtgataca catgaactga aacaaaagcg cacagactgc aaagctgtca
     2521 ttagcaccat ggaaggcagc tccttagaca gcagtggatt ttctctccac atcggtttgt
     2581 ctgctgccta tctcccaaga atgtgggttg aaaaacatcc agaaaaagaa agcgaggctt
     2641 gcatgcttgt ctttcaaccc gatctcgatg tcgacctccc tgacctagcc agtgagagcg
     2701 aagtgattat ttgtcttgac tgctccagtt ccatggaggg tgtgacattc ttgcaagcca
     2761 agcaaatcgc cttgcatgcg ctgtccttgg tgggtgagaa gcagaaagta aatattatcc
     2821 agttcggcac aggttacaag gagctatttt cgtatcctaa gcatatcaca agcaatacca
     2881 tggcagcaga gttcatcatg tctgccacac ctaccatggg gaacacagac ttctggaaaa
     2941 cactccgata tcttagctta ttgtaccctg ctcgagggtc acggaacatc ctcctggtgt
     3001 ctgatgggca cctccaggat gagagcctga cattacagct cgtgaagagg agccgcccgc
     3061 acaccaggtt attcgcctgc ggtatcggtt ctacagcaaa tcgtcacgtc ttaaggattt
     3121 tgtcccagtg tggtgccgga gtatttgaat attttaatgc aaaatccaag catagttgga
     3181 gaaaacagat agaagaccaa atgaccaggc tatgttctcc gagttgccac tctgtctccg
     3241 tcaaatggca gcaactcaat ccagatgtgc ccgaggccct gcaggcccca gcccaggtgc
     3301 cgtccttgtt tctcaatgat cgactccttg tctatggatt cattcctcac tgcacacagg
     3361 caactctgtg tgcactaatt caagagaaag aatttcgtac aatggtgtcg actactgagc
     3421 ttcagaagac aactggaact atgatccaca agctggcagc ccgagctcta atcagagatt
     3481 atgaagatgg cattcttcac gaaaatgaaa ccagtcatga gatgaaaaaa caaaccttga
     3541 aatctctgat tattaaactc agtaaagaaa actctctcat aacacaattt acaagctttg
     3601 tggcagttga gaaaagggat gagaatgagt cgccttttcc tgatattcca aaagtttctg
     3661 aacttattgc caaagaagat gtagacttcc tgccctacat gagctggcag ggggagcccc
     3721 aagaagccgt caggaaccag tctcttttag catcctctga gtggccagaa ttacgtttat
     3781 ccaaacgaaa acataggaaa attccatttt ccaaaagaaa aatggaatta tctcagccag
     3841 aagtttctga agattttgaa gaggatggct taggtgtact accagctttc acatcaaatt
     3901 tggaacgtgg aggtgtggaa aagctattgg atttaagttg gacagagtca tgtaaaccaa
     3961 cagcaactga accactattt aagaaagtca gtccatggga aacatctact tctagctttt
     4021 ttcctatttt ggctccggcc gttggttcct atcttccccc gactgcccgc gctcacagtc
     4081 ctgcttcctt gtcttttgcc tcatatcgtc aggtagctag tttcggttca gctgctcctc
     4141 ccagacagtt tgatgcatct caattcagcc aaggccctgt gcctggcact tgtgctgact
     4201 ggatcccaca gtcggcgtct tgtcccacag gacctcccca gaacccacct tcttcaccct
     4261 attgtggcat tgttttttca gggagctcat taagctctgc acagtctgct ccactgcaac
     4321 atcctggagg ctttactacc aggccttctg ctggcacctt ccctgagctg gattctcccc
     4381 agcttcattt ctctcttcct acagaccctg atcccatcag aggttttggg tcttatcatc
     4441 cctctgcttc ctctcctttt cattttcaac cttccgcagc ctctttgact gccaacctta
     4501 ggctgccaat ggcctctgct ttacctgagg ctctttgcag tcagtcccgg actaccccag
     4561 tagatctctg tcttctagaa gaatcagtag gcagtctcga aggaagtcga tgtcctgtct
     4621 ttgcttttca aagttctgac acagaaagtg atgagctatc agaagtactt caagacagct
     4681 gctttttaca aataaaatgt gatacaaaag atgacagtat cctgtgcttt ctggaagtaa
     4741 aagaagagga tgaaatagtg tgcatacaac actggcagga tgctgtgcct tggacagaac
     4801 tcctcagtct acagacagag gatggcttct ggaaacttac accagaactg ggacttatat
     4861 taaatcttaa tacaaatggt ttgcacagct ttcttaaaca aaaaggcatt caatctctag
     4921 gtgtaaaagg aagagaatgt ctcctggacc taattgccac aatgctggta ctacagttta
     4981 ttcgcaccag gttggaaaaa gagggaatag tgttcaaatc actgatgaaa atggatgacg
     5041 cttctatttc caggaatatt ccctgggctt ttgaggcaat aaagcaagca agtgaatggg
     5101 taagaagaac tgaaggacag tacccatcta tctgcccacg gcttgaactg gggaacgact
     5161 gggactctgc caccaagcag ttgctgggac tccagcccat aagcactgtg tcccctcttc
     5221 atagagtcct ccattacagt caaggctaag tcaaatgaaa ctgaatttta aactttttgc
     5281 atgcttctat gtagaaaata atcaaatgat aatagatact tataatgaaa cttcattaag
     5341 gtttcattca gtgtagcaat tactgtcttt aaaaattaag tggaagaaga attactttaa
     5401 tcaactaaca agcaataata aaatgaaact taaaata
//
