LOCUS       NM_001003931            2337 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 3 (PARP3),
            transcript variant 1, mRNA.
ACCESSION   NM_001003931
VERSION     NM_001003931.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   van Beek,L., McClay,E., Patel,S., Schimpl,M., Spagnolo,L. and Maia
            de Oliveira,T.
  TITLE     PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in
            DNA Damage Repair and Nucleosome Remodelling
  JOURNAL   Int J Mol Sci 22 (10), 5112 (2021)
   PUBMED   34066057
  REMARK    GeneRIF: PARP Power: A Structural Perspective on PARP1, PARP2, and
            PARP3 in DNA Damage Repair and Nucleosome Remodelling.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Suskiewicz,M.J., Palazzo,L., Hughes,R. and Ahel,I.
  TITLE     Progress and outlook in studying the substrate specificities of
            PARPs and related enzymes
  JOURNAL   FEBS J 288 (7), 2131-2142 (2021)
   PUBMED   32785980
  REMARK    GeneRIF: Progress and outlook in studying the substrate
            specificities of PARPs and related enzymes.
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2337)
  AUTHORS   Sharif-Askari,B., Amrein,L., Aloyz,R. and Panasci,L.
  TITLE     PARP3 inhibitors ME0328 and olaparib potentiate vinorelbine
            sensitization in breast cancer cell lines
  JOURNAL   Breast Cancer Res Treat 172 (1), 23-32 (2018)
   PUBMED   30039287
  REMARK    GeneRIF: Our results indicated this approach with PARP3 inhibitors
            and vinorelbine is unique and promising for breast cancer patients
            with metastases. This combination could significantly increase the
            survival of breast cancer patients with metastases
REFERENCE   5  (bases 1 to 2337)
  AUTHORS   Ji,M., Wang,L., Xue,N., Lai,F., Zhang,S., Jin,J. and Chen,X.
  TITLE     The Development of a Biotinylated NAD+-Applied Human
            Poly(ADP-Ribose) Polymerase 3 (PARP3) Enzymatic Assay
  JOURNAL   SLAS Discov 23 (6), 545-553 (2018)
   PUBMED   29676938
  REMARK    GeneRIF: The integral roles of PARP3 in DNA damage repair.
REFERENCE   6  (bases 1 to 2337)
  AUTHORS   Figueroa,J.D., Malats,N., Real,F.X., Silverman,D., Kogevinas,M.,
            Chanock,S., Welch,R., Dosemeci,M., Tardon,A., Serra,C., Carrato,A.,
            Garcia-Closas,R., Castano-Vinyals,G., Rothman,N. and
            Garcia-Closas,M.
  TITLE     Genetic variation in the base excision repair pathway and bladder
            cancer risk
  JOURNAL   Hum Genet 121 (2), 233-242 (2007)
   PUBMED   17203305
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2337)
  AUTHORS   Rouleau,M., McDonald,D., Gagne,P., Ouellet,M.E., Droit,A.,
            Hunter,J.M., Dutertre,S., Prigent,C., Hendzel,M.J. and Poirier,G.G.
  TITLE     PARP-3 associates with polycomb group bodies and with components of
            the DNA damage repair machinery
  JOURNAL   J Cell Biochem 100 (2), 385-401 (2007)
   PUBMED   16924674
  REMARK    GeneRIF: PARP-3 is a nuclear protein involved in transcriptional
            silencing and in the cellular response to DNA damage
REFERENCE   8  (bases 1 to 2337)
  AUTHORS   Augustin,A., Spenlehauer,C., Dumond,H., Menissier-De Murcia,J.,
            Piel,M., Schmit,A.C., Apiou,F., Vonesch,J.L., Kock,M., Bornens,M.
            and De Murcia,G.
  TITLE     PARP-3 localizes preferentially to the daughter centriole and
            interferes with the G1/S cell cycle progression
  JOURNAL   J Cell Sci 116 (Pt 8), 1551-1562 (2003)
   PUBMED   12640039
REFERENCE   9  (bases 1 to 2337)
  AUTHORS   Johansson,M.
  TITLE     A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA
            cloning of two novel poly(ADP-ribose) polymerase homologues
  JOURNAL   Genomics 57 (3), 442-445 (1999)
   PUBMED   10329013
REFERENCE   10 (bases 1 to 2337)
  AUTHORS   Bashford,C.L., Chance,B., Lloyd,D. and Poole,R.K.
  TITLE     Oscillations of redox states in synchronously dividing cultures of
            Acanthamoeba castellanii and Schizosaccharomyces pombe
  JOURNAL   Biophys J 29 (1), 1-11 (1980)
   PUBMED   7260241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CA394313.1, Y16836.1 and
            CA309713.1.
            
            On Jul 20, 2020 this sequence version replaced NM_001003931.3.
            
            Summary: The protein encoded by this gene belongs to the PARP
            family. These enzymes modify nuclear proteins by
            poly-ADP-ribosylation, which is required for DNA repair, regulation
            of apoptosis, and maintenance of genomic stability. This gene
            encodes the poly(ADP-ribosyl)transferase 3, which is preferentially
            localized to the daughter centriole throughout the cell cycle.
            Alternatively spliced transcript variants encoding different
            isoforms have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: Y16836.1, AY126341.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000398755.8/
                                                ENSP00000381740.4
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               CA394313.1         59-544
            487-1685            Y16836.1           504-1702
            1686-2337           CA309713.1         17-668              c
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..2337
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /note="poly(ADP-ribose) polymerase family member 3"
                     /db_xref="GeneID:10039"
                     /db_xref="HGNC:HGNC:273"
                     /db_xref="MIM:607726"
     exon            1..346
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            347..531
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             349..1950
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /EC_number="2.4.2.30"
                     /note="isoform a is encoded by transcript variant 1;
                     ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
                     polymerase)-like 2; ADP-ribosyltransferase (NAD+; poly
                     (ADP-ribose) polymerase)-like 3; NAD+
                     ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3;
                     poly [ADP-ribose] polymerase 3; ADPRT-3; poly[ADP-ribose]
                     synthetase 3; NAD(+) ADP-ribosyltransferase 3;
                     poly[ADP-ribose] synthase 3; ADP-ribosyltransferase
                     diphtheria toxin-like 3; DNA ADP-ribosyltransferase PARP3;
                     protein mono-ADP-ribosyltransferase PARP3"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP3
                     isoform a"
                     /protein_id="NP_001003931.4"
                     /db_xref="CCDS:CCDS43097.1"
                     /db_xref="GeneID:10039"
                     /db_xref="HGNC:HGNC:273"
                     /db_xref="MIM:607726"
                     /translation="MAPKPKPWVQTEGPEKKKGRQAGREEDPFRSTAEALKAIPAEKR
                     IIRVDPTCPLSSNPGTQVYEDYNCTLNQTNIENNNNKFYIIQLLQDSNRFFTCWNRWG
                     RVGEVGQSKINHFTRLEDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDE
                     AQEAVVKVDRGPVRTVTKRVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPL
                     GKLSKQQIARGFEALEALEEALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSP
                     ELLQAKKDMLLVLADIELAQALQAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAP
                     EYKVIQTYLEQTGSNHRCPTLQHIWKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVA
                     AILTSGLRIMPHSGGRVGKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREH
                     HINTDNPSLKSPPPGFDSVIARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSS
                     TFSQSEYLIYQESQCRLRYLLEVHL"
     exon            532..660
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            661..849
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            850..982
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1209
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1359
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1446
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1624
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1625..1780
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..2337
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2308..2313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /note="hexamer: CATAAA"
     polyA_site      2337
                     /gene="PARP3"
                     /gene_synonym="ADPRT3; ADPRTL2; ADPRTL3; ARTD3; IRT1;
                     PADPRT-3"
                     /note="major polyA site"
ORIGIN      
        1 accgcgcgac cggcagatgc gtgctgcagg ccccggccac atgagcagcg ctacggacgc
       61 gactgccccg gccttggata tgccagatcg agtgtccacc cgtccgtggg actggtcgcc
      121 tgactcggcc tgccccagcc tctgcttcac cccactggtg gccaaatagc cgatgtctaa
      181 tcccccacac aagctcatcc ccggcctctg gcgattgttg ggaattctct ccctaattca
      241 cgcctgaggc tcatggagag ttgctagacc tgggactgcc ctgggaggcg cacacaacca
      301 ggccgggtgg cagccaggac ctctcccatg tccctgcttt tcttggccat ggctccaaag
      361 ccgaagccct gggtacagac tgagggccct gagaagaaga agggccggca ggcaggaagg
      421 gaggaggacc ccttccgctc caccgctgag gccctcaagg ccatacccgc agagaagcgc
      481 ataatccgcg tggatccaac atgtccactc agcagcaacc ccgggaccca ggtgtatgag
      541 gactacaact gcaccctgaa ccagaccaac atcgagaaca acaacaacaa gttctacatc
      601 atccagctgc tccaagacag caaccgcttc ttcacctgct ggaaccgctg gggccgtgtg
      661 ggagaggtcg gccagtcaaa gatcaaccac ttcacaaggc tagaagatgc aaagaaggac
      721 tttgagaaga aatttcggga aaagaccaag aacaactggg cagagcggga ccactttgtg
      781 tctcacccgg gcaagtacac acttatcgaa gtacaggcag aggatgaggc ccaggaagct
      841 gtggtgaagg tggacagagg cccagtgagg actgtgacta agcgggtgca gccctgctcc
      901 ctggacccag ccacgcagaa gctcatcact aacatcttca gcaaggagat gttcaagaac
      961 accatggccc tcatggacct ggatgtgaag aagatgcccc tgggaaagct gagcaagcaa
     1021 cagattgcac ggggtttcga ggccttggag gcgctggagg aggccctgaa aggccccacg
     1081 gatggtggcc aaagcctgga ggagctgtcc tcacactttt acaccgtcat cccgcacaac
     1141 ttcggccaca gccagccccc gcccatcaat tcccctgagc ttctgcaggc caagaaggac
     1201 atgctgctgg tgctggcgga catcgagctg gcccaggccc tgcaggcagt ctctgagcag
     1261 gagaagacgg tggaggaggt gccacacccc ctggaccgag actaccagct tctcaagtgc
     1321 cagctgcagc tgctagactc tggagcacct gagtacaagg tgatacagac ctacttagaa
     1381 cagactggca gcaaccacag gtgccctaca cttcaacaca tctggaaagt aaaccaagaa
     1441 ggggaggaag acagattcca ggcccactcc aaactgggta atcggaagct gctgtggcat
     1501 ggcaccaaca tggccgtggt ggccgccatc ctcactagtg ggctccgcat catgccacat
     1561 tctggtgggc gtgttggcaa gggcatctac tttgcctcag agaacagcaa gtcagctgga
     1621 tatgttattg gcatgaagtg tggggcccac catgtcggct acatgttcct gggtgaggtg
     1681 gccctgggca gagagcacca tatcaacacg gacaacccca gcttgaagag cccacctcct
     1741 ggcttcgaca gtgtcattgc ccgaggccac accgagcctg atccgaccca ggacactgag
     1801 ttggagctgg atggccagca agtggtggtg ccccagggcc agcctgtgcc ctgcccagag
     1861 ttcagcagct ccacattctc ccagagcgag tacctcatct accaggagag ccagtgtcgc
     1921 ctgcgctacc tgctggaggt ccacctctga gtgcccgccc tgtcccccgg ggtcctgcaa
     1981 ggctggactg tgatcttcaa tcatcctgcc catctctggt acccctatat cactcctttt
     2041 tttcaagaat acaatacgtt gttgttaact atagtcacca tgctgtacaa gatccctgaa
     2101 cttatgcctc ctaactgaaa ttttgtattc tttgacacat ctgcccagtc cctctcctcc
     2161 cagcccatgg taaccagcat ttgactcttt acttgtataa gggcagcttt tataggttcc
     2221 acatgtaagt gagatcatgc agtgtttgtc tttctgtgcc tggcttattt cactcagcat
     2281 aatgtgcacc gggttcaccc atgttttcat aaatgacaag atttcctcct tttttaa
//
