LOCUS       NM_001042618            1827 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase 2 (PARP2), transcript
            variant 2, mRNA.
ACCESSION   NM_001042618
VERSION     NM_001042618.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Deeksha,W. and Rajakumara,E.
  TITLE     Regulatory apoptotic fragment of PARP1 complements catalytic
            fragment for PAR and DNA-dependent activity but inhibits
            DNA-induced catalytic stimulation of PARP2
  JOURNAL   DNA Repair (Amst) 133, 103593 (2024)
   PUBMED   38029688
  REMARK    GeneRIF: Regulatory apoptotic fragment of PARP1 complements
            catalytic fragment for PAR and DNA-dependent activity but inhibits
            DNA-induced catalytic stimulation of PARP2.
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Bilkis,R., Lake,R.J., Cooper,K.L., Tomkinson,A. and Fan,H.Y.
  TITLE     The CSB chromatin remodeler regulates PARP1- and PARP2-mediated
            single-strand break repair at actively transcribed DNA regions
  JOURNAL   Nucleic Acids Res 51 (14), 7342-7356 (2023)
   PUBMED   37326017
  REMARK    GeneRIF: The CSB chromatin remodeler regulates PARP1- and
            PARP2-mediated single-strand break repair at actively transcribed
            DNA regions.
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Antal,D., Por,A., Kovacs,I., Dull,K., Poliska,S., Ujlaki,G.,
            Demeny,M.A., Szollosi,A.G., Kiss,B., Szegedi,A., Bai,P. and
            Szanto,M.
  TITLE     PARP2 promotes inflammation in psoriasis by modulating estradiol
            biosynthesis in keratinocytes
  JOURNAL   J Mol Med (Berl) 101 (8), 987-999 (2023)
   PUBMED   37351597
  REMARK    GeneRIF: PARP2 promotes inflammation in psoriasis by modulating
            estradiol biosynthesis in keratinocytes.
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Bell,N.A.W. and Molloy,J.E.
  TITLE     Single-molecule force spectroscopy reveals binding and bridging
            dynamics of PARP1 and PARP2 at DNA double-strand breaks
  JOURNAL   Proc Natl Acad Sci U S A 120 (22), e2214209120 (2023)
   PUBMED   37216533
  REMARK    GeneRIF: Single-molecule force spectroscopy reveals binding and
            bridging dynamics of PARP1 and PARP2 at DNA double-strand breaks.
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Langelier,M.F., Billur,R., Sverzhinsky,A., Black,B.E. and
            Pascal,J.M.
  TITLE     HPF1 dynamically controls the PARP1/2 balance between initiating
            and elongating ADP-ribose modifications
  JOURNAL   Nat Commun 12 (1), 6675 (2021)
   PUBMED   34795260
  REMARK    GeneRIF: HPF1 dynamically controls the PARP1/2 balance between
            initiating and elongating ADP-ribose modifications.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Still,I.H., Vince,P. and Cowell,J.K.
  TITLE     Identification of a novel gene (ADPRTL1) encoding a potential
            Poly(ADP-ribosyl)transferase protein
  JOURNAL   Genomics 62 (3), 533-536 (1999)
   PUBMED   10644454
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Ame,J.C., Rolli,V., Schreiber,V., Niedergang,C., Apiou,F.,
            Decker,P., Muller,S., Hoger,T., Menissier-de Murcia,J. and de
            Murcia,G.
  TITLE     PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose)
            polymerase
  JOURNAL   J Biol Chem 274 (25), 17860-17868 (1999)
   PUBMED   10364231
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   Johansson,M.
  TITLE     A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA
            cloning of two novel poly(ADP-ribose) polymerase homologues
  JOURNAL   Genomics 57 (3), 442-445 (1999)
   PUBMED   10329013
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Berghammer,H., Ebner,M., Marksteiner,R. and Auer,B.
  TITLE     pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase
            gene related to truncated pADPRT homologues in plants and
            Caenorhabditis elegans
  JOURNAL   FEBS Lett 449 (2-3), 259-263 (1999)
   PUBMED   10338144
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Bashford,C.L., Chance,B., Lloyd,D. and Poole,R.K.
  TITLE     Oscillations of redox states in synchronously dividing cultures of
            Acanthamoeba castellanii and Schizosaccharomyces pombe
  JOURNAL   Biophys J 29 (1), 1-11 (1980)
   PUBMED   7260241
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA354586.1, AJ236912.1 and
            BU541261.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 21, 2020 this sequence version replaced NM_001042618.1.
            
            Summary: This gene encodes poly(ADP-ribosyl)transferase-like 2
            protein, which contains a catalytic domain and is capable of
            catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a
            catalytic domain which is homologous to that of poly (ADP-ribosyl)
            transferase, but lacks an N-terminal DNA binding domain which
            activates the C-terminal catalytic domain of poly (ADP-ribosyl)
            transferase. The basic residues within the N-terminal region of
            this protein may bear potential DNA-binding properties, and may be
            involved in the nuclear and/or nucleolar targeting of the protein.
            Two alternatively spliced transcript variants encoding distinct
            isoforms have been found. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) lacks an internal segment in
            the 5' coding region, as compared to variant 1. The reading frame
            is not changed but the transcript encodes 13 aa less than variant
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290079.1, AJ236912.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429687.8/ ENSP00000392972.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA354586.1         22-26
            6-1759              AJ236912.1         1-1754
            1760-1827           BU541261.1         660-727
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1827
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /note="poly(ADP-ribose) polymerase 2"
                     /db_xref="GeneID:10038"
                     /db_xref="HGNC:HGNC:272"
                     /db_xref="MIM:607725"
     exon            1..53
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1720
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /EC_number="2.4.2.30"
                     /note="isoform 2 is encoded by transcript variant 2; poly
                     (ADP-ribose) polymerase family, member 2;
                     ADP-ribosyltransferase (NAD+; poly(ADP-ribose)
                     polymerase)-like 2; poly (ADP-ribosyl) transferase-like 2;
                     ADPRT-2; hPARP-2; poly[ADP-ribose] synthetase 2; NAD(+)
                     ADP-ribosyltransferase 2; poly[ADP-ribose] synthase 2;
                     ADP-ribosyltransferase diphtheria toxin-like 2; DNA
                     ADP-ribosyltransferase PARP2; protein
                     poly-ADP-ribosyltransferase PARP2"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 2 isoform 2"
                     /protein_id="NP_001036083.1"
                     /db_xref="CCDS:CCDS45077.1"
                     /db_xref="GeneID:10038"
                     /db_xref="HGNC:HGNC:272"
                     /db_xref="MIM:607725"
                     /translation="MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQR
                     QESKKMPVAGGKANKDRTEDKQDESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVY
                     DVMLNQTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAK
                     EIFQKKFLDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPE
                     SQLDLRVQELIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCI
                     RAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLV
                     KTELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLF
                     EVEKDGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYF
                     ADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKM
                     APSSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNF
                     LQLW"
     exon            54..209
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            210..280
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..331
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            332..428
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            429..504
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            505..607
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..770
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            771..909
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..973
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1108
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1236
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1336
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1435
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1560
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1561..1827
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /note="hexamer: AATAAA"
     polyA_site      1827
                     /gene="PARP2"
                     /gene_synonym="ADPRT2; ADPRTL2; ADPRTL3; ARTD2; pADPRT-2;
                     PARP-2"
                     /note="major polyA site"
ORIGIN      
        1 gaattccatg gcggcgcggc ggcgacggag caccggcggc ggcagggcga gagcattaaa
       61 tgaaagcaaa agagttaata atggcaacac ggctccagaa gactcttccc ctgccaagaa
      121 aactcgtaga tgccagagac aggagtcgaa aaagatgcct gtggctggag gaaaagctaa
      181 taaggacagg acagaagaca agcaagatga atctgtgaag gccttgctgt taaagggcaa
      241 agctcctgtg gacccagagt gtacagccaa ggtggggaag gctcatgtgt attgtgaagg
      301 aaatgatgtc tatgatgtca tgctaaatca gaccaatctc cagttcaaca acaacaagta
      361 ctatctgatt cagctattag aagatgatgc ccagaggaac ttcagtgttt ggatgagatg
      421 gggccgagtt gggaaaatgg gacagcacag cctggtggct tgttcaggca atctcaacaa
      481 ggccaaggaa atctttcaga agaaattcct tgacaaaacg aaaaacaatt gggaagatcg
      541 agaaaagttt gagaaggtgc ctggaaaata tgatatgcta cagatggact atgccaccaa
      601 tactcaggat gaagaggaaa caaagaaaga ggaatctctt aaatctccct tgaagccaga
      661 gtcacagcta gatcttcggg tacaggagtt aataaagttg atctgtaatg ttcaggccat
      721 ggaagaaatg atgatggaaa tgaagtataa taccaagaaa gccccacttg ggaagctgac
      781 agtggcacaa atcaaggcag gttaccagtc tcttaagaag attgaggatt gtattcgggc
      841 tggccagcat ggacgagctc tcatggaagc atgcaatgaa ttctacacca ggattccgca
      901 tgactttgga ctccgtactc ctccactaat ccggacacag aaggaactgt cagaaaaaat
      961 acaattacta gaggctttgg gagacattga aattgctatt aagctggtga aaacagagct
     1021 acaaagccca gaacacccat tggaccaaca ctatagaaac ctacattgtg ccttgcgccc
     1081 ccttgaccat gaaagttatg agttcaaagt gatttcccag tacctacaat ctacccatgc
     1141 tcccacacac agcgactata ccatgacctt gctggatttg tttgaagtgg agaaggatgg
     1201 tgagaaagaa gccttcagag aggaccttca taacaggatg cttctatggc atggttccag
     1261 gatgagtaac tgggtgggaa tcttgagcca tgggcttcga attgccccac ctgaagctcc
     1321 catcacaggt tacatgtttg ggaaaggaat ctactttgct gacatgtctt ccaagagtgc
     1381 caattactgc tttgcctctc gcctaaagaa tacaggactg ctgctcttat cagaggtagc
     1441 tctaggtcag tgtaatgaac tactagaggc caatcctaag gccgaaggat tgcttcaagg
     1501 taaacatagc accaaggggc tgggcaagat ggctcccagt tctgcccact tcgtcaccct
     1561 gaatgggagt acagtgccat taggaccagc aagtgacaca ggaattctga atccagatgg
     1621 ttataccctc aactacaatg aatatattgt atataacccc aaccaggtcc gtatgcggta
     1681 ccttttaaag gttcagttta atttccttca gctgtggtga atgttgatat taaataaacc
     1741 agagatctga tcttcaagca agaaaataag cagtgttgta cttgtgaatt ttgtgatatt
     1801 ttatgtaata aaaactgtac aggtcta
//
