LOCUS       NM_001316943            2734 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 16 (PARP16),
            transcript variant 2, mRNA.
ACCESSION   NM_001316943 XM_005254516
VERSION     NM_001316943.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2734)
  AUTHORS   Su,H., Xu,J., Su,Z., Xiao,C., Wang,J., Zhong,W., Meng,C., Yang,D.
            and Zhu,Y.
  TITLE     Poly (ADP-ribose) polymerases 16 triggers pathological cardiac
            hypertrophy via activating IRE1alpha-sXBP1-GATA4 pathway
  JOURNAL   Cell Mol Life Sci 80 (6), 161 (2023)
   PUBMED   37219631
  REMARK    GeneRIF: Poly (ADP-ribose) polymerases 16 triggers pathological
            cardiac hypertrophy via activating IRE1alpha-sXBP1-GATA4 pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2734)
  AUTHORS   Challa,S., Khulpateea,B.R., Nandu,T., Camacho,C.V., Ryu,K.W.,
            Chen,H., Peng,Y., Lea,J.S. and Kraus,W.L.
  TITLE     Ribosome ADP-ribosylation inhibits translation and maintains
            proteostasis in cancers
  JOURNAL   Cell 184 (17), 4531-4546 (2021)
   PUBMED   34314702
REFERENCE   3  (bases 1 to 2734)
  AUTHORS   Kunhiraman,H., Ramachandran,V., Edatt,L. and Sameer Kumar,V.B.
  TITLE     Regulation of poly ADP-ribosylation of VEGF by an interplay between
            PARP-16 and TNKS-2
  JOURNAL   Mol Cell Biochem 471 (1-2), 15-27 (2020)
   PUBMED   32472322
  REMARK    GeneRIF: Regulation of poly ADP-ribosylation of VEGF by an
            interplay between PARP-16 and TNKS-2.
REFERENCE   4  (bases 1 to 2734)
  AUTHORS   Di Girolamo,M.
  TITLE     Regulation of nucleocytoplasmic transport by ADP-ribosylation: the
            emerging role of karyopherin-beta1 mono-ADP-ribosylation by ARTD15
  JOURNAL   Curr Top Microbiol Immunol 384, 189-209 (2015)
   PUBMED   25037261
  REMARK    GeneRIF: ARTD15 plays role in nucleocytoplasmic shuttling, through
            karyopherin-beta1 mono-ADP-ribosylation. [review]
            Review article
REFERENCE   5  (bases 1 to 2734)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2734)
  AUTHORS   Jwa,M. and Chang,P.
  TITLE     PARP16 is a tail-anchored endoplasmic reticulum protein required
            for the PERK- and IRE1alpha-mediated unfolded protein response
  JOURNAL   Nat Cell Biol 14 (11), 1223-1230 (2012)
   PUBMED   23103912
  REMARK    GeneRIF: PARP16 is a tail-anchored endoplasmic reticulum protein
            required for the PERK- and IRE1alpha-mediated unfolded protein
            response.
            Erratum:[Nat Cell Biol. 2013 Jan;15(1):123]
REFERENCE   7  (bases 1 to 2734)
  AUTHORS   Di Paola,S., Micaroni,M., Di Tullio,G., Buccione,R. and Di
            Girolamo,M.
  TITLE     PARP16/ARTD15 is a novel endoplasmic-reticulum-associated
            mono-ADP-ribosyltransferase that interacts with, and modifies
            karyopherin-ss1
  JOURNAL   PLoS One 7 (6), e37352 (2012)
   PUBMED   22701565
REFERENCE   8  (bases 1 to 2734)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 2734)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068213.7, AK000516.1, DA110379.1 and BC031074.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001316943.1.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice junction in the 3' end compared to variant 1. The resulting
            isoform (2) has the same N- and C-termini but is 1 aa shorter
            compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031074.1, AK058010.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649807.2/ ENSP00000496935.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                AC068213.7         9695-9734
            41-177              AK000516.1         1-137
            178-393             DA110379.1         1-216
            394-1017            BC031074.1         3-626
            1018-1018           AC068213.7         33299-33299
            1019-1294           BC031074.1         628-903
            1295-1821           AK000516.1         910-1436
            1822-1822           AC068213.7         37567-37567
            1823-2734           AK000516.1         1438-2349
FEATURES             Location/Qualifiers
     source          1..2734
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..2734
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /note="poly(ADP-ribose) polymerase family member 16"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
     exon            1..631
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     CDS             458..1426
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /EC_number="2.4.2.30"
                     /note="isoform 2 is encoded by transcript variant 2; poly
                     [ADP-ribose] polymerase 16; PARP-16;
                     ADP-ribosyltransferase diphtheria toxin-like 15; mono
                     [ADP-ribose] polymerase PARP16; protein
                     mono-ADP-ribosyltransferase PARP16"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP16
                     isoform 2"
                     /protein_id="NP_001303872.1"
                     /db_xref="CCDS:CCDS92018.1"
                     /db_xref="GeneID:54956"
                     /db_xref="HGNC:HGNC:26040"
                     /db_xref="MIM:620391"
                     /translation="MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFP
                     ASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGK
                     AEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFH
                     SIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVI
                     DHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPP
                     KRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR"
     exon            632..769
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     exon            770..976
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1148
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1290
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..2734
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /note="hexamer: AATAAA"
     polyA_site      2734
                     /gene="PARP16"
                     /gene_synonym="ARTD15; C15orf30; pART15"
                     /note="major polyA site"
ORIGIN      
        1 ggaaggcgcg cgcggcgcag cagcctcgcc cgtcgcggag agtgggctct gcccgccgtc
       61 ccccgggggc tgcttcccgc cccaggcctc cgcggaggac acgtgtcagc acgttcccgc
      121 ggttgtcatt ccattgtcat agcccttccc ctaggccggg aacccctccc ccccaccagc
      181 cccagttcct ttatccctgg gcccaacctc cccgccgacc cgcggtccag gcctcggtct
      241 ctctcttcgg cggcgagccg cggcccagac cccggcagag gacacttgtc ggcacgttct
      301 cacccctgtc atctcagccc cctgcctagc tccaccccag gcttgggaac ccggcccctg
      361 acggcccatt gtccgcgggc ccagcccccg cgctgaacgc acgctcgccc ttgcccctaa
      421 ccagcgcgtc taccccggca acgcgcagtg acctgggatg cagccctcag gctgggcggc
      481 cgccagggag gcggcgggcc gcgacatgct ggccgccgac ctccggtgca gcctcttcgc
      541 ctcggccctg cagagctaca agcgcgactc ggtgctgcgg cccttccccg cgtcctacgc
      601 ccgcggcgac tgtaaggact ttgaagccct gcttgcagat gccagcaagt tacctaacct
      661 gaaagaactt ctccagtcct ccggagacaa ccacaaacgg gcctgggacc tggtgagctg
      721 gattttatcc tcaaaggtcc tgacaatcca cagtgcaggg aaggcagagt ttgaaaagat
      781 ccaaaagctg actggggctc ctcacacgcc tgttcctgca ccggacttcc tgtttgaaat
      841 tgagtacttt gacccagcca acgccaaatt ttatgagacc aaaggagaac gagacctaat
      901 ctatgcattt catggtagcc gcctagaaaa cttccattcc attatccaca atggcctgca
      961 ctgccatctg aacaagacat ccttgttcgg agaggggacc tacctcacca gtgacttgag
     1021 cctggccctc atatacagcc cccatggcca tgggtggcag cacagcctcc tcggccccat
     1081 ccttagctgt gtggccgtgt gtgaggtcat tgaccatccg gacgtcaagt gccaaaccaa
     1141 gaagaaggat tccaaggaga tagatcgcag acgagcgaga atcaaacata gtgaaggggg
     1201 agacatccct cccaagtact tcgtggtcac caataaccag ctgctgcgag tgaagtacct
     1261 cctggtgtat tcacagaagc cacccaagag ggcttcgagc cagctctcct ggttttccag
     1321 ccattggttt accgtcatga tatccctgta tctgctgctg ctgctcatag tgagtgtcat
     1381 caactcctct gctttccaac acttttggaa tcgtgcgaaa agataatctt tctgggcctg
     1441 gtgtgggggc tacctcaact atgtgcctta tggtaacttg ttctgtacct cctatgcctc
     1501 atgtccagcc aggttgagcc taggggccag ttgggggacc acaggacaat tttcatatgg
     1561 cctaaatgta tccattgcct ttgatgatgt tcccagccat actccagtca acggggacta
     1621 ctagtccctc actcttaggt tttaggggag tccttccatc tgctccttct taaactgtcc
     1681 tagggagttg gcttttcagc cagggccaaa ggaaaaagcc ctgctgcatt taaaaacaaa
     1741 gtgtccaagc tgtcagtggt gtgtttacaa tctctcctgg cagaggttgg ccctttctct
     1801 aatgccttct ggaaggcgga aaatgtggga actataaatc actaggcggt tgccttgttt
     1861 tgacttgaga cacccaagag gaacagtcat gtttctcata aaaatcagtg ggatcatttt
     1921 tgaattccat cagcctttgt atgtgagtgc aaaacatttt aacagttttc tcaaatcaac
     1981 aaacagcctt ctcctatagc tgtacttgcc cccctcccca aaaaaccatg gatgagaaag
     2041 aaaggagtca ggggcctgat aaaaaataca gacttaatga gcaactcaag atgagaaaac
     2101 tgctcttttt ccaaaaatta ccaactgctg attacagctg aaatggaacc aaatgtttgt
     2161 tttctgattt ttttttaata gctgtttaac aaattagtct ttgctgagta aaaggggaaa
     2221 tttctaaacc tagtgcactg tttggccagt gtccacagcc tcttttctgg ctgtgtttta
     2281 gagaaaggga tttgagctat aggctcgcct cctgttctca ttctcacaaa gctgccttga
     2341 ctgtggcctg caaccacgag tgccatgctt tcaggtcttc tgtggcctac tggccttcaa
     2401 gacagaggcc tgccccagtg tgccacagat ccatgtggat ggagcctcct tcagaggggt
     2461 cacaggtctt tgagactcag cctgggcttt aatgtgtagg aaaagccttc tggccaccca
     2521 gagagccgga gccctgcttg ctgtattctc tgctcccttc ttcctgctgg gttttagcca
     2581 taatagggcc cggtacgatt tgggagtgac atttctgtaa agaagaggaa aaatcatttt
     2641 tctataattt gtaaagttgt gaaagagcca ctaccacagt ttttacattg attattggaa
     2701 catttcagaa taaataaaga tattttctta atga
//
