LOCUS       NM_001113523            5002 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 15 (PARP15),
            transcript variant 1, mRNA.
ACCESSION   NM_001113523
VERSION     NM_001113523.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5002)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5002)
  AUTHORS   Lee,M.K., Cheong,H.S., Koh,Y., Ahn,K.S., Yoon,S.S. and Shin,H.D.
  TITLE     Genetic Association of PARP15 Polymorphisms with Clinical Outcome
            of Acute Myeloid Leukemia in a Korean Population
  JOURNAL   Genet Test Mol Biomarkers 20 (11), 696-701 (2016)
   PUBMED   27610459
  REMARK    GeneRIF: The current study investigated the possible association
            between PARP15 single-nucleotide polymorphisms and the risk of
            acute myeloid leukemia (AML). The results from a Cox regression
            analysis for overall survival revealed that two polymorphisms
            associated with increased overall survival and the signal for
            rs17208928 was retained after correcting for multiple tests.
            rs17208928 showed a significant association with survival
REFERENCE   3  (bases 1 to 5002)
  AUTHORS   Karlberg,T., Klepsch,M., Thorsell,A.G., Andersson,C.D., Linusson,A.
            and Schuler,H.
  TITLE     Structural basis for lack of ADP-ribosyltransferase activity in
            poly(ADP-ribose) polymerase-13/zinc finger antiviral protein
  JOURNAL   J Biol Chem 290 (12), 7336-7344 (2015)
   PUBMED   25635049
REFERENCE   4  (bases 1 to 5002)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5002)
  AUTHORS   Teumer,A., Holtfreter,B., Volker,U., Petersmann,A., Nauck,M.,
            Biffar,R., Volzke,H., Kroemer,H.K., Meisel,P., Homuth,G. and
            Kocher,T.
  TITLE     Genome-wide association study of chronic periodontitis in a general
            German population
  JOURNAL   J Clin Periodontol 40 (11), 977-985 (2013)
   PUBMED   24024966
REFERENCE   6  (bases 1 to 5002)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
REFERENCE   7  (bases 1 to 5002)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 5002)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 5002)
  AUTHORS   Aguiar,R.C., Takeyama,K., He,C., Kreinbrink,K. and Shipp,M.A.
  TITLE     B-aggressive lymphoma family proteins have unique domains that
            modulate transcription and exhibit poly(ADP-ribose) polymerase
            activity
  JOURNAL   J Biol Chem 280 (40), 33756-33765 (2005)
   PUBMED   16061477
  REMARK    GeneRIF: BAL macro domains repress transcription when tethered to a
            promoter; BAL2 and BAL3, but not BAL1, exhibit PARP activity
REFERENCE   10 (bases 1 to 5002)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK309863.1, BX647656.1, DQ063586.1, BC101701.1, AK097916.1 and
            AC092908.9.
            
            On Nov 22, 2018 this sequence version replaced NM_001113523.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ063586.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000464300.7/ ENSP00000417214.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AK309863.1         49-189
            142-561             BX647656.1         166-585
            562-2108            DQ063586.1         529-2075
            2109-2143           BC101701.1         1484-1518
            2144-2644           AK097916.1         1456-1956
            2645-4740           AC092908.9         61431-63526         c
            4741-5002           BX647656.1         4180-4441
FEATURES             Location/Qualifiers
     source          1..5002
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..5002
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /note="poly(ADP-ribose) polymerase family member 15"
                     /db_xref="GeneID:165631"
                     /db_xref="HGNC:HGNC:26876"
                     /db_xref="MIM:612066"
     exon            1..204
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     CDS             19..2055
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /EC_number="2.4.2.30"
                     /note="isoform 1 is encoded by transcript variant 1; poly
                     [ADP-ribose] polymerase 15; B-aggressive lymphoma 3;
                     PARP-15; B-aggressive lymphoma protein 3;
                     ADP-ribosyltransferase diphtheria toxin-like 7; protein
                     mono-ADP-ribosyltransferase PARP15"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP15
                     isoform 1"
                     /protein_id="NP_001106995.1"
                     /db_xref="CCDS:CCDS46893.1"
                     /db_xref="GeneID:165631"
                     /db_xref="HGNC:HGNC:26876"
                     /db_xref="MIM:612066"
                     /translation="MAAPGPLPAAALSPGAPTPRELMHGVAGVTSRAGRDREAGSVLP
                     AGNRGARKASRRSSSRSMSRDNKFSKKDCLSIRNVVASIQTKEGLNLKLISGDVLYIW
                     ADVIVNSVPMNLQLGGGPLSRAFLQKAGPMLQKELDDRRRETEEKVGNIFMTSGCNLD
                     CKAVLHAVAPYWNNGAETSWQIMANIIKKCLTTVEVLSFSSITFPMIGTGSLQFPKAV
                     FAKLILSEVFEYSSSTRPITSPLQEVHFLVYTNDDEGCQAFLDEFTNWSRINPNKARI
                     PMAGDTQGVVGTVSKPCFTAYEMKIGAITFQVATGDIATEQVDVIVNSTARTFNRKSG
                     VSRAILEGAGQAVESECAVLAAQPHRDFIITPGGCLKCKIIIHVPGGKDVRKTVTSVL
                     EECEQRKYTSVSLPAIGTGNAGKNPITVADNIIDAIVDFSSQHSTPSLKTVKVVIFQP
                     ELLNIFYDSMKKRDLSASLNFQSTFSMTTCNLPEHWTDMNHQLFCMVQLEPGQSEYNT
                     IKDKFTRTCSSYAIEKIERIQNAFLWQSYQVKKRQMDIKNDHKNNERLLFHGTDADSV
                     PYVNQHGFNRSCAGKNAVSYGKGTYFAVDASYSAKDTYSKPDSNGRKHMYVVRVLTGV
                     FTKGRAGLVTPPPKNPHNPTDLFDSVTNNTRSPKLFVVFFDNQAYPEYLITFTA"
     exon            205..324
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            325..561
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            562..789
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            790..868
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1018
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1081
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1249
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1456
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1590
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1765
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..5002
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2624..2629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /note="hexamer: ATTAAA"
     polyA_site      2642
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
     regulatory      4976..4981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /note="hexamer: ATTAAA"
     polyA_site      5002
                     /gene="PARP15"
                     /gene_synonym="ARTD7; BAL3; pART7"
                     /note="major polyA site"
ORIGIN      
        1 agtcccagcg agctgaggat ggctgcgcca ggcccccttc ctgccgctgc tctgagtcca
       61 ggggctccga cccccagaga acttatgcac ggagttgcag gtgttacttc cagagccgga
      121 cgagatcggg aggcggggag cgtgctgccg gccgggaacc gtggggcgcg gaaggcctcc
      181 cggcgctctt cctcccggag tatgtccaga gacaacaagt tcagcaagaa agattgtctt
      241 tcaatcagga atgttgtagc ttcaatccaa accaaagaag gtctgaatct caagttgata
      301 agtggagatg ttctgtacat ctgggccgat gtcattgtca acagcgttcc catgaatctt
      361 cagcttggag gaggaccact atctcgggca tttttgcaga aagctggtcc catgctccag
      421 aaagagttag atgacagaag gcgggaaaca gaggaaaaag taggtaacat attcatgaca
      481 agcggctgca atctggactg caaagctgtg ctccatgctg tggctccata ctggaataat
      541 ggagcagaga cttcttggca gatcatggca aatataatca agaaatgttt gacaactgta
      601 gaagtgctat ctttctcatc aatcacattt cccatgattg gaacaggaag tttgcagttt
      661 cccaaagctg tttttgctaa actaatcctt tcagaagtgt tcgaatacag tagcagcaca
      721 aggccgataa ctagcccttt acaagaagtc cactttctgg tatatacaaa tgacgatgaa
      781 ggctgtcagg catttttaga tgaattcact aactggtcaa gaataaatcc caacaaggcc
      841 aggattccca tggcaggaga tacccaaggt gtggtcggga ctgtctctaa gccttgtttc
      901 acagcatatg aaatgaaaat cggtgcaatt acttttcagg ttgctactgg agatatagcc
      961 actgaacagg tagatgttat tgtaaactca acagcaagga catttaatcg gaaatcaggt
     1021 gtgtcaagag ctattttaga aggtgctgga caagctgtgg aaagtgaatg tgctgtacta
     1081 gctgcacagc ctcacagaga ttttataatt acaccaggtg gatgcttaaa gtgcaaaata
     1141 ataattcatg ttcctggggg aaaagatgtc aggaaaacgg tcaccagtgt tctagaagag
     1201 tgtgaacaga ggaagtacac atcggtttcc cttccagcca ttggaacagg aaatgccgga
     1261 aaaaacccta tcacagttgc tgataacata atcgatgcta ttgtagactt ctcatcacaa
     1321 cattccaccc catcattaaa aacagttaaa gttgtcattt ttcaacctga gctgctaaat
     1381 atattctacg acagcatgaa aaaaagagac ctctctgcat cactgaactt tcagtccaca
     1441 ttctccatga ctacatgtaa tcttcctgaa cactggactg acatgaatca tcagctgttt
     1501 tgcatggtcc agctagagcc aggacaatca gaatataata ccataaagga caagttcacc
     1561 cgaacttgtt cttcctacgc aatagagaag attgagagga tacagaatgc atttctctgg
     1621 cagagctacc aggtaaagaa aaggcaaatg gatatcaaga atgaccataa gaataatgag
     1681 agactcctct tccatgggac agatgcagac tcagtgccat atgtcaatca gcacggcttt
     1741 aatagaagtt gtgctgggaa aaatgctgta tcctatggaa aaggaaccta ttttgctgtg
     1801 gatgccagtt attctgccaa ggacacctac tccaagccag acagcaatgg gagaaagcac
     1861 atgtacgttg tgcgagtact tactggagtc ttcacaaagg gacgtgcagg attagtcacc
     1921 cctccaccca agaatcctca caatcccaca gatctctttg actcagtgac aaacaataca
     1981 cgatctccaa agctatttgt ggtattcttt gataatcagg cttacccaga atatctcata
     2041 actttcacgg cttaaaaata tttttatcat caaagagatg atttaagtca tctgtaagaa
     2101 caacatgcaa tctttgtctt tgcttctggc ctgtgtaagc agatgaaagt ttccctttta
     2161 ggtgccaaaa tgctgaaaat taccttttta aagtgctcta ttgctgcgat ttgtagcata
     2221 cctttttttc tcagcaaatt gatgggtgga agctgagaaa tgtatggtaa atgtcacaga
     2281 gctacaacca ttcacagaca ccaaatctct aggagaataa aaagcacatt attctttttc
     2341 tatcagaaaa aaacaagatg catcacctta aaaccaagat gacattgttc ttcttggaac
     2401 atgttaagac atcgaatggt ggcgggttaa actgtactgc ttaagtggag cggctaccgt
     2461 tatgcatcta tcacagttgg ggattttgcc ttattaagga aaacttgtca atagttcagc
     2521 tgaaatgact gaatcacaga atattaactc tgttatggaa caaatcataa cagattttac
     2581 ctgtttacat ttcaggtaaa aatgtatcgc attgttatct aatattaaaa aattaccccc
     2641 aattttagtg acttaatccc acacagtctt tatgggtcag gaattcaggc atggcttacc
     2701 tggatcattc tgctagggtc tctctgaagt tacagacaag atgtcagggg atgtggtcgt
     2761 ttgaaggctt gtctgggctg gaggtctatt tccaaggtga atcactcaca tacctggcac
     2821 gtttctgtca ggtattggca gtcctcagtt cctctcctct caggcctctc cacaggctgc
     2881 ttgagtgtcc tcatgacaca acagttggct tactccagag tgagcaactc aagagagagc
     2941 aaggcagaag ctaccaaatc tttatgtttg aagtcatgca ccatcttttc cacgagtatc
     3001 ctgttgatta ttttgatcag cttgttcagt ctgggaggga attgcacaag ggcatgaata
     3061 ctccactggc aaggatcatt gggggccatc ttggaagctg tgtgaatgag caaatgaatg
     3121 cacagataga atattagcag tgacaatgat gctagaggtc acctacccca ctgtcctctt
     3181 gtccttctcc cccaaccctc ccctgctccc aggcaagaag ccctctagcc tctgcttgat
     3241 cactttcagc actcaacatc ttcagggaac ctattccgcc gtgggacagt gttaattagt
     3301 ggaaaactct ttttcaaaag ttgaaatcag ttcctctgtg tctattacct gctgatcact
     3361 gtccagactt ctggaggaca cagagcaagt tttattcctc ttactgatgg tagcctttca
     3421 gatccatccc ttccctccag tatattagag ttacgtaaat tcttaaaatg cttagcagct
     3481 catttatcct gaagcatcac ttttgaagag ttacagacat ttaagaagta tttacattat
     3541 cataaataaa ttacatgcgc atttaaagag aacagaaaag tataaagaaa aataactcac
     3601 caaactcact cataattcca gcactaaggg aaaaccactg ccaatttctc atgtctccct
     3661 tccagtttct tctctgtcca aattcaacaa agtcaaaatc acattttgtt ctgtcacaaa
     3721 tcatataata ttatttctac catttttctt tttttaatct ttttttatta tactttaagt
     3781 tttagggtac atgtgcacaa tgtgcagttt agttacatat gtaaacatgt gccatgttgg
     3841 tgtgctgcac ccagtaactc atcatttagc attaggtata tctccaaatg ctatccctct
     3901 cccctctccc caccccacaa caggccccgg tgtgtgatgt tccccttcct gtgtccatgt
     3961 gttctcattg ttcaattccc acctgtgagt gagaacatgt ggtgtttggt tttttgtcct
     4021 tgcgatagtt tgctgagaat gatggtttcc agcttcatcc atgtccctac aaaggacatg
     4081 aactcatcat tttttatggc tgcatagtat tccatggtgt atatgtgcca cattttctta
     4141 atccagtcta tcattgttgg acatttgggt tggttccaag tctttgctat tgtgaatagt
     4201 gccgcaataa acatacgtgt gcatgtgtct ttacagcagc atgatttata atcctttggg
     4261 tatataccca gtaatgggat tgctgggtca aatggtattt ctagttctag atccccgagg
     4321 aatcgccaca ctgacttcca caatggttga actagtttac agtcccacca acagtgtaaa
     4381 agtgttccta tttctccaca tcctctccag cacctgttgc ttcctaactt tttaatgatt
     4441 gccattctaa cgggtgtggg atggtatctc attgttgttt tgatttgcat ttctctgatg
     4501 gccagtgatg atgagcattt tttcatgtgt tttttggctg cataaatgtc ttcttttgag
     4561 aagtgtccgt tcatatcctt tgcccacttt ttgatggggt tctttgtttt tttcttgtat
     4621 atttgtttga gttcattgta gattctggat attagccctt tgtcagatga gtagattgca
     4681 aaaattttct cccattctgt aggttgcctg ttcactctga tggtagtttc ttttgttgta
     4741 cagaagctct ttagtttaat tagatcccat atttctacca tttttcatta aacattacaa
     4801 gttgttctct tgtgttctta ttttttctgt aaacataatt ttaatggcag agatattctg
     4861 ctttatatct ttccctattt tatgtatata gaattataaa gtttttaaaa atgtaatcat
     4921 cattatttat agtttaataa tcagtttcat cttgcagtgt atcattttcc tcgtcattaa
     4981 atattttacg tatcattttt aa
//
