LOCUS       NM_017554               7694 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 14 (PARP14),
            mRNA.
ACCESSION   NM_017554 XM_291055
VERSION     NM_017554.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7694)
  AUTHORS   Zhang,H., Wang,H., Hu,Y., Gao,Y., Chen,J., Meng,Y., Qiu,Y., Hu,R.,
            Liao,P., Li,M., He,Y., Liang,Z., Xie,X. and Li,Y.
  TITLE     Targeting PARP14 with lomitapide suppresses drug resistance through
            the activation of DRP1-induced mitophagy in multiple myeloma
  JOURNAL   Cancer Lett 588, 216802 (2024)
   PUBMED   38467180
  REMARK    GeneRIF: Targeting PARP14 with lomitapide suppresses drug
            resistance through the activation of DRP1-induced mitophagy in
            multiple myeloma.
REFERENCE   2  (bases 1 to 7694)
  AUTHORS   Zhang,L., Chen,W., Shi,Z. and Shang,Z.
  TITLE     PARP14 correlates with GBM proliferation and poor prognosis by
            elevating expression of SAMD/SAMD9L
  JOURNAL   Ir J Med Sci 193 (2), 585-593 (2024)
   PUBMED   37612499
  REMARK    GeneRIF: PARP14 correlates with GBM proliferation and poor
            prognosis by elevating expression of SAMD/SAMD9L.
REFERENCE   3  (bases 1 to 7694)
  AUTHORS   Sturniolo,I., Varoczy,C., Regdon,Z., Mazlo,A., Muzsai,S., Bacsi,A.,
            Intili,G., Hegedus,C., Boothby,M.R., Holechek,J., Ferraris,D.,
            Schuler,H. and Virag,L.
  TITLE     PARP14 Contributes to the Development of the Tumor-Associated
            Macrophage Phenotype
  JOURNAL   Int J Mol Sci 25 (7), 3601 (2024)
   PUBMED   38612413
  REMARK    GeneRIF: PARP14 Contributes to the Development of the
            Tumor-Associated Macrophage Phenotype.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7694)
  AUTHORS   Wang,H., Luo,S., Wu,X., Ruan,Y., Qiu,L., Feng,H., Zhu,S., You,Y.,
            Li,M., Yang,W., Zhao,Y., Tao,X. and Jiang,H.
  TITLE     Exploration of glycosyltransferases mutation status in cervical
            cancer reveals PARP14 as a potential prognostic marker
  JOURNAL   Glycoconj J 40 (5), 513-522 (2023)
   PUBMED   37650946
  REMARK    GeneRIF: Exploration of glycosyltransferases mutation status in
            cervical cancer reveals PARP14 as a potential prognostic marker.
REFERENCE   5  (bases 1 to 7694)
  AUTHORS   Iansante,V., Choy,P.M., Fung,S.W., Liu,Y., Chai,J.G., Dyson,J., Del
            Rio,A., D'Santos,C., Williams,R., Chokshi,S., Anders,R.A.,
            Bubici,C. and Papa,S.
  TITLE     PARP14 promotes the Warburg effect in hepatocellular carcinoma by
            inhibiting JNK1-dependent PKM2 phosphorylation and activation
  JOURNAL   Nat Commun 6, 7882 (2015)
   PUBMED   26258887
  REMARK    GeneRIF: The PARP14-JNK1-PKM2 regulatory axis is an important
            determinant for the Warburg effect in tumour cells and provides a
            mechanistic link between apoptosis and metabolism.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7694)
  AUTHORS   Kleine,H., Poreba,E., Lesniewicz,K., Hassa,P.O., Hottiger,M.O.,
            Litchfield,D.W., Shilton,B.H. and Luscher,B.
  TITLE     Substrate-assisted catalysis by PARP10 limits its activity to
            mono-ADP-ribosylation
  JOURNAL   Mol Cell 32 (1), 57-69 (2008)
   PUBMED   18851833
REFERENCE   7  (bases 1 to 7694)
  AUTHORS   Goenka,S., Cho,S.H. and Boothby,M.
  TITLE     Collaborator of Stat6 (CoaSt6)-associated poly(ADP-ribose)
            polymerase activity modulates Stat6-dependent gene transcription
  JOURNAL   J Biol Chem 282 (26), 18732-18739 (2007)
   PUBMED   17478423
  REMARK    GeneRIF: PARP enzymatic activity is associated with CoaSt6, and
            this function of CoaSt6 can append ADP-ribose to itself and p100
REFERENCE   8  (bases 1 to 7694)
  AUTHORS   Schreiber,V., Dantzer,F., Ame,J.C. and de Murcia,G.
  TITLE     Poly(ADP-ribose): novel functions for an old molecule
  JOURNAL   Nat Rev Mol Cell Biol 7 (7), 517-528 (2006)
   PUBMED   16829982
  REMARK    Review article
REFERENCE   9  (bases 1 to 7694)
  AUTHORS   Aguiar,R.C., Takeyama,K., He,C., Kreinbrink,K. and Shipp,M.A.
  TITLE     B-aggressive lymphoma family proteins have unique domains that
            modulate transcription and exhibit poly(ADP-ribose) polymerase
            activity
  JOURNAL   J Biol Chem 280 (40), 33756-33765 (2005)
   PUBMED   16061477
  REMARK    GeneRIF: BAL macro domains repress transcription when tethered to a
            promoter; BAL2 and BAL3, but not BAL1, exhibit PARP activity
REFERENCE   10 (bases 1 to 7694)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092908.9 and AC048348.25.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_017554.2.
            
            Summary: This gene encodes a member of the poly(ADP-ribose)
            polymerase (PARP) protein family. The encoded anti-apoptotic
            protein may regulate aerobic glycolysis and promote survival of
            cancer cells. Increased expression of this gene has been reported
            in a variety of tumor types. [provided by RefSeq, Jul 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.20960.1,
                                           SRR1803611.274198.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000474629.7/ ENSP00000418194.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-232               AC092908.9         19146-19377         c
            233-366             AC092908.9         14898-15031         c
            367-400             AC092908.9         13103-13136         c
            401-643             AC092908.9         7673-7915           c
            644-880             AC092908.9         4554-4790           c
            881-1706            AC092908.9         1-826               c
            1707-3126           AC048348.25        97445-98864         c
            3127-3363           AC048348.25        95102-95338         c
            3364-3585           AC048348.25        94332-94553         c
            3586-3664           AC048348.25        90812-90890         c
            3665-3814           AC048348.25        85507-85656         c
            3815-3877           AC048348.25        85146-85208         c
            3878-4045           AC048348.25        84651-84818         c
            4046-4252           AC048348.25        80803-81009         c
            4253-4852           AC048348.25        80122-80721         c
            4853-4986           AC048348.25        78692-78825         c
            4987-5161           AC048348.25        71094-71268         c
            5162-7694           AC048348.25        68240-70772         c
FEATURES             Location/Qualifiers
     source          1..7694
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q21.1"
     gene            1..7694
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /note="poly(ADP-ribose) polymerase family member 14"
                     /db_xref="GeneID:54625"
                     /db_xref="HGNC:HGNC:29232"
                     /db_xref="MIM:610028"
     exon            1..232
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..5451
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /EC_number="2.4.2.30"
                     /note="collaborator of STAT6; poly [ADP-ribose] polymerase
                     14; B-aggressive lymphoma 2; b aggressive lymphoma protein
                     2; ADP-ribosyltransferase diphtheria toxin-like 8"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP14"
                     /protein_id="NP_060024.2"
                     /db_xref="CCDS:CCDS46894.1"
                     /db_xref="GeneID:54625"
                     /db_xref="HGNC:HGNC:29232"
                     /db_xref="MIM:610028"
                     /translation="MAVPGSFPLLVEGSWGPDPPKNLNTKLQMYFQSPKRSGGGECEV
                     RQDPRSPSRFLVFFYPEDVRQKVLERKNHELVWQGKGTFKLTVQLPATPDEIDHVFEE
                     ELLTKESKTKEDVKEPDVSEELDTKLPLDGGLDKMEDIPEECENISSLVAFENLKANV
                     TDIMLILLVENISGLSNDDFQVEIIRDFDVAVVTFQKHIDTIRFVDDCTKHHSIKQLQ
                     LSPRLLEVTNTIRVENLPPGADDYSLKLFFENPYNGGGRVANVEYFPEESSALIEFFD
                     RKVLDTIMATKLDFNKMPLSVFPYYASLGTALYGKEKPLIKLPAPFEESLDLPLWKFL
                     QKKNHLIEEINDEMRRCHCELTWSQLSGKVTIRPAATLVNEGRPRIKTWQADTSTTLS
                     SIRSKYKVNPIKVDPTMWDTIKNDVKDDRILIEFDTLKEMVILAGKSEDVQSIEVQVR
                     ELIESTTQKIKREEQSLKEKMIISPGRYFLLCHSSLLDHLLTECPEIEICYDRVTQHL
                     CLKGPSADVYKAKCEIQEKVYTMAQKNIQVSPEIFQFLQQVNWKEFSKCLFIAQKILA
                     LYELEGTTVLLTSCSSEALLEAEKQMLSALNYKRIEVENKEVLHGKKWKGLTHNLLKK
                     QNSSPNTVIINELTSETTAEVIITGCVKEVNETYKLLFNFVEQNMKIERLVEVKPSLV
                     IDYLKTEKKLFWPKIKKVNVQVSFNPENKQKGILLTGSKTEVLKAVDIVKQVWDSVCV
                     KSVHTDKPGAKQFFQDKARFYQSEIKRLFGCYIELQENEVMKEGGSPAGQKCFSRTVL
                     APGVVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKAAGPELQADCDQIVKRE
                     GRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEAPRCVYLLRRAVQLSLCLAEKYKYR
                     SIAIPAISSGVFGFPLGRCVETIVSAIKENFQFKKDGHCLKEIYLVDVSEKTVEAFAE
                     AVKTVFKATLPDTAAPPGLPPAAAGPGKTSWEKGSLVSPGGLQMLLVKEGVQNAKTDV
                     VVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRY
                     VLHVVAPEWRNGSTSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAE
                     LIISEVFKFSSKNQLKTLQEVHFLLHPSDHENIQAFSDEFARRANGNLVSDKIPKAKD
                     TQGFYGTVSSPDSGVYEMKIGSIIFQVASGDITKEEADVIVNSTSNSFNLKAGVSKAI
                     LECAGQNVERECSQQAQQRKNDYIITGGGFLRCKNIIHVIGGNDVKSSVSSVLQECEK
                     KNYSSICLPAIGTGNAKQHPDKVAEAIIDAIEDFVQKGSAQSVKKVKVVIFLPQVLDV
                     FYANMKKREGTQLSSQQSVMSKLASFLGFSKQSPQKKNHLVLEKKTESATFRVCGENV
                     TCVEYAISWLQDLIEKEQCPYTSEDECIKDFDEKEYQELNELQKKLNINISLDHKRPL
                     IKVLGISRDVMQARDEIEAMIKRVRLAKEQESRADCISEFIEWQYNDNNTSHCFNKMT
                     NLKLEDARREKKKTVDVKINHRHYTVNLNTYTATDTKGHSLSVQRLTKSKVDIPAHWS
                     DMKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQAKKKTMD
                     AKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRSYAGKNAVAYGKGTYFAVNANYSANDT
                     YSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYDTVTDNVHHPSLFV
                     AFYDYQAYPEYLITFRK"
     exon            233..366
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            367..400
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            401..643
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            644..880
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            881..3126
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3127..3363
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3364..3585
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3664
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3665..3814
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3877
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            3878..4045
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            4046..4252
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            4253..4852
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            4853..4986
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            4987..5161
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     exon            5162..7694
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7672..7677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /note="hexamer: AATAAA"
     polyA_site      7694
                     /gene="PARP14"
                     /gene_synonym="ARTD8; BAL2; PARP-14; pART8"
                     /note="major polyA site"
ORIGIN      
        1 ggagttggcg cggcccctgc agtccggcgg agagcggagc tgaggatggc tgtgcccggc
       61 tccttcccgc tgctggtcga gggctcctgg ggccccgacc ccccgaagaa cttgaacacc
      121 aagttgcaga tgtacttcca gagcccgaag aggtcgggag gcggcgagtg tgaggtccgc
      181 caggatccca ggagcccatc ccgcttcctg gtgttcttct acccggagga cgttcggcag
      241 aaggttctgg agagaaaaaa tcatgagttg gtatggcaag gaaaaggaac attcaagtta
      301 actgtccagt tacctgcaac cccagatgaa atcgatcatg tctttgaaga ggaacttcta
      361 acaaaagaat ccaagaccaa agaagatgtt aaagaaccag atgtgtcaga agaattggat
      421 acaaaactcc ctcttgatgg tggattagac aaaatggaag atatcccaga ggaatgtgaa
      481 aatatttcct ctttggtggc atttgaaaac ctcaaggcaa atgtgactga cataatgcta
      541 atcttgttag tggagaacat aagtggcctg tctaatgatg actttcaagt ggaaataata
      601 agagattttg atgttgctgt tgttaccttt caaaagcaca tagatactat aagatttgtt
      661 gatgattgta ccaagcacca ttcaattaaa caacttcagc tttctccaag acttctggaa
      721 gtgacaaaca caatcagggt tgaaaacctg ccacctggtg ctgatgacta cagtttaaaa
      781 cttttctttg aaaatcccta taatggaggg ggaagagttg ccaatgttga atattttcct
      841 gaagagagtt cagctctgat tgaatttttt gacagaaaag tgttagacac catcatggcc
      901 acaaaactcg acttcaataa aatgccactt tctgtgttcc catactatgc ctcattgggc
      961 acagccttgt atggaaagga gaagcctctg atcaagcttc cagcaccatt tgaagagtca
     1021 ctagatcttc ccttatggaa gttcttacag aaaaagaatc acctcattga ggagataaac
     1081 gatgaaatga ggcgttgtca ctgtgagctc acgtggtccc aactcagtgg taaagttacc
     1141 atcagaccag cagccacctt agtcaatgaa ggaagaccga gaatcaagac ctggcaggca
     1201 gatacttcca caacactctc tagcatcagg tctaaatata aagtcaaccc aattaaagtg
     1261 gatccaacaa tgtgggacac cataaaaaat gatgtgaaag atgacaggat tttgattgag
     1321 tttgatacac ttaaggagat ggtaatctta gcagggaaat cagaggatgt ccaaagcatt
     1381 gaggtacaag tcagggagtt aatagaaagc actactcaaa aaattaaaag ggaagagcaa
     1441 agtttgaagg aaaaaatgat catttctcca ggcaggtatt ttcttttgtg tcacagcagt
     1501 ctactggacc atttactcac ggagtgccca gagatagaga tttgttacga tagagtcact
     1561 caacacttgt gcttgaaagg acctagtgca gatgtgtata aagcaaagtg tgaaatccag
     1621 gaaaaggtgt acaccatggc tcagaaaaac attcaggttt ctcctgagat ttttcagttt
     1681 ttgcaacagg taaactggaa agaattctct aagtgtcttt tcatagcaca gaagattctt
     1741 gcactttatg agctagaggg tacaactgtt ctcttaacca gctgttcttc tgaagccctg
     1801 ttagaagcag aaaagcaaat gctcagtgcc ttaaattata agcgcattga agttgagaac
     1861 aaagaagttc ttcatggcaa gaaatggaaa gggctcactc acaatttgct taagaaacaa
     1921 aattcctccc caaacactgt aatcatcaat gagttaactt cagaaaccac agctgaagtc
     1981 atcattacag gctgtgtaaa agaagtaaat gaaacctata aattgctttt taacttcgtt
     2041 gaacaaaaca tgaaaataga gagactggtt gaagtaaagc cttccttagt tattgactat
     2101 ttaaagacag aaaagaagct attctggcca aagataaaga aggtaaatgt gcaggtaagt
     2161 ttcaatcctg agaacaaaca aaaaggcatt ttactaactg gctcaaagac cgaagtactg
     2221 aaggcagtgg acattgtcaa gcaagtctgg gattcagtct gtgttaaaag tgtccatact
     2281 gataagccag gagccaagca gttcttccag gataaagcac ggttttatca aagtgagatc
     2341 aaacggttgt ttggttgtta cattgaacta caggagaatg aagtaatgaa ggagggaggc
     2401 agccccgctg ggcagaagtg cttctctcgg acagtcttgg cccctggcgt tgtgctgatt
     2461 gtgcagcagg gtgacttggc acggcttcct gtcgatgtgg tggtgaatgc atctaatgag
     2521 gaccttaagc attatggtgg cctggccgct gcgctctcaa aagcagctgg ccctgagctc
     2581 caggccgact gtgaccagat agtgaagaga gagggcagac tcctaccggg caatgccacc
     2641 atctccaagg caggaaagct gccctaccac cacgtgatcc atgcagtggg gccccgctgg
     2701 agcggatatg aggccccgag gtgtgtgtac ctattaagga gagctgtgca actcagtctc
     2761 tgtctagccg aaaaatacaa gtaccgatcc atagccatcc cagctattag ttctggagtc
     2821 tttggctttc ccttaggccg atgcgtggag accattgttt ctgccatcaa ggaaaacttc
     2881 caattcaaga aggatggaca ctgcttgaaa gaaatctacc ttgtggatgt atctgagaag
     2941 actgttgagg cctttgcaga agctgtgaaa actgtattta aagccaccct gccagataca
     3001 gctgccccgc caggtttacc accagcagca gcggggcctg ggaaaacatc atgggaaaaa
     3061 ggaagcctgg tgtccccggg aggcctgcag atgctgttgg tgaaagaggg tgtgcagaat
     3121 gctaagaccg atgttgttgt caactccgtt cccttggatc tcgtgcttag tagagggcct
     3181 ctttctaagt ccctcttgga aaaagctgga ccagagctcc aggaggaatt ggacacagtt
     3241 ggacaagggg tggctgtcag catgggcaca gtgctcaaaa ccagcagctg gaatctggac
     3301 tgtcgctatg tgcttcacgt ggtagctccg gagtggagaa atggtagcac atcttcactc
     3361 aagataatgg aagacataat cagagaatgt atggagatca ctgagagctt gtccttaaaa
     3421 tcaattgcat ttccagcaat aggaacagga aacttgggat ttcctaaaaa catattcgct
     3481 gaattaatca tttcagaggt gttcaaattt agtagcaaga atcagctgaa aactttacaa
     3541 gaggttcact ttctgctgca cccgagtgat catgaaaata ttcaggcatt ttcagatgaa
     3601 tttgccagaa gggctaatgg aaatctcgtc agtgacaaaa ttccgaaggc taaagataca
     3661 caaggttttt atgggactgt ttctagccct gattcaggtg tgtatgaaat gaagattggc
     3721 tccatcatct tccaggtggc ttctggagat atcacgaaag aagaggcaga tgtgattgta
     3781 aattcaacat caaactcatt caatctcaaa gcaggggtct ccaaagcaat tttagaatgt
     3841 gctggacaaa atgtagaaag ggaatgttct cagcaagctc agcagcgcaa aaatgattat
     3901 ataatcaccg gaggtggatt tttgaggtgc aagaatatca ttcatgtaat tggtggaaat
     3961 gatgtcaaga gttcagtttc ctctgttttg caggagtgtg aaaaaaaaaa ttactcatcc
     4021 atttgcctcc cagccattgg gacaggaaat gccaaacaac acccagataa ggttgctgaa
     4081 gccataattg atgccattga agactttgtc cagaaaggat cagcccagtc tgtgaaaaaa
     4141 gttaaagttg ttatctttct gcctcaagta ctggatgtgt tttatgccaa catgaagaaa
     4201 agagaaggga ctcagctttc ttcccaacag tctgtgatgt ctaaacttgc atcatttttg
     4261 ggcttttcaa agcaatctcc ccaaaaaaag aatcatttgg ttttggaaaa gaaaacagaa
     4321 tcagcaactt ttcgggtgtg tggtgaaaat gtcacgtgtg tggaatatgc tatctcctgg
     4381 ctacaagacc tgattgaaaa agaacagtgt ccttacacca gtgaagatga gtgcatcaaa
     4441 gactttgatg aaaaggagta tcaggagttg aatgagctgc agaagaagtt aaatattaac
     4501 atttccctgg accataagag acctttgatt aaggttttgg gaattagcag agatgtgatg
     4561 caggctagag atgaaattga ggcgatgatc aagagagttc gattggccaa agaacaggaa
     4621 tcccgggcag attgtatcag tgagtttata gaatggcagt ataatgacaa taacacttct
     4681 cattgtttta acaaaatgac caatctgaaa ttagaggatg caaggagaga aaagaaaaaa
     4741 acagttgatg tcaaaattaa tcatcggcac tacacagtga acttgaacac atacactgcc
     4801 acagacacaa agggccacag tttatctgtt cagcgcctca cgaaatccaa agttgacatc
     4861 cctgcacact ggagtgatat gaagcagcag aatttctgtg tggtggagct gctgcctagt
     4921 gatcctgagt acaacacggt ggcaagcaag tttaatcaga cctgctcaca cttcagaata
     4981 gagaagattg agaggatcca gaatccagat ctctggaata gctaccaggc aaagaaaaaa
     5041 actatggatg ccaagaatgg ccagacaatg aatgagaagc aactcttcca tgggacagat
     5101 gccggctccg tgccacacgt caatcgaaat ggctttaacc gcagctatgc cggaaagaat
     5161 gctgtggcat atggaaaggg aacctatttt gctgtcaatg ccaattattc tgccaatgat
     5221 acgtactcca gaccagatgc aaatgggaga aagcatgtgt attatgtgcg agtacttact
     5281 ggaatctata cacatggaaa tcattcatta attgtgcctc cttcaaagaa ccctcaaaat
     5341 cctactgacc tgtatgacac tgtcacagat aatgtgcacc atccaagttt atttgtggca
     5401 ttttatgact accaagcata cccagagtac cttattacgt ttagaaaata acactttggt
     5461 atccttccca caaaattatt ctccatttgt acatatctag ttgtaaaaca agttttagct
     5521 ttttttttta attcctctta acagattttt ctaatatcca aggatcattc tttgtcgctg
     5581 aagtcagtct ttcttcagct tccctttcat aatggaaatg aacttattat cttgagagca
     5641 aataacttgg aaaatttaaa tgagataatg cagttgcaac tgtgtgtcca caagtatgga
     5701 catcaaatct gtgggaaaag aacaggtttg tattttcagg aaggagagaa taacagtctt
     5761 atagacagag ggcacagcta agcacagctg ccactgcagg agacaggccc catgtcagga
     5821 tgccatagtg ctgtggggag cacagtatta cccagtgggt agggcttctg tcttccctgg
     5881 gagcagggat ggtatcttag tcaatttttt tcccttgaga tgaggtctgt gcctgatgta
     5941 caacggatac tccataaatg tttgacaaac caacgaagaa tgaaaaaaag cctagtcaga
     6001 ctcccatcca aagtaggaac tatctcttta acattcttga ctcactatca ctttacctca
     6061 aattgaacag attccatgac ggaacttcat tcttcacaaa ctagccagtg acatgtggga
     6121 cagctctggc cagggctctg ggactgcagt gtacttgcgc tctgcacggt ccaggagctg
     6181 tgatgtggct gtggtctagg ggaatcctgc ctgccccatg gagttgcgca gcacaaccct
     6241 ggctccaatt gccagaaggc tctttttaat gctgaaccaa aatgtgcctt tttttttttt
     6301 tttttgagat ggagtttcac tcttgttgcc caggctggag tgcaatggcg cgatctcagc
     6361 tcactgcagc cactgcctcc caggttcaag tgattctcct gcctcagcct cccgagtagc
     6421 tgggattaca ggcatgcgct aacacaccca gctaattttg tatttttagt agagacgagg
     6481 tttctccatg ttcgacaggc tggtctcgaa ctcccacctc agcctcccaa actgctggga
     6541 ttacaggtgt gagccaccgt gaccagccaa tgtgccttct tatagtgtct actcattggt
     6601 ctttgttctg cccagtgata acaatgggat aacgcctgct acacatcttc attgtgaaac
     6661 ccttcccctg tgctgagatt aaatgaactc taagattatt aaatagtata ttttccttga
     6721 cagcctagcg tttgatgatt ttaaagcctt atgtataaat aaaccaaagg aagtaagcag
     6781 tcatattgct aatttgctaa ctcctatcta ttgaatggtg aagttttaaa aatttcccca
     6841 ggtaagttta agattcaaac accatctatt gagcacctac attgtgtgcc aggtagtaaa
     6901 ataggtgctt tcatacacat tgtctcaatt cctgtgaggt cagaattatc tctgcatttg
     6961 aaacttgagg aaacatgctc agagtgcaag aagcttcctt gcctgagatc acctagaaag
     7021 gaaccctcag agccggcaac tgaatcttgg tccctgtgat gtcaagccca ttgctctccc
     7081 actgcagaac atggcctcta gattaatgcc accgattcag gaacacctcc gacagtcttg
     7141 aaataccccc atgttgcctt gtttgttttt tccttctggc ttcttctatt acagtctctt
     7201 cattggaagc tctgtaggcc aaggccagag ctgatactga cacggagcca atgcagatag
     7261 cacatcagat gctaggggtc gctgggagga ttaagggact taatctgcta ggaacacctg
     7321 tacttgaagt ggaggaggct agggggccac agttgctgct tcattaacat agaggttttg
     7381 gatttttttc tcttgtggtt tgttttttaa gtggattggc agactccttg ttgcttaaga
     7441 gtggctttct aggcaggcca ctggcatctg aattcatcat tgacaataaa tgtaagaaat
     7501 tggaataaaa aagagagacc tgctgttatt cgcttttgtt ctccagtgat ttgattaact
     7561 cagggcaagg ctgaatatca gagtgtatcg cactgaagaa taataatcca ttcagtaatg
     7621 ttatagttat cctcaatcta aatatgtcaa ctgtcatttt gctacttttc aaataaaata
     7681 cttgaaaact gtca
//
