LOCUS       NM_022750               3021 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase family member 12 (PARP12),
            transcript variant 1, mRNA.
ACCESSION   NM_022750
VERSION     NM_022750.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Grimaldi,G., Filograna,A., Schembri,L., Lo Monte,M., Di Martino,R.,
            Pirozzi,M., Spano,D., Beccari,A.R., Parashuraman,S., Luini,A.,
            Valente,C. and Corda,D.
  TITLE     PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of Golgin-97
            is required for E-cadherin transport from Golgi to plasma membrane
  JOURNAL   Proc Natl Acad Sci U S A 119 (1) (2022)
   PUBMED   34969853
  REMARK    GeneRIF: PKD-dependent PARP12-catalyzed mono-ADP-ribosylation of
            Golgin-97 is required for E-cadherin transport from Golgi to plasma
            membrane.
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Shao,C., Qiu,Y., Liu,J., Feng,H., Shen,S., Saiyin,H., Yu,W.,
            Wei,Y., Yu,L., Su,W. and Wu,J.
  TITLE     PARP12 (ARTD12) suppresses hepatocellular carcinoma metastasis
            through interacting with FHL2 and regulating its stability
  JOURNAL   Cell Death Dis 9 (9), 856 (2018)
   PUBMED   30154409
  REMARK    GeneRIF: PARP12 is a tumor suppressor that plays an important role
            in HCC metastasis through the regulation of FHL2 stability and
            TGF-beta1 expression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3021)
  AUTHORS   Vyas,S., Matic,I., Uchima,L., Rood,J., Zaja,R., Hay,R.T., Ahel,I.
            and Chang,P.
  TITLE     Family-wide analysis of poly(ADP-ribose) polymerase activity
  JOURNAL   Nat Commun 5, 4426 (2014)
   PUBMED   25043379
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3021)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3021)
  AUTHORS   Matarin,M., Brown,W.M., Dena,H., Britton,A., De Vrieze,F.W.,
            Brott,T.G., Brown,R.D. Jr., Worrall,B.B., Case,L.D., Chanock,S.J.,
            Metter,E.J., Ferrucci,L., Gamble,D., Hardy,J.A., Rich,S.S.,
            Singleton,A. and Meschia,J.F.
  TITLE     Candidate gene polymorphisms for ischemic stroke
  JOURNAL   Stroke 40 (11), 3436-3442 (2009)
   PUBMED   19729601
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3021)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
  REMARK    GeneRIF: FLJ22693, TIPARP and ZAP proteins with TPH, WW and
            PARP-like domains constitute the TIPARP family.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004849.1, AC025816.1 and AC004961.2.
            
            On Jul 23, 2019 this sequence version replaced NM_022750.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081541.1, AL136766.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000263549.8/ ENSP00000263549.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-430               AC004849.1         124104-124533
            431-566             AC025816.1         2420-2555
            567-864             AC025816.1         3301-3598
            865-966             AC025816.1         5691-5792
            967-1090            AC004961.2         4626-4749
            1091-1286           AC004961.2         9794-9989
            1287-1428           AC004961.2         13777-13918
            1429-1525           AC004961.2         17302-17398
            1526-1601           AC004961.2         22945-23020
            1602-1732           AC004961.2         24227-24357
            1733-1884           AC004961.2         25285-25436
            1885-3021           AC004961.2         26748-27884
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..3021
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /note="poly(ADP-ribose) polymerase family member 12"
                     /db_xref="GeneID:64761"
                     /db_xref="HGNC:HGNC:21919"
                     /db_xref="MIM:612481"
     exon            1..430
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..2210
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /EC_number="2.4.2.30"
                     /note="zinc finger CCCH type domain containing 1;
                     ADP-ribosyltransferase diphtheria toxin-like 12; poly
                     [ADP-ribose] polymerase 12"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase PARP12"
                     /protein_id="NP_073587.1"
                     /db_xref="CCDS:CCDS5857.1"
                     /db_xref="GeneID:64761"
                     /db_xref="HGNC:HGNC:21919"
                     /db_xref="MIM:612481"
                     /translation="MAQAGVVGEVTQVLCAAGGALELPELRRRLRMGLSADALERLLR
                     QRGRFVVAVRAGGAAAAPERVVLAASPLRLCRAHQGSKPGCVGLCAQLHLCRFMVYGA
                     CKFLRAGKNCRNSHSLTTEHNLSVLRTHGVDHLSYNELCQLLFQNDPWLLPEICQHYN
                     KGDGPHGSCAFQKQCIKLHICQYFLQGECKFGTSCKRSHDFSNSENLEKLEKLGMSSD
                     LVSRLPTIYRNAHDIKNKSSAPSRVPPLFVPQGTSERKDSSGSVSPNTLSQEEGDQIC
                     LYHIRKSCSFQDKCHRVHFHLPYRWQFLDRGKWEDLDNMELIEEAYCNPKIERILCSE
                     SASTFHSHCLNFNAMTYGATQARRLSTASSVTKPPHFILTTDWIWYWSDEFGSWQEYG
                     RQGTVHPVTTVSSSDVEKAYLAYCTPGSDGQAATLKFQAGKHNYELDFKAFVQKNLVY
                     GTTKKVCRRPKYVSPQDVTTMQTCNTKFPGPKSIPDYWDSSALPDPGFQKITLSSSSE
                     EYQKVWNLFNRTLPFYFVQKIERVQNLALWEVYQWQKGQMQKQNGGKAVDERQLFHGT
                     SAIFVDAICQQNFDWRVCGVHGTSYGKGSYFARDAAYSHHYSKSDTQTHTMFLARVLV
                     GEFVRGNASFVRPPAKEGWSNAFYDSCVNSVSDPSIFVIFEKHQVYPEYVIQYTTSSK
                     PSVTPSILLALGSLFSSRQ"
     exon            431..566
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            567..864
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..966
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1090
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1286
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1428
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1525
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1601
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1732
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1733..1884
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..3021
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3005..3010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /note="hexamer: AAGAAA"
     polyA_site      3021
                     /gene="PARP12"
                     /gene_synonym="ARTD12; MST109; MSTP109; ZC3H1; ZC3HDC1"
                     /note="major polyA site"
ORIGIN      
        1 gtttcccgcc ggcgtctcca ccctgcgaga gccgcccgcc agccagcgtc cgccgccgtc
       61 cgcgtcgcgc cacccgcggt ccgacgggag caggcccagc ggccatggcc caggccggcg
      121 tcgtcggtga ggtcacccag gtgctgtgcg cggccggggg cgccctggag ttgcccgagc
      181 tgcggcgccg cttgcggatg ggcttgagcg ccgacgcgct ggagcggctg ctgcggcagc
      241 gtgggcgctt cgtggtggcg gtgcgggcgg gcggcgcagc cgcggccccg gagcgcgtgg
      301 tgctggccgc ctcgccgctg cgcctgtgtc gcgcgcacca gggctccaag ccgggctgcg
      361 tggggctctg cgcgcagctc cacctctgca ggttcatggt ctacggcgcc tgcaagttcc
      421 tgagagccgg gaagaactgt aggaatagtc acagcttgac aaccgaacac aacctgagtg
      481 tgctgagaac tcatggcgtt gaccacctga gctataatga gctatgccaa ctcttgtttc
      541 agaacgaccc ctggcttttg ccagaaattt gccaacatta caacaaagga gatggacccc
      601 acggctcttg tgcctttcaa aagcagtgca tcaagctcca tatctgccag tattttttac
      661 agggggaatg caagtttggc actagctgta agagatccca tgatttctct aattctgaga
      721 atctggaaaa attggagaag ttgggtatga gctcagacct ggtgagcagg ctgcctacca
      781 tttatagaaa tgcacatgac atcaagaata agagctctgc ccccagcaga gtgcctcctc
      841 tttttgtccc acaggggact tctgaaagaa aagacagttc aggttctgtg tccccaaaca
      901 ctcttagcca ggaggagggt gatcagatct gtttgtacca tatccggaaa agttgtagct
      961 ttcaagataa gtgccataga gttcatttcc atttgccgta tcgatggcaa ttcttggata
     1021 gaggcaaatg ggaggatttg gacaacatgg aacttattga agaggcatat tgcaatccca
     1081 aaatagaaag gatcctgtgc tctgagtcag ccagtacctt tcactctcat tgtctgaact
     1141 ttaacgccat gacttacggt gctacccagg ctcgccgcct ctccacggcc tcctctgtca
     1201 ccaaacctcc acacttcatc ctcaccactg actggatttg gtactggagt gatgagtttg
     1261 gttcttggca ggaatatgga agacagggca cggtgcaccc tgtgaccact gtcagcagta
     1321 gcgacgtgga gaaggcctac ctggcctact gtacaccggg gtctgacggc caggcagcca
     1381 ccttgaagtt ccaggccgga aagcacaact acgagttaga tttcaaagcc ttcgttcaga
     1441 aaaacctggt ctatggcaca actaaaaagg tttgccgcag acccaaatac gtgtctcccc
     1501 aggatgtgac gaccatgcaa acctgcaata ccaagtttcc aggcccgaag agcatcccag
     1561 actattggga ctcctctgcc ctgccagacc caggctttca gaagatcacc cttagttctt
     1621 cctcggaaga gtatcagaag gtctggaacc tctttaaccg cacgctgcct ttctactttg
     1681 ttcagaagat tgagcgagta cagaacctgg ccctctggga agtctaccag tggcaaaaag
     1741 gacagatgca gaagcagaac ggagggaagg ccgtggacga gcggcagctg ttccacggca
     1801 ccagcgccat ttttgtggac gccatctgcc agcagaactt tgactggcgg gtctgtggtg
     1861 ttcatggcac ttcctacggc aaggggagct actttgcccg agatgctgca tattcccacc
     1921 actacagcaa atccgacacg cagacccaca cgatgttcct ggcccgggtg ctggtgggcg
     1981 agttcgtcag gggcaatgcc tcctttgtcc gtccgccggc caaggagggc tggagcaacg
     2041 ccttctatga tagctgcgtg aacagtgtgt ccgacccctc catctttgtg atctttgaga
     2101 aacaccaggt ctacccagag tatgtcatcc agtacaccac ctcctccaag ccctcggtca
     2161 caccctccat cctgctggcc ttgggctccc tgttcagcag ccgacagtga gcgcacagga
     2221 gtgttccagg cctttcacct gctctgcctt gaaatggcta tttgggcctt tccttttctt
     2281 tttaaacaga aacttttaat gaactgttct cttaacattg acctctcaat gaagttatgt
     2341 tcttaatctc ttgctaataa tgatttttac ttttaagtca cttttgggtt cactagtgga
     2401 ttaaccagaa gtgattgtag ttgagtccag ttttgctttt taataatgtg ttgaagtttt
     2461 agtttttact ctttgttgac tttgctgctt attggcacca gggacagagt ttctagatac
     2521 aattttatgg attggtttta atttttatga gtttgtctct gcagtgattc ggtttctcag
     2581 agtctcatgg catcatagtt tttccagaat gacacagtag ccaccggtgg atgacagccc
     2641 acgggcggca cagtcacttc tgcctgttgc tctgacacca acccaggcag ctctgctgtg
     2701 gcttctcctg ggctctggca ttagttggtc tgtgtcacat tgtcagaaca ggtggctgct
     2761 gtgtggtgcc atcgagtccc tgctggttcc ccttgtcctg ggagggtcac ccattgccca
     2821 aggaagtgca tccacctggc aggtgacctg gaggagtagc ttccccgagg acccccaggc
     2881 ttggcctgtg attgcgcaaa cccacatttc ctaagcacac tggacaccct tcgagtgtgg
     2941 gttttaacat ccctgtgaga ttgaatactt gtgccacaca tgtcacaaaa gagtatggaa
     3001 ataaaagaaa atttatccga a
//
