LOCUS       NM_001618               3978 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens poly(ADP-ribose) polymerase 1 (PARP1), mRNA.
ACCESSION   NM_001618
VERSION     NM_001618.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3978)
  AUTHORS   Tyagi,W. and Das,S.
  TITLE     Temporal regulation of acetylation status determines PARP1 role in
            DNA damage response and metabolic homeostasis
  JOURNAL   Sci Adv 10 (42), eado7720 (2024)
   PUBMED   39423262
  REMARK    GeneRIF: Temporal regulation of acetylation status determines PARP1
            role in DNA damage response and metabolic homeostasis.
REFERENCE   2  (bases 1 to 3978)
  AUTHORS   Shu,Y., Jin,X., Ji,M., Zhang,Z., Wang,X., Liang,H., Lu,S., Dong,S.,
            Lin,Y., Guo,Y., Zhuang,Q., Wang,Y., Lei,Z., Guo,L., Meng,X.,
            Zhou,G., Zhang,W. and Chang,L.
  TITLE     Ku70 Binding to YAP Alters PARP1 Ubiquitination to Regulate Genome
            Stability and Tumorigenesis
  JOURNAL   Cancer Res 84 (17), 2836-2855 (2024)
   PUBMED   38862269
  REMARK    GeneRIF: Ku70 Binding to YAP Alters PARP1 Ubiquitination to
            Regulate Genome Stability and Tumorigenesis.
REFERENCE   3  (bases 1 to 3978)
  AUTHORS   Zhan,Z., Zhang,J., Liang,H., Wang,C., Hong,L. and Liu,W.
  TITLE     KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors in
            Ovarian Cancer
  JOURNAL   Adv Sci (Weinh) 11 (34), e2400140 (2024)
   PUBMED   38973255
  REMARK    GeneRIF: KAT6A Condensates Impair PARP1 Trapping of PARP Inhibitors
            in Ovarian Cancer.
REFERENCE   4  (bases 1 to 3978)
  AUTHORS   Bao,P., Wang,X., Zhang,X., Yu,Y., Ma,Y., Zhang,H., Wang,Y., Liu,X.,
            Gong,P., Zhang,N., Lee,S.O., Li,X. and Li,J.
  TITLE     Clonorchis sinensis aggravated liver fibrosis by activating PARP-1
            signaling to induce parthanatos via DNA damage
  JOURNAL   Vet Parasitol 330, 110217 (2024)
   PUBMED   38861911
  REMARK    GeneRIF: Clonorchis sinensis aggravated liver fibrosis by
            activating PARP-1 signaling to induce parthanatos via DNA damage.
REFERENCE   5  (bases 1 to 3978)
  AUTHORS   Belmonte,B., Di Lorenzo,G., Mangogna,A., Bortot,B., Bertolazzi,G.,
            Sammataro,S., Merighi,S., Martorana,A., Zito,G., Romano,F.,
            Giorgiutti,A., Bottin,C., Zanconati,F., Romano,A., Ricci,G. and
            Biffi,S.
  TITLE     PARP-1, EpCAM, and FRalpha as potential targets for intraoperative
            detection and delineation of endometriosis: a quantitative tissue
            expression analysis
  JOURNAL   Reprod Biol Endocrinol 22 (1), 92 (2024)
   PUBMED   39085882
  REMARK    GeneRIF: PARP-1, EpCAM, and FRalpha as potential targets for
            intraoperative detection and delineation of endometriosis: a
            quantitative tissue expression analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3978)
  AUTHORS   Schreiber,V., Molinete,M., Boeuf,H., de Murcia,G. and Menissier-de
            Murcia,J.
  TITLE     The human poly(ADP-ribose) polymerase nuclear localization signal
            is a bipartite element functionally separate from DNA binding and
            catalytic activity
  JOURNAL   EMBO J 11 (9), 3263-3269 (1992)
   PUBMED   1505517
REFERENCE   7  (bases 1 to 3978)
  AUTHORS   Baumgartner,M., Schneider,R., Auer,B., Herzog,H., Schweiger,M. and
            Hirsch-Kauffmann,M.
  TITLE     Fluorescence in situ mapping of the human nuclear NAD+
            ADP-ribosyltransferase gene (ADPRT) and two secondary sites to
            human chromosomal bands 1q42, 13q34, and 14q24
  JOURNAL   Cytogenet Cell Genet 61 (3), 172-174 (1992)
   PUBMED   1424803
REFERENCE   8  (bases 1 to 3978)
  AUTHORS   Simonin,F., Menissier-de Murcia,J., Poch,O., Muller,S.,
            Gradwohl,G., Molinete,M., Penning,C., Keith,G. and de Murcia,G.
  TITLE     Expression and site-directed mutagenesis of the catalytic domain of
            human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is
            critical for activity
  JOURNAL   J Biol Chem 265 (31), 19249-19256 (1990)
   PUBMED   2121735
REFERENCE   9  (bases 1 to 3978)
  AUTHORS   Gradwohl,G., Menissier de Murcia,J.M., Molinete,M., Simonin,F.,
            Koken,M., Hoeijmakers,J.H. and de Murcia,G.
  TITLE     The second zinc-finger domain of poly(ADP-ribose) polymerase
            determines specificity for single-stranded breaks in DNA
  JOURNAL   Proc Natl Acad Sci U S A 87 (8), 2990-2994 (1990)
   PUBMED   2109322
REFERENCE   10 (bases 1 to 3978)
  AUTHORS   Ogura,T., Nyunoya,H., Takahashi-Masutani,M., Miwa,M., Sugimura,T.
            and Esumi,H.
  TITLE     Characterization of a putative promoter region of the human
            poly(ADP-ribose) polymerase gene: structural similarity to that of
            the DNA polymerase beta gene
  JOURNAL   Biochem Biophys Res Commun 167 (2), 701-710 (1990)
   PUBMED   2108670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB097441.1, BC037545.1,
            J03473.1 and AK225654.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001618.3.
            
            Summary: This gene encodes a chromatin-associated enzyme,
            poly(ADP-ribosyl)transferase, which modifies various nuclear
            proteins by poly(ADP-ribosyl)ation. The modification is dependent
            on DNA and is involved in the regulation of various important
            cellular processes such as differentiation, proliferation, and
            tumor transformation and also in the regulation of the molecular
            events involved in the recovery of cell from DNA damage. In
            addition, this enzyme may be the site of mutation in Fanconi
            anemia, and may participate in the pathophysiology of type I
            diabetes. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK225654.1, J03473.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366794.10/ ENSP00000355759.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-567               DB097441.1         8-574
            568-1015            BC037545.1         548-995
            1016-1219           J03473.1           947-1150
            1220-2448           BC037545.1         1200-2428
            2449-3864           J03473.1           2380-3795
            3865-3978           AK225654.1         3837-3950
FEATURES             Location/Qualifiers
     source          1..3978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..3978
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /note="poly(ADP-ribose) polymerase 1"
                     /db_xref="GeneID:142"
                     /db_xref="HGNC:HGNC:270"
                     /db_xref="MIM:173870"
     exon            1..284
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..3209
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /EC_number="2.4.2.30"
                     /note="poly(ADP-ribose) synthetase; ADP-ribosyltransferase
                     NAD(+); poly (ADP-ribose) polymerase family, member 1;
                     ADP-ribosyltransferase (NAD+; poly (ADP-ribose)
                     polymerase); poly(ADP-ribosyl)transferase;
                     poly[ADP-ribose] synthase 1; NAD(+) ADP-ribosyltransferase
                     1; ADP-ribosyltransferase diphtheria toxin-like 1; DNA
                     ADP-ribosyltransferase PARP1; protein
                     poly-ADP-ribosyltransferase PARP1"
                     /codon_start=1
                     /product="poly [ADP-ribose] polymerase 1"
                     /protein_id="NP_001609.2"
                     /db_xref="CCDS:CCDS1554.1"
                     /db_xref="GeneID:142"
                     /db_xref="HGNC:HGNC:270"
                     /db_xref="MIM:173870"
                     /translation="MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMF
                     DGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGI
                     GSKAEKTLGDFAAEYAKSNRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHP
                     GCFVKNREELGFRPEYSASQLKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDE
                     VAKKKSKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGE
                     SAILDRVADGMVFGALLPCEECSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWV
                     TPKEFREISYLKKLKVKKQDRIFPPETSASVAATPPPSTASAPAAVNSSASADKPLSN
                     MKILTLGKLSRNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEAN
                     IRVVSEDFLQDVSASTKSLQELFLAHILSPWGAEVKAEPVEVVAPRGKSGAALSKKSK
                     GQVKEEGINKSEKRMKLTLKGGAAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGT
                     NSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGN
                     AWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESM
                     KKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLI
                     PHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLK
                     TDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHN
                     RRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGD
                     PIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLG
                     TGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW"
     exon            285..450
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            451..566
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            567..781
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            782..881
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            882..998
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1175
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1323
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1464
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1465..1707
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1776
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1909
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2105
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2234
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2235..2318
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2441
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2570
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2669
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2822
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2823..2950
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            2951..3012
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3127
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     exon            3128..3978
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3954..3959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /note="hexamer: ATTAAA"
     polyA_site      3978
                     /gene="PARP1"
                     /gene_synonym="ADPRT; ADPRT 1; ADPRT1; ARTD1; pADPRT-1;
                     PARP; PARP-1; PARS; Poly-PARP; PPOL"
                     /note="major polyA site"
ORIGIN      
        1 agcaatctat cagggaacgg cggtggccgg tgcggcgtgt tcggtggcgg ctctggccgc
       61 tcaggcgcct gcggctgggt gagcgcacgc gaggcggcga ggcggcagcg tgtttctagg
      121 tcgtggcgtc gggcttccgg agctttggcg gcagctaggg gaggatggcg gagtcttcgg
      181 ataagctcta tcgagtcgag tacgccaaga gcgggcgcgc ctcttgcaag aaatgcagcg
      241 agagcatccc caaggactcg ctccggatgg ccatcatggt gcagtcgccc atgtttgatg
      301 gaaaagtccc acactggtac cacttctcct gcttctggaa ggtgggccac tccatccggc
      361 accctgacgt tgaggtggat gggttctctg agcttcggtg ggatgaccag cagaaagtca
      421 agaagacagc ggaagctgga ggagtgacag gcaaaggcca ggatggaatt ggtagcaagg
      481 cagagaagac tctgggtgac tttgcagcag agtatgccaa gtccaacaga agtacgtgca
      541 aggggtgtat ggagaagata gaaaagggcc aggtgcgcct gtccaagaag atggtggacc
      601 cggagaagcc acagctaggc atgattgacc gctggtacca tccaggctgc tttgtcaaga
      661 acagggagga gctgggtttc cggcccgagt acagtgcgag tcagctcaag ggcttcagcc
      721 tccttgctac agaggataaa gaagccctga agaagcagct cccaggagtc aagagtgaag
      781 gaaagagaaa aggcgatgag gtggatggag tggatgaagt ggcgaagaag aaatctaaaa
      841 aagaaaaaga caaggatagt aagcttgaaa aagccctaaa ggctcagaac gacctgatct
      901 ggaacatcaa ggacgagcta aagaaagtgt gttcaactaa tgacctgaag gagctactca
      961 tcttcaacaa gcagcaagtg ccttctgggg agtcggcgat cttggaccga gtagctgatg
     1021 gcatggtgtt cggtgccctc cttccctgcg aggaatgctc gggtcagctg gtcttcaaga
     1081 gcgatgccta ttactgcact ggggacgtca ctgcctggac caagtgtatg gtcaagacac
     1141 agacacccaa ccggaaggag tgggtaaccc caaaggaatt ccgagaaatc tcttacctca
     1201 agaaattgaa ggttaaaaaa caggaccgta tattcccccc agaaaccagc gcctccgtgg
     1261 cggccacgcc tccgccctcc acagcctcgg ctcctgctgc tgtgaactcc tctgcttcag
     1321 cagataagcc attatccaac atgaagatcc tgactctcgg gaagctgtcc cggaacaagg
     1381 atgaagtgaa ggccatgatt gagaaactcg gggggaagtt gacggggacg gccaacaagg
     1441 cttccctgtg catcagcacc aaaaaggagg tggaaaagat gaataagaag atggaggaag
     1501 taaaggaagc caacatccga gttgtgtctg aggacttcct ccaggacgtc tccgcctcca
     1561 ccaagagcct tcaggagttg ttcttagcgc acatcttgtc cccttggggg gcagaggtga
     1621 aggcagagcc tgttgaagtt gtggccccaa gagggaagtc aggggctgcg ctctccaaaa
     1681 aaagcaaggg ccaggtcaag gaggaaggta tcaacaaatc tgaaaagaga atgaaattaa
     1741 ctcttaaagg aggagcagct gtggatcctg attctggact ggaacactct gcgcatgtcc
     1801 tggagaaagg tgggaaggtc ttcagtgcca cccttggcct ggtggacatc gttaaaggaa
     1861 ccaactccta ctacaagctg cagcttctgg aggacgacaa ggaaaacagg tattggatat
     1921 tcaggtcctg gggccgtgtg ggtacggtga tcggtagcaa caaactggaa cagatgccgt
     1981 ccaaggagga tgccattgag cacttcatga aattatatga agaaaaaacc gggaacgctt
     2041 ggcactccaa aaatttcacg aagtatccca aaaagttcta ccccctggag attgactatg
     2101 gccaggatga agaggcagtg aagaagctga cagtaaatcc tggcaccaag tccaagctcc
     2161 ccaagccagt tcaggacctc atcaagatga tctttgatgt ggaaagtatg aagaaagcca
     2221 tggtggagta tgagatcgac cttcagaaga tgcccttggg gaagctgagc aaaaggcaga
     2281 tccaggccgc atactccatc ctcagtgagg tccagcaggc ggtgtctcag ggcagcagcg
     2341 actctcagat cctggatctc tcaaatcgct tttacaccct gatcccccac gactttggga
     2401 tgaagaagcc tccgctcctg aacaatgcag acagtgtgca ggccaaggtg gaaatgcttg
     2461 acaacctgct ggacatcgag gtggcctaca gtctgctcag gggagggtct gatgatagca
     2521 gcaaggatcc catcgatgtc aactatgaga agctcaaaac tgacattaag gtggttgaca
     2581 gagattctga agaagccgag atcatcagga agtatgttaa gaacactcat gcaaccacac
     2641 acaatgcgta tgacttggaa gtcatcgata tctttaagat agagcgtgaa ggcgaatgcc
     2701 agcgttacaa gccctttaag cagcttcata accgaagatt gctgtggcac gggtccagga
     2761 ccaccaactt tgctgggatc ctgtcccagg gtcttcggat agccccgcct gaagcgcccg
     2821 tgacaggcta catgtttggt aaagggatct atttcgctga catggtctcc aagagtgcca
     2881 actactgcca tacgtctcag ggagacccaa taggcttaat cctgttggga gaagttgccc
     2941 ttggaaacat gtatgaactg aagcacgctt cacatatcag caagttaccc aagggcaagc
     3001 acagtgtcaa aggtttgggc aaaactaccc ctgatccttc agctaacatt agtctggatg
     3061 gtgtagacgt tcctcttggg accgggattt catctggtgt gaatgacacc tctctactat
     3121 ataacgagta cattgtctat gatattgctc aggtaaatct gaagtatctg ctgaaactga
     3181 aattcaattt taagacctcc ctgtggtaat tgggagaggt agccgagtca cacccggtgg
     3241 ctctggtatg aattcacccg aagcgcttct gcaccaactc acctggccgc taagttgctg
     3301 atgggtagta cctgtactaa accacctcag aaaggatttt acagaaacgt gttaaaggtt
     3361 ttctctaact tctcaagtcc cttgttttgt gttgtgtctg tggggagggg ttgttttggg
     3421 gttgtttttg ttttttcttg ccaggtagat aaaactgaca tagagaaaag gctggagaga
     3481 gattctgttg catagactag tcctatggaa aaaaccaagc ttcgttagaa tgtctgcctt
     3541 actggtttcc ccagggaagg aaaaatacac ttccaccctt ttttctaagt gttcgtcttt
     3601 agttttgatt ttggaaagat gttaagcatt tatttttagt taaaaataaa aactaatttc
     3661 atactattta gattttcttt tttatcttgc acttattgtc ccctttttag ttttttttgt
     3721 ttgcctcttg tggtgagggg tgtgggaaga ccaaaggaag gaacgctaac aatttctcat
     3781 acttagaaac aaaaagagct ttccttctcc aggaatactg aacatgggag ctcttgaaat
     3841 atgtagtatt aaaagttgca tttgaaattc ttgactttct tatgggcact tttgtcttcc
     3901 aaattaaaac tctaccacaa atatacttac ccaagggcta atagtaatac tcgattaaaa
     3961 atgcagatgc cttctcta
//
