LOCUS       NM_015393               5011 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens prostate androgen-regulated mucin-like protein 1
            (PARM1), mRNA.
ACCESSION   NM_015393
VERSION     NM_015393.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5011)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5011)
  AUTHORS   Liu,Y.R., Hu,Y., Zeng,Y., Li,Z.X., Zhang,H.B., Deng,J.L. and
            Wang,G.
  TITLE     Neurexophilin and PC-esterase domain family member 4 (NXPE4) and
            prostate androgen-regulated mucin-like protein 1 (PARM1) as
            prognostic biomarkers for colorectal cancer
  JOURNAL   J Cell Biochem 120 (10), 18041-18052 (2019)
   PUBMED   31297877
  REMARK    GeneRIF: Neurexophilin and PC-esterase domain family member 4
            (NXPE4) and prostate androgen-regulated mucin-like protein 1
            (PARM1) as prognostic biomarkers for colorectal cancer.
REFERENCE   3  (bases 1 to 5011)
  AUTHORS   Charfi,C., Levros,L.C. Jr., Edouard,E. and Rassart,E.
  TITLE     Characterization and identification of PARM-1 as a new potential
            oncogene
  JOURNAL   Mol Cancer 12, 84 (2013)
   PUBMED   23902727
  REMARK    GeneRIF: Our results strongly suggest the oncogenic potential of
            PARM-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5011)
  AUTHORS   Wittler,L., Hilger,A., Proske,J., Pennimpede,T., Draaken,M.,
            Ebert,A.K., Rosch,W., Stein,R., Nothen,M.M., Reutter,H. and
            Ludwig,M.
  TITLE     Murine expression and mutation analyses of the prostate
            androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate
            for human epispadias
  JOURNAL   Gene 506 (2), 392-395 (2012)
   PUBMED   22766399
  REMARK    GeneRIF: PARM1 does not play a major role in the development of
            epispadias
REFERENCE   5  (bases 1 to 5011)
  AUTHORS   Fladeby,C., Gupta,S.N., Barois,N., Lorenzo,P.I., Simpson,J.C.,
            Saatcioglu,F. and Bakke,O.
  TITLE     Human PARM-1 is a novel mucin-like, androgen-regulated gene
            exhibiting proliferative effects in prostate cancer cells
  JOURNAL   Int J Cancer 122 (6), 1229-1235 (2008)
   PUBMED   18027867
  REMARK    GeneRIF: Ectopic expression of hPARM-1 in PC3 prostate cancer cells
            increased colony formation, suggesting a probable role in cell
            proliferation.
REFERENCE   6  (bases 1 to 5011)
  AUTHORS   Cornet,A.M., Hanon,E., Reiter,E.R., Bruyninx,M., Nguyen,V.H.,
            Hennuy,B.R., Hennen,G.P. and Closset,J.L.
  TITLE     Prostatic androgen repressed message-1 (PARM-1) may play a role in
            prostatic cell immortalisation
  JOURNAL   Prostate 56 (3), 220-230 (2003)
   PUBMED   12772192
REFERENCE   7  (bases 1 to 5011)
  AUTHORS   Bruyninx,M., Hennuy,B., Cornet,A., Houssa,P., Daukandt,M.,
            Reiter,E., Poncin,J., Closset,J. and Hennen,G.
  TITLE     A novel gene overexpressed in the prostate of castrated rats:
            hormonal regulation, relationship to apoptosis and to acquired
            prostatic cell androgen independence
  JOURNAL   Endocrinology 140 (10), 4789-4799 (1999)
   PUBMED   10499539
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098825.3, AC110760.3 and AI767320.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015393.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.213330.1,
                                           SRR1803614.29287.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307428.7/ ENSP00000370224.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-255               AC098825.3         153175-153429
            256-981             AC110760.3         58726-59451
            982-1060            AC110760.3         80184-80262
            1061-4778           AC110760.3         92464-96181
            4779-5011           AI767320.1         18-250              c
FEATURES             Location/Qualifiers
     source          1..5011
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q13.3"
     gene            1..5011
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /note="prostate androgen-regulated mucin-like protein 1"
                     /db_xref="GeneID:25849"
                     /db_xref="HGNC:HGNC:24536"
                     /db_xref="MIM:617688"
     exon            1..255
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1145
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /note="prostatic androgen-regulated mucin-like protein 1;
                     WSC4, cell wall integrity and stress response component 4
                     homolog; prostatic androgen-repressed message 1;
                     castration-induced prostatic apoptosis-related protein 1"
                     /codon_start=1
                     /product="prostate androgen-regulated mucin-like protein 1
                     precursor"
                     /protein_id="NP_056208.2"
                     /db_xref="CCDS:CCDS47077.1"
                     /db_xref="GeneID:25849"
                     /db_xref="HGNC:HGNC:24536"
                     /db_xref="MIM:617688"
                     /translation="MVYKTLFALCILTAGWRVQSLPTSAPLSVSLPTNIVPPTTIWTS
                     SPQNTDADTASPSNGTHNNSVLPVTASAPTSLLPKNISIESREEEITSPGSNWEGTNT
                     DPSPSGFSSTSGGVHLTTTLEEHSSGTPEAGVAATLSQSAAEPPTLISPQAPASSPSS
                     LSTSPPEVFSASVTTNHSSTVTSTQPTGAPTAPESPTEESSSDHTPTSHATAEPVPQE
                     KTPPTTVSGKVMCELIDMETTTTFPRVIMQEVEHALSSGSIAAITVTVIAVVLLVFGV
                     AAYLKIRHSSYGRLLDDHDYGSWGNYNNPLYDDS"
     exon            256..981
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1060
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..5011
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4991..4996
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /note="hexamer: ATTAAA"
     polyA_site      5011
                     /gene="PARM1"
                     /gene_synonym="Cipar1; DKFZP564O0823; PARM-1; WSC4"
                     /note="major polyA site"
ORIGIN      
        1 agaagagcgc ggagcaccgg agggcacgca gctgacggag ctgcgctgcg ttcgcctcgt
       61 ttgcctcgcg ccctccactg gagctgttcg cgcctcccgg ctcccaccgc agcccacccg
      121 gcagaggagt cgctaccagc gcccagtgcg ctctgtcagt ccgcaaactc cttgccgccc
      181 gccccgggct gggcaccaaa taccaggcta ccatggtcta caagactctc ttcgctcttt
      241 gcatcttaac tgcaggatgg agggtacaga gtctgcctac atcagctcct ttgtctgttt
      301 ctcttccgac aaacattgta ccaccgacca ccatctggac tagctctcca caaaacactg
      361 atgcagacac tgcctcccca tccaacggca ctcacaacaa ctcggtgctc ccagttacag
      421 catcagcccc aacatctctg cttcctaaga acatttccat agagtccaga gaagaggaga
      481 tcaccagccc aggttcgaat tgggaaggca caaacacaga cccctcacct tctgggttct
      541 cgtcaacaag cggtggagtc cacttaacaa ccacgttgga ggaacacagc tcgggcactc
      601 ctgaagcagg cgtggcagct acactgtcgc agtccgctgc tgagcctccc acactcatct
      661 cccctcaagc tccagcctca tcaccctcat ccctatcaac ctcaccacct gaggtctttt
      721 ctgcctccgt tactaccaac catagctcca ctgtgaccag cacccaaccc actggagctc
      781 caactgcacc agagtccccg acagaggagt ccagctctga ccacacaccc acttcacatg
      841 ccacagctga gccagtaccc caggagaaaa cacccccaac aactgtgtca ggcaaagtga
      901 tgtgtgagct catagacatg gagaccacca ccacctttcc cagggtgatc atgcaggaag
      961 tagaacatgc attaagttca ggcagcatcg ccgccattac cgtgacagtc attgccgtgg
     1021 tgctgctggt gtttggagtt gcagcctacc taaaaatcag gcattcctcc tatggaagac
     1081 ttttggacga ccatgactac gggtcctggg gaaactacaa caaccctctg tacgatgact
     1141 cctaacaatg gaatatggcc tgggatgagg attaactgtt ctttatttat aagtgcttat
     1201 ccagtagaat taataagtac ctgatgcgca ttgaacgaca atcttaagcc ctgttttgtt
     1261 ggtatggttg tttttgtttt cctccctctc ctctggctgc tacaacttcc cctttctggt
     1321 acaagaagaa ccattcttta aaggtgagtg gaggctgatt tgcagctgaa gtgggccagc
     1381 cttgcaccag ccaggccaga ccaccatggt gaaggcttct ttccccactg caggacccac
     1441 tttgagaagg accgaggagg aggatttggg ttgttttgtt aggggttact ttcaggggaa
     1501 catttcattt gtgttatttc ttaaacttct atttaggaaa ttacattaag tattaatgag
     1561 gggaaaggaa atgagctcta cgaggatttc accctgcatg ggagagagca gggttttctc
     1621 agattccttt ttaatctcta tttatctggt tgtttctgac aggatgctgc ctgcttggct
     1681 ctacaagctg gaaagcagct tcttagctgc ctaattaatg aaagatgaaa ataggaagtg
     1741 ccctggaggg ggccagcagg tcacggggca gaatctctca ggttgctgtg ggatctcagt
     1801 gtgcccctac ctgttctccc ctccaggcca cctgtctctg taaaggatgt ctgctctgtt
     1861 caaaaggcag ctgggatccc agcccacaag tgatcagcag agttgcattt ccaaagaaaa
     1921 aggctatgag atgagctgag ttatagagag aaagggagag gcatgtacgg tgtggggaag
     1981 tggaagagaa gctggcgggg gagaaggagg ctaacctgca ctgagtactt cattaggaca
     2041 agtgagaatc agctattgat aatggccaga gatatccaca gcttggagga gcccagagac
     2101 cgtttgcttt atacccacac agcaactggt ccactgcttt actgtctgtt ggataatggc
     2161 tgtaaaatgt ttaaaaacaa aacaaaacaa aaaagaggca ctagtctatc tgcaattact
     2221 caacgaggca ttttcatagg aaacagacta tgattaatcc atttattctt cccacacact
     2281 taccttacta agtctttgct ttaataaatg agcaaccctg ggtatagtct taaaattctg
     2341 cacaataaat tttgagaaag aattgttcct ctttgtaggt atctgtgtat tgcaatcatt
     2401 ctcaaccagg aggtgatttt gccccctgac tccaccccag ggacattcaa aaatgtctgg
     2461 tgacagtttt cattgtcatg acttgggggt gctactagaa gccaggaatg ctgccaaaca
     2521 ttctaccatg cacagcacaa cctacaacag caaagaatca tccaccccaa aatatcagta
     2581 gtgccgagat tgagaaaccc tgatttatca caatgcccac tgtgacagaa caagacactc
     2641 acagattagt gatacgtttt atttttaaca aaatgaaatg atgtgttaag tttttatttc
     2701 caaagtgttt agtttattgg ctgatgggtt gttcttggta tgcatggtga cctttttatt
     2761 tctgtgtgct tcctagagag ctttatttca tggcgacaac tctgtcttct tgtaacagct
     2821 gatattagca agcagcatct tatgtcctga tttcatatag tagaaaacaa acattgggtc
     2881 cgacttcaaa atgtgttgta ttgtcctaca gtgtcataaa gaacctgaaa atgaactttt
     2941 gtttctaaag ttggaccttg ctgccatgac tgtttagttt acagaaactt gaccccggct
     3001 catcctgtct ctggctgtgg cccggcaaag cactgaaaac ccctctggtc tcagagacag
     3061 taggggcagt gccactttct acaacctgcc aacccacaca ctggagtaat tctgaaaaaa
     3121 attattccta aactctctaa gtgtggacgg agaatgagca agccccagaa gtattttaca
     3181 accagagtgg gtaatgagga gggggcttac tggaatcgtc atatctctga atattgaaaa
     3241 caacaactaa aaaagtggac cttctcagaa aaaaagggca gcaaatgacc aagggcgccc
     3301 cttctggccg tgcttggctt gagtaactgt ctctctttcc ccacccccat cacagggctt
     3361 tcagtttggc aaaggaaaag cagataaaaa cagaacattc catatgtttc tttctccatc
     3421 ggccaaaaac attttgacac aatgtttgtg aaacaccttt ggagaggtgc acttctgaat
     3481 gctgcctctg ccgtaaatcc tggggcaagg gatcagcctc ttcccaggaa ccatcgcctt
     3541 ctataaaccg tgaactcaag caggcatttt ttttttctta ccgaaaggct gctattgtgc
     3601 aagggcacat aatgggtctg ttgctcttat tggcttccaa atgtgcatgg caaagagaga
     3661 gatgtgggcc tagagcagat atattcagca aggtgacagc ttcccataac aattctaaca
     3721 cttcttatct tatgtgagaa taaaatattt aagggttgaa ccttattttg ccaaatgtat
     3781 cttttctgct tttgaattgg gcagaagatt ttagcaacta tattctacaa atgttactta
     3841 taacacacac acacacatct gaaatatatg ccgaaaattg acgtctttga cctcagggag
     3901 agcacctgtc caggtctgcc taaaggaaat ggctccagtg ggtctaaaca accacatcct
     3961 atccatggat aggtctagtc ataacacttt agagagaatg tcagagcagg agggaggcaa
     4021 gccgcctctt ctcggccatc gactgcagat gatgaaagag cgggattcaa ctttgttttc
     4081 ttttcctgtg gccccagtga aacctcctgc cctccctgca cgtctgtgtc ttcatttcta
     4141 aaatgggggt gatgctttca tattgacctc accccatact acctcacaga tgtgttgtga
     4201 ggattaataa aattatgtct atggtatttt cagtttctgg agaaaaatac ttatagacag
     4261 tttaactatt acatagatat ataagtgatc tcagtttctt gtttgctgtg atactaatgt
     4321 gttgttttaa cttattccat aaaatgacag ttgtgtccta gccacatcag acagctatct
     4381 aagctctgga ctaccccttt gtgcagctga atcactgcag ggttgaccat gcctggtgcc
     4441 acagccatgg tttccatttc tagatgaaag gatggcctag gacataggtc tcaaagactc
     4501 ttggatcaga atcaggagat tagggaaaac aggatggata cctgagcact aacagcagta
     4561 gacgtagacc tctgtccttt accatctgag gtcttctgga ttctttgtgg ggttaatttt
     4621 gatttgatgt catctgtttg cccttcatct tgcttgcaag tgtgcatggt tcaatccctc
     4681 acatccagga aatgaatttt gcaattgggc cagatgctaa tttgcacgtt gattcacctt
     4741 ctttgccttt aagccttttt tttctttttt ttttttttgg caaatgaatg taccatttca
     4801 actttgattt taatagtgct agttgatatt ggtaataatg ctaaccaaga gatcaatgcc
     4861 agatttttct cttggggtaa gttagctgaa gtcatttaaa gatggaaagg tgggaaaatt
     4921 ctttgatatt tgatgtcatt gtatccacat ttgttgtaag acatattgca taccaattat
     4981 aattatatca attaaagttg ataaaagctt c
//
