LOCUS       NM_032510               3836 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens par-6 family cell polarity regulator gamma (PARD6G),
            mRNA.
ACCESSION   NM_032510 XM_938856
VERSION     NM_032510.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 3836)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 3836)
  AUTHORS   Kennedy,S.A., Jarboui,M.A., Srihari,S., Raso,C., Bryan,K.,
            Dernayka,L., Charitou,T., Bernal-Llinares,M., Herrera-Montavez,C.,
            Krstic,A., Matallanas,D., Kotlyar,M., Jurisica,I., Curak,J.,
            Wong,V., Stagljar,I., LeBihan,T., Imrie,L., Pillai,P., Lynn,M.A.,
            Fasterius,E., Al-Khalili Szigyarto,C., Breen,J., Kiel,C.,
            Serrano,L., Rauch,N., Rukhlenko,O., Kholodenko,B.N.,
            Iglesias-Martinez,L.F., Ryan,C.J., Pilkington,R., Cammareri,P.,
            Sansom,O., Shave,S., Auer,M., Horn,N., Klose,F., Ueffing,M.,
            Boldt,K., Lynn,D.J. and Kolch,W.
  TITLE     Extensive rewiring of the EGFR network in colorectal cancer cells
            expressing transforming levels of KRASG13D
  JOURNAL   Nat Commun 11 (1), 499 (2020)
   PUBMED   31980649
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3836)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3836)
  AUTHORS   Marques,E., Englund,J.I., Tervonen,T.A., Virkunen,E., Laakso,M.,
            Myllynen,M., Makela,A., Ahvenainen,M., Lepikhova,T., Monni,O.,
            Hautaniemi,S. and Klefstrom,J.
  TITLE     Par6G suppresses cell proliferation and is targeted by
            loss-of-function mutations in multiple cancers
  JOURNAL   Oncogene 35 (11), 1386-1398 (2016)
   PUBMED   26073086
  REMARK    GeneRIF: This paper shows Par6G as a negative regulator of the
            phosphatidylinositol 3'-kinase/phosphoinositide-dependent protein
            kinase 1/Akt pathway and epithelial cell proliferation and evidence
            for frequent inactivation of Par6G gene in epithelial cancers.
REFERENCE   6  (bases 1 to 3836)
  AUTHORS   Brajenovic,M., Joberty,G., Kuster,B., Bouwmeester,T. and Drewes,G.
  TITLE     Comprehensive proteomic analysis of human Par protein complexes
            reveals an interconnected protein network
  JOURNAL   J Biol Chem 279 (13), 12804-12811 (2004)
   PUBMED   14676191
REFERENCE   7  (bases 1 to 3836)
  AUTHORS   Kohjima,M., Noda,Y., Takeya,R., Saito,N., Takeuchi,K. and
            Sumimoto,H.
  TITLE     PAR3beta, a novel homologue of the cell polarity protein PAR3,
            localizes to tight junctions
  JOURNAL   Biochem Biophys Res Commun 299 (4), 641-646 (2002)
   PUBMED   12459187
REFERENCE   8  (bases 1 to 3836)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J Cell Biol 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   9  (bases 1 to 3836)
  AUTHORS   Noda,Y., Takeya,R., Ohno,S., Naito,S., Ito,T. and Sumimoto,H.
  TITLE     Human homologues of the Caenorhabditis elegans cell polarity
            protein PAR6 as an adaptor that links the small GTPases Rac and
            Cdc42 to atypical protein kinase C
  JOURNAL   Genes Cells 6 (2), 107-119 (2001)
   PUBMED   11260256
REFERENCE   10 (bases 1 to 3836)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC060797.1, AC139100.4 and AA502508.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032510.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC060797.1, SRR1163655.155917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142348, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353265.8/ ENSP00000343144.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1681              BC060797.1         1-1681
            1682-3831           AC139100.4         175504-177653       c
            3832-3836           AA502508.1         310-314
FEATURES             Location/Qualifiers
     source          1..3836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..3836
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="par-6 family cell polarity regulator gamma"
                     /db_xref="GeneID:84552"
                     /db_xref="HGNC:HGNC:16076"
                     /db_xref="MIM:608976"
     exon            1..238
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1297
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="PAR-6 gamma protein; PAR6D; par-6 partitioning
                     defective 6 homolog gamma"
                     /codon_start=1
                     /product="partitioning defective 6 homolog gamma"
                     /protein_id="NP_115899.1"
                     /db_xref="CCDS:CCDS12022.1"
                     /db_xref="GeneID:84552"
                     /db_xref="HGNC:HGNC:16076"
                     /db_xref="MIM:608976"
                     /translation="MNRSFHKSQTLRFYDCSAVEVKSKFGAEFRRFSLDRHKPGKFED
                     FYKLVVHTHHISNSDVTIGYADVHGDLLPINNDDNFCKAVSSANPLLRVFIQKREEAE
                     RGSLGAGSLCRRRRALGALRDEGPRRRAHLDIGLPRDFRPVSSIIDVDLVPETHRRVR
                     LHRHGCEKPLGFYIRDGASVRVTPHGLEKVPGIFISRMVPGGLAESTGLLAVNDEVLE
                     VNGIEVAGKTLDQVTDMMIANSHNLIVTVKPANQRNNVVRGGRALGSSGPPSDGTAGF
                     VGPPAPRVLQNFHPDEAESDEDNDVVIEGTLEPARPPQTPGAPAGSLSRVNGAGLAQR
                     LQRDLALDGGLQRLLSSLRADPRHSLALPPGGVEEHGPAVTL"
     exon            239..461
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:2.1.0"
     exon            462..3836
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="hexamer: AATAAA"
     polyA_site      3836
                     /gene="PARD6G"
                     /gene_synonym="PAR-6G; PAR6gamma"
                     /note="major polyA site"
ORIGIN      
        1 gaggcgcgcg gccagcccag ctcgggcccg cagcaccggg agcagcccgc cggccaagcg
       61 agcgcgggcc ggggccgggg ccggggcctg ggggcgccgc ccccgggagt ctttctgcgg
      121 cccctgagga gcgagggcga cggcgaggct gaccggggcc gaaaccatga accgaagttt
      181 tcacaagtct cagaccttgc gattctacga ttgcagcgca gtggaagtca agagcaagtt
      241 tggggcggaa ttccgaaggt tctctctgga ccgtcataag cctgggaagt ttgaagattt
      301 ctacaagctg gttgtgcaca cccaccatat ctccaacagt gatgtaacta ttggctatgc
      361 agatgtgcac ggagacctgc tgcccatcaa caatgatgac aacttctgca aggcggtttc
      421 tagtgcaaat cccctgctca gggtcttcat ccagaaacga gaggaggccg agcgtggcag
      481 cctcggcgcg ggctcgctgt gcaggcggag gcgggcgctg ggcgcgctgc gtgatgaagg
      541 accccggcgg cgtgcacacc tggacatcgg cctcccgcgc gacttccgcc ccgtatcatc
      601 catcatcgat gtggacctgg tccccgagac gcaccggcga gtgcggctgc accggcacgg
      661 ctgcgagaag ccgctgggct tctacatccg cgatggcgcc agcgtgcgcg tgaccccgca
      721 cgggctggag aaggtgcccg gcatcttcat ctcgcgcatg gtacccgggg gcctggcgga
      781 gagcaccggg ctgctggctg tgaatgacga ggtcctggag gtgaacggca ttgaggtggc
      841 cgggaagacg ctggaccagg tcacggacat gatgatcgcc aacagccaca acctcatcgt
      901 caccgtcaag cccgccaacc agcgcaacaa cgtggtgcgc ggcggccgcg cgttgggcag
      961 ctcgggaccg ccctcggacg gcaccgcggg cttcgtgggt ccccccgccc cgcgcgtcct
     1021 gcagaacttc caccccgacg aggcggagag cgatgaggac aacgacgtcg tcatcgaggg
     1081 cacactggag cctgcacgtc ccccccagac cccgggcgcg cccgcaggca gcctctcccg
     1141 ggtcaatggc gcgggcctgg cgcagcggct gcagcgggac ctggccctgg acggcggcct
     1201 ccagcggctg ctcagctccc tgcgggccga cccccgtcac agcctggcgc tgccgccagg
     1261 cggcgtggag gagcacgggc ccgcggtcac gctctagact cccgagaggc ccccaaatcc
     1321 tagctccagt tccccggtaa ggacagggac aggacctgca gactgcatcc gctcattttt
     1381 tgttgttttt gtgaccacaa aaacaacgct gctctttgtt tcaacttccg gatataaaaa
     1441 cacaagtatt gcctattttt atagaatttc gccacagaac ttaaaatgaa cgcctgtaga
     1501 gacactctat accaggcctg agtgcaggtc ttggcgcctt tgcaaagtga tagaaaagat
     1561 ctgaccaagt gcaaaaaaat gctttttaaa atttttacaa atactttgtt tttaaagtga
     1621 agctttaaaa ttactttttt aaaatagtca aattcatgtt tttaagtaag ttggcccatg
     1681 caacatatct cagcattctt gctgtgctct ctgctgactt gcaggcgagg ccgactgtgc
     1741 tgatgtacgt gacaagaggc tggtttttaa taacgaatgc agccaggtgc agtggctcac
     1801 gtctgtaatc ccagcacttt gggaggccta cgtgggctga tcacgaggtc aggaggtcga
     1861 gaccagcatg gccaacatgg tgaaaccctg tctctactaa aaatataaaa attagccagg
     1921 tgtggtggca ggcgcctgta atcccagcta ccttgggagg ctgaggcagg agaatcgctt
     1981 gaacccggga ggcagaggtt gcagtgagct gagatcgcac cactgcactc cagcctgggt
     2041 gacagagcaa gactctgtct cgggaaaaaa aaaaaataca cccaaacctg tccatgtaca
     2101 accatggaga tgaattccag attttcacac tgttcatagt cataattcgg ttgggacagg
     2161 agagctccca ccagcacact tatggcaccc gcagctgtgg aattgttccg gggctttttt
     2221 ttgtttgttt tgagacatag tgtcttgttc tgtcatccaa gctggaggga tctcagctca
     2281 ctgcaacctc cgcctcctgg gttcaagcaa ttctcctgcc tcagcctccc aaggagctgg
     2341 gacaggcaca tgccaccata cccagctaat ttttgtattt ttagtagaga tgggatttca
     2401 ccacgttggt caggctggtc ttgaactcct gacctcaggt gatacggtcc cccctcagcc
     2461 tccaaaaatg ctaggattat agacgtgagc cacagcacca gaccaggggc tatttttgtg
     2521 acccacatag gtggcccatt cagcctcaag gggaaatcca gggtaggaag cagcagctct
     2581 gctggactgg gctcagcagt cccatttggg atgtaagcct ctattgcctc taagatgacc
     2641 cttttcctgt gggttgactg actctgaggg cgatttcgga aatgttttca gcagaaatga
     2701 aggataagca tcgcacatgt ccagcaatgt ctttgagaat gcagtcattt gcacgtgagt
     2761 tctcatcttt gttttctgaa acagacgttt cttttagtaa gtcacaatac atgctaattt
     2821 tcatttctag aatggtcact ggcagttctc acttttaact ataagaagtc acgtggaact
     2881 tagtgatttt taacaaatac taaattcatc ctcactttat gttgatcttc cagcaacgtt
     2941 tatatattta gtaattttaa aaattcctat ttgatacaat taaattttat ataatgtgtt
     3001 ttgcttgaat aaaatgttac atttatactt tgagaactct gaccaaatct ttcatacaga
     3061 tacaggtaaa gaaatatttt tctaggttgt cggagctgcg tacctcccgc tgcttctcct
     3121 tgtggtccag caccacctgc tggtcagtgg cagaactgtc ctgacttcgt gaacatggaa
     3181 ctgctaagag ggaaaactgc atctcagcat tttcattttt tctgaatatt aagtgaaaag
     3241 caagttctat ttttaagaaa tagcttttgc tgaggagttg tgaattcctg cacctgtgtt
     3301 tgatgttatt tgtatgcaat ggattgctgg ccctttgttc ctaagcaaga gaagaccaaa
     3361 gatgcttccc catgacctct ccggtgagga tccgcacccc ccggacttgc tctctgatga
     3421 agggcatgtc gttcagtgcc ccagcagtca gaagcagttt ttgtggaact aaaactaata
     3481 atgttaccct cacaaaggaa atgttctttt actaagttat tgctgattct tgaatgtctg
     3541 ttatataact gggtcggcta tcaagaagga aggttatatt tcttatcaca ttttaagttg
     3601 ttaagcaaat gtgagttttt ttttaagaaa tgaggctttc actgagattt gtgtgctatt
     3661 cataatttta ggaattactg cttagaacag ctgcttgggt gtatttttct acacaggtct
     3721 gtacttctgc cactttctcc ttttaaaaaa acaaaactat gcatattatg tattaaagtt
     3781 ttcttggttt tatatatcag agaataaaaa cttttttgac ttttgagtaa acaaaa
//
