LOCUS       NM_016948               1247 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens par-6 family cell polarity regulator alpha (PARD6A),
            transcript variant 1, mRNA.
ACCESSION   NM_016948
VERSION     NM_016948.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Huang,Y., Liu,P., Luo,J., Zhu,C., Lu,C., Zhao,N., Zhao,W., Cui,W.
            and Yang,X.
  TITLE     Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through
            a LIN28/let-7d Positive Feedback Loop
  JOURNAL   Mol Neurobiol 60 (3), 1626-1644 (2023)
   PUBMED   36542194
  REMARK    GeneRIF: Par6 Enhances Glioma Invasion by Activating MEK/ERK
            Pathway Through a LIN28/let-7d Positive Feedback Loop.
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Lu,Z., Yuan,S., Ruan,L., Tu,Z. and Liu,H.
  TITLE     Partitioning defective 6 homolog alpha (PARD6A) promotes
            epithelial-mesenchymal transition via integrin beta1-ILK-SNAIL1
            pathway in ovarian cancer
  JOURNAL   Cell Death Dis 13 (4), 304 (2022)
   PUBMED   35379775
  REMARK    GeneRIF: Partitioning defective 6 homolog alpha (PARD6A) promotes
            epithelial-mesenchymal transition via integrin beta1-ILK-SNAIL1
            pathway in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Dong,W., Lu,J., Zhang,X., Wu,Y., Lettieri,K., Hammond,G.R. and
            Hong,Y.
  TITLE     A polybasic domain in aPKC mediates Par6-dependent control of
            membrane targeting and kinase activity
  JOURNAL   J Cell Biol 219 (7) (2020)
   PUBMED   32580209
  REMARK    GeneRIF: A polybasic domain in aPKC mediates Par6-dependent control
            of membrane targeting and kinase activity.
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J Cell Biol 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J Cell Sci 113 (Pt 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   9  (bases 1 to 1247)
  AUTHORS   Qiu,R.G., Abo,A. and Steven Martin,G.
  TITLE     A human homolog of the C. elegans polarity determinant Par-6 links
            Rac and Cdc42 to PKCzeta signaling and cell transformation
  JOURNAL   Curr Biol 10 (12), 697-707 (2000)
   PUBMED   10873802
REFERENCE   10 (bases 1 to 1247)
  AUTHORS   Rousset,R., Fabre,S., Desbois,C., Bantignies,F. and Jalinot,P.
  TITLE     The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction
            with the PDZ domain of cellular proteins
  JOURNAL   Oncogene 16 (5), 643-654 (1998)
   PUBMED   9482110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB043634.1.
            
            On Jun 2, 2019 this sequence version replaced NM_016948.2.
            
            Summary: This gene is a member of the PAR6 family and encodes a
            protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a
            semi-Cdc42/Rac interactive binding (CRIB) domain. This cell
            membrane protein is involved in asymmetrical cell division and cell
            polarization processes as a member of a multi-protein complex. The
            protein also has a role in the epithelial-to-mesenchymal transition
            (EMT) that characterizes the invasive phenotype associated with
            metastatic carcinomas. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043634.1, AJ277095.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1247              AB043634.1         2-1248
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1247
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="par-6 family cell polarity regulator alpha"
                     /db_xref="GeneID:50855"
                     /db_xref="HGNC:HGNC:15943"
                     /db_xref="MIM:607484"
     exon            1..142
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1120
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="isoform 1 is encoded by transcript variant 1;
                     partitioning-defective protein 6; Tax-interacting protein
                     40; partitioning defective 6 homolog alpha; PAR-6 alpha;
                     tax interaction protein 40; par-6 partitioning defective 6
                     homolog alpha"
                     /codon_start=1
                     /product="partitioning defective 6 homolog alpha isoform
                     1"
                     /protein_id="NP_058644.1"
                     /db_xref="CCDS:CCDS10843.1"
                     /db_xref="GeneID:50855"
                     /db_xref="HGNC:HGNC:15943"
                     /db_xref="MIM:607484"
                     /translation="MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSR
                     LLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSG
                     LAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRL
                     HKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEV
                     NGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEP
                     DSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWG
                     SRIRGDGSGFSL"
     exon            143..365
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     exon            366..1247
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="hexamer: ATTAAA"
     polyA_site      1247
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgggc cggccgggct gtgcacctgc gcctcggcgg gccgcctggg gcaccgtccc
       61 cggcccgccc ggccccgcca tggcccggcc gcagaggact ccggcgcgca gtcccgatag
      121 catcgtcgag gtgaagagca aatttgacgc cgagttccga cgcttcgcgc tgcctcgcgc
      181 ttcggtgagc ggcttccagg agttctcgcg gttgctgcgg gcggtgcacc agatcccggg
      241 cctggacgtg ctacttggct atacggatgc tcatggcgac ctgctgcccc tcaccaacga
      301 cgacagcctg caccgggccc tggccagcgg gcccccgcca ctgcgcctac tggtgcagaa
      361 gcgggcagaa gctgactcca gcggcctggc ttttgcctcc aactctctgc agcggcgcaa
      421 gaaagggctc ttgctgcggc cagtggcacc cctgcgcacc cggccaccct tgctaatcag
      481 cctgccccaa gatttccgcc aggtttcctc agtcatagac gtggacctac tgcctgagac
      541 ccaccgacgg gtgcggctgc acaagcatgg ttcagaccgc cccctgggct tctacatccg
      601 agatggcatg agcgtgcgtg tggctcccca gggcctggag cgggttccag gaatcttcat
      661 ctcccgcctg gtacgtgggg gtctggctga gagtacaggg ctgctggcgg tcagtgatga
      721 gatcctcgag gtcaatggca ttgaagtagc cgggaagacc ttggaccaag tgacggacat
      781 gatggttgcc aacagccata acctcattgt cactgtcaag cccgccaacc agcgcaataa
      841 cgtggtgcga ggggcatctg ggcgtttgac aggtcctccc tctgcagggc ctgggcctgc
      901 tgagcctgat agtgacgatg acagcagtga cctggtcatt gagaaccgcc agcctcccag
      961 ttccaatggg ctgtctcagg ggcccccgtg ctgggacctg caccctggct gccgacatcc
     1021 tggtacccgc agctctctgc cctccctgga tgaccaggag caggccagtt ctggctgggg
     1081 gagtcgcatt cgaggagatg gtagtggctt cagcctctga cagtcaggat gaagccccat
     1141 gccactccac actgctggga catggcaggg acttcacagt gggggttttt agctggctca
     1201 cagggctccc tcagcctggg gaacattaaa ggttttctac aaataca
//
