LOCUS       NM_001037281            1244 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens par-6 family cell polarity regulator alpha (PARD6A),
            transcript variant 2, mRNA.
ACCESSION   NM_001037281
VERSION     NM_001037281.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1244)
  AUTHORS   Li,L., Sun,X., Zhang,M., Zhang,B., Yang,Y. and Wang,S.
  TITLE     FOXN2, identified as a novel biomarker in serum, modulates the
            transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer
  JOURNAL   Growth Factors 42 (2), 62-73 (2024)
   PUBMED   38954805
  REMARK    GeneRIF: FOXN2, identified as a novel biomarker in serum, modulates
            the transforming growth factor-beta signaling pathway through its
            interaction with partitioning defective 6 homolog alpha,
            contributing to the pathogenesis of gastric cancer.
REFERENCE   2  (bases 1 to 1244)
  AUTHORS   Huang,Y., Liu,P., Luo,J., Zhu,C., Lu,C., Zhao,N., Zhao,W., Cui,W.
            and Yang,X.
  TITLE     Par6 Enhances Glioma Invasion by Activating MEK/ERK Pathway Through
            a LIN28/let-7d Positive Feedback Loop
  JOURNAL   Mol Neurobiol 60 (3), 1626-1644 (2023)
   PUBMED   36542194
  REMARK    GeneRIF: Par6 Enhances Glioma Invasion by Activating MEK/ERK
            Pathway Through a LIN28/let-7d Positive Feedback Loop.
REFERENCE   3  (bases 1 to 1244)
  AUTHORS   Lu,Z., Yuan,S., Ruan,L., Tu,Z. and Liu,H.
  TITLE     Partitioning defective 6 homolog alpha (PARD6A) promotes
            epithelial-mesenchymal transition via integrin beta1-ILK-SNAIL1
            pathway in ovarian cancer
  JOURNAL   Cell Death Dis 13 (4), 304 (2022)
   PUBMED   35379775
  REMARK    GeneRIF: Partitioning defective 6 homolog alpha (PARD6A) promotes
            epithelial-mesenchymal transition via integrin beta1-ILK-SNAIL1
            pathway in ovarian cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1244)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1244)
  AUTHORS   Dong,W., Lu,J., Zhang,X., Wu,Y., Lettieri,K., Hammond,G.R. and
            Hong,Y.
  TITLE     A polybasic domain in aPKC mediates Par6-dependent control of
            membrane targeting and kinase activity
  JOURNAL   J Cell Biol 219 (7) (2020)
   PUBMED   32580209
  REMARK    GeneRIF: A polybasic domain in aPKC mediates Par6-dependent control
            of membrane targeting and kinase activity.
REFERENCE   6  (bases 1 to 1244)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J Cell Biol 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   7  (bases 1 to 1244)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J Cell Sci 113 (Pt 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   8  (bases 1 to 1244)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
REFERENCE   9  (bases 1 to 1244)
  AUTHORS   Qiu,R.G., Abo,A. and Steven Martin,G.
  TITLE     A human homolog of the C. elegans polarity determinant Par-6 links
            Rac and Cdc42 to PKCzeta signaling and cell transformation
  JOURNAL   Curr Biol 10 (12), 697-707 (2000)
   PUBMED   10873802
REFERENCE   10 (bases 1 to 1244)
  AUTHORS   Rousset,R., Fabre,S., Desbois,C., Bantignies,F. and Jalinot,P.
  TITLE     The C-terminus of the HTLV-1 Tax oncoprotein mediates interaction
            with the PDZ domain of cellular proteins
  JOURNAL   Oncogene 16 (5), 643-654 (1998)
   PUBMED   9482110
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF252292.1 and BC015626.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001037281.1.
            
            Summary: This gene is a member of the PAR6 family and encodes a
            protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a
            semi-Cdc42/Rac interactive binding (CRIB) domain. This cell
            membrane protein is involved in asymmetrical cell division and cell
            polarization processes as a member of a multi-protein complex. The
            protein also has a role in the epithelial-to-mesenchymal transition
            (EMT) that characterizes the invasive phenotype associated with
            metastatic carcinomas. Alternate transcriptional splice variants,
            encoding different isoforms, have been characterized. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region, compared to variant 1, resulting
            in a protein (isoform 2) that is one amino acid shorter than
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB041642.1, AF252292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458121.7/ ENSP00000392388.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AF252292.1         55-89
            36-1244             BC015626.2         28-1236
FEATURES             Location/Qualifiers
     source          1..1244
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q22.1"
     gene            1..1244
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="par-6 family cell polarity regulator alpha"
                     /db_xref="GeneID:50855"
                     /db_xref="HGNC:HGNC:15943"
                     /db_xref="MIM:607484"
     exon            1..142
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1117
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="isoform 2 is encoded by transcript variant 2;
                     partitioning-defective protein 6; Tax-interacting protein
                     40; partitioning defective 6 homolog alpha; PAR-6 alpha;
                     tax interaction protein 40; par-6 partitioning defective 6
                     homolog alpha"
                     /codon_start=1
                     /product="partitioning defective 6 homolog alpha isoform
                     2"
                     /protein_id="NP_001032358.1"
                     /db_xref="CCDS:CCDS45514.1"
                     /db_xref="GeneID:50855"
                     /db_xref="HGNC:HGNC:15943"
                     /db_xref="MIM:607484"
                     /translation="MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSR
                     LLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKREADSSGL
                     AFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLH
                     KHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVN
                     GIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPD
                     SDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGS
                     RIRGDGSGFSL"
     exon            143..365
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     exon            366..1244
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1222..1227
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="hexamer: ATTAAA"
     polyA_site      1244
                     /gene="PARD6A"
                     /gene_synonym="PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40;
                     TIP-40"
                     /note="major polyA site"
ORIGIN      
        1 gcgggcgggc cggccgggct gtgcacctgc gcctcggcgg gccgcctggg gcaccgtccc
       61 cggcccgccc ggccccgcca tggcccggcc gcagaggact ccggcgcgca gtcccgatag
      121 catcgtcgag gtgaagagca aatttgacgc cgagttccga cgcttcgcgc tgcctcgcgc
      181 ttcggtgagc ggcttccagg agttctcgcg gttgctgcgg gcggtgcacc agatcccggg
      241 cctggacgtg ctacttggct atacggatgc tcatggcgac ctgctgcccc tcaccaacga
      301 cgacagcctg caccgggccc tggccagcgg gcccccgcca ctgcgcctac tggtgcagaa
      361 gcgggaagct gactccagcg gcctggcttt tgcctccaac tctctgcagc ggcgcaagaa
      421 agggctcttg ctgcggccag tggcacccct gcgcacccgg ccacccttgc taatcagcct
      481 gccccaagat ttccgccagg tttcctcagt catagacgtg gacctactgc ctgagaccca
      541 ccgacgggtg cggctgcaca agcatggttc agaccgcccc ctgggcttct acatccgaga
      601 tggcatgagc gtgcgtgtgg ctccccaggg cctggagcgg gttccaggaa tcttcatctc
      661 ccgcctggta cgtgggggtc tggctgagag tacagggctg ctggcggtca gtgatgagat
      721 cctcgaggtc aatggcattg aagtagccgg gaagaccttg gaccaagtga cggacatgat
      781 ggttgccaac agccataacc tcattgtcac tgtcaagccc gccaaccagc gcaataacgt
      841 ggtgcgaggg gcatctgggc gtttgacagg tcctccctct gcagggcctg ggcctgctga
      901 gcctgatagt gacgatgaca gcagtgacct ggtcattgag aaccgccagc ctcccagttc
      961 caatgggctg tctcaggggc ccccgtgctg ggacctgcac cctggctgcc gacatcctgg
     1021 tacccgcagc tctctgccct ccctggatga ccaggagcag gccagttctg gctgggggag
     1081 tcgcattcga ggagatggta gtggcttcag cctctgacag tcaggatgaa gccccatgcc
     1141 actccacact gctgggacat ggcagggact tcacagtggg ggtttttagc tggctcacag
     1201 ggctccctca gcctggggaa cattaaaggt tttctacaaa taca
//
