LOCUS       NM_001302769            8492 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens par-3 family cell polarity regulator beta (PARD3B),
            transcript variant 1, mRNA.
ACCESSION   NM_001302769 XM_005246273
VERSION     NM_001302769.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8492)
  AUTHORS   Xu,H., Lin,X., Li,Z., He,X., Li,Y., Qiu,L., Lu,L., Liu,B., Zhan,M.
            and He,K.
  TITLE     VIRMA facilitates intrahepatic cholangiocarcinoma progression
            through epigenetic augmentation of TMED2 and PARD3B mRNA
            stabilization
  JOURNAL   J Gastroenterol 58 (9), 925-944 (2023)
   PUBMED   37391589
  REMARK    GeneRIF: VIRMA facilitates intrahepatic cholangiocarcinoma
            progression through epigenetic augmentation of TMED2 and PARD3B
            mRNA stabilization.
REFERENCE   2  (bases 1 to 8492)
  AUTHORS   Thompson,B.J.
  TITLE     Par-3 family proteins in cell polarity & adhesion
  JOURNAL   FEBS J 289 (3), 596-613 (2022)
   PUBMED   33565714
  REMARK    GeneRIF: Par-3 family proteins in cell polarity & adhesion.
            Review article
REFERENCE   3  (bases 1 to 8492)
  AUTHORS   Li,T., Liu,X., Jiang,Q., Lei,X. and Liu,D.
  TITLE     High expression of partitioning defective 3-like protein is
            associated with malignancy in colorectal cancer
  JOURNAL   Tumour Biol 39 (4), 1010428317698393 (2017)
   PUBMED   28443499
  REMARK    GeneRIF: artitioning defective 3-like protein may serve as a
            promising prognostic marker and a potential therapeutic target for
            colorectal cancer treatment. Further study is necessary to
            understand the regulatory mechanism of partitioning defective
            3-like protein in colorectal cancer and the feasibility of its
            application in clinic.
REFERENCE   4  (bases 1 to 8492)
  AUTHORS   Li,T., Liu,D., Lei,X. and Jiang,Q.
  TITLE     Par3L enhances colorectal cancer cell survival by inhibiting
            Lkb1/AMPK signaling pathway
  JOURNAL   Biochem Biophys Res Commun 482 (4), 1037-1041 (2017)
   PUBMED   27908725
  REMARK    GeneRIF: Par3L interacts with Lkb1 and regulates the activity of
            AMPK signaling cascade.
REFERENCE   5  (bases 1 to 8492)
  AUTHORS   Ebejer,J.L., Duffy,D.L., van der Werf,J., Wright,M.J.,
            Montgomery,G., Gillespie,N.A., Hickie,I.B., Martin,N.G. and
            Medland,S.E.
  TITLE     Genome-wide association study of inattention and
            hyperactivity-impulsivity measured as quantitative traits
  JOURNAL   Twin Res Hum Genet 16 (2), 560-574 (2013)
   PUBMED   23527680
REFERENCE   6  (bases 1 to 8492)
  AUTHORS   Izaki,T., Kamakura,S., Kohjima,M. and Sumimoto,H.
  TITLE     Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human
            Par3-related cell polarity protein
  JOURNAL   Biochem Biophys Res Commun 329 (1), 211-218 (2005)
   PUBMED   15721295
  REMARK    GeneRIF: binding of 14-3-3 to Par3beta is dependent on
            phosphorylation
REFERENCE   7  (bases 1 to 8492)
  AUTHORS   Jin,J., Smith,F.D., Stark,C., Wells,C.D., Fawcett,J.P.,
            Kulkarni,S., Metalnikov,P., O'Donnell,P., Taylor,P., Taylor,L.,
            Zougman,A., Woodgett,J.R., Langeberg,L.K., Scott,J.D. and Pawson,T.
  TITLE     Proteomic, functional, and domain-based analysis of in vivo 14-3-3
            binding proteins involved in cytoskeletal regulation and cellular
            organization
  JOURNAL   Curr Biol 14 (16), 1436-1450 (2004)
   PUBMED   15324660
REFERENCE   8  (bases 1 to 8492)
  AUTHORS   Kohjima,M., Noda,Y., Takeya,R., Saito,N., Takeuchi,K. and
            Sumimoto,H.
  TITLE     PAR3beta, a novel homologue of the cell polarity protein PAR3,
            localizes to tight junctions
  JOURNAL   Biochem Biophys Res Commun 299 (4), 641-646 (2002)
   PUBMED   12459187
  REMARK    GeneRIF: PAR3beta, expressed intrinsically or extrinsically,
            localizes to the tight junctions, indicating that the localization
            does not require the ternary complex formation.
REFERENCE   9  (bases 1 to 8492)
  AUTHORS   Gao,L., Macara,I.G. and Joberty,G.
  TITLE     Multiple splice variants of Par3 and of a novel related gene,
            Par3L, produce proteins with different binding properties
  JOURNAL   Gene 294 (1-2), 99-107 (2002)
   PUBMED   12234671
REFERENCE   10 (bases 1 to 8492)
  AUTHORS   Hadano,S., Hand,C.K., Osuga,H., Yanagisawa,Y., Otomo,A.,
            Devon,R.S., Miyamoto,N., Showguchi-Miyata,J., Okada,Y.,
            Singaraja,R., Figlewicz,D.A., Kwiatkowski,T., Hosler,B.A.,
            Sagie,T., Skaug,J., Nasir,J., Brown,R.H. Jr., Scherer,S.W.,
            Rouleau,G.A., Hayden,M.R. and Ikeda,J.E.
  TITLE     A gene encoding a putative GTPase regulator is mutated in familial
            amyotrophic lateral sclerosis 2
  JOURNAL   Nat Genet 29 (2), 166-173 (2001)
   PUBMED   11586298
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC016903.3, BF434006.1, AF428250.1, AC009316.3, AC008171.3,
            AC007465.4 and AC007385.3.
            
            On Nov 22, 2018 this sequence version replaced NM_001302769.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (Par3La).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB092439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000406610.7/ ENSP00000385848.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-318               AC016903.3         56260-56577         c
            319-525             BF434006.1         1-207
            526-863             AF428250.1         1-338
            864-864             AC009316.3         11184-11184         c
            865-1979            AF428250.1         340-1454
            1980-1980           AC008171.3         20001-20001
            1981-2732           AF428250.1         1456-2207
            2733-2733           AC007465.4         34365-34365
            2734-3686           AF428250.1         2209-3161
            3687-3687           AC007385.3         169438-169438       c
            3688-4143           AF428250.1         3163-3618
            4144-8492           AC007385.3         49289-53637         c
FEATURES             Location/Qualifiers
     source          1..8492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..8492
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /note="par-3 family cell polarity regulator beta"
                     /db_xref="GeneID:117583"
                     /db_xref="HGNC:HGNC:14446"
                     /db_xref="MIM:619353"
     exon            1..645
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..4143
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /note="isoform Par3La is encoded by transcript variant 1;
                     partitioning-defective 3-beta; amyotrophic lateral
                     sclerosis 2 (juvenile) chromosome region, candidate 19;
                     partitioning defective 3 homolog B; PAR3-L protein;
                     partitioning defective 3-like protein; amyotrophic lateral
                     sclerosis 2 chromosomal region candidate gene 19 protein;
                     par-3 partitioning defective 3 homolog B"
                     /codon_start=1
                     /product="partitioning defective 3 homolog B isoform
                     Par3La"
                     /protein_id="NP_001289698.1"
                     /db_xref="CCDS:CCDS77511.1"
                     /db_xref="GeneID:117583"
                     /db_xref="HGNC:HGNC:14446"
                     /db_xref="MIM:619353"
                     /translation="MKVTVCFGRTGIVVPCKEGQLRVGELTQQALQRYLKTREKGPGY
                     WVKIHHLEYTDGGILDPDDVLADVVEDKDKLIAVFEEQEPLHKIESPSGNPADRQSPD
                     AFETEVAAQLAAFKPIGGEIEVTPSALKLGTPLLVRRSSDPVPGPPADTQPSASHPGG
                     QSLKLVVPDSTQNLEDREVLNGVQTELLTSPRTKDTLSDMTRTVEISGEGGPLGIHVV
                     PFFSSLSGRILGLFIRGIEDNSRSKREGLFHENECIVKINNVDLVDKTFAQAQDVFRQ
                     AMKSPSVLLHVLPPQNREQYEKSVIGSLNIFGNNDGVLKTKVPPPVHGKSGLKTANLT
                     GTDSPETDASASLQQNKSPRVPRLGGKPSSPSLSPLMGFGSNKNAKKIKIDLKKGPEG
                     LGFTVVTRDSSIHGPGPIFVKNILPKGAAIKDGRLQSGDRILEVNGRDVTGRTQEELV
                     AMLRSTKQGETASLVIARQEGHFLPRELKGEPDCCALSLETSEQLTFEIPLNDSGSAG
                     LGVSLKGNKSRETGTDLGIFIKSIIHGGAAFKDGRLRMNDQLIAVNGESLLGKSNHEA
                     METLRRSMSMEGNIRGMIQLVILRRPERPMEDPAECGAFSKPCFENCQNAVTTSRRND
                     NSILHPLGTCSPQDKQKGLLLPNDGWAESEVPPSPTPHSALGLGLEDYSHSSGVDSAV
                     YFPDQHINFRSVTPARQPESINLKASKSMDLVPDESKVHSLAGQKSESPSKDFGPTLG
                     LKKSSSLESLQTAVAEVRKNDLPFHRPRPHMVRGRGCNESFRAAIDKSYDGPEEIEAD
                     GLSDKSSHSGQGALNCESAPQGNSELEDMENKARKVKKTKEKEKKKEKGKLKVKEKKR
                     KEENEDPERKIKKKGFGAMLRFGKKKEDKGGKAEQKGTLKHGGLREEELEKMKEERER
                     IGAKHQELREKQARGLLDYATGAIGSVYDMDDDEMDPNYARVNHFREPCTSANVFRSP
                     SPPRAGPFGYPRDGHPLSPERDHLEGLYAKVNKPYHPLVPADSGRPTGGSTDRIQKLR
                     KEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDGNAHNLRFEGMERQYASLPRG
                     GPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSYPRPTELRVADLRYPQHYPPP
                     PAPQHKGPFRQDVPPSPPQHQRMPAYQETGRPGPRGGSPDQYPYRTQDSRQKNPMTAA
                     V"
     exon            646..747
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            748..919
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1029
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1118
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1205
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1331
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1690
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1830
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1959
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            1960..2145
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2146..2316
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2317..2449
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2450..2549
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2550..2665
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2666..2710
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2711..2917
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            2918..3155
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3156..3266
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3267..3569
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3705
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3706..3785
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..8492
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8469..8474
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /note="hexamer: AATAAA"
     polyA_site      8492
                     /gene="PARD3B"
                     /gene_synonym="ALS2CR19; PAR3B; PAR3beta; PAR3L"
                     /note="major polyA site"
ORIGIN      
        1 accgcaggag cccagagcgc gggcgccgca gaggagttgg gagccggcgc aaaagtttcc
       61 tcccaactct ggccccgtgc gccgccgccg ccgccgccca ctccagcccc cggcttgggg
      121 ccggccctgc caacgccgcc agggccaggg ccagggccag gaccagcgac agggcagggc
      181 cggcagtttc gctttggtgg gcgcggagca gccgcctggg ccgggcagga gtaggagcgg
      241 gaggaggagg aggaggagcc ggtgccgcgg agctgccgcg tcccgggccg ccgggcacct
      301 gggaggtaac ccctttccgc ggccgcccct ccccgattcc cgccacctgc cgcctggcca
      361 ggtggaaggg gcgctgccgc gagcctccgg gcctcagggt gttccgggga gcggcgcccc
      421 gggtctctgg gcccacccgc cccgggcgtc ctccgagagt gggggctgcg cccgcggggt
      481 cagacacctg ttcggcccgg cccggcgtgg tcgccggggg ccaggatgaa agtgaccgtg
      541 tgcttcggca ggacgggcat cgtggtgccc tgcaaggagg gccagctgcg cgtcggcgag
      601 ctcacccagc aggcgctgca gcggtacctg aagacccggg agaagggtcc tggttactgg
      661 gtgaagattc atcacttaga atatacagat ggaggaatcc tggatccaga tgatgtcttg
      721 gcagatgttg ttgaagataa agacaagctg attgctgtgt ttgaagaaca agaaccactc
      781 cacaagattg agagccccag tggaaaccct gcagatcggc agagcccaga tgcttttgag
      841 acagaagtgg ccgcccaact ggccgcattt aagccaattg gtggggagat tgaagtaacc
      901 ccttctgctc taaaactagg cactccactg ctggtgagga gaagcagtga cccagtgcca
      961 ggcccacctg ctgataccca gccaagcgct tcacaccctg gtggccagag tctgaaactg
     1021 gttgttccag attccacgca gaacttggaa gacagagaag ttttgaatgg tgtacagaca
     1081 gaactactaa cttcgccaag aactaaggac acattgagtg atatgacaag aacagtggag
     1141 atttctgggg aaggaggccc attgggaata catgtagtgc ccttcttttc atctctgagt
     1201 ggaaggattc taggactctt catccgaggc attgaagaca acagcaggtc caagcgggag
     1261 ggactatttc acgaaaatga atgtattgta aaaatcaaca atgtggatct cgtagacaaa
     1321 acctttgctc aggctcaaga tgtcttccgc caggcaatga aatctccaag tgtgctcctc
     1381 cacgtgcttc ctccacaaaa ccgtgaacag tatgaaaagt cagtcattgg ctctcttaac
     1441 atttttggta ataatgatgg cgttttgaaa accaaagtgc cgcctcctgt ccatggaaaa
     1501 tcgggactaa agacagcaaa tctcacagga accgatagtc ctgaaacaga tgcatcagct
     1561 tccctgcaac aaaacaagag tccccgagta ccaaggctgg gaggaaaacc atcctctccc
     1621 tcactctcgc ctctcatggg atttggcagc aataaaaatg caaagaaaat taagattgac
     1681 ctaaagaaag gccctgaagg acttggtttc actgtggtta ccagagactc ttccatacat
     1741 ggtcccggtc ccatttttgt aaaaaacatt ttaccaaagg gagcagcaat aaaagatggc
     1801 cgcctacaat caggggacag aattttggag gtaaatggga gagatgtcac cggacgaacc
     1861 caggaagagc ttgtggccat gctcaggagc accaagcagg gggagacagc atcgctggtc
     1921 attgcccgcc aagaaggaca ttttctgccc cgagagttga aaggagaacc tgactgctgt
     1981 gcactctctc tggagacaag cgagcagctc acctttgaga tccccctgaa tgattcaggt
     2041 tctgctggcc tcggggtgag cttaaaaggg aacaaatcca gagaaactgg aacagacttg
     2101 gggattttta tcaaatccat cattcatgga ggcgctgctt ttaaggatgg tcgtctgcga
     2161 atgaatgacc agctgattgc agttaatggg gaatctcttt tgggaaagtc caaccacgaa
     2221 gctatggaaa cacttaggcg gtcaatgtcc atggagggaa acatccgagg gatgatccag
     2281 ttggtgattc tgaggaggcc agagagacca atggaggatc ctgcagagtg tggggcattt
     2341 tccaagccat gctttgagaa ctgtcaaaat gctgtaacca cctctaggcg aaatgataat
     2401 agtatcctgc atccacttgg cacttgcagt ccacaagaca aacagaaagg tctattgctg
     2461 cccaatgacg gatgggccga gagtgaagtt ccaccttctc caacaccaca ttctgctctg
     2521 ggattgggcc tcgaagatta cagccacagc tctggggtgg attcagcagt atattttcca
     2581 gatcagcaca tcaacttcag atctgtgaca ccggccaggc agcctgaatc aattaatttg
     2641 aaagcctcga agagcatgga ccttgtgcca gatgaaagca aggttcactc attggctgga
     2701 caaaaatcgg aatctccaag caaagatttt ggtccaactc tgggtttgaa aaagtccagc
     2761 tccttggaga gtctgcagac tgcagtggcc gaggtcagga agaatgacct tccctttcac
     2821 aggccccggc cgcacatggt tcgaggccga ggctgcaatg agagctttag agcagccatt
     2881 gacaaatcct acgatggacc tgaagaaata gaagctgacg gtctgtctga taagagctct
     2941 cactctggcc aaggagctct gaattgtgag tctgcccctc aggggaattc ggagctagag
     3001 gacatggaaa ataaagccag gaaagtcaaa aaaacgaaag agaaggagaa gaaaaaggaa
     3061 aagggcaaat tgaaagtcaa ggagaaaaag cgcaaagagg agaatgaaga tccagaaagg
     3121 aaaataaaga agaagggctt cggcgccatg ctgagatttg gaaagaagaa agaggataag
     3181 ggtggaaagg ctgagcagaa aggtactctg aaacatggtg gcctgagaga agaagagctg
     3241 gagaaaatga aagaagagcg tgaaaggatt ggagcaaaac atcaggagct aagggaaaag
     3301 caggcaagag gtcttcttga ttatgctact ggtgcaattg gatcagtgta tgatatggat
     3361 gatgatgaaa tggaccccaa ttatgccaga gtgaaccact ttcgggaacc atgcacatca
     3421 gcaaatgtct ttagatctcc atctccccct cgagctggac catttggtta ccctcgggat
     3481 ggccatccac tgtctccaga aagagaccac ttagagggtc tctatgccaa ggtcaacaag
     3541 ccataccatc cactggttcc agctgacagt ggccgtccta cgggtggaag cactgaccgt
     3601 atccagaagt tgcggaaaga gtattatcag gctcggaggg aaggtttccc tttatatgaa
     3661 gacgacgaag gaagagcaag gccatctgag tatgacctac tctgggtgcc tggaaggggt
     3721 ccagatggga atgcacacaa cctccgcttt gaagggatgg agaggcagta cgcatcctta
     3781 cccaggggag gacccgcaga tcctgtagac tatctgccag cagcacctcg ggggctctac
     3841 aaggaaaggg agcttcccta ttatccaggg gctcatccta tgcaccctcc caaagggagc
     3901 tatccccgcc ccacagagct cagggtggca gatctccggt atcctcagca ctacccaccc
     3961 ccgccagctc cccagcacaa aggacccttt cgacaagacg ttccgccttc ccctccccag
     4021 caccaaagaa tgccagccta tcaggaaaca ggcagaccag ggccccgtgg gggcagccca
     4081 gaccagtacc cttaccgaac ccaggattcc cggcagaaga accccatgac tgcagccgta
     4141 tagctgagtg ccaccgaggc cagcccggtc cagaaaggaa ggtgtctact ctacctttgc
     4201 cctttctaaa cctgaagacc tccttggtgt taggaattct ccatgttact gataagcttt
     4261 ttctcactga cattgtaacg catgactgct aatcagagag aaaaagaagg ggaagggaat
     4321 tggggaggaa aaaaaatcag aaggaagacg aaagatgggg ctataaaaac aaaactacct
     4381 gatagttgaa acgctttcag agttgttcaa atcagtgaga gtggcaacgg aacacacaaa
     4441 caactaatta tggaactcta ctctggggat cctctctggc tagataacct gtgctgatgt
     4501 gcagacacgt ggacatcccc ctctgagact ggcggtccag aggcagtctc tgccaggcag
     4561 cattacccgc tccgaggtgg agcctcagcc cccttcttag agctgttaag tctaaggtgt
     4621 ggcagagcag acagagatag aggcatctga agtgagtata ggttttttga ctaagaaaaa
     4681 aaacaacagc aaacatgact agtgatcttg aaatattttg taccgagaga aagactgcat
     4741 ttatttgtag aatttatcag gtttctgata ccactcattg gatgtaaaca tttcatgttt
     4801 cctcactttt gatatgaaag tcggtaaaat gcagtattag tcccgggagg atgtgcacag
     4861 ctggtcagag cttccagaag gaatatcttc cgaggactaa ggtgatcagg ttaagagggt
     4921 tcaacatccc acggccctca ccttcctccc tcccacattc caggcatgga gatatctggt
     4981 ttcagagtca gccccaaatc tcctgcctat aattacttta actggggtct ctaaggttcc
     5041 cacttgaggg ctaaaatgta gttgggaaag agggcctact ggggaggtct cacaggaggc
     5101 agtgccctgg gaaatgccaa gtccagactc agtgccaagc agtaaccatc tgcactcggg
     5161 gacagcgagg agctgaccat ggcctctgat gaccagcagg tattagatgg aagtgaatga
     5221 gagagagaga gagagagagt atgtgtgtgt gtgtgtatgt gtgtgttcga acacatatga
     5281 ttgccagtat ggagaatgaa agattaataa tgctttctgg agagtttgat gcaaaagtgg
     5341 gggaaacgga gaaaaggcgc taaggctaaa tccatctgca tttgctatat ttcattagct
     5401 aaagtcaggt cagggcaggg ccaaggcctc caattggcaa aggacagtgt tatggcttta
     5461 aaaagctgaa accccaacct ctaagtagat cacaatgttt tctgagcttt gcagtaattt
     5521 tctatggaaa ctaaaacctc taaaacatac aagctggccc aaatgagaac acaagcaaaa
     5581 gatgtggaag acagcaaaac ctgagcactg gtttgaacca ggcactgaca tttgaaatgc
     5641 tttaagcctt ttcacattcc ttctttattc cctccaaaaa aaaaagtctt gagtttaatt
     5701 taggtctatt ttggctgaga ttagcatacc tctgactcac aggatttaat aaattatagt
     5761 attattgaat acataggaca tccctctacc ccagcttact cttatctttt taatttaaaa
     5821 tagtattctg ctaccaagaa ggatgcaact gctagtttta gatgtaaata gtgttattta
     5881 ctggactttg tgatattatt ttcttaacta cactttacta tggccctgtt gaaaacagac
     5941 tatcaagttt tttgtctctg ttctgtcatc tctcttaagc caggcacctt tagagtgttt
     6001 gcaatttgtt cgaagtggtt gaggatctca ggccctgctc acgtgaggtg gagtgcaggg
     6061 gagctaccgg tttccctgct gacctgctga atgctacctt cccctcgagt tgaatacacc
     6121 ttaaggaaaa tgataacacg agggacgtgt aacttgtttt gaagcattaa aaaccagcag
     6181 ctcttcacta tgttccatat tttaaccaaa ctactgtaga ctactaaaca tagccaagcc
     6241 agaacattcc ttctggatta agcctaggcc acttgagggg cagccagggg tgatggtgtc
     6301 aggtgagaat cctgtgtctt gaaggagtgg cctttacagg aagagtgccc atgttttcac
     6361 ctgcagcgtt gccaccagag tgtgcaatac ctcctgcaca caggctcagg gtaaactgct
     6421 ccaaagctgg gttttgtgtt gcatacaaag tcaataaaat agttgctaat cctgaatggc
     6481 agccagtgat gtgaaggtac tattaaagtg aacaaaaact agattgcaac agttttcttt
     6541 ccttgcttga agtataacac acgctccatt tgatcctgcc tgaaagaagc taacattata
     6601 tttgtgacag acagaggctc catcaagcca agcaacaatt aacagctcaa gtgtaagatt
     6661 tataaatgcc cgtgtactca cccttcaatt gttaccaccc agaggttaca ggactctttc
     6721 ccagcattta ggggaacagg cttttagagt atttagaaga ccaggctata atcagtaatg
     6781 tgcctgggag caggaaatag ctcccaattt atttatggcc ttgggaaaac tcaatccggt
     6841 gtctccttgt agctcagaac actaatagcc cccctggaag agagtggcac attgagctcc
     6901 aaacccaatc aacatacatc cacttggctg cagatctgac tgctgggtca tgaaggccgt
     6961 gaaatgatgt ttgccctcaa gtcactagat attttaagaa gccctatttt tctccctttt
     7021 tgcaggagta gagagatgaa agaggacaga ccattgaaaa cttttagatg caggagaatt
     7081 gagacttcca caagggagag aaacacagcc tccccagaat ccattatgcc atcgggttgt
     7141 ggcactctca cccttgccat aataccgttt cctaacaata tcaaatcagt ggatgaaata
     7201 caagctcaga aacaggaaca ttttcctaaa tcataaccta atagcaaaca aaaattgaaa
     7261 aaacaattat tctgaagctc attattctta gatctgtaga tatatatgtg ttgactccca
     7321 caggatggca ccaagtaaag atcttaagag catagtaggg gttctgagac cgactgtcac
     7381 ccgtggatcc tgatggggaa gaacagaggc ttcactgtag ctatagtttt ccaccaagtc
     7441 aatcaaatta aaacatgact cattgtcccc tccaaagatt cataaaattc ttgagctaaa
     7501 gtgatcttct gaagaaaagc cacctaacaa tgttaggagg ctcataaagc tcatttctct
     7561 tttccctggt atgcacaaat atcaagccta taaaaaagta attatttccc caaacctgta
     7621 accactgcat tcgttttctt tggaggaaca ttgtagcatt tcaggagggt cgagagatct
     7681 aaagagtttg gtctgaatgt gtgtctgtac aattcccttt ggcattaaac tctgaaacct
     7741 acaatcaatg gccttcaaat tggtgttaaa ttgggagaac accctactgc tttctgagtc
     7801 tacgagcaac agaaagactg gtcttagtgc aattaggcag gagggatttg gactcagaaa
     7861 cagccacaga agtatttctc agcactccca gttcctgcca acttagctgg aaacgatgcc
     7921 acagcgagac cagaaagagg agtcgcctta aggtatccct acaaagtcac ctttctgata
     7981 aaaaggaggg aaaaaaaagt tagatatcta aaataagcct agaatctcac acacagctgt
     8041 gacttctaag tgaaactctt ttctccctca tgtccttaaa tagtcacaga atcacacaca
     8101 gcctgacttt taaagacaag cttggctaca ggaaatgaac caaccccaaa gactcttcta
     8161 acctgtctcc tgactgggct ccttcagaaa gtgttctcct gttccatctg tagggctgct
     8221 tactactgga acctaaaaca aaacctgttg tttgtaccat cactttttct ggtgtttcct
     8281 gtgcttttgt gattccaagt ctgttcataa gttctgaaga taaattatgt gaaatcatat
     8341 tttggcatat gggggtggag gatgaattct ttacagactt tttaagatga tccatttgta
     8401 ccacagaaaa cattttggaa gttgttatat atgagtatat aaatttttct tttcatattt
     8461 tacattaaaa taaagcttta ttcagtcatt aa
//
