LOCUS       NM_001184785            5971 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens par-3 family cell polarity regulator (PARD3),
            transcript variant 2, mRNA.
ACCESSION   NM_001184785
VERSION     NM_001184785.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5971)
  AUTHORS   Zhang,J., Shi,Y., Ding,K., Yu,W., He,J. and Sun,B.
  TITLE     DCAF1 interacts with PARD3 to promote hepatocellular carcinoma
            progression and metastasis by activating the Akt signaling pathway
  JOURNAL   J Exp Clin Cancer Res 43 (1), 136 (2024)
   PUBMED   38711082
  REMARK    GeneRIF: DCAF1 interacts with PARD3 to promote hepatocellular
            carcinoma progression and metastasis by activating the Akt
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5971)
  AUTHORS   Wu,J., Tan,H.Y., Chan,Y.T., Lu,Y., Feng,Z., Yuan,H., Zhang,C.,
            Feng,Y. and Wang,N.
  TITLE     PARD3 drives tumorigenesis through activating Sonic Hedgehog
            signalling in tumour-initiating cells in liver cancer
  JOURNAL   J Exp Clin Cancer Res 43 (1), 42 (2024)
   PUBMED   38317186
  REMARK    GeneRIF: PARD3 drives tumorigenesis through activating Sonic
            Hedgehog signalling in tumour-initiating cells in liver cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5971)
  AUTHORS   Gunji,D., Narumi,R., Muraoka,S., Isoyama,J., Ikemoto,N., Ishida,M.,
            Tomonaga,T., Sakai,Y., Obama,K. and Adachi,J.
  TITLE     Integrative analysis of cancer dependency data and comprehensive
            phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer
            vulnerability in KRAS-mutant colorectal cancer
  JOURNAL   Mol Omics 19 (8), 624-639 (2023)
   PUBMED   37232035
  REMARK    GeneRIF: Integrative analysis of cancer dependency data and
            comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis
            as a cancer vulnerability in KRAS-mutant colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5971)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 5971)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 5971)
  AUTHORS   Ebnet,K., Suzuki,A., Horikoshi,Y., Hirose,T., Meyer Zu
            Brickwedde,M.K., Ohno,S. and Vestweber,D.
  TITLE     The cell polarity protein ASIP/PAR-3 directly associates with
            junctional adhesion molecule (JAM)
  JOURNAL   EMBO J 20 (14), 3738-3748 (2001)
   PUBMED   11447115
REFERENCE   7  (bases 1 to 5971)
  AUTHORS   Suzuki,A., Yamanaka,T., Hirose,T., Manabe,N., Mizuno,K.,
            Shimizu,M., Akimoto,K., Izumi,Y., Ohnishi,T. and Ohno,S.
  TITLE     Atypical protein kinase C is involved in the evolutionarily
            conserved par protein complex and plays a critical role in
            establishing epithelia-specific junctional structures
  JOURNAL   J Cell Biol 152 (6), 1183-1196 (2001)
   PUBMED   11257119
REFERENCE   8  (bases 1 to 5971)
  AUTHORS   Noda,Y., Takeya,R., Ohno,S., Naito,S., Ito,T. and Sumimoto,H.
  TITLE     Human homologues of the Caenorhabditis elegans cell polarity
            protein PAR6 as an adaptor that links the small GTPases Rac and
            Cdc42 to atypical protein kinase C
  JOURNAL   Genes Cells 6 (2), 107-119 (2001)
   PUBMED   11260256
REFERENCE   9  (bases 1 to 5971)
  AUTHORS   Johansson,A., Driessens,M. and Aspenstrom,P.
  TITLE     The mammalian homologue of the Caenorhabditis elegans polarity
            protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and
            Rac1
  JOURNAL   J Cell Sci 113 (Pt 18), 3267-3275 (2000)
   PUBMED   10954424
REFERENCE   10 (bases 1 to 5971)
  AUTHORS   Joberty,G., Petersen,C., Gao,L. and Macara,I.G.
  TITLE     The cell-polarity protein Par6 links Par3 and atypical protein
            kinase C to Cdc42
  JOURNAL   Nat Cell Biol 2 (8), 531-539 (2000)
   PUBMED   10934474
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL450337.24, AL138768.23,
            AL360233.21, AL392123.12, AL390766.16 and AL160409.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001184785.1.
            
            Summary: This gene encodes a member of the PARD protein family.
            PARD family members interact with other PARD family members and
            other proteins; they affect asymmetrical cell division and direct
            polarized cell growth. Multiple alternatively spliced transcript
            variants have been described for this gene. [provided by RefSeq,
            Oct 2011].
            
            Transcript Variant: This variant (2) uses a different splice site,
            compared to variant 1. The resulting protein (isoform 2) is shorter
            when it is compared to isoform 1. This variant has also been called
            the 'long variant' and 'variant b'.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF196185.1, AF467003.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374788.8/ ENSP00000363920.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               AL450337.24        21924-22344         c
            422-523             AL138768.23        168860-168961       c
            524-704             AL360233.21        97337-97517         c
            705-883             AL360233.21        50443-50621         c
            884-1015            AL360233.21        30675-30806         c
            1016-1107           AL392123.12        84541-84632         c
            1108-1191           AL392123.12        82045-82128         c
            1192-1317           AL392123.12        66844-66969         c
            1318-1700           AL392123.12        65255-65637         c
            1701-1840           AL392123.12        60682-60821         c
            1841-1969           AL392123.12        57589-57717         c
            1970-2008           AL392123.12        55213-55251         c
            2009-2197           AL392123.12        42786-42974         c
            2198-2368           AL392123.12        41862-42032         c
            2369-2519           AL392123.12        30680-30830         c
            2520-2709           AL392123.12        24342-24531         c
            2710-2861           AL392123.12        19990-20141         c
            2862-2906           AL392123.12        18914-18958         c
            2907-3134           AL392123.12        13832-14059         c
            3135-3366           AL390766.16        190953-191184       c
            3367-3477           AL390766.16        157981-158091       c
            3478-3720           AL390766.16        143503-143745       c
            3721-3841           AL390766.16        5309-5429           c
            3842-3969           AL160409.12        97657-97784         c
            3970-5971           AL160409.12        87605-89606         c
FEATURES             Location/Qualifiers
     source          1..5971
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p11.22-p11.21"
     gene            1..5971
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /note="par-3 family cell polarity regulator"
                     /db_xref="GeneID:56288"
                     /db_xref="HGNC:HGNC:16051"
                     /db_xref="MIM:606745"
     exon            1..421
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     CDS             302..4363
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     partitioning defective 3 homolog; atypical PKC
                     isotype-specific interacting protein; PAR3-alpha; CTCL
                     tumor antigen se2-5; bazooka; par-3 partitioning defective
                     3 homolog; par-3 family cell polarity regulator alpha;
                     protein phosphatase 1, regulatory subunit 118"
                     /codon_start=1
                     /product="partitioning defective 3 homolog isoform 2"
                     /protein_id="NP_001171714.1"
                     /db_xref="CCDS:CCDS53515.1"
                     /db_xref="GeneID:56288"
                     /db_xref="HGNC:HGNC:16051"
                     /db_xref="MIM:606745"
                     /translation="MKVTVCFGRTRVVVPCGDGHMKVFSLIQQAVTRYRKAIAKDPNY
                     WIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPE
                     IFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSVSDSNF
                     SSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDTSNWSNQFQRDNA
                     RSSLSASHPMVGKWLEKQEQDEDGTEEDNSRVEPVGHADTGLEHIPNFSLDDMVKLVE
                     VPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEHENLFRENDCIVRINDGDLRN
                     RRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSRFSPDSQYIDNR
                     SVNSAGLHTVQRAPRLNHPPEQIDSHSRLPHSAHPSGKPPSAPASAPQNVFSTTVSSG
                     YNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAG
                     DRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQIP
                     KETKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSI
                     INGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVAR
                     RISKCNELKSPGSPPGPELPIETALDDRERRISHSLYSGIEGLDESPSRNAALSRIMG
                     KYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTADAGTWAKAAIS
                     DSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIAD
                     ETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIR
                     GRGCNESFRAAIDKSYDKPAVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLE
                     RQMNGNQEKGDKTDRKKDKTGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDD
                     KIEKTGKIKIQESFTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTFG
                     CDDELMYGGVSSYEGSMALNARPQSPREGHMMDALYAQVKKPRNSKPSPVDSNRSTPS
                     NHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPNARPATQSGRHSVSVEVQMQRQR
                     QEERESSQQAQRQYSSLPRQSRKNASSVSQDSWEQNYSPGEGFQSAKENPRYSSYQGS
                     RNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPSEGPSNYDSYKKVQDPSYAP
                     PKGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS"
     exon            422..523
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            524..704
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            705..883
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..1015
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1107
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1191
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1317
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1700
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1840
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..1969
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            1970..2008
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2197
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2368
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2369..2519
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2520..2709
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2861
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..2906
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3134
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3135..3366
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3367..3477
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3720
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3721..3841
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..3969
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     exon            3970..5971
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4395..4400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /note="hexamer: AATAAA"
     polyA_site      4417
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /note="major polyA site"
     regulatory      5947..5952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
                     /note="hexamer: AATAAA"
     polyA_site      5971
                     /gene="PARD3"
                     /gene_synonym="ASIP; Baz; PAR3; PAR3alpha; PARD-3; PARD3A;
                     PPP1R118; SE2-5L16; SE2-5LT1; SE2-5T2"
ORIGIN      
        1 acacagcccc gggcagccgc cggcgagcgc gccgcgacgc cgaacaggtg gccggaggct
       61 gcgggcgccg cggcggggag aggcgaggca agccccgggc gaagcgaggc gaggcgaggg
      121 cggccgggcc gggcatgcga gctgagcggc cccccggcgt cgccgccgcc tgcccgcgcc
      181 cctagccgcc cgcgcgcccg agtccccagc ggctcctccg cgcccagcgt cctcggtccc
      241 ggcctcggct gctccggctg cgctcggcga ggggcgcggg cccgcccgcg gcggcggcgg
      301 catgaaagtg accgtgtgct tcggacggac ccgggtggtc gtgccgtgcg gggacggcca
      361 catgaaagtt ttcagcctca tccagcaggc ggtgacccgc taccggaagg ccatcgccaa
      421 ggatccaaac tactggatac aggtgcatcg cttggaacat ggagatggag gaatactaga
      481 ccttgatgac attctttgtg atgtagcaga cgataaagac agactggtag cagtgtttga
      541 tgagcaggat ccacatcacg gaggtgatgg caccagtgcc agttccacgg gtacccagag
      601 cccagagata tttggtagtg agcttggcac caacaatgtc tcagcctttc agccttacca
      661 agcaacaagt gaaattgagg tcacaccttc agtccttcga gcaaatatgc ctcttcatgt
      721 tcgacgcagt agtgacccag ctctaattgg cctctccact tctgtcagtg atagtaattt
      781 ttcctctgaa gagccttcaa ggaaaaatcc cacacgctgg tcaacaacag ctggcttcct
      841 caagcagaac actgctggga gtcctaaaac ctgcgacagg aagaaagatg aaaactacag
      901 aagcctcccg cgggatacta gtaactggtc taaccaattt cagagagaca atgctcgctc
      961 gtctctgagt gccagtcacc caatggtggg caagtggctg gagaaacaag aacaggatga
     1021 ggatgggaca gaagaggata acagtcgtgt tgaacctgtt ggacatgctg acacgggttt
     1081 ggagcatata cccaactttt ctctggatga tatggtaaag ctcgtagaag tccccaacga
     1141 tggagggcct ctgggaatcc acgtagtgcc tttcagtgct cgaggcggca gaaccctggg
     1201 gttattagta aaacgattgg agaaaggtgg taaagctgaa catgaaaatc tttttcgtga
     1261 gaatgattgc attgtcagga ttaatgatgg cgaccttcga aatagaagat ttgaacaagc
     1321 acaacatatg tttcgccaag ccatgcgtac acccatcatt tggttccatg tggttcctgc
     1381 agcaaataaa gagcagtatg aacaactatc ccaaagtgag aagaacaatt actattcaag
     1441 ccgttttagc cctgacagcc agtatattga caacaggagt gtgaacagtg cagggcttca
     1501 cacggtgcag agagcacccc gactgaacca cccgcctgag cagatagact ctcactcaag
     1561 actacctcat agcgcacacc cctcgggaaa accaccatcc gctccagcct cggcacctca
     1621 gaatgtattt agtacgactg taagcagtgg ttataacacc aaaaaaatag gcaagaggct
     1681 taatatccag cttaagaaag gtacagaagg tttgggattc agcatcactt ccagagatgt
     1741 aacaataggt ggctcagctc caatctatgt gaaaaacatt ctcccccggg gggcggccat
     1801 tcaggatggc cgacttaagg caggagacag acttatagag gtaaatggag tagatttagt
     1861 gggcaaatcc caagaggaag ttgtttcgct gttgagaagc accaagatgg aaggaactgt
     1921 gagccttctg gtctttcgcc aggaagacgc cttccaccca agggaactga atgcagagcc
     1981 aagccagatg cagattccaa aagaaacgaa agcagaagat gaggatattg ttcttacacc
     2041 tgatggcacc agggaatttc tgacatttga agtcccactt aatgattcag gatctgcagg
     2101 ccttggtgtc agtgtcaaag gtaaccggtc aaaagagaac cacgcagatt tgggaatctt
     2161 tgtcaagtcc attattaatg gaggagcagc atctaaagat ggaaggcttc gggtgaatga
     2221 tcaactgata gcagtaaatg gagaatccct gttgggcaag acaaaccaag atgccatgga
     2281 aaccctaaga aggtctatgt ctactgaagg caataaacga ggaatgatcc agcttattgt
     2341 tgcaaggaga ataagcaagt gcaatgagct gaagtcacct gggagccccc ctggacctga
     2401 gctgcccatt gaaacagcgt tggatgatag agaacgaaga atttcccatt ccctctacag
     2461 tgggattgag gggcttgatg aatcgcccag cagaaatgct gccctcagta ggataatggg
     2521 taaataccag ctgtccccta cagtgaatat gccccaagat gacactgtca ttatagaaga
     2581 tgacaggttg ccagtgcttc ctccacatct ctctgaccag tcctcttcca gctcccatga
     2641 tgatgtgggg tttgtgacgg cagatgctgg tacttgggcc aaggctgcaa tcagtgattc
     2701 agccgactgc tctttgagtc cagatgttga tccagttctt gcttttcaac gagaaggatt
     2761 tggacgtcag agtatgtcag aaaaacgcac aaagcaattt tcagatgcca gtcaattgga
     2821 tttcgttaaa acacgaaaat caaaaagcat ggatttaggt atagctgacg agactaaact
     2881 caatacagtg gatgaccaga aagcaggttc tcccagcaga gatgtgggtc cttccctggg
     2941 tctgaagaag tcaagctcgt tggagagtct gcagaccgca gttgccgagg tgactttgaa
     3001 tggggatatt cctttccatc gtccacggcc gcggataatc agaggcaggg gatgcaatga
     3061 gagcttcaga gctgccatcg acaaatctta tgataaaccc gcggtagatg atgatgatga
     3121 aggcatggag accttggaag aagacacaga agaaagttca agatcaggga gagagtctgt
     3181 atccacagcc agtgatcagc cttcccactc tctggagaga caaatgaatg gaaaccaaga
     3241 gaaaggtgat aagactgata gaaaaaagga taaaactgga aaagaaaaga agaaagatag
     3301 agataaggag aaggataaaa tgaaagccaa gaagggaatg ctgaagggct tgggagacat
     3361 gttcaggttt ggcaaacatc gaaaagatga caagattgag aaaacgggta aaataaaaat
     3421 acaggaatcc tttacatcag aagaggagag gatacgaatg aagcaggagc aggagaggat
     3481 tcaagccaaa actcgagaat ttagggaacg acaagctcga gagcgtgact atgctgaaat
     3541 tcaagatttt catcggacat ttggctgtga tgatgagtta atgtatgggg gagtttcttc
     3601 ttatgaaggt tccatggctc tcaacgctag acctcagagc ccacgagaag ggcatatgat
     3661 ggatgctttg tatgcccaag tcaagaagcc gcggaattcc aaaccctcac ctgtagacag
     3721 taacagatca actcctagca atcatgatcg gatacagcgt ctgaggcaag aatttcagca
     3781 agcaaagcaa gatgaagatg tagaagatcg tcggcggacc tatagttttg agcaaccctg
     3841 gccgaacgca cggccggcga cgcagagcgg gcgacactcg gtgtccgtgg aggtgcagat
     3901 gcagcggcag cggcaggagg agcgcgagag ctcccagcag gcccagcgcc agtacagctc
     3961 tctgcctcgg caaagcagga aaaatgccag ctcggtctcc caggactctt gggagcagaa
     4021 ctactcccct ggggaaggct tccagagtgc caaagagaac cccaggtact ccagctacca
     4081 aggctccagg aacggctacc tgggaggaca tggcttcaac gccagggtca tgctggaaac
     4141 tcaggagctc cttcgccagg aacagaggcg gaaggagcag cagatgaaga agcagcctcc
     4201 ttccgagggg cccagcaact atgactcgta taagaaagtc caggacccca gttacgcccc
     4261 tcccaagggg cccttccggc aagatgtgcc cccctcccct tctcaggttg cgaggctgaa
     4321 cagacttcag actcctgaga aagggaggcc cttctattcc tgagcacgca aataacggat
     4381 gcttcatgtc gcgcaataaa agacattttc ctatgaagac ttgtattttg ggagtttttt
     4441 taaaacctcg atggtactat ggagtatttc tgttgttggt atcagtgcct ttaagcggtg
     4501 taggcaaaga aatggaaggc cttaatgtct ttgccactat gtctcaagtg tctgtttcat
     4561 ggaaggattt cccaccctgt gacaatcatc tgtttgaggt gttcatatgc tctgcgcctc
     4621 tccacagtac caggaatctc ggccctactc atgagttgtc cgcggcttgg ttgtaacatc
     4681 cctgcaccac ttgcagtgac aaattcacct gaagtggagg atgacgtgcg gccctgtttc
     4741 tccctctaag ttctcttagc tatgggatga catcttagtc tctggtggag gaaaagtggg
     4801 cgacatacac caaaaattgg ggctttctgg tacttcacag cacagccatt tgtcgtactt
     4861 tgtcatcact gtggttttct ctttcctttc tcagctcttt gtgacgggag agtcggtcat
     4921 cctattacag aagctaagcc atagtccaac attgtttggt caccatgggg gtccttttgt
     4981 aactgcctta tgactcaaca ttaccaataa agtgatgatc ctggtctgcg tttatacata
     5041 cgcttgttcg gtcctgttcc tgacacgtgg gttgagtcac cacagctctg tgtggggaac
     5101 gtgggagaca ggagtggctc ctgccggggg aagctgggcc tgccattggc cctgtgtcta
     5161 tcatgagggg agagctaaga aagaaattct cctaggaaga gctcatggcc cagtacatcc
     5221 tagtaattat tttaattagt ttttgttctg acagcttgtc aggaagggca cagaatggga
     5281 cagagataaa ccagacagtc attttgatct gctctctacg gtttttcaag tcagaggcaa
     5341 ttgatgcttg tctaatgcat ccacacactg catgtctgac tggcgatgcc gcgctcctaa
     5401 gtagttctgc catgaaacat aaaagacaaa ggaaaagccg ttacacatca cacagagaac
     5461 attttcgggt cccacagcgg tggtggcagg aagctcactc tcgcgtcagt attagagtgt
     5521 gtgtgtgggt ctcggggatc tcggtggctc ccatcttcct tcattgttct gaacatcctg
     5581 tattgtaaac catggctggg gtgctaaagt gcctgtgaat cccgatgtgg aaaaagctgg
     5641 aggtgaaagc tcagcatacc atgtatttac tttaaaaaca gaaaaaaaga catgtatgga
     5701 tatgtctatt ttttttttat tggcacattg tatttttgtg ttgacttgtt tttagaaatg
     5761 atgtgtccac acacgtaccc gtgtctcttc tgcatttctg tgtcatggtt ctgtttctta
     5821 atcacgtgcg gcggtgtcta agtggtgtta ccagtgtacg cgcagtgacc ttggatgaca
     5881 gtggctcttt ctcacagcct cccctgagct gtgagaaaca gctttctctg tacatatgca
     5941 actcctaata aaaggcatat ttcttcctgt t
//
