LOCUS       NM_133367               4715 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 8 (PAQR8),
            mRNA.
ACCESSION   NM_133367
VERSION     NM_133367.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4715)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4715)
  AUTHORS   Charles,N.J., Thomas,P. and Lange,C.A.
  TITLE     Expression of membrane progesterone receptors (mPR/PAQR) in ovarian
            cancer cells: implications for progesterone-induced signaling
            events
  JOURNAL   Horm Cancer 1 (4), 167-176 (2010)
   PUBMED   21761364
  REMARK    GeneRIF: Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and
            mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms)
            mRNA expression and mPRalpha protein expression in a panel of
            commonly used ovarian cancer cell lines.
REFERENCE   3  (bases 1 to 4715)
  AUTHORS   Smith,J.L., Kupchak,B.R., Garitaonandia,I., Hoang,L.K., Maina,A.S.,
            Regalla,L.M. and Lyons,T.J.
  TITLE     Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in
            yeast confirms their ability to function as membrane progesterone
            receptors
  JOURNAL   Steroids 73 (11), 1160-1173 (2008)
   PUBMED   18603275
  REMARK    GeneRIF: Heterologous expression of MPRB in yeast confirms its
            ability to function as a membrane progesterone receptor.
REFERENCE   4  (bases 1 to 4715)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   5  (bases 1 to 4715)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   6  (bases 1 to 4715)
  AUTHORS   Hammes,S.R.
  TITLE     The further redefining of steroid-mediated signaling
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2168-2170 (2003)
   PUBMED   12606724
REFERENCE   7  (bases 1 to 4715)
  AUTHORS   Zhu,Y., Bond,J. and Thomas,P.
  TITLE     Identification, classification, and partial characterization of
            genes in humans and other vertebrates homologous to a fish membrane
            progestin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2237-2242 (2003)
   PUBMED   12601167
REFERENCE   8  (bases 1 to 4715)
  AUTHORS   Zhu,Y., Rice,C.D., Pang,Y., Pace,M. and Thomas,P.
  TITLE     Cloning, expression, and characterization of a membrane progestin
            receptor and evidence it is an intermediary in meiotic maturation
            of fish oocytes
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2231-2236 (2003)
   PUBMED   12574519
REFERENCE   9  (bases 1 to 4715)
  AUTHORS   Wistow,G., Bernstein,S.L., Ray,S., Wyatt,M.K., Behal,A.,
            Touchman,J.W., Bouffard,G., Smith,D. and Peterson,K.
  TITLE     Expressed sequence tag analysis of adult human iris for the NEIBank
            Project: steroid-response factors and similarities with retinal
            pigment epithelium
  JOURNAL   Mol Vis 8, 185-195 (2002)
   PUBMED   12107412
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 4715)
  AUTHORS   Suzuki,T., Ganesh,S., Agarwala,K.L., Morita,R., Sugimoto,Y.,
            Inazawa,J., Delgado-Escueta,A.V. and Yamakawa,K.
  TITLE     A novel gene in the chromosomal region for juvenile myoclonic
            epilepsy on 6p12 encodes a brain-specific lysosomal membrane
            protein
  JOURNAL   Biochem Biophys Res Commun 288 (3), 626-636 (2001)
   PUBMED   11676489
  REMARK    GeneRIF: LMPB1 is indeed an integral membrane protein that targets
            to lysosomal structures.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN283490.1, BC030664.2, AF347029.1, AK128085.1, CN395844.1,
            AI655504.1, AI656485.1 and CD672455.1.
            
            On Nov 22, 2018 this sequence version replaced NM_133367.4.
            
            Sequence Note: An in-frame AUG is located 5 codons upstream of the
            annotated translation start site but is not being annotated as a
            start site since it is not conserved and is in a weak Kozak
            sequence context.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.265430.1,
                                           SRR1660803.195772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000442253.3/
                                                ENSP00000406197.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CN283490.1         26-93
            69-203              BC030664.2         67-201
            204-1686            AF347029.1         217-1699
            1687-3086           AK128085.1         1930-3329
            3087-3343           AF347029.1         3100-3356
            3344-3868           CN395844.1         120-644
            3869-4172           AF347029.1         3882-4185
            4173-4607           AI655504.1         15-449              c
            4608-4642           AI656485.1         67-101              c
            4643-4715           CD672455.1         22-94               c
FEATURES             Location/Qualifiers
     source          1..4715
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.2"
     gene            1..4715
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="progestin and adipoQ receptor family member 8"
                     /db_xref="GeneID:85315"
                     /db_xref="HGNC:HGNC:15708"
                     /db_xref="MIM:607780"
     exon            1..99
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /inference="alignment:Splign:2.1.0"
     exon            100..4715
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /inference="alignment:Splign:2.1.0"
     CDS             152..1216
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="lysosomal membrane protein in brain-1; mPR beta;
                     progestin and adipoQ receptor family member VIII; membrane
                     progesterone receptor beta; membrane progesterone P4
                     receptor beta; progesterone and adipoQ receptor family
                     member 8"
                     /codon_start=1
                     /product="membrane progestin receptor beta"
                     /protein_id="NP_588608.1"
                     /db_xref="CCDS:CCDS4941.1"
                     /db_xref="GeneID:85315"
                     /db_xref="HGNC:HGNC:15708"
                     /db_xref="MIM:607780"
                     /translation="MTTAILERLSTLSVSGQQLRRLPKILEDGLPKMPCTVPETDVPQ
                     LFREPYIRTGYRPTGHEWRYYFFSLFQKHNEVVNVWTHLLAALAVLLRFWAFAEAEAL
                     PWASTHSLPLLLFILSSITYLTCSLLAHLLQSKSELSHYTFYFVDYVGVSVYQYGSAL
                     AHFFYSSDQAWYDRFWLFFLPAAAFCGWLSCAGCCYAKYRYRRPYPVMRKICQVVPAG
                     LAFILDISPVAHRVALCHLAGCQEQAAWYHTLQILFFLVSAYFFSCPVPEKYFPGSCD
                     IVGHGHQIFHAFLSICTLSQLEAILLDYQGRQEIFLQRHGPLSVHMACLSFFFLAACS
                     AATAALLRHKVKARLTKKDS"
     regulatory      2726..2731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="hexamer: TATAAA"
     polyA_site      2750
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="major polyA site"
     regulatory      3068..3073
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="hexamer: AATAAA"
     polyA_site      3088
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="major polyA site"
     regulatory      4693..4698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
                     /note="hexamer: ATTAAA"
     polyA_site      4715
                     /gene="PAQR8"
                     /gene_synonym="C6orf33; LMPB1; MPRB"
ORIGIN      
        1 acagccaccc gcgggaagct cgtggccggg accccgaggc gggagcgcgg gctgggccgg
       61 gctgggctac gcgcacgggc tcggccgccg cccctgccgg ttgcataccc tgtcctgagg
      121 gcgcggcacg gagtgcatgc gggccgctgc catgacgacc gccatcttgg agcgcctgag
      181 caccctgtcg gtcagcgggc agcagctgcg ccgcctgccc aagatcctgg aggatgggct
      241 tcccaagatg ccttgcactg tcccagaaac ggatgtgccc cagctcttcc gggagcctta
      301 catccgcacc ggctaccgcc ccacggggca cgagtggcgc tactacttct tcagcctctt
      361 tcagaaacac aacgaggtgg tcaacgtctg gacccattta ctggcagccc tggccgtcct
      421 cttgcgattc tgggcctttg ccgaggctga ggccttgcca tgggcgtcta cccactccct
      481 gcctctgctc ctcttcatcc tgtcgtcaat cacttacctc acctgcagcc ttctggccca
      541 cctgctgcag tccaagtcag agctctccca ctacaccttc tactttgtgg actatgttgg
      601 cgtgagcgtt taccaatatg gcagtgcttt ggctcatttc ttctacagct ctgaccaggc
      661 ctggtatgac cggttctggc ttttcttctt gccagcagct gccttctgtg gctggttatc
      721 ttgtgctggc tgttgctatg ccaaatatcg ttaccggagg ccttatccag tcatgaggaa
      781 gatctgtcaa gtggtgccag caggtctggc ttttatccta gacatcagcc ctgtggcaca
      841 ccgtgtggcg ctctgtcacc tggctggctg ccaggagcaa gcagcctggt accacaccct
      901 ccagatcctc ttcttcctgg ttagcgctta tttcttctcc tgccccgtgc ctgagaagta
      961 cttcccgggt tcctgtgaca tcgtgggcca tgggcatcag atcttccatg catttctgtc
     1021 catctgtacg ctctcccagc tggaggccat cctcctggac taccaggggc ggcaggagat
     1081 cttcctgcag cgccatggac ccctatctgt ccacatggcc tgcctctcct tcttcttcct
     1141 ggctgcctgc agtgctgcca ccgcagccct tctgaggcac aaagtcaagg ccagactgac
     1201 caagaaagat tcctgaggct ggcaagtggg gcaacgtgtg gaggaagccc ctcataattt
     1261 ggagaaaact tgatacaata gaagctgact tttaaggcat tggcttttaa attaatacat
     1321 atatccaagg atatgttata gctgcagtgt ttgaaagcca aaggatttaa gagttttgtt
     1381 gttgttaata aaaggaatac tccttttcct tttggatcat agcttaacaa ggcacaggaa
     1441 gggaagggat cttgactaag attcatgaga cattgaatta aggagaatca tcttcatgcc
     1501 tgaaaattta gcaaaattcc gactatggcc tccaggggca attcctaaaa gctgaatgga
     1561 taataaaatt ggactggaaa gtaagtaggt ggctggtcct caccctgttg gaatggctat
     1621 cctactatgc tgttctttgg taatggaata aattgaccca aggaccgaat ttcatttgga
     1681 tttcaaattg tccagagtgg aaaagccttc aagatgacat gatgaattac tcagttcatc
     1741 tgatttctgg tccctccttt ctcgacaact ataatactaa cccttttctc aggataactg
     1801 tctacacctg gcagttttct ctgacgtgct gttcactcac atccctacct tgcatggtaa
     1861 tataaaggac taggaagcag tcatacttcc aggaaatgct tggattcatg tggacattca
     1921 ggaagcttat tctcatataa tactaatcta aacagtacta gaaattacag tgccaagagc
     1981 caccaggagg cccagccaat aagcatagat actatatggt atcatgggac ccatctattt
     2041 tttaccagtg gactacagga ttacttgaga gttatcaggg ctgcctaaca gaccaggaga
     2101 tctgggggtt gcaccaggga atcgccatat ttgaccagca tgttttaaaa gctcttggta
     2161 ggattagttg gttctaagga tccctctagg gacctcatta tttcaagagg aacccaaagt
     2221 ccagcctcct acatagatgc tgccccacga aggacccaca aaactaacct agttcagggt
     2281 tctcaggcag gcagttctgc ttcagcttag agcagaaccc ataaaatact caagtactgg
     2341 gataggcaag catgtgtgtt tactgtggat tggtccctga aggctccttt gggtgagaac
     2401 atgtgaacca ggcaccctgg tttgtttgga gcattgctgc ccagaagctt ctatgggata
     2461 ggtggtgctt gggattgatg tgttgtggcc atgcagccct ccctgaggat tgacttctgc
     2521 actaatccag tgaaggaggc tgtgtcaaaa gaagggctca gaagccctct tttcagaggc
     2581 aatgattcct gtcagtatga ggtcccttag ttactaaaaa gggacatgat ttaactccag
     2641 tttgatgaac ctcctccgag tttactttat tgtcttcaaa tcttttgttt tcttcctttt
     2701 tgtgagattt gtgggttttg tgccttataa atggaaatgt atgaacacaa tatatgctca
     2761 tgtagaattt tctgttctgg gttattggga taagaaaaaa tatatattgc tcttcaacta
     2821 gtgaatgaaa gaaacttcag aaagctagaa ttgcttatca atcaaaagac tttctcaatc
     2881 tattttggcc acaaacaaac atattcaact gaagctttcc aataatcttt atatcaagaa
     2941 agcatgcgtc ttgtcagcta cattgttttc ttagatggat ttctcctgtt aatcctcaaa
     3001 tatctgaact tctgtgttac ccaagtgtct tatacaagct tctggtgtct aggacaaatt
     3061 tatggcaaat aaaattagca aaactgaact gggttgaact gaacaagagg atgggggaat
     3121 tgtgcaaata cgttgttagt agaaggtcaa tttaaaatag ggactagaaa ttatttgaag
     3181 ttttctttat tacggattca aagacttatt ttgaaagttg gaaggagaag ggagggaaga
     3241 gagcagaagg gaagaaggtg taagtcaagc tcttgaatat aactggtggt attgtgggca
     3301 gagatcttta gttcaaatcc acgtattttt taaaagagag aaccggaggt agagcaatga
     3361 tcagatgggt gcacagacca gtgccaatct gaacattgtt aatggcctgt gacatgatga
     3421 gcacaggaac aggcatgaag atattgccat acaattttaa tttatacaag tattggcccc
     3481 tcaagtggtt ggaaattttt tttttaatct ctttttctga gacagggtct tactctgtcg
     3541 cccaggctgg agtgcagtga tgcaatcacg gctcactgca gcctcgacct ccccagctca
     3601 agcaatcctc ccacctcagc ctcctaagta cctggtacta caggcgcgtg ccaccacacc
     3661 tggctaattt ttgcattttt tgtagagaca gggttttgcc acgttgctta ggctggtctt
     3721 gaactcctga actcaagtga tccgcccacc tcagcctccc aaagtgttgg gattacagac
     3781 attagccatc acgcctgccc tagaaacagt tttttaatag gagatatttg agaggcattg
     3841 aggtaggaga ctctatgaca tgccctcaga atatcagaat cttcttagaa ataaactagg
     3901 aaatgcagat gtttttaact actcagactt ttgaggaatt aatcctttta aaacattttt
     3961 gttaaagtta gtgtatcagt aagaaacaga cctagtttaa aaggaataat caacaatttt
     4021 ataaaggaga tggcttattc aaccatagcc cctccaacat atctactgga aattctgctg
     4081 gttaacttta tctctctctc tcttaattta gactttcaac ctatgaaaat gtaaatacct
     4141 ttgaaaaaac taaactatca gtcatttaca tcctctcatg aatgaaatgc agtgtaggga
     4201 gaggagatgg caggacacag caaacaggac acatttgcct gcttctctct tgcctaattc
     4261 ttcctgacct gtatttactg atgcttaata atacttgtaa gactctaggg gttcatttcc
     4321 catttcagcg gaaagtactt cactcaacaa caatattctc aagagtcttc tactggaagc
     4381 tagaaagaaa taggaattta agtccataga atgaaggtag ttattcctgc ctgtgttgcc
     4441 cacctgttca caaaaagtac ctttatgctt gaaaacatta ggttctttgg ttactgcact
     4501 gtagtttcaa atggatcctc cagatggcat tcatgtctta ctcagaaagg gcactgccat
     4561 tgtccccaag gcttctgtct actaattcta ttggtcttgt gttttgcttg cttggcaaaa
     4621 aaaaaaaaaa aaaaaaaaaa aaaaaaaatg gagctatttt ctgtctatat aaatctactt
     4681 atatgaataa ccattaaagt gattttgtat atgca
//
