LOCUS       NM_178422               2685 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 7 (PAQR7),
            mRNA.
ACCESSION   NM_178422 XM_005245745
VERSION     NM_178422.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Li,J., Liu,Y., He,J., Wu,Z., Wang,F., Huang,J., Zheng,L. and Luo,T.
  TITLE     Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic
            effect of P4 on human granulosa cells and its deficiency reduces
            ovarian function in female mice
  JOURNAL   J Ovarian Res 17 (1), 35 (2024)
   PUBMED   38317224
  REMARK    GeneRIF: Progestin and adipoQ receptor 7 (PAQR7) mediate the
            anti-apoptotic effect of P4 on human granulosa cells and its
            deficiency reduces ovarian function in female mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Thomas,P., Pang,Y. and Kelder,J.
  TITLE     Membrane progesterone receptors on the cell membrane: A review
            highlighting potential export motifs in mPRalpha regulating its
            trafficking to the cell surface
  JOURNAL   Steroids 199, 109295 (2023)
   PUBMED   37558174
  REMARK    GeneRIF: Membrane progesterone receptors on the cell membrane: A
            review highlighting potential export motifs in mPRalpha regulating
            its trafficking to the cell surface.
            Review article
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Castelnovo,L.F. and Thomas,P.
  TITLE     Progesterone exerts a neuroprotective action in a Parkinson's
            disease human cell model through membrane progesterone receptor
            alpha (mPRalpha/PAQR7)
  JOURNAL   Front Endocrinol (Lausanne) 14, 1125962 (2023)
   PUBMED   36967764
  REMARK    GeneRIF: Progesterone exerts a neuroprotective action in a
            Parkinson's disease human cell model through membrane progesterone
            receptor alpha (mPRalpha/PAQR7).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Castelnovo,L.F. and Thomas,P.
  TITLE     Membrane Progesterone Receptor alpha (mPRalpha/PAQR7) Promotes
            Survival and Neurite Outgrowth of Human Neuronal Cells by a Direct
            Action and Through Schwann Cell-like Stem Cells
  JOURNAL   J Mol Neurosci 72 (10), 2067-2080 (2022)
   PUBMED   35974286
  REMARK    GeneRIF: Membrane Progesterone Receptor alpha (mPRalpha/PAQR7)
            Promotes Survival and Neurite Outgrowth of Human Neuronal Cells by
            a Direct Action and Through Schwann Cell-like Stem Cells.
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Jyoti,M.M.S., Rana,M.R., Ali,M.H. and Tokumoto,T.
  TITLE     Establishment of a steroid binding assay for membrane progesterone
            receptor alpha (PAQR7) by using graphene quantum dots (GQDs)
  JOURNAL   Biochem Biophys Res Commun 592, 1-6 (2022)
   PUBMED   35007844
  REMARK    GeneRIF: Establishment of a steroid binding assay for membrane
            progesterone receptor alpha (PAQR7) by using graphene quantum dots
            (GQDs).
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Yu,S., Viswakarma,N., Batra,S.K., Sambasiva Rao,M. and Reddy,J.K.
  TITLE     Identification of promethin and PGLP as two novel up-regulated
            genes in PPARgamma1-induced adipogenic mouse liver
  JOURNAL   Biochimie 86 (11), 743-761 (2004)
   PUBMED   15589683
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Hammes,S.R.
  TITLE     The further redefining of steroid-mediated signaling
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2168-2170 (2003)
   PUBMED   12606724
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Zhu,Y., Bond,J. and Thomas,P.
  TITLE     Identification, classification, and partial characterization of
            genes in humans and other vertebrates homologous to a fish membrane
            progestin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2237-2242 (2003)
   PUBMED   12601167
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Zhu,Y., Rice,C.D., Pang,Y., Pace,M. and Thomas,P.
  TITLE     Cloning, expression, and characterization of a membrane progestin
            receptor and evidence it is an intermediary in meiotic maturation
            of fish oocytes
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2231-2236 (2003)
   PUBMED   12574519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL033528.20.
            
            On or before Jan 21, 2020 this sequence version replaced
            XM_005245745.3, NM_178422.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.4379688.1,
                                           SRR14038193.3293241.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142348 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000675840.1/ ENSP00000502514.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-221               AL033528.20        44895-45115
            222-307             AL033528.20        49909-49994
            308-2685            AL033528.20        56742-59119
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..2685
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /note="progestin and adipoQ receptor family member 7"
                     /db_xref="GeneID:164091"
                     /db_xref="HGNC:HGNC:23146"
                     /db_xref="MIM:607779"
     exon            1..221
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            222..307
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /inference="alignment:Splign:2.1.0"
     exon            308..2685
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..1370
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /note="2310021M12Rik; mPR alpha; progestin and adipoQ
                     receptor family member VII; membrane progesterone receptor
                     alpha; membrane progesterone P4 receptor alpha;
                     progesterone and adipoQ receptor family member 7"
                     /codon_start=1
                     /product="membrane progestin receptor alpha"
                     /protein_id="NP_848509.1"
                     /db_xref="CCDS:CCDS267.1"
                     /db_xref="GeneID:164091"
                     /db_xref="HGNC:HGNC:23146"
                     /db_xref="MIM:607779"
                     /translation="MAMAQKLSHLLPSLRQVIQEPQLSLQPEPVFTVDRAEVPPLFWK
                     PYIYAGYRPLHQTWRFYFRTLFQQHNEAVNVWTHLLAALVLLLRLALFVETVDFWGDP
                     HALPLFIIVLASFTYLSFSALAHLLQAKSEFWHYSFFFLDYVGVAVYQFGSALAHFYY
                     AIEPAWHAQVQAVFLPMAAFLAWLSCIGSCYNKYIQKPGLLGRTCQEVPSVLAYALDI
                     SPVVHRIFVSSDPTTDDPALLYHKCQVVFFLLAAAFFSTFMPERWFPGSCHVFGQGHQ
                     LFHIFLVLCTLAQLEAVALDYEARRPIYEPLHTHWPHNFSGLFLLTVGSSILTAFLLS
                     QLVQRKLDQKTK"
     regulatory      2662..2667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="PAQR7"
                     /gene_synonym="MPRA; mSR; PGLP"
                     /note="major polyA site"
ORIGIN      
        1 gcgtgcaaca cgtgggcctg gcggggcaga gctgcttgtg cgcggcgggc ggggtgcggg
       61 gcgctcggcg tcgcctgggc ccgcggaggc ggctgtagcc agagcgcccg aggccgcccg
      121 ccctcccccg gcttggggcg gggccgctgc ccggctgctc ttttatctgc cagctccgcc
      181 gacccggccc ccgcggccct cccagctcgg ctccggctca gtggacagga accactgaag
      241 tttgcctgac accatcaacc aggccctagt cacctggctt tgcctttgcc ctgctgtgtg
      301 atcttagctc cctgcccagg cccacagcca tggccatggc ccagaaactc agccacctcc
      361 tgccgagtct gcggcaggtc atccaggagc ctcagctatc tctgcagcca gagcctgtct
      421 tcacggtgga tcgagctgag gtgccgccgc tcttctggaa gccgtacatc tatgcgggct
      481 accggccgct gcatcagacc tggcgcttct atttccgcac gctgttccag cagcacaacg
      541 aggccgtgaa tgtctggacc cacctgctgg cggccctggt actgctgctg cggctggccc
      601 tctttgtgga gaccgtggac ttctggggag acccacacgc cctgcccctc ttcatcattg
      661 tccttgcctc tttcacctac ctctccttca gtgccttggc tcacctcctg caggccaagt
      721 ctgagttctg gcattacagc ttcttcttcc tggactatgt gggggtggcc gtgtaccagt
      781 ttggcagtgc cttggcacac ttctactatg ctatcgagcc cgcctggcat gcccaggtgc
      841 aggctgtttt tctgcccatg gctgcctttc tcgcctggct ttcctgcatt ggctcctgct
      901 ataacaagta catccagaaa ccaggcctgc tgggccgcac atgccaggag gtgccctccg
      961 tcctggccta cgcactggac attagtcctg tggtgcatcg tatcttcgtg tcctccgacc
     1021 ccaccacgga tgatccagct cttctctacc acaagtgcca ggtggtcttc tttctgctgg
     1081 ctgctgcctt cttctctacc ttcatgcccg agcgctggtt ccctggcagc tgccatgtct
     1141 tcgggcaggg ccaccaactt ttccacatct tcttggtgct gtgcacgctg gctcagctgg
     1201 aggctgtggc actggactat gaggcccgac ggcccatcta tgagcctctg cacacgcact
     1261 ggcctcacaa cttttctggc ctcttcctgc tcacggtggg cagcagcatc ctcactgcat
     1321 tcctcctgag ccagctggta cagcgcaaac ttgatcagaa gaccaagtga agggggatgg
     1381 catctggtag ggagggaggt atagttgggg gacaggggtc tgggtttggc tccaggtggg
     1441 aacaaggcct ggtaaagttg tttgtgtctg gcccacagtg actctctgtg cacgactcaa
     1501 ctgccaaggg catcactggc caattcttgg atttagggat tggctaggag ttgctggggt
     1561 ccactcctgg gcctgcccca gctccttgcc cagggagagg gaaagagtta acggtgtggg
     1621 ccactccagc ttgcccttcc actgccactc actggggtga ggctgggggt cagcttggtg
     1681 aggattgggg cttctagatt gtctaggcag gaggtgaaac ttaggccaga gtcagatttg
     1741 agctgagcca ggggaggcct tggcaaccta cttctactca gatttcattg ctggatgcgg
     1801 aaggggtagg cccaaaatat atacaggatc ttactgtccc ttgaagccca gccacaagtg
     1861 ttggagctgc agagagaccc caaaggtagt agattgtgcc agatacaaat gggtcccatc
     1921 cagtgcttca tactccttca gtcactatcc cagacagtga gccccagatc tcctagctct
     1981 ggcttctgtg tcccacacgg cctgttccca gcttctctcc tggttccctt gttacggatt
     2041 catttatcca ttcagtgttt cctgggcctc tgctcagagg caggtcacca ctgggccctg
     2101 tggatcaatg caagatgaca aaggcttttt tttttttttt tttttttttt ttttttgagg
     2161 agtttcgctc ttgttggcta ggctggagta aaatggtgcg atctcggctc actgcacctc
     2221 cgcctcccag gttcaagcga ttttcctgcc tcagcctccc gagtagctgg ggttacaggc
     2281 atgcaccacc atgcctggct aattttctgt atttttagta gagacggggt ttctccatgt
     2341 tggtcaggct ggtcttgaac tcctgacctc aggtgatctg cccgtctcgg cctcccaaag
     2401 tgctgggatt accggcatga gccactgcgc ctggccgaca aaggctttga tatcagaatg
     2461 aactgtcaag ggaggtgctg gagagggatt aacctgtgct gcctgggacc ctcagggtct
     2521 taggttgggg agtgtgaata ggagtttgca gatggagaat aggaagggca ttccaggcag
     2581 agggaaacct gtgcagagac caagaggtgt ggaaggaaaa gtggggttgg ggctgggtgg
     2641 tctggattat ggcctggatg caataaagta ctgtgacagt agcca
//
