LOCUS       NM_198406               1969 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 6 (PAQR6),
            transcript variant 2, mRNA.
ACCESSION   NM_198406
VERSION     NM_198406.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1969)
  AUTHORS   Yang,M., Li,J.C., Tao,C., Wu,S., Liu,B., Shu,Q., Li,B. and Zhu,R.
  TITLE     PAQR6 Upregulation Is Associated with AR Signaling and Unfavorite
            Prognosis in Prostate Cancers
  JOURNAL   Biomolecules 11 (9), 1383 (2021)
   PUBMED   34572596
  REMARK    GeneRIF: PAQR6 Upregulation Is Associated with AR Signaling and
            Unfavorite Prognosis in Prostate Cancers.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1969)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1969)
  AUTHORS   Pang,Y., Dong,J. and Thomas,P.
  TITLE     Characterization, neurosteroid binding and brain distribution of
            human membrane progesterone receptors delta and {epsilon} (mPRdelta
            and mPR{epsilon}) and mPRdelta involvement in neurosteroid
            inhibition of apoptosis
  JOURNAL   Endocrinology 154 (1), 283-295 (2013)
   PUBMED   23161870
  REMARK    GeneRIF: The results suggest that PAQR6 and PAQR9 (mPRdelta and
            mPRepsilon) function as mPRs coupled to G proteins and are
            potential intermediaries of nonclassical antiapoptotic actions of
            neurosteroids in the central nervous system.
REFERENCE   4  (bases 1 to 1969)
  AUTHORS   Kamatani,Y., Matsuda,K., Okada,Y., Kubo,M., Hosono,N., Daigo,Y.,
            Nakamura,Y. and Kamatani,N.
  TITLE     Genome-wide association study of hematological and biochemical
            traits in a Japanese population
  JOURNAL   Nat Genet 42 (3), 210-215 (2010)
   PUBMED   20139978
REFERENCE   5  (bases 1 to 1969)
  AUTHORS   Smith,J.L., Kupchak,B.R., Garitaonandia,I., Hoang,L.K., Maina,A.S.,
            Regalla,L.M. and Lyons,T.J.
  TITLE     Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in
            yeast confirms their ability to function as membrane progesterone
            receptors
  JOURNAL   Steroids 73 (11), 1160-1173 (2008)
   PUBMED   18603275
  REMARK    GeneRIF: PAQR6 is a previously uncharacterized PAQR which is also
            capable of responding to progesterone.
REFERENCE   6  (bases 1 to 1969)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   7  (bases 1 to 1969)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   8  (bases 1 to 1969)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP217276.1, BC058509.1, AF455047.1, AK026325.1, AA310453.1 and
            AL135927.14.
            
            On Jun 2, 2019 this sequence version replaced NM_198406.2.
            
            Transcript Variant: This variant (2) uses alternate splice sites in
            the 5' UTR and coding region and initiates translation at an
            alternate start codon, compared to variant 1. Variants 2 and 3
            encode the same isoform (2), which has distinct N- and C-termini
            and is shorter, compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7410570.111199.1,
                                           SRR1803616.58619.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292291.10/ ENSP00000292291.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BP217276.1         62-116
            56-1822             BC058509.1         1-1767
            1823-1866           AF455047.1         1723-1766
            1867-1874           AK026325.1         1368-1375
            1875-1968           AA310453.1         292-385
            1969-1969           AL135927.14        131008-131008       c
FEATURES             Location/Qualifiers
     source          1..1969
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1969
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /note="progestin and adipoQ receptor family member 6"
                     /db_xref="GeneID:79957"
                     /db_xref="HGNC:HGNC:30132"
                     /db_xref="MIM:614579"
     exon            1..100
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            101..176
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1160
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /note="isoform 2 is encoded by transcript variant 2; mPR
                     delta; membrane progesterone receptor delta; progestin and
                     adipoQ receptor family member VI; membrane progesterone P4
                     receptor delta; progesterone and adipoQ receptor family
                     member 6; membrane progestin receptor delta"
                     /codon_start=1
                     /product="membrane progestin receptor delta isoform 2"
                     /protein_id="NP_940798.1"
                     /db_xref="CCDS:CCDS1136.1"
                     /db_xref="GeneID:79957"
                     /db_xref="HGNC:HGNC:30132"
                     /db_xref="MIM:614579"
                     /translation="MLSLKLPQLLQVHQVPRVFWEDGIMSGYRRPTSSALDCVLSSFQ
                     MTNETVNIWTHFLPTWYFLWRLLALAGGPGFRAEPYHWPLLVFLLPACLYPFASCCAH
                     TFSSMSPRMRHICYFLDYGALSLYSLGCAFPYAAYSMPASWLHGHLHQFFVPAAALNS
                     FLCTGLSCYSRFLELESPGLSKVLRTGAFAYPFLFDNLPLFYRLGLCWGRGHGCGQEA
                     LSTSHGYHLFCALLTGFLFASHLPERLAPGRFDYIGHSHQLFHICAVLGTHFQLEAVL
                     ADMGSRRAWLATQEPALGLAGTVATLVLAAAGNLLIIAAFTATLLRAPSTCPLLQGGP
                     LEGGTQAKQQ"
     exon            177..304
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            305..510
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            511..637
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            638..734
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            735..885
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1969
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1856..1861
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /note="hexamer: AATAAA"
     polyA_site      1874
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /note="major polyA site"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
                     /note="hexamer: CATAAA"
     polyA_site      1969
                     /gene="PAQR6"
                     /gene_synonym="PRdelta"
ORIGIN      
        1 actcttcctc catcagcctg gctggcagca gccttggact ccgcccgtgg agccctgggc
       61 ctgttgaccc accagcttag gagcacccac caagctctgg gtcaacgtgg aggtaccagg
      121 ccaccatgct cagtctcaag ctgccccaac ttcttcaagt ccaccaggtc ccccgggtgt
      181 tctgggaaga tggcatcatg tctggctacc gccgccccac cagctcggct ttggactgtg
      241 tcctcagctc cttccagatg accaacgaga cggtcaacat ctggactcac ttcctgccca
      301 cctggtactt cctgtggcgg ctcctggcgc tggcgggcgg ccccggcttc cgtgcggagc
      361 cgtaccactg gccgctgctg gtcttcctgc tgcccgcctg cctctacccc ttcgcgtcgt
      421 gctgcgcgca caccttcagc tccatgtcgc cccgcatgcg ccacatctgc tacttcctcg
      481 actacggcgc gctcagcctc tacagtctgg gctgcgcctt cccctatgcc gcctactcca
      541 tgccggcctc ctggctgcac ggccacctgc accagttctt tgtgcctgcc gccgcactca
      601 actccttcct gtgcaccggc ctctcctgct actcccgttt cctggagctg gaaagccctg
      661 ggctcagtaa ggtcctccgc acaggagcct tcgcctatcc attcctgttc gacaacctcc
      721 cactctttta tcggctcggg ctgtgctggg gcaggggcca cggctgtggg caggaggccc
      781 tgagcaccag ccatggctac catctcttct gcgcgctgct cactggcttc ctcttcgcct
      841 cccacctgcc tgaaaggctg gcaccaggac gctttgatta catcggccac agccaccagt
      901 tattccacat ctgtgcagtg ctgggcaccc acttccagct ggaggcagtg ctggctgata
      961 tgggatcacg cagagcctgg ctggccacac aggaacctgc cctgggcctg gcaggcacag
     1021 tggccacact ggtcttggct gcagctggga acctactcat tattgctgct ttcacagcca
     1081 ccctgcttcg ggcccccagt acatgccctc tgctgcaggg tggcccactg gaggggggta
     1141 cccaggccaa acaacagtga ggccccatcc ctgaccctgt cctggagggg gcagaggcca
     1201 ggccccagtg ctgacgagga gcccagattt gggcctaatc aggtggggac gcatctcagc
     1261 ctggaaccaa caggggctga ggagagaggg cacaggagag agggcagaga agaggagggg
     1321 tgtctagggg gactggcaga gtgtgagagg gaccgtgagg gggctcttga tgggagtgga
     1381 agaagtgctg agggtctgag aggggagatg catgcgtgtc caggctgaag atgcccctat
     1441 attctgtcaa aggttggcgg ggggaggtgt tggggtcctt tcatctggct ccgtttctgg
     1501 tgcttctgga agtctctgct cagcacaggg aagaactaac acgactaacc taggcctacc
     1561 ctgaatgctt cttgctaacc aggccgagag gccacacact tgccccccca tccccacaaa
     1621 ccaggtaatg ccagtttgcc agcagctatt tgcctataga gatgagtctg tcctggtcat
     1681 aactgtgtgc tcaaggtgtc caggcttttg ggggtgggcc tatctgggtg cattatggat
     1741 ggtttggtgg attgaggtgt ggggaggagg gtcctaggct agagggggta tccctagtta
     1801 gactttggga agccaccttc aacgttttct ggaacaaggc aggtacaaat aaaaaaataa
     1861 aactttggaa agcactttct agaactgaag aaggtaaaac ctcctcaccc ccatcctcct
     1921 gacacctccc tcccacactc cataaactgg acagactcac aggcccaca
//
