LOCUS       NM_017705               5372 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 5 (PAQR5),
            transcript variant 2, mRNA.
ACCESSION   NM_017705
VERSION     NM_017705.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5372)
  AUTHORS   Wang,L., Yue,Y., Zhang,L., Jing,M., Ma,M., Liu,C., Li,Y., Xu,S.,
            Wang,K., Wang,X., Fan,J. and Zhang,M.
  TITLE     PAQR5 inhibits the growth and metastasis of clear cell renal cell
            carcinoma by suppressing the JAK/STAT3 signaling pathway
  JOURNAL   Cell Oncol (Dordr) 46 (5), 1317-1332 (2023)
   PUBMED   37126128
  REMARK    GeneRIF: PAQR5 inhibits the growth and metastasis of clear cell
            renal cell carcinoma by suppressing the JAK/STAT3 signaling
            pathway.
REFERENCE   2  (bases 1 to 5372)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 5372)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5372)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 5372)
  AUTHORS   Wang,K.S., Liu,X.F. and Aragam,N.
  TITLE     A genome-wide meta-analysis identifies novel loci associated with
            schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 124 (1-3), 192-199 (2010)
   PUBMED   20889312
REFERENCE   6  (bases 1 to 5372)
  AUTHORS   Charles,N.J., Thomas,P. and Lange,C.A.
  TITLE     Expression of membrane progesterone receptors (mPR/PAQR) in ovarian
            cancer cells: implications for progesterone-induced signaling
            events
  JOURNAL   Horm Cancer 1 (4), 167-176 (2010)
   PUBMED   21761364
  REMARK    GeneRIF: Data show abundant mPRalpha (PAQR7), mPRbeta (PAQR8), and
            mPRgamma (PAQR5), but not classical nuclear PR (A or B isoforms)
            mRNA expression and mPRalpha protein expression in a panel of
            commonly used ovarian cancer cell lines.
REFERENCE   7  (bases 1 to 5372)
  AUTHORS   Smith,J.L., Kupchak,B.R., Garitaonandia,I., Hoang,L.K., Maina,A.S.,
            Regalla,L.M. and Lyons,T.J.
  TITLE     Heterologous expression of human mPRalpha, mPRbeta and mPRgamma in
            yeast confirms their ability to function as membrane progesterone
            receptors
  JOURNAL   Steroids 73 (11), 1160-1173 (2008)
   PUBMED   18603275
  REMARK    GeneRIF: Heterologous expression of MPRG in yeast confirms its
            ability to function as a membrane progesterone receptor.
REFERENCE   8  (bases 1 to 5372)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
REFERENCE   9  (bases 1 to 5372)
  AUTHORS   Zhu,Y., Bond,J. and Thomas,P.
  TITLE     Identification, classification, and partial characterization of
            genes in humans and other vertebrates homologous to a fish membrane
            progestin receptor
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2237-2242 (2003)
   PUBMED   12601167
REFERENCE   10 (bases 1 to 5372)
  AUTHORS   Zhu,Y., Rice,C.D., Pang,Y., Pace,M. and Thomas,P.
  TITLE     Cloning, expression, and characterization of a membrane progestin
            receptor and evidence it is an intermediary in meiotic maturation
            of fish oocytes
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2231-2236 (2003)
   PUBMED   12574519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC026992.12, BC039234.1, BE747523.1, AC027237.8 and AW779994.1.
            
            On May 17, 2019 this sequence version replaced NM_017705.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.153441.1, BC039234.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395407.7/ ENSP00000378803.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC026992.12        127887-127929
            44-299              BC039234.1         1-256
            300-492             BE747523.1         38-230
            493-1501            BC039234.1         450-1458
            1502-5227           AC027237.8         92226-95951         c
            5228-5229           AW779994.1         5-6                 c
            5230-5372           AC027237.8         92081-92223         c
FEATURES             Location/Qualifiers
     source          1..5372
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..5372
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /note="progestin and adipoQ receptor family member 5"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
     exon            1..145
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            146..306
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            307..472
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     CDS             422..1414
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /note="mPR gamma; progestin and adipoQ receptor family
                     member V; membrane progesterone receptor gamma; membrane
                     progesterone P4 receptor gamma; progesterone and adipoQ
                     receptor family member 5"
                     /codon_start=1
                     /product="membrane progestin receptor gamma"
                     /protein_id="NP_060175.3"
                     /db_xref="CCDS:CCDS10232.1"
                     /db_xref="GeneID:54852"
                     /db_xref="HGNC:HGNC:29645"
                     /db_xref="MIM:607781"
                     /translation="MLSLKLPRLFSIDQIPQVFHEQGILFGYRHPQSSATACILSLFQ
                     MTNETLNIWTHLLPFWFFAWRFVTALYMTDIKNDSYSWPMLVYMCTSCVYPLVSSCAH
                     TFSSMSKNARHICYFLDYGAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNT
                     ILSTGLSCYSRFLEIQKPRLCKVIRVLAFAYPYTWDSLPIFYRLFLFPGESAQNEATS
                     YHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHMQMEAILLDK
                     TLRKEWLLATSKPFSFSQIAGAILLCIIFSLSNIIYFSAALYRIPKPELHKKET"
     exon            473..600
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            601..806
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            807..933
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1030
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1172
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..5372
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5207..5212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /note="hexamer: AATAAA"
     regulatory      5230..5235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /note="hexamer: CATAAA"
     polyA_site      5231
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
                     /note="major polyA site"
     polyA_site      5256
                     /gene="PAQR5"
                     /gene_synonym="MPRG"
ORIGIN      
        1 atgggtaggc gcggcgaccc gcagggccag gtgcagggcc cgcgagtccg gggtcgccgc
       61 agcccgggag gagtgtctgg tctccggcct gcctgtgctg tccccgcgcc ctgtccactg
      121 gactcccgag acccttggaa cccaggacac cattggagaa actgggcatt ttaccaagga
      181 tttgactgga atggcatgct tcctttaaag atgaaagttg acttttagag ccaattaaag
      241 ccctttgggg aatctggcct cataccttgt ccacacagag ttcctgtaca aggttcctga
      301 cctgtgggaa gcggcacagc accagctagg cagagacgcc ccaggccatg ttagagcttt
      361 gagtgaggcc tggtaacagg gaggcgctgt cacctactgg ccttgccaat ccagctccaa
      421 gatgctgagc ctgaagctcc ccaggctgtt tagcatagac cagatacccc aggtgttcca
      481 tgagcaaggc atcctgttcg gctaccgcca tccacagagt tctgccactg cctgcatcct
      541 cagccttttc caaatgacca atgagactct caacatttgg actcacttgc tgcccttctg
      601 gttctttgca tggaggtttg tgactgcact gtatatgaca gacatcaaga atgacagcta
      661 ctcctggccc atgcttgtgt acatgtgcac cagctgcgtg tacccacttg tgtccagctg
      721 tgcgcacacc ttcagctcta tgtccaagaa tgcccggcac atttgctact tcctggacta
      781 tggtgccgtc aacctcttca gcctgggctc agccattgcc tactctgcat acacgttccc
      841 ggatgcgctc atgtgcacca ctttccatga ctactacgtg gccctggctg tactgaacac
      901 catcctcagc acaggcctct cctgctactc caggtttctt gaaatccaga agcccagact
      961 ctgtaaggtg attcgtgtcc tcgcctttgc ttatccgtac acctgggact ccctccccat
     1021 cttctacagg ctattcctgt tcccagggga gagtgcacaa aatgaagcca cctcgtacca
     1081 ccagaagcac atgatcatga ccctcctggc ctctttcttg tactctgcac atctgccaga
     1141 acgcctagcc cctggacgct ttgactacat cggtcacagt caccagctgt ttcacgtgtg
     1201 tgtgatcctg gccacgcaca tgcagatgga agccatactt ctggacaaga ctctgaggaa
     1261 ggaatggctc ctggccacct ccaagccctt ctctttctct cagatagctg gagccatact
     1321 tctgtgcatc atcttcagcc tcagcaacat aatttatttc tcagctgctc tgtatcggat
     1381 tcccaagcca gaattacata aaaaagaaac atgactcaga ccataagctt ttcatgccag
     1441 atgtcaacat taagctgcaa catcctaacc accataagcc ggaggtggtt acagcttatc
     1501 atggcctaaa atattcataa tggttggtgt cttttgaatg aattcatgtc aaaaatgtta
     1561 ttcagctggg gaaatttctc taaatgtaca ctgattctgt gtgtgtgatt ttaaaaggag
     1621 aatatggttc aagcaagtcc ttgttaaggc aaactattga tatttcatta attttaaatt
     1681 tacttaaaat gtggttttaa attctattta aacatttgga ttaagcatat tactctggag
     1741 ctttgtatta ttctttaaaa atgaatcttg cttcatttga tgaatttcat gtcacaaagc
     1801 ttctctcaag agctctcgta gtggcctgtc aaccactttc ggagaatgag ccaggtcagt
     1861 cactgggagg acctgtgaaa gaaagttggt cactgagtgc cttggggact ggcaaaacat
     1921 tccagaatga agagagctgt ctggggagag cccttcttcc cttctccacc tagtgaaggg
     1981 agaacagaag gggagtcctc tcttcccaca agtccattct gccttcaaag tgtaagttct
     2041 catgtcatta tggatttgga gtttgtcagt ttttttctta aaagtccaca gcggggtgtc
     2101 atgtgttctg ttatgttctg ttttctggtt gccagtttga tctgcaaagt atttttcagt
     2161 gcaggtaaaa tgtgttaaac cataagagtt gactgagtta atcccaattg gttgtgctca
     2221 tatgccacct tttaaaccaa tggaaattgc tatatttggg gatgtcatac atttgatatt
     2281 gcttcagcat ttcaaatatg ttgcaaaatt tagtatccat atgcataaga agttaatcac
     2341 cttgccagtg gggtggtcac atatagtgtt ctcaagcttt actgtgaatc agaaacatcc
     2401 agtaagcttg tgacaaatgc agactcctag ggaaaaccag ggggttctgc ttcactaggt
     2461 taaatgtagg ttttgtagag gagatctgca ctggagcaag tctcccagat gattctaata
     2521 caggagggcc agaggccaaa cttgaagaac tgctggtgtt acatgttcca aaaggcatta
     2581 gacctatcag ctttgtttcg cctgatctca agttttagca actcaccaac taaggcgtaa
     2641 cctcatttta tgttccagcg ttttctactc tgaatagttc taaaacactg agcattttct
     2701 catttgttgc attactgatt aaagttcagt atttcatggt gttttcaggg aacacagaaa
     2761 tgcggatgca aaacaacttt tgacagaggc ccatcaaacc cagatctgca cttggtaatg
     2821 acttaggggg gcttcctcac aatgcaggat cctctttgct gactcaggaa tactccatat
     2881 tttagactac tgcctctacc attaactagc ccagacattt gaatggcctt gtaaacagct
     2941 cactgtctaa tactcgaagg acaagtaaca atttatattg gatgagagtg gtcaagaaat
     3001 atgatttcgt tagttttatt atctgtttac ttcctctggg gaaggcagac tgataaaatt
     3061 atatgggctg gtaaattttt ggtacattaa ttgcaagctg catgacaaaa tttgtttttc
     3121 tggcaacaat ctgacattat tagtggaatt ccacaccaac agggcttgtg agcttccatt
     3181 tcatcttact gtaacttcaa ttttatggca aaaaaaggta caaagtttaa ataccccttt
     3241 ctagtaatgc caaagacata cagtgtttta cattctctcc tttataggta acaaaataat
     3301 gtttagctca gtaagtactg aaataatgag tgaccaattt gaaggatttt tagattattt
     3361 aatctttgct tatgttgctt tttcacatgc ttaatgatgg aaatgaaatg ttaaatcaac
     3421 aaaataagat ccagtgtttc ataacatttt tataagtttg gtaaacttta gtcccattat
     3481 atacttttgg ggacagtgtt ataaatcaga attttacgac agtttgcaga acactgattt
     3541 gaaagcttcc tatgcaaaat gagaaggggt tcaaatatat taattatcat taagtattaa
     3601 ataataggca ttagatgtct aatgtgagta taatttcatc caagccatct cagaaagtct
     3661 aaaaggttgg cagggggtca gctgaagacc tcactggagt gggtcttaat ttttaaaaag
     3721 tgtctcacta catttaagac atgtgacaca ttcccattgg taacaattgc tcaccatggc
     3781 attgtctcaa aaaagactat ggtggggagg gtggcacatt cctaatggga tgtacctctc
     3841 cccactcccc ttgcttgaga agcactactc aaaaatttac cagaccttac aactgtgata
     3901 aaacttgaat gtgtatgatg aataaggcca ttcagttaac tttacctccc tttacccatt
     3961 gaaggggttc cttttccatt gctcagtttt tagaaaataa ttctcatctt ttttctaaag
     4021 aaatgaattt gtggctggtc tgaaggtagt gagttagctc aattgattgt tcgcagtcag
     4081 ttatagatca agctccttgt tctactcttc ccctcttctc actactgcac ttgactagtc
     4141 ttaaaacaaa gaaagaacga atgaatgaat gaatctgtgg ctggatgcag tggctcatgc
     4201 ctgtaatccc agcactttgg gaggctgaag tgggaggact gcttgggccc aagaattcag
     4261 gaccagtctg ggcaacagag ccagacactg tctctataaa aaaaagttaa aactagctgg
     4321 ttgtggtggt gcacacctgt ggtcccagct actgtggagg gtgatgtggg aggattgctt
     4381 gaacccagga gttggatgct gcagtgagct atgattgcgc cattgcgctc cagactgggc
     4441 aacagggcaa gaccctgcct caaaaaaaaa aaaaaaagaa tttgtaattg ttggtaggat
     4501 gttatgggaa atttagaggt cttctgagta taaagtggtt taaatatttg gtctgctgaa
     4561 gtctttctgg aagtgttgtt ccccctgctg ccccgcccag tagaaacttg ctcatatgag
     4621 aggttctgag gtaggtgcgg tgtagtagaa tggcattgtc agatatgttc aagaaaccct
     4681 tcatttgaca ctattttgta ccttatggta ccctttaaca ttttttaatt aaaaaaaata
     4741 ttttttgaga cagggtcttg ttctgttgcc caggctggag tgtagtgttg caatcttggc
     4801 tcactgcaac ctctgcctga caggcttcag tgatctttcc acctcagcct cctgagtagc
     4861 tgggactaca ggtgcatgcc accaagcctg gctaactttt tgtagagata gggttttgcc
     4921 atgctgccca ggctggctta gaattcctga attcaagtga tttgtctgcc tcaggctccc
     4981 aaagtgctgg gattacaggc atgagccaca ctgcacccag tccatgctac cctttttata
     5041 tgaaacacct attaacacgg tacaacaaca cttcaaaaca tattatttga atttcggcct
     5101 ctgattttct agtcaacaat ccattaaggc aaagacctgt ttccaaactc agatgttctc
     5161 caacttacac taatgtctgg ttttcttgaa ctatgtgaga gaaaaaaata aacagaattt
     5221 atttattatc ataaagtcat cctgtttgcc acttaatttg gttatgtttt atctaccaca
     5281 ctgcaaatat gttaattcac catgagaaac agatccctgt acacatgtgt atcagtaaat
     5341 cattcaatga atagttagtg cttaggatgt at
//
