LOCUS       NM_152341               2685 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 4 (PAQR4),
            transcript variant 1, mRNA.
ACCESSION   NM_152341
VERSION     NM_152341.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2685)
  AUTHORS   Zhu,Q., Chen,S., Funcke,J.B., Straub,L.G., Lin,Q., Zhao,S.,
            Joung,C., Zhang,Z., Kim,D.S., Li,N., Gliniak,C.M., Lee,C.,
            Cebrian-Serrano,A., Pedersen,L., Halberg,N., Gordillo,R.,
            Kusminski,C.M. and Scherer,P.E.
  TITLE     PAQR4 regulates adipocyte function and systemic metabolic health by
            mediating ceramide levels
  JOURNAL   Nat Metab 6 (7), 1347-1366 (2024)
   PUBMED   38961186
REFERENCE   2  (bases 1 to 2685)
  AUTHORS   Liu,C., Cai,W., Tang,P. and Li,C.
  TITLE     High PAQR4 mRNA Expression May Play a Key Role in Prognosis of
            Kidney Renal Papillary Cell Carcinoma
  JOURNAL   Ann Clin Lab Sci 53 (5), 701-711 (2023)
   PUBMED   37945022
  REMARK    GeneRIF: High PAQR4 mRNA Expression May Play a Key Role in
            Prognosis of Kidney Renal Papillary Cell Carcinoma.
REFERENCE   3  (bases 1 to 2685)
  AUTHORS   Shi,X., Zhao,P. and Zhao,G.
  TITLE     VEZF1, destabilized by STUB1, affects cellular growth and
            metastasis of hepatocellular carcinoma by transcriptionally
            regulating PAQR4
  JOURNAL   Cancer Gene Ther 30 (2), 256-266 (2023)
   PUBMED   36241701
  REMARK    GeneRIF: VEZF1, destabilized by STUB1, affects cellular growth and
            metastasis of hepatocellular carcinoma by transcriptionally
            regulating PAQR4.
REFERENCE   4  (bases 1 to 2685)
  AUTHORS   Qu,C., Ma,T., Yan,X., Li,X. and Li,Y.
  TITLE     Overexpressed PAQR4 predicts poor overall survival and construction
            of a prognostic nomogram based on PAQR family for hepatocellular
            carcinoma
  JOURNAL   Math Biosci Eng 19 (3), 3069-3090 (2022)
   PUBMED   35240821
  REMARK    GeneRIF: Overexpressed PAQR4 predicts poor overall survival and
            construction of a prognostic nomogram based on PAQR family for
            hepatocellular carcinoma.
REFERENCE   5  (bases 1 to 2685)
  AUTHORS   Zhao,G., Shi,X., Sun,Z., Zhao,P. and Lu,Z.
  TITLE     PAQR4 promotes the development of hepatocellular carcinoma by
            activating PI3K/AKT pathway
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 53 (12), 1602-1613 (2021)
   PUBMED   34718369
  REMARK    GeneRIF: PAQR4 promotes the development of hepatocellular carcinoma
            by activating PI3K/AKT pathway.
REFERENCE   6  (bases 1 to 2685)
  AUTHORS   Xu,P., Jiang,L., Yang,Y., Wu,M., Liu,B., Shi,Y., Shen,Q., Jiang,X.,
            He,Y., Cheng,D., Xiong,Q., Yang,Z., Duan,L., Lin,J., Zhao,S.,
            Shi,P., Yang,C. and Chen,Y.
  TITLE     PAQR4 promotes chemoresistance in non-small cell lung cancer
            through inhibiting Nrf2 protein degradation
  JOURNAL   Theranostics 10 (8), 3767-3778 (2020)
   PUBMED   32206121
  REMARK    GeneRIF: PAQR4 promotes chemoresistance in non-small cell lung
            cancer through inhibiting Nrf2 protein degradation.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2685)
  AUTHORS   Feng,Y., Sun,T., Yu,Y., Gao,Y., Wang,X. and Chen,Z.
  TITLE     MicroRNA-370 inhibits the proliferation, invasion and EMT of
            gastric cancer cells by directly targeting PAQR4
  JOURNAL   J Pharmacol Sci 138 (2), 96-106 (2018)
   PUBMED   30322804
  REMARK    GeneRIF: PAQR4 (Progestin and AdipoQ Receptor 4) expression is
            closely associated with progression of many cancers and microRNA
            (miRNA) processing.
REFERENCE   8  (bases 1 to 2685)
  AUTHORS   Zhang,H., Han,R., Ling,Z.Q., Zhang,F., Hou,Y., You,X., Huang,M.,
            Zhao,Z., Wang,Z. and Chen,Y.
  TITLE     PAQR4 has a tumorigenic effect in human breast cancers in
            association with reduced CDK4 degradation
  JOURNAL   Carcinogenesis 39 (3), 439-446 (2018)
   PUBMED   29228296
  REMARK    GeneRIF: Data indicate that PAQR4 has a tumorigenic effect on human
            breast cancers, and such effect is associated with a modulatory
            activity of PAQR4 on protein degradation of CDK4
REFERENCE   9  (bases 1 to 2685)
  AUTHORS   Wang,L., Zhang,R., You,X., Zhang,H., Wei,S., Cheng,T., Cao,Q.,
            Wang,Z. and Chen,Y.
  TITLE     The steady-state level of CDK4 protein is regulated by antagonistic
            actions between PAQR4 and SKP2 and involved in tumorigenesis
  JOURNAL   J Mol Cell Biol 9 (5), 409-421 (2017)
   PUBMED   28992327
REFERENCE   10 (bases 1 to 2685)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004235.1, AL832527.1 and BC033703.1.
            
            On May 17, 2019 this sequence version replaced NM_152341.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033703.1, AL832527.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318782.9/ ENSP00000321804.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-284               AC004235.1         25298-25581
            285-680             AL832527.1         1-396
            681-1460            BC033703.1         442-1221
            1461-2685           AL832527.1         1177-2401
FEATURES             Location/Qualifiers
     source          1..2685
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..2685
                     /gene="PAQR4"
                     /note="progestin and adipoQ receptor family member 4"
                     /db_xref="GeneID:124222"
                     /db_xref="HGNC:HGNC:26386"
                     /db_xref="MIM:614578"
     exon            1..493
                     /gene="PAQR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..1149
                     /gene="PAQR4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     progestin and adipoQ receptor family member IV"
                     /codon_start=1
                     /product="progestin and adipoQ receptor family member 4
                     isoform 1"
                     /protein_id="NP_689554.2"
                     /db_xref="CCDS:CCDS10485.1"
                     /db_xref="GeneID:124222"
                     /db_xref="HGNC:HGNC:26386"
                     /db_xref="MIM:614578"
                     /translation="MAFLAGPRLLDWASSPPHLQFNKFVLTGYRPASSGSGCLRSLFY
                     LHNELGNIYTHGLALLGFLVLVPMTMPWGQLGKDGWLGGTHCVACLAPPAGSVLYHLF
                     MCHQGGSAVYARLLALDMCGVCLVNTLGALPIIHCTLACRPWLRPAALVGYTVLSGVA
                     GWRALTAPSTSARLRAFGWQAAARLLVFGARGVGLGSGAPGSLPCYLRMDALALLGGL
                     VNVARLPERWGPGRFDYWGNSHQIMHLLSVGSILQLHAGVVPDLLWAAHHACPRD"
     exon            494..715
                     /gene="PAQR4"
                     /inference="alignment:Splign:2.1.0"
     exon            716..2685
                     /gene="PAQR4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2664..2669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR4"
                     /note="hexamer: AATAAA"
     polyA_site      2685
                     /gene="PAQR4"
                     /note="major polyA site"
ORIGIN      
        1 agagagacta ccggccaccg ccgccgccgc cgccgcgagc tgtccctgcg gcgcgtctgc
       61 cttggcggag ccgaccgcag tgcgctcagg cgtccggtgc gtccccagcc tccgccccgg
      121 cgcgggggcg acggactcgc gcgtgcgcag cgccggaggg gcgcgggctg ggacccccta
      181 gccagcgcgt gcgccgatcg agcgcagggc gatgggtggg cgccgggcgc cgggcgccag
      241 gcagtgatgg gccttcccgc gctgcggccc cactgaggag gaggctcggg gacagcagga
      301 gcacgggctg cccgcgcggt gcggaccatg gcgttcctgg ccgggccgcg cctgctggac
      361 tgggccagct cgccgccgca cctgcagttc aataagttcg tgctgaccgg gtaccggccc
      421 gccagcagcg gctcgggctg cctgcgcagc ctcttctacc tgcacaacga actgggcaac
      481 atctacacgc acgggctggc cctgctgggc ttcctggtgc tggtgccaat gaccatgccc
      541 tggggtcagc tgggcaagga tggctggctg ggaggcacac attgcgtggc ctgccttgca
      601 ccccctgcag gctccgtgct ctatcacctc tttatgtgcc accaaggggg cagcgctgtg
      661 tacgcccggc tcctcgccct ggacatgtgt ggggtctgcc ttgtcaacac ccttggggcc
      721 ctgcccatca tccactgcac cctggcctgc aggccctggc tgcgcccggc tgccctggtg
      781 ggctacactg tgttgtcggg tgtggccggc tggcgtgctc tcaccgcccc ctccaccagt
      841 gctcggctcc gggcatttgg atggcaggct gctgcccgcc tactggtatt tggggcccgg
      901 ggagtgggtc tgggttcagg ggctccaggc tccctgccct gctacctgcg catggacgca
      961 ctggcgctgc ttgggggact ggtaaatgta gcccgtctgc ccgagcgctg gggacctggc
     1021 cgctttgact actggggcaa ctcccaccag atcatgcacc tgctgagcgt gggctccatc
     1081 ctgcagctgc acgccggcgt cgtgcccgac ctgctctggg ctgcccacca cgcctgtccc
     1141 cgggactgag ctgccatgcc agcctgccca cagcagcctc ctagagttag caacaccagg
     1201 tgttcctccc aactcgtctg caaggggctg gctccttgga tgcttccagc tcatgagatg
     1261 tctcagcagg agccctgttc acccgttctt ccctgtggac tgacctcttc cacccacgcc
     1321 gtggcgctcc aacttccttc cctgcctttt ccctccaagc tcctatttta ctgtgtcagc
     1381 tggaaggaaa cctttccctc ttgggacctc tttaccctct gtgacctgtg gggttagacc
     1441 agagagggac tctggggtca cgtcttgctc tgagagttca agtcctgcca ggccgccagc
     1501 ccagagcctc ctcaccctat cctgttcctc ccaccaggcc tgtggccagt cttcctgatc
     1561 tccatctttc tgccctgcat accagccctc ccagcagcca caagcttgcc cgccctggct
     1621 ccctctgccc agagactatg gagtaaggca ttcaggacaa aaggaccaag ggggcgtgga
     1681 cccgtcttgt accagctggc cacaggcaca agggctgcag ctgcttcttc caggaaactg
     1741 acacagggag ctcagcggcc tcagatcctg ggacccctgg gccgtgcctg ccctccacct
     1801 tgagtgccat actcccaaca gctccaggta cccaccgggg gatgtgcctg ctcaggaaac
     1861 ctctttgctc cacacagcat ggggcttcag ctgctggccc aaggccagga gcgctgggtt
     1921 ctgcagcagg gctcagcctc aggggcgtta agaccctgga tgacatcaat aaagggacag
     1981 gaagggccat gttgccacat gagcaagctt gggtgctccc aaggttcaaa tactttttat
     2041 tagacacggc caggcagaga agaccatggg agttcccgag gggccccagc tttcaagggc
     2101 gacgggagag acacaggata aaaggttaaa agtgcagagg cagagtctgg ggctcaggtt
     2161 gggtctaggg tgtcctcaaa caggctgagg aggttccgag gctcaaagga ggggaaggag
     2221 ccccgaggag gctctgagtt gatgtcactt aggtccaggg catccctggg aggagagagt
     2281 agtgacactc aggatccaaa agctagccct gcccacccca gcccctggac ctgcttacct
     2341 gggtgtgcac ctgctccggg gggtggaggt gctccccaca gtccgggcca ggacagcctc
     2401 aggggagagt gaaggcctgc aggagggcag gcgagacaag gagggtgtcc agggctaggg
     2461 agtgccggat gaaaccagct ctgtccctgt gcaggctcca ggctcccgcc tgacaaacag
     2521 gcagggagcc acagtcaggg acaataaaaa cttggtgcac tctgaaagca gcacttggac
     2581 agccttcaaa gtccttccat ctggctgcac tccaaggccc cctctgtcct tttcagaaca
     2641 catggacttg gaggcagatt tgaaataaac ttttagtaaa tgtaa
//
