LOCUS       NM_001040202            9811 bp    mRNA    linear   PRI 10-DEC-2024
DEFINITION  Homo sapiens progestin and adipoQ receptor family member 3 (PAQR3),
            transcript variant 1, mRNA.
ACCESSION   NM_001040202
VERSION     NM_001040202.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9811)
  AUTHORS   Ling,Z.N., Hong,L.L., Wu,J. and Ling,Z.Q.
  TITLE     Systematic pan-cancer analyses of the potential function of the
            Golgi scaffold protein PAQR3
  JOURNAL   Sci Rep 14 (1), 3030 (2024)
   PUBMED   38321173
  REMARK    GeneRIF: Systematic pan-cancer analyses of the potential function
            of the Golgi scaffold protein PAQR3.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9811)
  AUTHORS   Wu,Y.L., Hong,L.L., Ling,Z.N., Hu,X.Y., Liu,Z., Li,P. and Ling,Z.Q.
  TITLE     Golgi scaffold protein PAQR3 as a candidate suppressor of gastric
            cardia adenocarcinoma via regulating TGF-beta/Smad pathway
  JOURNAL   J Clin Lab Anal 36 (9), e24617 (2022)
   PUBMED   35870178
  REMARK    GeneRIF: Golgi scaffold protein PAQR3 as a candidate suppressor of
            gastric cardia adenocarcinoma via regulating TGF-beta/Smad pathway.
REFERENCE   3  (bases 1 to 9811)
  AUTHORS   Zhang,C., Liu,P., Huang,J., Liao,Y., Pan,C., Liu,J., Du,Q., Liu,T.,
            Shang,C., Ooi,S., Chen,R., Xia,M., Jiang,H., Xu,M., Zou,Q.,
            Zhou,Y., Huang,H., Pan,Y., Yuan,L., Wang,W. and Yao,S.
  TITLE     Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth
            and metastasis via miR-203a-3p/PAQR3 axis
  JOURNAL   Cell Death Dis 12 (10), 888 (2021)
   PUBMED   34588429
  REMARK    GeneRIF: Circular RNA hsa_circ_0043280 inhibits cervical cancer
            tumor growth and metastasis via miR-203a-3p/PAQR3 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9811)
  AUTHORS   Jin,L. and Tong,L.
  TITLE     PAQR3 inhibits proliferation and aggravates ferroptosis in acute
            lymphoblastic leukemia through modulation Nrf2 stability
  JOURNAL   Immun Inflamm Dis 9 (3), 827-839 (2021)
   PUBMED   33955706
  REMARK    GeneRIF: PAQR3 inhibits proliferation and aggravates ferroptosis in
            acute lymphoblastic leukemia through modulation Nrf2 stability.
REFERENCE   5  (bases 1 to 9811)
  AUTHORS   Qi,L.Q., Sun,B., Yang,B.B. and Lu,S.
  TITLE     MiR-15b facilitates breast cancer progression via repressing tumor
            suppressor PAQR3
  JOURNAL   Eur Rev Med Pharmacol Sci 24 (2), 740-748 (2020)
   PUBMED   32016977
  REMARK    GeneRIF: MiR-15b facilitates breast cancer progression via
            repressing tumor suppressor PAQR3.
REFERENCE   6  (bases 1 to 9811)
  AUTHORS   Garitaonandia,I., Smith,J.L., Kupchak,B.R. and Lyons,T.J.
  TITLE     Adiponectin identified as an agonist for PAQR3/RKTG using a
            yeast-based assay system
  JOURNAL   J Recept Signal Transduct Res 29 (1), 67-73 (2009)
   PUBMED   19519172
  REMARK    GeneRIF: Data show that adiponectin functions as an agonist of
            PAQR3.
REFERENCE   7  (bases 1 to 9811)
  AUTHORS   Luo,X., Feng,L., Jiang,X., Xiao,F., Wang,Z., Feng,G.S. and Chen,Y.
  TITLE     Characterization of the topology and functional domains of RKTG
  JOURNAL   Biochem J 414 (3), 399-406 (2008)
   PUBMED   18547165
  REMARK    GeneRIF: Analysis in detail of the topology and functional domains
            of RKTG (Raf kinase trapping to Golgi).
REFERENCE   8  (bases 1 to 9811)
  AUTHORS   Fan,F., Feng,L., He,J., Wang,X., Jiang,X., Zhang,Y., Wang,Z. and
            Chen,Y.
  TITLE     RKTG sequesters B-Raf to the Golgi apparatus and inhibits the
            proliferation and tumorigenicity of human malignant melanoma cells
  JOURNAL   Carcinogenesis 29 (6), 1157-1163 (2008)
   PUBMED   18515281
  REMARK    GeneRIF: RKTG may play a suppressive role in human melanoma that
            harbors an oncogenic B-Raf mutation via its antagonistic action on
            B-Raf.
REFERENCE   9  (bases 1 to 9811)
  AUTHORS   Feng,L., Xie,X., Ding,Q., Luo,X., He,J., Fan,F., Liu,W., Wang,Z.
            and Chen,Y.
  TITLE     Spatial regulation of Raf kinase signaling by RKTG
  JOURNAL   Proc Natl Acad Sci U S A 104 (36), 14348-14353 (2007)
   PUBMED   17724343
  REMARK    GeneRIF: reveal a paradigm of spatial regulation of Raf kinase by
            RKTG via sequestrating Raf-1 to the Golgi apparatus and thereby
            inhibiting the ERK signaling pathway.
REFERENCE   10 (bases 1 to 9811)
  AUTHORS   Tang,Y.T., Hu,T., Arterburn,M., Boyle,B., Bright,J.M., Emtage,P.C.
            and Funk,W.D.
  TITLE     PAQR proteins: a novel membrane receptor family defined by an
            ancient 7-transmembrane pass motif
  JOURNAL   J Mol Evol 61 (3), 372-380 (2005)
   PUBMED   16044242
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC093841.3, DA410845.1,
            AY424281.1 and BX648346.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001040202.1.
            
            Summary: This gene encodes a seven-transmembrane protein localized
            in the Golgi apparatus in mammalian cells. The encoded protein
            belongs to the progestin and adipoQ receptor (PAQR) family. This
            protein functions as a tumor suppressor by inhibiting the
            Raf/MEK/ERK signaling cascade. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.233484.1,
                                           SRR1660803.55156.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152798 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000512733.5/ ENSP00000421981.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC093841.3         36294-36303         c
            11-83               DA410845.1         1-73
            84-986              AY424281.1         1-903
            987-1483            BX648346.1         608-1104
            1484-3749           AC093841.3         14805-17070         c
            3750-9811           AC093841.3         8743-14804          c
FEATURES             Location/Qualifiers
     source          1..9811
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.21"
     gene            1..9811
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="progestin and adipoQ receptor family member 3"
                     /db_xref="GeneID:152559"
                     /db_xref="HGNC:HGNC:30130"
                     /db_xref="MIM:614577"
     exon            1..399
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1150
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="isoform 1 is encoded by transcript variant 1; Raf
                     kinase trapping to Golgi; progestin and adipoQ receptor
                     family member III"
                     /codon_start=1
                     /product="progestin and adipoQ receptor family member 3
                     isoform 1"
                     /protein_id="NP_001035292.1"
                     /db_xref="CCDS:CCDS34020.1"
                     /db_xref="GeneID:152559"
                     /db_xref="HGNC:HGNC:30130"
                     /db_xref="MIM:614577"
                     /translation="MHQKLLKSAHYIELGSYQYWPVLVPRGIRLYTYEQIPGSLKDNP
                     YITDGYRAYLPSRLCIKSLFILSNETVNIWSHLLGFFLFFTLGIYDMTSVLPSASASR
                     EDFVICSICLFCFQVCMLCSVGYHLFSCHRSEKTCRRWMALDYAGISIGILGCYVSGV
                     FYAFYCNNYWRQVYLITVLAMILAVFFAQIHPNYLTQQWQRLRSIIFCSVSGYGVIPT
                     LHWVWLNGGIGAPIVQDFAPRVIVMYMIALLAFLFYISKVPERYFPGQLNYLGSSHQI
                     WHILAVVMLYWWHQSTVYVMQYRHSKPCPDYVSHL"
     exon            400..562
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            563..718
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            719..916
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1007
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..9811
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3728..3733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: AATAAA"
     polyA_site      3747
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="major polyA site"
     regulatory      6470..6475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: AATAAA"
     polyA_site      6491
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
     regulatory      6791..6796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: ATTAAA"
     polyA_site      6811
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
     regulatory      7609..7614
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: ATTAAA"
     polyA_site      7633
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
     regulatory      8693..8698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: AATAAA"
     polyA_site      8710
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
     regulatory      9789..9794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
                     /note="hexamer: AATACA"
     polyA_site      9811
                     /gene="PAQR3"
                     /gene_synonym="RKTG"
ORIGIN      
        1 agaggaggct gcgacgctgc cgggtccgcc gcggcgctgg cggcagtggc cggtgtgagc
       61 gcagagccgg gccctgggca gcagcggcag cgcggtagga cctcgcgcag cgtccgcggg
      121 ctccggggcg ggggcgccag cggcgaagcc ccctccccgg ggaggcggga cctgggggag
      181 ctcccgagcc ggggagcggc ggcggccggg aacgatgcat cagaagctgc tgaagagcgc
      241 gcattacatc gagctgggca gctaccagta ctggccggtc ctggtgcccc gtggcatccg
      301 cctgtacacc tacgagcaga tccccgggtc cctcaaggac aacccgtaca tcaccgacgg
      361 ctaccgggcc tacctgccgt ccaggctgtg tatcaaaagt ttgtttattt tatctaatga
      421 gacagtaaac atctggagtc atttgctggg tttctttctc ttcttcaccc tgggaatata
      481 tgacatgaca tctgtgttac cttcagcaag tgcgtccaga gaagattttg taatttgttc
      541 tatttgtctt ttctgcttcc aggtctgtat gctttgctct gtgggctatc atcttttttc
      601 ctgccatcgg tcagaaaaaa catgtcgaag atggatggca ttagattatg caggaatttc
      661 tattggaata ctgggctgct atgtctcagg agtattttac gcattttatt gtaataacta
      721 ctggcgtcag gtgtacttga tcacagtgct tgctatgatc ctggcagtgt tctttgcgca
      781 gattcatccc aattacctca cgcagcaatg gcaaaggctc cgttctatca tcttttgttc
      841 tgtttcggga tatggagtga ttcctactct tcactgggtt tggctcaatg gaggaattgg
      901 tgctcctatt gtacaggact ttgcaccccg tgtaattgtg atgtatatga ttgctcttct
      961 tgctttccta ttctacattt ccaaagtccc agagcggtac tttccaggac aactaaacta
     1021 cctcggatca agccaccaaa tatggcatat ccttgcagta gtgatgttat attggtggca
     1081 tcagtcaaca gtgtatgtca tgcagtacag acatagcaag ccttgtcctg actatgtttc
     1141 acatttgtga attaggtatg gccacctggt gaattcagtt gttaagcaat atataatggg
     1201 gaattgtata ccccactatt tctaagattc ccattagttt tccctttttc ctttttaata
     1261 tgagtaatgc tttataaaaa tgggaaaaaa agtatactta aggatctgta gtaataactg
     1321 ctttacaaaa tccttaaaac tactaatttg ctgcttgtac agaaagtgaa aattagttgg
     1381 caatcataag aaacatctga ataacaacga tgaatgggaa actagtgttg aaataggatt
     1441 cattttactt agcaccagct taatttcctt aggaagggct catgtccatt agaaaatgga
     1501 gtcatcttat gtgcttaatt attttcagtt aattgtcaag tttaagtgcc taatcaaggc
     1561 aagtgttgtt tcagcctatg cttaatgcaa gctaggatag tgattttaaa taatcactaa
     1621 aatcactaga tttaaataat cactaaaatg atttgtgaga aactggcact tcagatatta
     1681 tatcctttag ctataggttc ttctctccct aagaacatta gatattttag ttttccagaa
     1741 caaaagcttt aaacttctgc agtaagttga gagaagggtt gagaagagga aaagaacttc
     1801 tcattttcta tcagataaga atcacattag aaactaagta caagattaga caacaaatta
     1861 tgtggtcaaa taatatagtc attagccacc taaacatttt aattccagat attatttaat
     1921 tccatataat aactgaattc ttgtgagtgg attacaggtt tttgatccca aaattccaga
     1981 gctttcaact ctctgaattt gtagtcctga atatcccagt ggtgggggtt cccagcattg
     2041 tgggtgctac ttgcaaggcc atagaatcta gatggccctg tcttgaccct gaaatgaacc
     2101 ttaagcctta gaacaaagtc atgcagatgc cccatttgat aataatctta ttcacctgtg
     2161 ctctggtcct cggtttctgc atgtgttagc attgcattga taactcagaa tcttgataaa
     2221 cacttaatat ttgggcctga agcattaaac tttcttttta ttgtatatac ttaaaaaata
     2281 gaactcactg ccctatcata cattgtagcc ctcttattct ttggtctttc atatgcatta
     2341 gttaaatccc ttaaagtaga cattcataaa aacttacatt gtttattgga gtataaaata
     2401 ttacccaagt ttcttcatga gttgacatga gctgttttaa atactggtgt attttcagaa
     2461 cagtaaaatt actgaatatc agaaaaaatg ttaattgatg atgaagctta ttcccaaaat
     2521 gccttttgtg catatgatac ttggaaagtc actaatgtgc ctcagttaat acatcagtaa
     2581 aatgttgtgt ttcttttcca gtgtagtgtt tttggaatat aaattcccca tgctagtata
     2641 gtatctcagc aaagagaatt tccccccagg aggctcagta aaggaatacc gtgtcttacc
     2701 catcgttatg atggaaggct gctttgaaaa tggctgtttt accttataag gttaaaattt
     2761 tgatccatat gttaagtgat agaagatttt ggtgcaacag tagtaggata tatttctcct
     2821 agaacatccc ttattggctt acatgatttt attgcctttt aatagatatt ttgtcatttt
     2881 ggccaaacaa aagacactga gtagttacac ttaagttaaa aatgagggga aaatcattat
     2941 tttaggtgtg gagccatttt tattataaaa ctttctcaaa ataaaaaaac attgaatcat
     3001 ttcaattttt gcagtccctg tattagtata tgaatacata cttgccattt gaattaataa
     3061 catgaaaaga gtatactgtg tttttaaatc cgtgtttctt tgaatttaaa gggtgtacag
     3121 gtctttctgt agggaaaatt attccatgta aacatttcaa ctctgtatga aaatgttaaa
     3181 tattgtaaga aagttatcct ctcatttttt cactgctatg atatatttat tataaaatag
     3241 ggaatgaatg aatgaatatg gattgctgtt aactagaaac acttctgtat gtcagtcagc
     3301 atttaatgac cacctactgt gtgcacagca ctactggtaa aattttgaag acattgttaa
     3361 cattaaaaaa tattttaaag ttgtctacaa atctgagcct tgtaatgatg tatatttaag
     3421 ttatttttgt ttttatagat taaagtaaga ttaaaatata ctatccagtt ttattactaa
     3481 aaaagactgg ttttaatttt accaatgtgt gaactataaa agctttttgc ctacagattt
     3541 tacattttaa aattatctat ggctgtttta aattgtctag caatttatat ggttgtggtt
     3601 aactcattta agaaacaatt atctttctat attaagccat tttcaaatag caagacagtg
     3661 cttgtctttt tttgttatta cactaactgc aattcagtaa gctgcatgac aaaatatgta
     3721 ttatgtaaat aaactgggtt tactaaatat ttttaactgc tgcttgtcat tctttgtaat
     3781 acataacagc tttaaaatca tattttagaa tcaggaacga agattcaggg aatgtctgtc
     3841 acatcttatg gcatcccacc tggacagaat atccgatttg aagattgtga ttgacttccg
     3901 taaaactgta caactctcca tttggcaggt acctactaga taatactttg ccctgtatta
     3961 aatgtcaagg ggcaaagcct attcctgtga attcctgctg gttgctttgc tgcattaggt
     4021 ccctgtccac tgtaaatcat cattcctggg aattctactt ctgcccaagt gtgtaaagaa
     4081 tcagctcacc tattagagaa ggggtagaaa taccttctgt gtgcattatc acaataactg
     4141 tgtttacact aaagaggtgt aaatacagtc ctctgaaatt ttgtaccaga attcccaagt
     4201 agtgtaatga gataatgatc cagaactgaa actaccctta agaaaacatt tttggaaggg
     4261 agaggtaaat agcagtaggg ggtttcttgt gaaaaattaa cctccatcct taagagggct
     4321 gaaatgaaca gccaccaagg ttctagtcct gctctataaa atctgagatc aaaatactac
     4381 ctaacctgca cataatctca attgtgacaa ccatctgaac tatctcattt aatatgtaac
     4441 aacaaataca agctcaagct ttcaatatga gaatattaac tacatgttac atatgatgct
     4501 tgacctgggc ttccttaaaa aggtattcgt tatccaaaat aaatagctca aattgcagca
     4561 tatattcatc tcaagtaact ataactgaat ttgaacagta atacactgca aactattctt
     4621 tgttaataga acttttctaa tcatttgtgt tattttgctt tgtaccattc attttcatta
     4681 aaaagataca aagccccttt ttttcacata actttagata aatgttacaa cttcagaaaa
     4741 agttaattca taaaaatagg atgaaccttt ccacaggcta ccaaagactc cagtttttgg
     4801 aataatacat attataacct tgatgccaag cttagtccat caatccaata aataggtttt
     4861 ctctttaatg tgtcatagcc tcttttctga tataattgag gattacaatg ttatttaagc
     4921 aaataaccag tattaattca gccaaagatg ttatcagttt taaagatttt taaaaattta
     4981 taatgtggaa gctgtaaaat aagttattca gaaggcacta cacaatattg tttttgcctt
     5041 actgtcatca ctcgagtatc agtaattatg actcactgaa aaagtcgtgc tattaagtgt
     5101 tcttgtggca aaaactctta agtcaaatgg gttttcttac ctaaattgta aactctgagc
     5161 tccttaagaa tagggatcta atcttagcaa cttttctatt ccactagctg ctacataata
     5221 ggtgcttaat gtttgtggtg tgaatgaaat aactgaattt gaatagaagt ttacatccaa
     5281 aagtcataat aagacaaata atgaaaaact ccaaagtcac tgattataaa gaatatgcaa
     5341 tccatttggg atttattgca tttaaagaaa acagattaaa acaggtatga taaatacagt
     5401 aagaaaataa ctttaaattt caaacaaaac agtgaatcag ggacagaatt cagtcaaaaa
     5461 gaataagcag tgtaaaggca ataaagtaat aaaatcagtt agtgcttaat tagatatggc
     5521 aggggaaaag gggtgggagg gggagactga gtctatctca taattgtttc ccagctatat
     5581 ttgaggactg aagttacttt agcaagtatg ttttgtaaca agtagaaata caataaagat
     5641 gtaaatttgc tttatttaaa ggttaaagtt atttgcttag tggtacataa aaggcttcag
     5701 aaaattcaag tttaacaaaa aatggaagtg taatcaaaga aagtgcactt aaagctgttt
     5761 gccagcaatt aaaaagtagc ttctatacag cttctattag atgacttttc aatcacaaaa
     5821 agagcatagt cataaaaaca attctttcaa aagtagcagt ataaatttta aaataaaaca
     5881 aaaataaccc caaatcatga ccctttgcat tatcatctac cttattctct tagtagcttt
     5941 tgtaaaccct cactaggagt gaatgttctc ttagatatga ttgtggttgc aattccattt
     6001 tttaaaaatt cacattaact ccacagtaga gagatgtgac atgcatgtgt gtacatattt
     6061 ttatcttaat atataaaaca ccactgagta taaaagttct caaataaact attcatcatt
     6121 tatggtattc tcacagtaga tatgtcatct cattctcaca gtagactgtc aactcaataa
     6181 ttggacctaa aataacaagt ttgctaaaaa gaaaaaaaaa tgagaaaaaa gtttactgca
     6241 cattctaaat atattaaaaa caaatgtacc caagcgcctc aaaactagtg atattaatac
     6301 acttgtacct tctaacagtg cttacgtgaa gtaccaaaac ctaaaataaa ccaagcagag
     6361 tagctgactt gtaagaaaac tgctctgcct ggtgaacttc agcatagaag agtgggctcc
     6421 accttagatt ttccaccagc aagaggacaa cagtctatca ctcttaaaca ataaacaggg
     6481 taagactgaa agttgtgtct atttgcaaat ccggataatg tcgtaactat acccaacacg
     6541 tacacaggga ttggggtaag ggaaaataat tacactcctg aataaatgtt ctagtcagtt
     6601 aaattttcat ccggcctaca acctttcctc ctccacctat tatacttacc atgcaatttt
     6661 tgtgtcttag cagatacatt cttcaatgcc ataaaaagct gatcttttta atactaacat
     6721 tttactgacg tgatattaaa ataagcaaat ggtccacttt ttaaaggatt attcaaaatc
     6781 aacaagcatt attaaagctg ttaagaaaca actttggcct caagattttt gctagcttca
     6841 taataattta cttctcttag tgatgttcaa gtataacagg tttagttata actacatcct
     6901 aaagaagcac aggggacacc caaataatat tagggaaaaa aaaccccaaa tatatatata
     6961 tatatatatt tgcttagtgg tacatatata ataacctttc ttccttcctt aaaccagaat
     7021 tgaaccatcc cataatagag ccaaactttt attgagtgct gtgtgccagg tactgtgtta
     7081 agcactttca catatcttgg gagctttatt ctcataattc tcacaaggga ataacctgag
     7141 catcagctgt gtggagtgac ctacaccttg accatgattc tgggggatga tgaatgaaaa
     7201 tgcaaagtat aaatctatac tccttaggaa aatgcctcta ctacaacaca aaggaatctc
     7261 tccatttcta tcctattgaa cccccaattg aatcctgtat cttttctctg agctacaatc
     7321 ttgaaagaag aaagtcactg tgctgtgtta taagaatgta aatattttat gctgtcagtt
     7381 gtttcctcag aatttataag tcaaagggtc tacatcagtg tcagaatcat ttaaaattat
     7441 tcagtgtatt gaaaagcaag taaaactcta ggtatttcat gtttacatct gaaggagaca
     7501 ttagttcatc ctctacccct tttctaaatg atgaaactca tgaggtctag cagagaccaa
     7561 ggactaatac aatcaagaag catattgtgt acacctcaac agattttcat taaaaaaaat
     7621 tgtttgatac aaacctactg tagttcatga atttactatg tgtaatcatc aactcttcac
     7681 ttttaaaaga aagtatcact tgaatctatt ttgtaaagtt tttaaacatc tacttgagca
     7741 tttgcattag cagtattaat caacctgaga atcagaaaaa aaaaaaaagg tgcaaacata
     7801 tttgcctttg gcacgaggac aagtaattgg tgcagtccag ctctaaataa taatgtaatg
     7861 cttggtctgc ctctgctaca ttgtgattca catattgctt ccctatccac aaatctatat
     7921 ttgatttagc atataaaaga agggaaaaag caataaaaag acaaatatgt ggtttagtta
     7981 catatacttt gcttctttcc aagttcagaa ctgtgaaaat aggcaaatag cttatcccat
     8041 tggggcacta taagagattc ctaataaaat tactcgtaaa atatactttg agatcgaaga
     8101 gagttaattt aaaatataaa aatcaaagag agtgccagtt gatgagtttc tactcctttc
     8161 tgtaaatagc attaactgtt ctagaaactt ccaaatgtta atctgatagc gcagcacaat
     8221 tatatcttaa aatagtcata gacacaggaa gcacagatac tatattcaca ttaattcaca
     8281 tatgtaatct ctatcattaa atgatttcta taaaacctca agtttctaat taggatttgt
     8341 ggtgtaaaaa aaggcaaatt ggtagctggg ttcttttcag taaagacaca atcaactagc
     8401 agaattaaga tgctagtcca ccttatatgc attttaggat ctggtatatt agtgcagagg
     8461 tacttgcagc aggatgcatg aatcctgcct ttatataagg ctttgtgggt gtcaccattc
     8521 tgtgcacttt attaaaacta ctccaccccc caaaacctaa taaaaataat tgttgcttat
     8581 gacttgggga atatttggtg aagttgctaa taaagtacat tgttaaatgc aacatgattt
     8641 cacattgtaa atgtcttgaa aattcagttt ccgctacata ttttcttcat aaaataaaat
     8701 ttttatacaa cccttgtcct ccaatttttc caataatctg ctttattagg gccatcacaa
     8761 taaaagtttg gggcaagaag ccatgcataa agtgtttcta aagtagtgaa tgttttctgt
     8821 tctgtatctt tttttcttct tataatttct ttacaaatgt cagatatttc tcttcatatt
     8881 tttgttctag gcttctgtgc gacgatagtc cattttttta atttgtttta actgacaaaa
     8941 attatatata tttatcatgt ataacattgt tttggaatat gtaagttgtg gaatagttaa
     9001 attgagctaa ttacacatta tttcatatgc ttatcattag atattccatt ttaatggcac
     9061 ttgtttttaa aaatgaaaca gagttttagg cacaatagtc agttacttct ggctctgctt
     9121 tgtggagaaa ggtgtatgga ctgaaatctc tgcactctcc agataataac tttctaatgc
     9181 tttaagataa ctagattgtt tttaactgtc tggaaattaa aagagacctt aaaaaaaatt
     9241 cacaagtgta actagtgtat gtagaaataa ccctaatttt agggatatgc acataaaaat
     9301 gacattctga tatcaaaaat aacagtttca ctgtcccttc tcagtggcta cacacctaga
     9361 aaggtgccat gtgctttcac tggaagtacc acacttgcat ttctgtgttg tgatgtcagt
     9421 agcagaaacc cttagttaga gcttgcaatt tagctccctt ttctcctgaa gaggaatcaa
     9481 gttactaccc tgtagagata cttcattctt ctatttggtt tatttagaaa tcacctattc
     9541 tgactgatct ttaagaatga atgctataaa gagctaccaa attttctttc aaattcataa
     9601 aactgttcac acttttttga aacaggagtt aatgccgaga atccatcaga agtatctact
     9661 gtttagaagg aaatggagca gcaccaaatg ggtctaattc gactggttgg gactgttggg
     9721 actgatgtgg agtgatgctt tgcaccacaa gttctgtaaa gggcacggca ccaaaatcat
     9781 ccattttcaa tacatctgca ctatggaatg a
//
