LOCUS       NM_005443               2513 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens 3'-phosphoadenosine 5'-phosphosulfate synthase 1
            (PAPSS1), mRNA.
ACCESSION   NM_005443
VERSION     NM_005443.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2513)
  AUTHORS   Zhu,X., Zhu,P., Chen,X., Zhang,L., Wu,C., Zhang,H., Shen,X., Qi,Y.,
            Chen,M., Wang,S. and Yi,X.
  TITLE     Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1
            (PAPSS1) expression with clinical parameters and prognosis in
            esophageal squamous cell carcinoma
  JOURNAL   Histol Histopathol 38 (11), 1327-1335 (2023)
   PUBMED   36734141
  REMARK    GeneRIF: Correlation of 3'-phosphoadenosine-5'-phosphosulfate
            synthase 1 (PAPSS1) expression with clinical parameters and
            prognosis in esophageal squamous cell carcinoma.
REFERENCE   2  (bases 1 to 2513)
  AUTHORS   Sun,L., Ji,W.X., Li,Y., Li,Z.L., Duan,C.C., Xia,B.R. and Xiao,L.
  TITLE     The PAPSS1 gene is a modulator of response to cisplatin by
            regulating estrogen receptor alpha signaling activity in ovarian
            cancer cells
  JOURNAL   J Ovarian Res 16 (1), 187 (2023)
   PUBMED   37684671
  REMARK    GeneRIF: The PAPSS1 gene is a modulator of response to cisplatin by
            regulating estrogen receptor alpha signaling activity in ovarian
            cancer cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2513)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2513)
  AUTHORS   Leung,A.W.Y., Veinotte,C.J., Melong,N., Oh,M.H., Chen,K.,
            Enfield,K.S.S., Backstrom,I., Warburton,C., Yapp,D., Berman,J.N.,
            Bally,M.B. and Lockwood,W.W.
  TITLE     In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate
            synthase 1) as a Cisplatin-sensitizing Therapeutic Target
  JOURNAL   Clin Cancer Res 23 (21), 6555-6566 (2017)
   PUBMED   28790117
  REMARK    GeneRIF: These results suggest that PAPSS1 inhibition enhances
            cisplatin activity in multiple preclinical model systems and that
            low PAPSS1 expression may serve as a biomarker for platin
            sensitivity in cancer patients. Developing strategies to target
            PAPSS1 activity in conjunction with platinum-based chemotherapy may
            offer an approach to improving treatment outcomes
REFERENCE   5  (bases 1 to 2513)
  AUTHORS   Zhu,W., Gliddon,B.L., Jarman,K.E., Moretti,P.A.B., Tin,T.,
            Parise,L.V., Woodcock,J.M., Powell,J.A., Ruszkiewicz,A.,
            Pitman,M.R. and Pitson,S.M.
  TITLE     CIB1 contributes to oncogenic signalling by Ras via modulating the
            subcellular localisation of sphingosine kinase 1
  JOURNAL   Oncogene 36 (18), 2619-2627 (2017)
   PUBMED   27941888
  REMARK    GeneRIF: we found that ectopic expression of oncogenic KRas and
            HRas in cells resulted in elevated CIB1 expression. We previously
            described the Ca(2+)-myristoyl switch function of CIB1, and its
            ability to facilitate agonist-induced plasma membrane localisation
            of sphingosine kinase 1 (SK1), a location where SK1 is known to
            elicit oncogenic signalling.
REFERENCE   6  (bases 1 to 2513)
  AUTHORS   Faiyaz ul Haque,M., King,L.M., Krakow,D., Cantor,R.M.,
            Rusiniak,M.E., Swank,R.T., Superti-Furga,A., Haque,S., Abbas,H.,
            Ahmad,W., Ahmad,M. and Cohn,D.H.
  TITLE     Mutations in orthologous genes in human spondyloepimetaphyseal
            dysplasia and the brachymorphic mouse
  JOURNAL   Nat Genet 20 (2), 157-162 (1998)
   PUBMED   9771708
REFERENCE   7  (bases 1 to 2513)
  AUTHORS   Venkatachalam,K.V., Akita,H. and Strott,C.A.
  TITLE     Molecular cloning, expression, and characterization of human
            bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its
            functional domains
  JOURNAL   J Biol Chem 273 (30), 19311-19320 (1998)
   PUBMED   9668121
REFERENCE   8  (bases 1 to 2513)
  AUTHORS   Kurima,K., Warman,M.L., Krishnan,S., Domowicz,M., Krueger,R.C. Jr.,
            Deyrup,A. and Schwartz,N.B.
  TITLE     A member of a family of sulfate-activating enzymes causes murine
            brachymorphism
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8681-8685 (1998)
   PUBMED   9671738
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Sep 29;95(20):12071]
REFERENCE   9  (bases 1 to 2513)
  AUTHORS   Yanagisawa,K., Sakakibara,Y., Suiko,M., Takami,Y., Nakayama,T.,
            Nakajima,H., Takayanagi,K., Natori,Y. and Liu,M.C.
  TITLE     cDNA cloning, expression, and characterization of the human
            bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase
            enzyme
  JOURNAL   Biosci Biotechnol Biochem 62 (5), 1037-1040 (1998)
   PUBMED   9648242
REFERENCE   10 (bases 1 to 2513)
  AUTHORS   Girard,J.P., Baekkevold,E.S. and Amalric,F.
  TITLE     Sulfation in high endothelial venules: cloning and expression of
            the human PAPS synthetase
  JOURNAL   FASEB J 12 (7), 603-612 (1998)
   PUBMED   9576487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU132232.1, BQ437924.1 and BC011392.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005443.4.
            
            Summary: Three-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS)
            is the sulfate donor cosubstrate for all sulfotransferase (SULT)
            enzymes (Xu et al., 2000 [PubMed 10679223]). SULTs catalyze the
            sulfate conjugation of many endogenous and exogenous compounds,
            including drugs and other xenobiotics. In humans, PAPS is
            synthesized from adenosine 5-prime triphosphate (ATP) and inorganic
            sulfate by 2 isoforms, PAPSS1 and PAPSS2 (MIM 603005).[supplied by
            OMIM, Mar 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF105227.1, SRR3476690.94533.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000265174.5/ ENSP00000265174.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-73                AU132232.1         30-102
            74-809              BQ437924.1         31-766
            810-2513            BC011392.1         712-2415
FEATURES             Location/Qualifiers
     source          1..2513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2513
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /note="3'-phosphoadenosine 5'-phosphosulfate synthase 1"
                     /db_xref="GeneID:9061"
                     /db_xref="HGNC:HGNC:8603"
                     /db_xref="MIM:603262"
     exon            1..115
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1930
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /EC_number="2.7.1.25"
                     /EC_number="2.7.7.4"
                     /note="3-prime-phosphoadenosine 5-prime-phosphosulfate
                     synthase 1; SK 1; PAPSS 1; PAPS synthase 1; sulfurylase
                     kinase 1; adenylyl-sulfate kinase; sulfate
                     adenylyltransferase"
                     /codon_start=1
                     /product="bifunctional 3'-phosphoadenosine
                     5'-phosphosulfate synthase 1"
                     /protein_id="NP_005434.4"
                     /db_xref="CCDS:CCDS3676.1"
                     /db_xref="GeneID:9061"
                     /db_xref="HGNC:HGNC:8603"
                     /db_xref="MIM:603262"
                     /translation="MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVV
                     GTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFS
                     PEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDA
                     PLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVE
                     LLQERDIVPVDASYEVKELYVPENKLHLAKTDAETLPALKINKVDMQWVQVLAEGWAT
                     PLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALMYEGRR
                     VAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVMEQGDWLIGGDLQVLDRVYWNDG
                     LDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLL
                     LHPLGGWTKDDDVPLMWRMKQHAAVLEEGVLNPETTVVAIFPSPMMYAGPTEVQWHCR
                     ARMVAGANFYIVGRDPAGMPHPETGKDLYEPSHGAKVLTMAPGLITLEIVPFRVAAYN
                     KKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLTEYYKSLEKA
                     "
     exon            116..230
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            231..466
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            467..605
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            606..724
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            725..838
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            839..950
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1156
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1292
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1561
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1791
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..2513
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2488..2493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /note="hexamer: AATAAA"
     polyA_site      2513
                     /gene="PAPSS1"
                     /gene_synonym="ATPSK1; PAPSS; SK1"
                     /note="major polyA site"
ORIGIN      
        1 ctcttgctac cctcccggcg cagagaaccc cggctgctca gcgcgctccg cggtcatgga
       61 gatccccggg agcctgtgca agaaagtcaa actgagcaat aacgcgcaga actggggaat
      121 gcagagagca accaatgtca cctaccaagc ccatcatgtc agcaggaaca agagaggtca
      181 ggtggtgggg accagaggtg gctttcgtgg ttgcacagtt tggctaacag gcttgtctgg
      241 agcgggaaag actactgtga gcatggcctt ggaggagtac ctggtttgtc atggtattcc
      301 atgctacact ctggatggtg acaatattcg tcaaggtctc aataaaaatc ttggctttag
      361 tcctgaagac agagaagaga atgttcgacg catcgcagaa gttgctaaac tgtttgcaga
      421 tgctggctta gtgtgcatca caagtttcat atcaccttac actcaggatc gcaacaatgc
      481 aaggcaaatt catgaaggtg caagtttacc gttttttgaa gtatttgttg atgctcctct
      541 gcatgtttgt gaacagaggg atgtcaaagg actctacaaa aaagcccggg caggagaaat
      601 taaaggtttc actgggatcg attctgaata tgaaaagcca gaggcccctg agttggtgct
      661 gaaaacagac tcctgtgatg taaatgactg tgtccagcaa gttgtggaac ttctacagga
      721 acgggatatt gtacctgtgg atgcatctta tgaagtaaaa gaactatatg tgccagaaaa
      781 taaacttcat ttggcaaaaa cagatgcgga aacattacca gcactgaaaa ttaataaagt
      841 ggatatgcag tgggtgcagg ttttggcaga aggttgggca accccattga atggctttat
      901 gagagagagg gagtacttgc agtgccttca ttttgattgt cttctggatg gaggtgtcat
      961 taacttgtca gtacctatag ttctgactgc gactcatgaa gataaagaga ggctggacgg
     1021 ctgtacagca tttgctctga tgtatgaggg ccgccgtgtg gccattcttc gcaatccaga
     1081 gttttttgag cacaggaaag aggagcgctg tgccagacag tggggaacga catgcaagaa
     1141 ccacccctat attaagatgg tgatggaaca aggagattgg ctgattggag gagatcttca
     1201 agtcttggat cgagtttatt ggaatgatgg tcttgatcag tatcgtctta ctcctactga
     1261 gctaaagcag aaatttaaag atatgaatgc tgatgctgtc tttgcatttc aactacgcaa
     1321 cccagtgcac aatggacatg ccctgttaat gcaggatacc cataagcaac ttctagagag
     1381 gggctaccgg cgccctgtcc tcctcctcca ccctctgggt ggctggacaa aggatgacga
     1441 tgttcctttg atgtggcgta tgaagcagca tgctgcagtg ttggaggaag gagttctgaa
     1501 tcctgagacg acagtggtgg ccatcttccc atctcccatg atgtatgctg gaccaactga
     1561 ggtccagtgg cattgcagag cacggatggt tgcaggagcc aacttttaca ttgttggacg
     1621 agaccctgct ggcatgcctc atccagaaac agggaaggat ctttatgagc caagtcatgg
     1681 tgccaaagtg ctgacgatgg cccctggttt aatcactttg gaaatagttc cctttcgagt
     1741 tgcagcttac aacaagaaaa agaagcgtat ggactactat gactctgaac accatgaaga
     1801 ctttgaattt atttcaggaa cacgaatgcg caaacttgct cgagaaggcc agaaaccacc
     1861 tgaaggtttc atggctccca aggcttggac cgtgctgaca gaatactaca aatccttgga
     1921 gaaagcttag gctgttaacc cagtcactcc acctttgaca cattactagt aacaagaggg
     1981 gaccacatag tctctgttgg catttctttg tggtgtctgt ctggacatgc ttcctaaaaa
     2041 cagaccattt tccttaactt gcatcagttt tggtctgcct tatgagttct gttttgaaca
     2101 agtgtaacac actgatggtt ttaatgtatc ttttccactt attatagtta tattcctaca
     2161 atacaatttt aaaattgtct ttttatatta tatttatgct tctgtgtcat gattttttca
     2221 agctgttata ttagttgtaa ccagtagtat tcacattaaa tcttgctttt tttcccctta
     2281 aaaaaagaaa aaaattacca aacaataaac ttggctagac cttgttttga ggattttaca
     2341 agacctttgt agcgattaga ttttttttct acattgaaaa tagaaactgc ttcctttctt
     2401 ctttccagtc agctattggt ctttccagct gttataatct aaagtattct tatgatctgt
     2461 gtaagctctg aatgaacttc tttactcaat aaaattaatt ttttggcttc tta
//
