LOCUS       NM_022894               7348 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens poly(A) polymerase gamma (PAPOLG), mRNA.
ACCESSION   NM_022894
VERSION     NM_022894.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7348)
  AUTHORS   Contreras,X., Depierre,D., Akkawi,C., Srbic,M., Helsmoortel,M.,
            Nogaret,M., LeHars,M., Salifou,K., Heurteau,A., Cuvier,O. and
            Kiernan,R.
  TITLE     PAPgamma associates with PAXT nuclear exosome to control the
            abundance of PROMPT ncRNAs
  JOURNAL   Nat Commun 14 (1), 6745 (2023)
   PUBMED   37875486
  REMARK    GeneRIF: PAPgamma associates with PAXT nuclear exosome to control
            the abundance of PROMPT ncRNAs.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7348)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7348)
  AUTHORS   Yang,Q., Nausch,L.W., Martin,G., Keller,W. and Doublie,S.
  TITLE     Crystal structure of human poly(A) polymerase gamma reveals a
            conserved catalytic core for canonical poly(A) polymerases
  JOURNAL   J Mol Biol 426 (1), 43-50 (2014)
   PUBMED   24076191
  REMARK    GeneRIF: An analysis of residue conservation reveals a conserved
            catalytic binding pocket, whereas residues at the surface of the
            polymerase are more divergent.
            GeneRIF: PAP gamma structurally closely resembles its PAP alpha
            ortholog. It possesses a conserved catalytic binding pocket,
            whereas residues at the surface of the polymerase are more
            divergent.
REFERENCE   4  (bases 1 to 7348)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   5  (bases 1 to 7348)
  AUTHORS   Lee,Y.S., Johnson,K.A., Molineux,I.J. and Yin,Y.W.
  TITLE     A single mutation in human mitochondrial DNA polymerase Pol gammaA
            affects both polymerization and proofreading activities of only the
            holoenzyme
  JOURNAL   J Biol Chem 285 (36), 28105-28116 (2010)
   PUBMED   20513922
  REMARK    GeneRIF: Arg(232) substitutions have no effect on independent Pol
            gammaA activities but show major defects in the Pol gammaA-Pol
            gammaB holoenzyme.
REFERENCE   6  (bases 1 to 7348)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 7348)
  AUTHORS   Kyriakopoulou,C.B., Nordvarg,H. and Virtanen,A.
  TITLE     A novel nuclear human poly(A) polymerase (PAP), PAP gamma
  JOURNAL   J Biol Chem 276 (36), 33504-33511 (2001)
   PUBMED   11431479
REFERENCE   8  (bases 1 to 7348)
  AUTHORS   Topalian,S.L., Kaneko,S., Gonzales,M.I., Bond,G.L., Ward,Y. and
            Manley,J.L.
  TITLE     Identification and functional characterization of neo-poly(A)
            polymerase, an RNA processing enzyme overexpressed in human tumors
  JOURNAL   Mol Cell Biol 21 (16), 5614-5623 (2001)
   PUBMED   11463842
REFERENCE   9  (bases 1 to 7348)
  AUTHORS   Perumal,K., Sinha,K., Henning,D. and Reddy,R.
  TITLE     Purification, characterization, and cloning of the cDNA of human
            signal recognition particle RNA 3'-adenylating enzyme
  JOURNAL   J Biol Chem 276 (24), 21791-21796 (2001)
   PUBMED   11287430
REFERENCE   10 (bases 1 to 7348)
  AUTHORS   Weichs an der Glon,C., Ashe,M., Eggermont,J. and Proudfoot,N.J.
  TITLE     Tat-dependent occlusion of the HIV poly(A) site
  JOURNAL   EMBO J 12 (5), 2119-2128 (1993)
   PUBMED   8491200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB082179.1, BC111701.1,
            AB209304.1, AC011245.13 and AI419423.1.
            
            On Nov 22, 2018 this sequence version replaced NM_022894.3.
            
            Summary: This gene encodes a member of the poly(A) polymerase
            family which catalyzes template-independent extension of the 3' end
            of a DNA/RNA strand. This enzyme shares 60% identity to the well
            characterized poly(A) polymerase II (PAPII) at the amino acid
            level. These two enzymes have similar organization of structural
            and functional domains. This enzyme is exclusively localized in the
            nucleus and exhibits both nonspecific and CPSF (cleavage and
            polyadenylation specificity factor)/AAUAAA-dependent
            polyadenylation activity. This gene is located on chromosome 2 in
            contrast to the PAPII gene, which is located on chromosome 14.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.233884.1,
                                           SRR1803612.281775.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238714.8/ ENSP00000238714.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-531               DB082179.1         39-569
            532-4064            BC111701.1         444-3976
            4065-4903           AB209304.1         2792-3630
            4904-5470           AB209304.1         3646-4212
            5471-5521           AC011245.13        10645-10695
            5522-7127           AB209304.1         4264-5869
            7128-7348           AI419423.1         1-221               c
FEATURES             Location/Qualifiers
     source          1..7348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p16.1"
     gene            1..7348
                     /gene="PAPOLG"
                     /note="poly(A) polymerase gamma"
                     /db_xref="GeneID:64895"
                     /db_xref="HGNC:HGNC:14982"
                     /db_xref="MIM:616865"
     exon            1..228
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2422
                     /gene="PAPOLG"
                     /EC_number="2.7.7.19"
                     /note="nuclear poly(A) polymerase gamma; SRP RNA 3'
                     adenylating enzyme/pap2; neo-PAP; PAP-gamma; neo-poly(A)
                     polymerase; SRP RNA 3'-adenylating enzyme; polynucleotide
                     adenylyltransferase gamma; SRP RNA-adenylating enzyme;
                     signal recognition particle RNA-adenylating enzyme"
                     /codon_start=1
                     /product="poly(A) polymerase gamma"
                     /protein_id="NP_075045.2"
                     /db_xref="CCDS:CCDS1863.1"
                     /db_xref="GeneID:64895"
                     /db_xref="HGNC:HGNC:14982"
                     /db_xref="MIM:616865"
                     /translation="MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDA
                     MKPFGVFEDEEELNHRLVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSY
                     RLGVHTKGADIDALCVAPRHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEF
                     DGIEIDLVFARLAIQTISDNLDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKET
                     FRLTLRAVKLWAKRRGIYSNMLGFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFS
                     KWEWPNPVLLKQPEESNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRT
                     VMVEEFKQGLAVTDEILQGKSDWSKLLEPPNFFQKYRHYIVLTASASTEENHLEWVGL
                     VESKIRVLVGNLERNEFITLAHVNPQSFPGNKEHHKDNNYVSMWFLGIIFRRVENAES
                     VNIDLTYDIQSFTDTVYRQANNINMLKEGMKIEATHVKKKQLHHYLPAEILQKKKKQS
                     LSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNGTPFNSPASKSDSPSVGETERNSAEPA
                     AVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSPPTVCTIPTVVGRNVIPRITTPHNP
                     AQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKDVEKFIRLESTFKDPRTAEERKR
                     KSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPANNIRVIKNSIRLTLNR"
     exon            229..390
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            391..457
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            458..539
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            540..649
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            650..703
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            704..815
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            816..905
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1044
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1117
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1238
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1323
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1377
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1497
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1607
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1729
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1890
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..1979
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2200
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            2201..2266
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            2267..2323
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..7348
                     /gene="PAPOLG"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3730
                     /gene="PAPOLG"
                     /note="major polyA site"
     regulatory      4133..4138
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAPOLG"
                     /note="hexamer: AGTAAA"
     polyA_site      4156
                     /gene="PAPOLG"
     regulatory      7327..7332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAPOLG"
                     /note="hexamer: AATAAA"
     polyA_site      7348
                     /gene="PAPOLG"
ORIGIN      
        1 attggcgtcg gccgcgctgt attgtcataa atagagccgg ttttgtggtg ttttcactac
       61 tcggttggat gcctcagcca tagtaagtgg gaaagtgagc gagcaagcga gctactagcg
      121 accggaggaa agtgaacagg gggagaaggg aacagcaaga acaggactcc agagcgataa
      181 acactcgctg gagagggaga cgcaggaagc gatgaaagag atgtctgcaa acaccgtgct
      241 ggacagccag cgtcaacaaa agcattatgg aattacctcc ccaattagtt tggcatctcc
      301 taaagaaatt gatcatattt acacacagaa attaattgac gccatgaaac catttggagt
      361 gtttgaagat gaggaagaat tgaaccacag gctggtggtt cttggtaaat tgaacaattt
      421 agtaaaagaa tggatttctg atgtcagcga gagtaagaac ctcccacctt ctgttgtggc
      481 tactgttggt ggtaaaattt tcacatttgg atcctatagg cttggagtac acaccaaagg
      541 agctgacatt gatgcacttt gtgtagctcc aagacatgtg gaaagatctg atttttttca
      601 gtcttttttt gaaaaattga aacatcaaga tggcattaga aacttaagag ctgtagaaga
      661 tgcctttgta cctgttataa aatttgaatt tgatggtatt gaaattgatc tagtctttgc
      721 aagactggca atacaaacca tatcagataa tttagatcta agagacgact ctcgcctgag
      781 aagccttgat ataaggtgta ttcgcagctt aaatggttgt agagttactg atgaaatttt
      841 gcatttagtg ccaaataaag aaacttttag actcacccta agagctgtca aattatgggc
      901 aaaacgacgt ggtatttatt ccaacatgct aggattcctt ggtggtgtct cctgggcaat
      961 gctagttgca agaacttgcc aattgtatcc aaatgcagca gcatctactt tagttcataa
     1021 gttcttttta gttttttcca agtgggaatg gccaaatcct gtgctgctga agcaaccaga
     1081 agaaagcaat ttgaatttgc ctgtctggga tcctcgggta aatccatcag ataggtatca
     1141 tctcatgccc ataatcaccc ctgcctaccc acaacagaat tctacgtata atgtgtccac
     1201 atcaactcga acagtaatgg tagaagaatt taaacaaggt cttgcagtca cagatgaaat
     1261 tcttcaagga aagtcagatt ggtccaaact acttgagcca ccgaatttct ttcaaaagta
     1321 tagacattat atagtattga ctgccagcgc atcaacagaa gaaaaccatc tagagtgggt
     1381 tggattagta gaatctaaaa tccgtgtact tgttggaaac ttggaacgga atgaatttat
     1441 tactcttgcc catgtgaatc cccagtcatt cccagggaat aaggaacatc ataaagacaa
     1501 caattacgta tcaatgtggt tccttgggat aatttttcgg agagtagaaa atgcagaaag
     1561 tgtcaacata gacttgacat atgatataca gtcatttact gatacagtgt acagacaggc
     1621 aaacaatata aatatgctaa aggagggaat gaaaattgaa gcaactcatg taaagaaaaa
     1681 acaacttcac cactaccttc ctgcagaaat tcttcaaaag aagaaaaagc aaagtctctc
     1741 tgatgtcaat cgaagctcgg gcggacttca atccaaaaga ttgtctctgg atagcagttg
     1801 tctggatagc tccagagaca ctgataatgg aacacctttt aattctccag cgtccaagtc
     1861 tgatagccct tctgtaggag aaacagaaag gaatagtgct gagcctgctg ctgtaattgt
     1921 ggagaagcca ctgagtgtac caccagccca aggactttcc attccagtga ttggcgcaaa
     1981 agttgactct acagtaaaaa ctgtatcacc ccccactgtg tgtaccattc ctaccgtagt
     2041 aggacgaaat gtcattccta gaatcacaac acctcacaac cctgcccagg gacaaccgca
     2101 tctgaatgga atgtcaaata taactaagac tgttacacct aagagatccc attccccatc
     2161 catagatggg actcctaaga ggttgaaaga cgtagaaaag tttattcgac ttgaatcaac
     2221 atttaaggac ccccgcactg ctgaagaaag aaaaagaaaa tcagtggatg ccattggagg
     2281 agaatctatg cctattccaa ctattgatac atcacgcaaa aagagactac ccagtaaaga
     2341 actaccagat tcatcatctc cagttccagc aaacaacatc cgtgtcatca aaaattccat
     2401 tcgactgacc cttaatcggt aaaagcagtg cctcctcact taagtgaaca agcaatcatt
     2461 tagtggcata gatgcagcca cttgtttttt aaatagaagt ggctgtcata cgtgaaataa
     2521 ggtgaaagtg acagccttca gtctaataac cttgaagtgg tttttgaact gtcaaacttt
     2581 gacctgtaga tgctgtagca ttctctcact gattgctaca tacacttctc tgaggatcac
     2641 ctgctgtcaa attgccatct acagtattac agctttgcat ttgggggttt tactgcctta
     2701 actttcaatg cttgttatgg gaaccagttc ttagccactt ggacactgat aacaagtcct
     2761 gaactccttt tttgttttgt tttttgtgtt tttctttttt tgtcttatgt tgtaatcatt
     2821 gtatagagct aaaaaaattg aaaacaaaca aaaaaattgt cttgtatttt ccaaatgtta
     2881 atacatttac tttagcattg aagccacttt gaaacctgag ataaatgaat gtgaggtatc
     2941 ttttctgctt tcctcatttg tgtagatgta ctgtctgttc tgttgattta aattattttt
     3001 ttccagattg gcacatgaaa tatttaaact tttttgtgtg cctttctgtc caaatgttgc
     3061 atagttacca gggaagatta gtccagtgat tacataagag ttgggcacca taaattctct
     3121 atattttgcc tcccatggag gcctttgaaa tgcatcttta ttaaaaatca aaatataacc
     3181 aggatactga aagtcagtat atgaatggta aaattgttac atatcctatt tcatgccatt
     3241 cttgttagtt gactggtatt ttttactgag gagcaactca ttccagcatc aacaataaga
     3301 taacctttaa gtatggcaca cttgtatttt tgaggtgtaa aattaacttg gcatgataat
     3361 tcctgatcat tatttacccc acaacttcaa atagtttctt cacggactag gcatgcagaa
     3421 ataagcagtg gattttattg aaacctaaag gcattttgaa tgacattgtt accaaccatt
     3481 aattggctca ggacctttgt aatttttatt taactatatg agttgtcttt ttttacgctg
     3541 cttttttcaa tgcatttctt aatatttttt aagtttcatg aatgcatgct cagtttatta
     3601 aaatccataa ccatgtaatt cttgtaatat gttgattcag tgttttgtaa atgaagtcgt
     3661 atgtattttc agagtatttt tgtatgtact gtaagatacc atcttttcaa agagaaacgt
     3721 ttaaaacctt tattgtctct ccttagtcta attttttaaa tatggattat gcttgaatta
     3781 ctatatttaa aatgaaaatg tatagattac acagccagga atgctagtat ctaccacctt
     3841 ctttagattt cactcagcat ttagtaggtc cagtaggaaa aacccaaaat ggtacattga
     3901 gtagtgtggg gaagacacct cgtgtattat aggactcacg ggatgccatc tagcaagtgg
     3961 agaaatagca gtccattttc tcttgcaagc cctttaccat tgagttgaaa ttcttgaatt
     4021 gccagagagc cgtatcctcc aggtcccact cctgttcatt gccccttagg tctccaaaat
     4081 gtaaattcta atgtttacct tgtaccatgg aaaacatgaa aagagtctta gaagtaaaga
     4141 acaacaagga aaaaaatgtt tgttctatta ttcccttttt atatagcagc aaaagataag
     4201 aataaaatca cataaccaag ttgaagcttc cttggcaaag ctgttgtctt agctgactct
     4261 ttccctttat tcagatgttt tgggattgtt ctacaaatag tctatttgag caaaaatgaa
     4321 tgattatgaa agaaccgaag aattatcacc tgacttcaac ttttgaaagc tttagtaagg
     4381 aatttgatta aattttatat actggatgtg tatgcatttc tgcatttcat atcttttgct
     4441 tttaaatcag ccttcaaagt atctttagga attccttctg tatccatgtt taccccatta
     4501 tgtaaataga tctttggagt gactagtgga gtttttcttt aataaggaag caacaagtct
     4561 aaccttgtac tataggatag gcatttattt tagattaagg agcccattca acatgtcaat
     4621 gagtcaacat tagagtcctc aaagatagca ttcttcaacc tgtttggtaa ctgaggagtt
     4681 gataaaatac ttttgagatg gtggggtttg tcagaaataa aatattttct atcctgacca
     4741 gtaggtagaa ctttgagtac atttcgttaa cttggtggga agcttccatt gtactagttc
     4801 caagtaaaaa aggagaaagt atgatctggg attttgtgtt atgatgagag gcactaagta
     4861 catgtgtttg ttttgttttg ttttgttttg ttttgttttg tttgagacag agttttgctc
     4921 ttgttgccca ggctggagtg cagtagccca atctcggctc actgcaacct tcacctcccg
     4981 agttcaagct attctcttgc ctcagcctcc caagtagctg ggattacagg cacccaccac
     5041 ctcgcccagc taatttttgt atttttagta cagacagcgt ttcaccatgt tggccaggct
     5101 ggtctcgaac ttgtgacctc aggtgatcca cctgcctcgg cgtcccaaag tgctgggatt
     5161 acaggcgtga accaccgcac ccggccgtgt ttgttttcaa gtgtgaaaaa atacctagaa
     5221 gtatatttta tgaagtcaaa taatctgttc ttcagtatat agacacatgt tcattttcac
     5281 aagggcatta cattttaatt tgctcatttt tcagtagctc tggagaatat gtatgaaagg
     5341 aaaacaatta cctgctagct taaaccttag ggacttaacc aattcaagat agaggtacat
     5401 ggcttaaaac tttgtaaaac tgggacagga gaattattat ttttttattt tttatttttt
     5461 tatgaagaca agagtttcac tctgtcaccc agtctggagc acagtggcat gatctcacct
     5521 cactgcaacc tctgcctccc gggttcaagt gattctcttg cctcagcctc ccaagtagct
     5581 ggaattacag gcctgtgcca tgcccagcta attttcgtat tttcagtaga aatgggattt
     5641 caccatgttg gccagggtgg tcttgaactc ctcacctcaa gtgatctggc tgcttcggcc
     5701 accctaagtg ctgggattac aggcataagc tactgtgccc agccaggaga atgaatttta
     5761 aaaatctatg ttagtgttta aaatgagtgc tttgttttaa agcagcaatt tagtagcatt
     5821 attaaaatgc ttacttcact atagtagcaa ttaggtaaag atgggcaata tcaaaatggg
     5881 ctaaacttat tttccactat gttccacacc tttgaaatag gaattcctaa cttgagaatc
     5941 atgaaccctt agggaatcct ttataattgt gtataagaag ttctagttta catgcatttt
     6001 tcttggggaa agtgcatagt ttagatcagc ttctcgaagt ggcaaaagta tgggagttag
     6061 ggttaggaac caccaggatt gaataatcct ggaatattat ataattttct acttttgatt
     6121 ttgctgtggt atatttctga aaatgtgctg tggctcctaa ctagtaaaat gggctggtga
     6181 gggactctgg aattctgaat ttctaagttt ataacctaaa atgaaactgt aaagtcctcg
     6241 gtatttagaa aaatgcttaa tctcagattt acagatggcc tcatgataac ttagattcgt
     6301 taacagggtc aaactttagt tcaacaaatt tcaacccaat attatcacag tacaatagct
     6361 tagaatgatc attagaaatg gtagaaaata gaataaatca ttaaagatcc caaaatgttg
     6421 agttctgtag catgaaaact ctcttgctcc tccatgtttg tagttcaggc cagaacaaac
     6481 taaacagacc aataaatata aaagtgatag tttagggaaa aaaaaaaact ttgtataaat
     6541 aaaattgtat gtgtgttcaa ataactacct attaaatcat ccaaagctta gaatttaaat
     6601 tggtcatagt agcaaatagt gcagatgatg gaagaaaacc agtctcaata atggtttttt
     6661 ttttccaatt gcataaggtc acgtcatccc ccaaattgtc tattttttct tttctttttt
     6721 tttaagatgg agtctcgctc cgtcacccag gctggaatgc agtggcgcaa tcttggctca
     6781 ttgcaacctc cacctcccag gtgcaagcga ttctcctacc tcagcctccc aagtagctgg
     6841 gactacaggc gcccgccacc atgtgggcct ggctaatttt tgtagagatg gggtttcaac
     6901 atgttggcca ggctggtctc aaactcctga cctccagtga tgcacccgcc tcggcctccc
     6961 aaagttctgg gattacaggc gtgagccacc gtgcccagcc cctatttttt ctgaaataat
     7021 ttttcggata tacttttata tttgaaatta gttgaacata agatgatcat caagcttgct
     7081 ataagtttta agctattgct acatttgaac aaagacccac gtacttatct tagaaagtac
     7141 ttaggatatc tttgagatta atggtgctac atcactctac agtactatgt aaaatgaatg
     7201 gagctgctgt tcctttctag ctagctgttt gtgtagttca tattaattta ccctgccttt
     7261 tatttggatt gtctgatttc ttagttgtac acatgaacct cattatttgc ctggaataag
     7321 taatcaaata aaattgcttt gataaata
//
