LOCUS       NM_001365906            5889 bp    mRNA    linear   PRI 29-OCT-2022
DEFINITION  Homo sapiens papilin, proteoglycan like sulfated glycoprotein
            (PAPLN), transcript variant 4, mRNA.
ACCESSION   NM_001365906 XM_011537290 XM_017021750
VERSION     NM_001365906.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5889)
  AUTHORS   Tola EN, Koroglu N, Yildirim GY and Koca HB.
  TITLE     The role of ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of
            uterosacral and cardinal ligaments in the etiopathogenesis of
            pelvic organ prolapse among women without stress urinary
            incontinence
  JOURNAL   Eur J Obstet Gynecol Reprod Biol 231, 158-163 (2018)
   PUBMED   30388611
  REMARK    GeneRIF: ADAMTS-2, collagen type-1, TIMP-3 and papilin levels of
            the uterosacral ligament play essential roles in the
            etiopathogenesis of pelvic organ prolapse among postmenopausal
            women without stress urinary incontinence.
REFERENCE   2  (bases 1 to 5889)
  AUTHORS   Apte SS.
  TITLE     A disintegrin-like and metalloprotease (reprolysin-type) with
            thrombospondin type 1 motif (ADAMTS) superfamily: functions and
            mechanisms
  JOURNAL   J Biol Chem 284 (46), 31493-31497 (2009)
   PUBMED   19734141
  REMARK    Review article
REFERENCE   3  (bases 1 to 5889)
  AUTHORS   Laje G, Allen AS, Akula N, Manji H, John Rush A and McMahon FJ.
  TITLE     Genome-wide association study of suicidal ideation emerging during
            citalopram treatment of depressed outpatients
  JOURNAL   Pharmacogenet Genomics 19 (9), 666-674 (2009)
   PUBMED   19724244
  REMARK    GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 5889)
  AUTHORS   Kramerova IA, Kawaguchi N, Fessler LI, Nelson RE, Chen Y, Kramerov
            AA, Kusche-Gullberg M, Kramer JM, Ackley BD, Sieron AL, Prockop DJ
            and Fessler JH.
  TITLE     Papilin in development; a pericellular protein with a homology to
            the ADAMTS metalloproteinases
  JOURNAL   Development 127 (24), 5475-5485 (2000)
   PUBMED   11076767
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004846.2.
            
            On or before Nov 30, 2019 this sequence version replaced
            XM_011537290.3, NM_001365906.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.9052.1,
                                           SRR18074969.2100357.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000644200.2/ ENSP00000495882.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC004846.2         119364-119450       c
            88-147              AC004846.2         117124-117183       c
            148-263             AC004846.2         112197-112312       c
            264-324             AC004846.2         111260-111320       c
            325-427             AC004846.2         110781-110883       c
            428-558             AC004846.2         106842-106972       c
            559-682             AC004846.2         105926-106049       c
            683-763             AC004846.2         105390-105470       c
            764-936             AC004846.2         105120-105292       c
            937-1060            AC004846.2         104815-104938       c
            1061-1187           AC004846.2         104181-104307       c
            1188-1395           AC004846.2         102995-103202       c
            1396-1578           AC004846.2         102261-102443       c
            1579-1720           AC004846.2         101938-102079       c
            1721-1801           AC004846.2         97897-97977         c
            1802-2078           AC004846.2         97411-97687         c
            2079-2199           AC004846.2         96127-96247         c
            2200-2338           AC004846.2         95662-95800         c
            2339-2816           AC004846.2         94129-94606         c
            2817-2954           AC004846.2         93174-93311         c
            2955-3079           AC004846.2         92621-92745         c
            3080-3218           AC004846.2         92230-92368         c
            3219-3356           AC004846.2         91449-91586         c
            3357-3484           AC004846.2         90328-90455         c
            3485-3593           AC004846.2         90125-90233         c
            3594-3760           AC004846.2         88233-88399         c
            3761-5889           AC004846.2         82333-84461         c
FEATURES             Location/Qualifiers
     source          1..5889
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.2"
     gene            1..5889
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /note="papilin, proteoglycan like sulfated glycoprotein"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
     exon            1..87
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            88..147
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..3930
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 4"
                     /codon_start=1
                     /product="papilin isoform 2 precursor"
                     /protein_id="NP_001352835.1"
                     /db_xref="CCDS:CCDS91898.1"
                     /db_xref="GeneID:89932"
                     /db_xref="HGNC:HGNC:19262"
                     /db_xref="MIM:617785"
                     /translation="MRLLLLVPLLLAPAPGSSAPKVRRQSDTWGPWSQWSPCSRTCGG
                     GVSFRERPCYSQRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCAEFDGAEFQGR
                     RYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDGSCRVVGCD
                     HELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRGYNQILIVPMGATSILIDEAAA
                     SRNFLAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAPERLHARGPTSE
                     PLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTID
                     HEAYPDHMCQRQPRPADRRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISS
                     DGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTC
                     RGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQ
                     VICAIGPPSHCGSLQHSKPVDVEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLGPQES
                     PASDSRGQWWAAQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSG
                     SGPHDCRHSPHGCCPDGHTASLGPQWQGCPGAPCQQSRYGCCPDRVSVAEGPHHAGCT
                     KSYGGDSTGGMPRSRAVASTVHNTHQPQAQQNEPSECRGSQFGCCYDNVATAAGPLGE
                     GCVGQPSHAYPVRCLLPSAHGSCADWAARWYFVASVGQCNRFWYGGCHGNANNFASEQ
                     ECMSSCQGSLHGPRRPQPGASGRSTHTDGGGSSPAGEQEPSQHRTGAAVQRKPWPSGG
                     LWRQDQQPGPGEAPHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGV
                     EPSLVQAALGQLVRLSCSDDTAPESQAAWQKDGQPISSDRHRLQFDGSLIIHPLQAED
                     AGTYSCGSTRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLG
                     AIPSSHPQPANRLRLDQNQPRVVDASPGQRIRMTCRAEGFPPPAIEWQRDGQPVSSPR
                     HQLQPDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPE
                     GDTARLLCVVAGESVNIRWSRNGLPVQADGHRVHQSPDGTLLIYNLRARDEGSYTCSA
                     YQGSQAVSRSTEVKVVSPAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFC
                     CASCSRFQPHAQPIWQ"
     exon            148..263
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            264..324
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            325..427
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            428..558
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            559..682
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            683..763
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            764..936
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1060
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1187
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1395
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1578
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1720
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1801
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..2078
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2199
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2338
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2816
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..2954
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3079
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3218
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3356
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3484
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3485..3593
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3760
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     exon            3761..5889
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5868..5873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /note="hexamer: AATAAA"
     polyA_site      5889
                     /gene="PAPLN"
                     /gene_synonym="PPN"
                     /note="major polyA site"
ORIGIN      
        1 gcggcccggc cgacctcgcg ggcttgggcc tgggcgggca ccgacggagc ggccctggct
       61 gcagcctccc ggcgccagcg aagacaggct gagatgcggc tgctcctgct cgtgccgctg
      121 ctgctggctc cagcgcccgg gtcctcggct cccaaggtga ggcggcagag tgacacctgg
      181 ggaccctgga gccagtggag cccctgcagc cggacctgtg gagggggtgt cagcttccgg
      241 gagcgcccct gctactccca gaggagagat ggaggctcca gctgcgtggg ccccgcccgg
      301 agccaccgct cttgtcgcac ggagagctgc cccgacggcg cccgggactt ccgggccgag
      361 cagtgcgcgg agttcgacgg agcggagttc caggggcggc ggtatcggtg gctgccctac
      421 tacagcgccc caaacaagtg tgaactgaac tgcattccca agggggagaa cttctactac
      481 aagcacaggg aggctgtggt tgatgggacg ccctgcgagc ctggcaagag ggatgtctgt
      541 gtggatggca gctgccgggt tgtcggctgt gatcacgagc tggactcgtc caagcaggag
      601 gacaagtgtc tgcggtgtgg gggtgacggc acgacctgct accccgtcgc aggcaccttt
      661 gacgctaatg acctcagccg aggctacaac cagatcctca tagttcccat gggtgccacc
      721 agcatcctca tcgacgaggc tgctgccagc aggaacttcc tggctgtgaa gaatgttcgt
      781 ggggaatact acctcaatgg gcactggacc atcgaggcgg cccgggccct gccagcagcc
      841 agcaccatcc tgcattacga gcggggtgct gagggggacc tggcccctga gcgactccat
      901 gcccggggcc ccacctcgga gcccctggtc atcgagctca tcagccagga gcccaacccc
      961 ggtgtgcact atgagtacca cctgcccctg cgccgcccca gccccggctt cagctggagc
     1021 cacggctcat ggagtgactg cagcgcggag tgtggcggag gtcaccagtc ccgcctggtg
     1081 ttctgcacca tcgaccatga ggcctacccc gaccacatgt gccagcgcca gccacggcca
     1141 gctgaccggc gttcctgcaa tcttcaccct tgcccggaga ccaagcgctg gaaggcaggg
     1201 ccatgggcac cctgctcagc ctcctgtgga ggaggctccc agtcccgctc cgtgtactgc
     1261 atctcgtctg acggggccgg catccaggag gccgtggagg aggctgagtg tgccgggctg
     1321 cctgggaagc cccctgccat tcaggcctgt aacctgcagc gctgtgcagc ctggagcccg
     1381 gagccctggg gagagtgttc tgtcagttgt ggcgttggcg tccggaagcg gagcgttact
     1441 tgccggggtg aaaggggttc tttgctccat accgcagcgt gctccttgga agaccggcca
     1501 cctctgactg agccctgtgt gcatgaggac tgccccctcc tcagtgacca ggcctggcat
     1561 gttggcacct ggggtctatg ctccaagagc tgcagctcgg gcactcggag gcgacaggtc
     1621 atctgtgcca ttgggccgcc cagccactgc gggagcctgc agcactccaa gcctgtggat
     1681 gtggagcctt gtaacacgca gccctgtcat ctcccccagg aggtccccag catgcaggat
     1741 gtgcacaccc ctgccagcaa cccctggatg ccgttgggcc ctcaggagtc ccctgcctca
     1801 gactccagag gccagtggtg ggcagcccag gaacacccct cagccagggg tgaccacagg
     1861 ggagaacgag gtgaccccag gggcgaccaa ggcacccacc tgtcagccct gggccccgct
     1921 ccctctctgc agcagccccc ataccagcaa cccctgcggt cgggctcagg gccccacgac
     1981 tgcagacaca gtcctcacgg gtgctgcccc gatggccaca cggcatctct cgggcctcag
     2041 tggcaaggct gccctggggc cccctgtcag cagagcaggt acgggtgctg ccctgacagg
     2101 gtatctgtcg ctgaggggcc ccatcacgct ggctgcacaa agtcgtatgg tggtgacagc
     2161 accgggggca tgcccaggtc aagggcagtg gcttctacag tccacaacac ccaccagccc
     2221 caggcccagc agaatgagcc cagtgagtgc cggggctccc agtttggctg ttgctatgac
     2281 aacgtggcca ctgcagccgg tcctcttggg gaaggctgtg tgggccagcc cagccatgcc
     2341 taccccgtgc ggtgcctgct gcccagtgcc catggctctt gcgcagactg ggctgcccgc
     2401 tggtacttcg ttgcctctgt gggccaatgt aaccgcttct ggtatggcgg ctgccatggc
     2461 aatgccaata actttgcctc ggagcaagag tgcatgagca gctgccaggg atctctccat
     2521 gggccccgtc gtccccagcc tggggcttct ggaaggagca cccacacgga tggtggcggc
     2581 agcagtcctg caggcgagca ggaacccagc cagcacagga caggggccgc ggtgcagaga
     2641 aagccctggc cttctggtgg tctctggcgg caagaccaac agcctgggcc aggggaggcc
     2701 ccccacaccc aggcctttgg agaatggcca tgggggcagg agcttgggtc cagggcccct
     2761 ggactgggtg gagatgccgg atcaccagcg ccacccttcc acagctcctc ctacaggatt
     2821 agcttggcag gtgtggagcc ctcgttggtg caggcagccc tggggcagtt ggtgcggctc
     2881 tcctgctcag acgacactgc cccggaatcc caggctgcct ggcagaaaga tggccagccc
     2941 atctcctctg acaggcacag gctgcagttc gacggatccc tgatcatcca ccccctgcag
     3001 gcagaggacg cgggcaccta cagctgtggc agcacccggc caggccgcga ctcccagaag
     3061 atccaacttc gcatcatagg gggtgacatg gccgtgctgt ctgaggctga gctgagccgc
     3121 ttccctcagc ccagggaccc agctcaggac tttggccaag cgggggctgc tgggcccctg
     3181 ggggccatcc cctcttcaca cccacagcct gcaaacaggc tgcgtttgga ccagaaccag
     3241 ccccgggtgg tggatgccag tccaggccag cggatccgga tgacctgccg tgccgaaggc
     3301 ttcccgcccc cagccatcga gtggcagaga gatgggcagc ctgtctcttc tcccagacac
     3361 cagctgcagc ctgatggctc cctggtcatt agccgagtgg ctgtagaaga tggcggcttc
     3421 tacacctgtg tcgctttcaa tgggcaggac cgagaccagc gatgggtcca gctcagagtt
     3481 ctgggggagc tgacaatctc aggactgccc cctactgtga cagtgccaga gggtgatacg
     3541 gccaggctat tgtgtgtggt agcaggagaa agtgtgaaca tcaggtggtc caggaacggg
     3601 ctacctgtgc aggctgatgg ccaccgtgtc caccagtccc cagatggcac gctgctcatt
     3661 tacaacttgc gggccaggga tgagggctcc tacacgtgca gtgcctacca ggggagccag
     3721 gcagtcagcc gcagcaccga ggtgaaggtg gtctcaccag cacccaccgc ccagcccagg
     3781 gaccctggca gggactgcgt cgaccagcca gagctggcca actgtgattt gatcctgcag
     3841 gcccagcttt gtggcaatga gtattactcc agcttctgct gtgccagctg ttcacgtttc
     3901 cagcctcacg ctcagcccat ctggcagtag ggatgaaggc tagttccagc cccagtccaa
     3961 aatagttcat agggctaggg agaaaggaag atggactctt ggcttcctct ctctggctgg
     4021 caaagggagt tatcttctgg aatacattag ctctttcaaa aacccaccca gtgtttagcc
     4081 tcaacggcag ccagttacca gcttctctct gtagccttca gcagtgtttg catctctgac
     4141 ataaccacag gctgctgttt tcaagaagag caatctgttt ggataagaaa aacctttact
     4201 ttacagcttc cctttataat ttgttacaca ggaatagtta aatgcatttg tttgtttgtt
     4261 ttttgagaca gagtttcact cttgttgccc aggctggagg gcaatggcgc gatctcagct
     4321 cactgcaacc tccgtctcct gggttcttga ttctcctgtg tcagccttct gagtagctag
     4381 gattacagat gcctatcacc atgcctgggt aatttttgta tttttagttg agatggggtt
     4441 tcaccatgtt ggccaggctg gtctcgaact tctgacctca gatgatctgc ccgcctcagc
     4501 ctcccaaagt gctgggatta caggcatgag ccaccacgcc cagccatcaa tgcatttttt
     4561 ttattttttt tttgagacag agtttcgcac ttcttgccca ggctggagta caatggtgcg
     4621 atcttggctc actgcaacct ccacctcctg ggttcaagcg cttctccagc ctcagcctcc
     4681 tgagtagctg ggattacagg tatgtgccac catgcctggc taattttgta tttttagtag
     4741 agacggggtt tctccatgtt ggtcagactg gtcttgaact cccgacctca ggtaatccgc
     4801 ccgcctcggc ctcccaaaat gctgggatta gaggtgtgag ccactgtgcc cagcccatca
     4861 atgtgtttta aagctagctg tcagggttcc acttaattta aagctgggca gggagatgtg
     4921 taatgatttc aaagttaaca cctgtttgtt ttctaaaggg catgccaagt cctgctgtat
     4981 cagggaagta ttctgtgcta aaatcagcga tggttcattg ctctagtctc tctcaccctt
     5041 ctaggcagtg catcagtcag ctctaaatct ggtgcagagg gttaacagca taacccttgt
     5101 tggcaaaatg gaatagatgt taagacctca aatagggatt tgggatgaaa cagctgcagt
     5161 tagcactgtt atctgagcat gaaagaactg gaaacgctcc ttacgtcgag atgttggacc
     5221 ttgaagccct cctgaggcca acatgcaaat ctggctgtga cggttcatct gacacctgtg
     5281 taaagctgac cagcctgctc tgtacagtga caatgaggag cccctctctt ccttaagtag
     5341 gaatctgtga agcaaaatgt ttgctgccaa agacaaatca gactgtcagt cattaaaaac
     5401 agcattagca ggatgaggat agcaatgggg aagggttgtg ggcaatgcag taacagggaa
     5461 atggcttcag aaatggtttg agttggaaga caacattctt catctctcag gacttctaat
     5521 tccttgatgc taaaagaaga ggcatggatt ctatgagctt ccaagtccct ttccacttta
     5581 accttctaca aatctttcag aggactgcct agtagcaaag gttattcctg gacacaggaa
     5641 agacgggcat tacagggacc aaagctctga aaggtgactt ttattaccaa cacactggct
     5701 ggaaaaggga caaaccacat cacgggtgag tgatacttct cagtcttctc tactcattca
     5761 acaaaggaaa tgtgggctgg ggcagaggtc ttttttcatt taatactgga aaaatattga
     5821 agagcatcca tgttcactta tggctggttt tgctatagaa attggaaaat aaaggccact
     5881 tttttgaaa
//
