LOCUS       NM_152911               1830 bp    mRNA    linear   PRI 15-AUG-2022
DEFINITION  Homo sapiens polyamine oxidase (PAOX), transcript variant 1, mRNA.
ACCESSION   NM_152911
VERSION     NM_152911.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1830)
  AUTHORS   Kim JH and Lee ST.
  TITLE     Polyamine Oxidase Expression Is Downregulated by 17beta-Estradiol
            via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells
  JOURNAL   Int J Mol Sci 23 (14), 7521 (2022)
   PUBMED   35886868
  REMARK    GeneRIF: Polyamine Oxidase Expression Is Downregulated by
            17beta-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast
            Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1830)
  AUTHORS   Wang K, Huang Q, Zhao G, Yang J, Yang K and Huang Y.
  TITLE     Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX rs1046175
            affect the diagnostic value of plasma Pro-SFTPB and DAS in Chinese
            Han non-small-cell lung cancer patients
  JOURNAL   J Cell Biochem 120 (9), 14804-14812 (2019)
   PUBMED   31016788
  REMARK    GeneRIF: Gene polymorphisms of SFTPB rs7316, rs9752 and PAOX
            rs1046175 affect the diagnostic value of plasma Pro-SFTPB and DAS
            in Chinese Han non-small-cell lung cancer patients.
REFERENCE   3  (bases 1 to 1830)
  AUTHORS   Salati S, Zini R, Nuzzo S, Guglielmelli P, Pennucci V, Prudente Z,
            Ruberti S, Rontauroli S, Norfo R, Bianchi E, Bogani C, Rotunno G,
            Fanelli T, Mannarelli C, Rosti V, Salmoiraghi S, Pietra D, Ferrari
            S, Barosi G, Rambaldi A, Cazzola M, Bicciato S, Tagliafico E,
            Vannucchi AM and Manfredini R.
  CONSRTM   AGIMM (AIRC Gruppo Italiano Malattie Mieloproliferative)
            investigators
  TITLE     Integrative analysis of copy number and gene expression data
            suggests novel pathogenetic mechanisms in primary myelofibrosis
  JOURNAL   Int J Cancer 138 (7), 1657-1669 (2016)
   PUBMED   26547506
  REMARK    GeneRIF: copy number gain in the polyamine oxidase (PAOX) gene
            locus was accompanied by a coordinated transcriptional
            up-regulation in Primary myelofibrosis patients
REFERENCE   4  (bases 1 to 1830)
  AUTHORS   Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R, Huang J,
            Arnold M, Erte I, Forgetta V, Yang TP, Walter K, Menni C, Chen L,
            Vasquez L, Valdes AM, Hyde CL, Wang V, Ziemek D, Roberts P, Xi L,
            Grundberg E, Waldenberger M, Richards JB, Mohney RP, Milburn MV,
            John SL, Trimmer J, Theis FJ, Overington JP, Suhre K, Brosnan MJ,
            Gieger C, Kastenmuller G, Spector TD and Soranzo N.
  CONSRTM   Multiple Tissue Human Expression Resource (MuTHER) Consortium
  TITLE     An atlas of genetic influences on human blood metabolites
  JOURNAL   Nat Genet 46 (6), 543-550 (2014)
   PUBMED   24816252
REFERENCE   5  (bases 1 to 1830)
  AUTHORS   Bjelakovic G, Beninati S, Bjelakovic B, Sokolovic D, Jevtovic T,
            Stojanovic I, Rossi S, Tabolacci C, Kocic G, Pavlovic D, Saranac Lj
            and Zivic S.
  TITLE     Does polyamine oxidase activity influence the oxidative metabolism
            of children who suffer of diabetes mellitus?
  JOURNAL   Mol Cell Biochem 341 (1-2), 79-85 (2010)
   PUBMED   20405312
  REMARK    GeneRIF: PAO activity in children with type 1 diabetes mellitus was
            very high; higher blood HbA(1C) and MDA levels confirm the presence
            of oxidant stress demonstrate that PAO activity may participate in
            these circumstances
REFERENCE   6  (bases 1 to 1830)
  AUTHORS   Jarvinen A, Keinanen TA, Grigorenko NA, Khomutov AR, Uimari A,
            Vepsalainen J, Narvanen A, Alhonen L and Janne J.
  TITLE     Guide molecule-driven stereospecific degradation of
            alpha-methylpolyamines by polyamine oxidase
  JOURNAL   J Biol Chem 281 (8), 4589-4595 (2006)
   PUBMED   16354669
  REMARK    GeneRIF: polyamine oxidase degrades alpha-methylpolyamines in a
            stereospecific manner
REFERENCE   7  (bases 1 to 1830)
  AUTHORS   Pledgie A, Huang Y, Hacker A, Zhang Z, Woster PM, Davidson NE and
            Casero RA Jr.
  TITLE     Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is
            the primary source of cytotoxic H2O2 in polyamine analogue-treated
            human breast cancer cell lines
  JOURNAL   J Biol Chem 280 (48), 39843-39851 (2005)
   PUBMED   16207710
  REMARK    GeneRIF: SSAT and SMO(PAOh1) activities are the major mediators of
            the cellular response of breast tumor cells to polyamines while PAO
            plays little or no role in this response
REFERENCE   8  (bases 1 to 1830)
  AUTHORS   Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J,
            Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D,
            Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS,
            Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M,
            Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J,
            Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods
            K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard
            A, Wood WI, Godowski P and Gray A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1830)
  AUTHORS   Wu T, Yankovskaya V and McIntire WS.
  TITLE     Cloning, sequencing, and heterologous expression of the murine
            peroxisomal flavoprotein, N1-acetylated polyamine oxidase
  JOURNAL   J Biol Chem 278 (23), 20514-20525 (2003)
   PUBMED   12660232
REFERENCE   10 (bases 1 to 1830)
  AUTHORS   Vujcic S, Liang P, Diegelman P, Kramer DL and Porter CW.
  TITLE     Genomic identification and biochemical characterization of the
            mammalian polyamine oxidase involved in polyamine back-conversion
  JOURNAL   Biochem J 370 (Pt 1), 19-28 (2003)
   PUBMED   12477380
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF312698.1 and BE646315.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152911.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032778.1, SRR1163657.289408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000278060.10/ ENSP00000278060.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1581              AF312698.1         72-1652
            1582-1830           BE646315.1         3-251               c
FEATURES             Location/Qualifiers
     source          1..1830
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.3"
     gene            1..1830
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /note="polyamine oxidase"
                     /db_xref="GeneID:196743"
                     /db_xref="HGNC:HGNC:20837"
                     /db_xref="MIM:615853"
     exon            1..236
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1591
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /EC_number="1.5.3.13"
                     /note="isoform 1 is encoded by transcript variant 1;
                     peroxisomal N1-acetyl-spermine/spermidine oxidase;
                     peroxisomal N(1)-acetyl-spermine/spermidine oxidase;
                     polyamine oxidase (exo-N4-amino)"
                     /codon_start=1
                     /product="peroxisomal N(1)-acetyl-spermine/spermidine
                     oxidase isoform 1"
                     /protein_id="NP_690875.1"
                     /db_xref="CCDS:CCDS7683.1"
                     /db_xref="GeneID:196743"
                     /db_xref="HGNC:HGNC:20837"
                     /db_xref="MIM:615853"
                     /translation="MESTGSVGEAPGGPRVLVVGGGIAGLGAAQRLCGHSAFPHLRVL
                     EATARAGGRIRSERCFGGVVEVGAHWIHGPSRGNPVFQLAAEYGLLGEKELSQENQLV
                     ETGGHVGLPSVSYASSGASVSLQLVAEMATLFYGLIDQTREFLHAAETPVPSVGEYLK
                     KEIGQHVAGWTEDEETRKLKLAVLNSFFNLECCVSGTHSMDLVALAPFGEYTVLPGLD
                     CTFSKGYQGLTNCMMAALPEDTVVFEKPVKTIHWNGSFQEAAFPGETFPVSVECEDGD
                     RFPAHHVIVTVPLGFLREHLDTFFDPPLPAEKAEAIRKIGFGTNNKIFLEFEEPFWEP
                     DCQLIQLVWEDTSPLEDAAPELQDAWFRKLIGFVVLPAFASVHVLCGFIAGLESEFME
                     TLSDEEVLLCLTQVLRRVTGNPRLPAPKSVLRSRWHSAPYTRGSYSYVAVGSTGGDLD
                     LLAQPLPADGAGAQLQILFAGEATHRTFYSTTHGALLSGWREADRLLSLWAPQVQQPR
                     PRL"
     exon            237..723
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     exon            724..923
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1176
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1289
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1447
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1830
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1809..1814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /note="hexamer: CATAAA"
     polyA_site      1830
                     /gene="PAOX"
                     /gene_synonym="PAO"
                     /note="major polyA site"
ORIGIN      
        1 gagagctcca gacctcccgg ctactcagaa gccctcggac tgcccggacc gcgcgatgga
       61 gtcgaccggc agcgtcgggg aggccccggg cggaccccgg gtgctggtgg tgggcggcgg
      121 catcgcgggg ctgggcgcgg cgcagaggct ctgcggccac tccgccttcc cgcacctgcg
      181 ggtcctggag gccacggccc gcgccggggg ccgcatccgc tcggagcgct gcttcggtgg
      241 cgtggtggag gtgggcgcgc actggatcca tgggccctcc cggggtaacc ccgtcttcca
      301 gctggctgct gagtacgggc tgctggggga gaaggagctg tcccaggaga accagctggt
      361 ggagaccggg ggtcacgtgg gcctgccctc cgtgagctac gccagctccg gggccagcgt
      421 gagcctccag ctggtggcgg agatggcgac tctgttctac ggcctgatag accagacccg
      481 ggagttcctg cacgctgcag agaccccggt gcccagcgtc ggggagtacc tcaagaagga
      541 gattggccag cacgtggccg gctggacaga ggatgaggag accaggaagc tgaagctggc
      601 cgtcctgaac tccttcttca acctggaatg ctgtgtgagc ggcacccaca gcatggacct
      661 ggtggccctg gcaccctttg gggagtatac cgtgctgccg gggctggact gcaccttttc
      721 taagggctat caaggactca caaactgcat gatggccgcc ctgccggagg acactgtagt
      781 ttttgagaag cctgtgaaga ccatccactg gaacgggtcc ttccaggagg cagcctttcc
      841 cggggagacc tttccagtgt cggtagagtg tgaggatgga gaccggttcc cggcgcacca
      901 tgtcatcgtc accgtgccct taggttttct tagggaacat ttggacacct tctttgaccc
      961 tcccctgccg gctgagaagg cagaagcaat caggaagata ggctttggga ccaacaacaa
     1021 aatcttcctg gagtttgagg agcccttctg ggagccagac tgccagctga tccagctggt
     1081 gtgggaggac acgtcgcccc tggaggatgc tgcccctgag ctacaggacg cctggttccg
     1141 gaagctcatt ggctttgtgg tcctgcctgc ctttgcgtct gtccacgttc tctgtgggtt
     1201 cattgccgga cttgagtctg agttcatgga gactctgtcg gatgaagaag tacttctgtg
     1261 tctcacccaa gtgctccgga gagtgacagg aaacccacgg ctccccgcgc ccaagagcgt
     1321 cctgcggtct cgctggcaca gcgccccgta cactaggggg tcctacagct acgtggccgt
     1381 gggcagtact gggggcgacc tggacctgct ggctcagccc ctccctgcag acggcgccgg
     1441 cgcccagctc cagatcctgt ttgcggggga agccacacat cgcacgtttt actccacgac
     1501 gcacggggct ctgctgtcgg gatggaggga ggccgaccgc ctcctcagtc tgtgggcccc
     1561 gcaggtgcag cagcccaggc ccaggctcta gctgggccca gcctactctg ttccacccgt
     1621 gtcgggggta ggctgggacc ctcatttctt ctgacagatt tcagtctggc ttgaaatttg
     1681 gggatgttaa tgagggtcct ctggtttttg gtaaccaggg ccaccttctc agttcttgtg
     1741 tctgttattg gagtctggcc agggttgact tgagctgaga caccagatgc tcacggagat
     1801 gctggacaca taaagcaagt tacagccaca
//
