LOCUS       NM_052959               1729 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens pannexin 3 (PANX3), mRNA.
ACCESSION   NM_052959
VERSION     NM_052959.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Belonogova,N.M., Kirichenko,A.V., Freidin,M.B., Williams,F.M.K.,
            Suri,P., Aulchenko,Y.S., Axenovich,T.I. and Tsepilov,Y.A.
  TITLE     Noncoding rare variants in PANX3 are associated with chronic back
            pain
  JOURNAL   Pain 164 (4), 864-869 (2023)
   PUBMED   36448979
  REMARK    GeneRIF: Noncoding rare variants in PANX3 are associated with
            chronic back pain.
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Guerrero,J., Oliveira,H., Aid,R., Bareille,R., Siadous,R.,
            Letourneur,D., Mao,Y., Kohn,J. and Amedee,J.
  TITLE     Influence of the three-dimensional culture of human bone marrow
            mesenchymal stromal cells within a macroporous polysaccharides
            scaffold on Pannexin 1 and Pannexin 3
  JOURNAL   J Tissue Eng Regen Med 12 (4), e1936-e1949 (2018)
   PUBMED   29222846
  REMARK    GeneRIF: Influence of the three-dimensional culture of human bone
            marrow mesenchymal stromal cells within a macroporous
            polysaccharides scaffold on Pannexin 1 and Pannexin 3.
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Hainz,N., Beckmann,A., Schubert,M., Haase,A., Martin,U.,
            Tschernig,T. and Meier,C.
  TITLE     Human stem cells express pannexins
  JOURNAL   BMC Res Notes 11 (1), 54 (2018)
   PUBMED   29357945
  REMARK    GeneRIF: All three pannexins Panx1, Panx2, and Panx3 mRNAs were
            expressed in all of the analyzed undifferentiated stem cell lines.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Song,F., Sun,H., Wang,Y., Yang,H., Huang,L., Fu,D., Gan,J. and
            Huang,C.
  TITLE     Pannexin3 inhibits TNF-alpha-induced inflammatory response by
            suppressing NF-kappaB signalling pathway in human dental pulp cells
  JOURNAL   J Cell Mol Med 21 (3), 444-455 (2017)
   PUBMED   27679980
  REMARK    GeneRIF: Panx3 has a defensive role in dental pulp inflammation.
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Song,F., Sun,H., Huang,L., Fu,D. and Huang,C.
  TITLE     The Role of Pannexin3-Modified Human Dental Pulp-Derived
            Mesenchymal Stromal Cells in Repairing Rat Cranial Critical-Sized
            Bone Defects
  JOURNAL   Cell Physiol Biochem 44 (6), 2174-2188 (2017)
   PUBMED   29241211
  REMARK    GeneRIF: Panx3 was upregulated during osteogenic differentiation in
            a time-dependent manner. Panx3 overexpression promoted osteogenic
            differentiation of human dental pulp-derived mesenchymal stromal
            cells, whereas depletion of Panx3 resulted in a decline of
            differentiation.
REFERENCE   6  (bases 1 to 1729)
  AUTHORS   Iwamoto,T., Nakamura,T., Doyle,A., Ishikawa,M., de Vega,S.,
            Fukumoto,S. and Yamada,Y.
  TITLE     Pannexin 3 regulates intracellular ATP/cAMP levels and promotes
            chondrocyte differentiation
  JOURNAL   J Biol Chem 285 (24), 18948-18958 (2010)
   PUBMED   20404334
  REMARK    GeneRIF: Panx3 functions to switch the chondrocyte cell fate from
            proliferation to differentiation by regulating the intracellular
            ATP/cAMP levels
REFERENCE   7  (bases 1 to 1729)
  AUTHORS   Bhalla-Gehi,R., Penuela,S., Churko,J.M., Shao,Q. and Laird,D.W.
  TITLE     Pannexin1 and pannexin3 delivery, cell surface dynamics, and
            cytoskeletal interactions
  JOURNAL   J Biol Chem 285 (12), 9147-9160 (2010)
   PUBMED   20086016
  REMARK    GeneRIF: although Panx1 and Panx3 share a common endoplasmic
            reticulum to Golgi secretory pathway to Cx43, their ultimate cell
            surface residency appears to be independent of cell contacts and
            the need for intact microtubules
REFERENCE   8  (bases 1 to 1729)
  AUTHORS   Penuela,S., Bhalla,R., Gong,X.Q., Cowan,K.N., Celetti,S.J.,
            Cowan,B.J., Bai,D., Shao,Q. and Laird,D.W.
  TITLE     Pannexin 1 and pannexin 3 are glycoproteins that exhibit many
            distinct characteristics from the connexin family of gap junction
            proteins
  JOURNAL   J Cell Sci 120 (Pt 21), 3772-3783 (2007)
   PUBMED   17925379
  REMARK    GeneRIF: These studies show that Panx1 and Panx3 have many
            characteristics that are distinct from Cx43 and that these proteins
            probably play an important biological role as single membrane
            channels.
REFERENCE   9  (bases 1 to 1729)
  AUTHORS   Baranova,A., Ivanov,D., Petrash,N., Pestova,A., Skoblov,M.,
            Kelmanson,I., Shagin,D., Nazarenko,S., Geraymovych,E., Litvin,O.,
            Tiunova,A., Born,T.L., Usman,N., Staroverov,D., Lukyanov,S. and
            Panchin,Y.
  TITLE     The mammalian pannexin family is homologous to the invertebrate
            innexin gap junction proteins
  JOURNAL   Genomics 83 (4), 706-716 (2004)
   PUBMED   15028292
REFERENCE   10 (bases 1 to 1729)
  AUTHORS   Bruzzone,R., Hormuzdi,S.G., Barbe,M.T., Herb,A. and Monyer,H.
  TITLE     Pannexins, a family of gap junction proteins expressed in brain
  JOURNAL   Proc Natl Acad Sci U S A 100 (23), 13644-13649 (2003)
   PUBMED   14597722
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001524.4 and AF406650.1.
            
            On May 17, 2019 this sequence version replaced NM_052959.2.
            
            Summary: The protein encoded by this gene belongs to the innexin
            family. Innexin family members are known to be the structural
            components of gap junctions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF406650.1, SRR1660807.73215.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2142853 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000284288.3/ ENSP00000284288.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AP001524.4         86400-86528
            130-1729            AF406650.1         1-1600
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..1729
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /note="pannexin 3"
                     /db_xref="GeneID:116337"
                     /db_xref="HGNC:HGNC:20573"
                     /db_xref="MIM:608422"
     exon            1..310
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1308
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /note="gap junction protein pannexin 3"
                     /codon_start=1
                     /product="pannexin-3"
                     /protein_id="NP_443191.1"
                     /db_xref="CCDS:CCDS8447.1"
                     /db_xref="GeneID:116337"
                     /db_xref="HGNC:HGNC:20573"
                     /db_xref="MIM:608422"
                     /translation="MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVG
                     SPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMK
                     SLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQH
                     MLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLI
                     FTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSS
                     VAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLR
                     ANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
                     "
     exon            311..453
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /inference="alignment:Splign:2.1.0"
     exon            454..668
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /inference="alignment:Splign:2.1.0"
     exon            669..1729
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /note="hexamer: AATAAA"
     polyA_site      1729
                     /gene="PANX3"
                     /gene_synonym="PX3"
                     /note="major polyA site"
ORIGIN      
        1 agagatatcc ataaggctgg ggtggcaggc actgtctgcc caaagtcagc tgcctgaagc
       61 tgccgtctcc tcattccacc atcccaggac ccctgctgcc acctctgcac ccccaagctc
      121 agcagcatca tgtcacttgc acacacagct gcagagtaca tgctctcaga tgccctgctg
      181 cctgaccgca ggggaccccg cctcaaagga ctgcgtctgg aactgcccct ggaccggata
      241 gtcaagttcg tagctgtggg ctcccccttg ttgctgatgt ccctggcatt cgcccaggag
      301 ttctcctctg ggtctccgat cagctgcttc tctcccagta acttcagcat ccggcaggca
      361 gcctacgtgg acagctcctg ctgggactca ctgcttcacc ataagcagga cgggcctggc
      421 caggacaaaa tgaaatctct ctggccccac aaggccctcc cctactccct gctggccctg
      481 gccttgctca tgtacctgcc ggtgctgctg tggcagtatg cagctgtgcc agccctcagc
      541 tccgatctgc tgttcatcat cagcgaactg gacaaatctt ataatcgctc catccgcctc
      601 gtgcagcaca tgctgaagat ccggcagaag agttccgacc cctatgtgtt ctggaatgag
      661 ctggagaagg ctcggaaaga acgatacttt gaattccctt tgctagagcg gtacctggca
      721 tgtaagcagc gttcacattc gctagtggct acctacctcc tgaggaactc cctcttgctc
      781 atcttcacct ccgccactta cctatacctt ggtcatttcc atctggatgt cttcttccag
      841 gaagaattca gctgctccat caagacaggg ctgctaagtg atgagaccca tgtccccaat
      901 ctgatcacat gcaggctgac atcactgtcc attttccaga ttgttagcct ctccagtgta
      961 gcaatataca ccatattggt tccagtgata atatacaacc tcacacggct atgtcggtgg
     1021 gacaaacgac ttttatctgt ctatgagatg ctcccagctt ttgatctcct cagcagaaag
     1081 atgctaggat gtcccatcaa tgacctcaat gtgatccttc ttttcctccg agctaacatc
     1141 tctgagctca tctcttttag ctggctgagt gtcttatgtg tgttgaagga tacaaccacc
     1201 cagaagcaca atattgacac agtagttgat tttatgactt tattggctgg cttagaaccc
     1261 tcaaaaccca aacacctcac caactcggca tgtgatgaac acccatagtt aagaaaccat
     1321 ggagcaagaa agcttgtgga aagtctctct ccttcctcat aagacatgca cactaataca
     1381 catacacacc aaaaaattac acattttaaa actgctaagc ttggatttaa ctgaatcata
     1441 tatcttttat catgttatcc taaaagtgag aagacataac caagacatgg aaataaatgt
     1501 gaaagctgga gccgaagagt caaagagcta aaaaattaag tctagaacat tctatgagga
     1561 tagtataaat aaaaagaaat acagtctaga catgctgcaa ggaaagaaga ttctaaagtc
     1621 cgtttatgga ggcaattcca tatcctttct tgaacgcaca ttcagcttac cccagagagc
     1681 aagtgaggca atctggcaaa agattaataa agatgtaaac ccctggaaa
//
